The DOI matches its Crossref record; 39 of the 39 references it cites were found in a registry or an index.
The cost-effectiveness of universal screening in pregnancy for subclinical hypothyroidism
Abstract
Objective The purpose of this study was to determine whether routine screening for subclinical hypothyroidism during pregnancy would be cost-effective.Study design We developed a decision analysis model to compare the cost-effectiveness of 2 screening strategies during pregnancy for subclinical hypothyroidism: (1) no routine screening of serum thyroid-stimulating hormone (TSH) levels (standard) and (2) routine screening of TSH levels. In the latter, women with subclinical hypothyroidism received thyroid hormone replacement. We assumed that thyroid hormone replacement could reduce the incidence of an offspring IQ < 85 for pregnancies with subclinical hypothyroidism. The main outcome measure was marginal cost per quality-adjusted life year (QALY) gained.Results Our model predicts that universal screening is the dominant strategy. For every 100,000 pregnant women who were screened, $8,356,383 are saved, and 589.3 QALYs are gained. When subclinical hypothyroidism prevalence is reduced to 0.25%, screening remains cost-effective at $21,664/QALY gained.Conclusion Screening for subclinical hypothyroidism in pregnancy will be a cost-effective strategy under a wide range of circumstances.
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“two recent initiatives in the US 98 and Europe 99 have included prevention among the top priorities for mental health research.”
From Preventive strategies for mental health (2018) · cites this paper as [98]
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Low Serum Thyrotropin Concentrations as a Risk Factor for Atrial Fibrillation in Older Persons
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Stagnaro-Green, A., Abalovich, M., Alexander, E., Azizi, F., Mestman, J., Negro, R., Nixon, A., Pearce, E. N., Soldin, O. P., Sullivan, S., et al. (2011) · Thyroid · doi:10.1089/thy.2011.0087 · Cited by 2,942
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Preventive strategies for mental health
Arango, C., Díaz-Caneja, C. M., McGorry, P. D., Rapoport, J., Sommer, I. E., Vorstman, J. A., McDaid, D., Marín, O., Serrano-Drozdowskyj, E., Freedman, R., et al. (2018) · The Lancet Psychiatry · doi:10.1016/s2215-0366(18)30057-9 · Cited by 1,271
Metadata
- Authors
- Thung, S. F., Funai, E. F., & Grobman, W. A.
- Affiliations
- Yale University (US)
- Northwestern University (US)
- Venue
- American Journal of Obstetrics and Gynecology
- Publisher
- Elsevier BV
- Published
- 2009-03
- Volume
- 200
- Issue
- 3
- Pages
- 267.e1-267.e7
- ISSN
- 0002-9378 (ISSN-L)
- OpenAlex
- W2006626665
- Cited by
- 115
- References
- 39
- Citations by year
- 2025: 3 · 2024: 1 · 2023: 4 · 2022: 3 · 2021: 3 · 2020: 3 · 2019: 7 · 2018: 5 · 2017: 10 · 2016: 4 · 2015: 7 · 2014: 9 · 2013: 15 · 2012: 18
- FWCI
- 5.08
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- American Journal of Obstetrics and Gynecology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
- Social Sciences › Economics, Econometrics and Finance › Economics and Econometrics › Health Systems, Economic Evaluations, Quality of Life
- Health Sciences › Medicine › Surgery › Thyroid and Parathyroid Surgery
- Keywords
- subclinical hypothyroidism, pregnancy, universal screening, cost-effectiveness, thyroid-stimulating hormone, thyroid hormone replacement, quality-adjusted life years, decision-analytic model
- MeSH terms
- Cost-Benefit Analysis, Decision Trees, Female, Humans, Hypothyroidism, Infant, Newborn, Mass Screening, Pregnancy, Pregnancy Complications, Thyrotropin, Incidence, Prevalence, Quality-Adjusted Life Years
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