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Maternal immunization with tetanus–diphtheria–pertussis vaccine: effect on maternal and neonatal serum antibody levels
Abstract
Objective We sought to determine whether tetanus-diphtheria-pertussis vaccination (Tdap) in pregnancy provides newborns antibodies against pertussis when compared to mothers who did not receive Tdap. Study design Paired maternal and umbilical cord blood samples were collected at the time of delivery and the serum stored at -86°C. For each paired sample of maternal and cord blood, the medical chart and vaccine history was reviewed to determine whether Tdap was received or not. Results Newborns born from mothers who received Tdap during pregnancy had significantly higher concentrations of diphtheria antitoxin (P Conclusion Administering Tdap during pregnancy increases antibody titers against diphtheria and pertussis antigens. Maternal Tdap may prevent neonatal pertussis infection.
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“maternal vaccination against pertussis has been demonstrated to have an effectiveness of over 90% at preventing disease in infants up to 3 months of age (22–24).”
From Factors Affecting the FcRn-Mediated Transplacental Transfer of Antibodies and Implications for Vaccination in Pregnancy (2017) · cites this paper as [23]
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Metadata
- Authors
- Gall, S. A., Myers, J., & Pichichero, M.
- Affiliations
- University of Louisville (US)
- Rochester General Hospital (US)
- Venue
- American Journal of Obstetrics and Gynecology
- Publisher
- Elsevier BV
- Published
- 2011-04
- Volume
- 204
- Issue
- 4
- Pages
- 334.e1-334.e5
- ISSN
- 0002-9378 (ISSN-L)
- OpenAlex
- W1975504291
- Cited by
- 226
- References
- 20
- Citations by year
- 2026: 4 · 2025: 4 · 2024: 3 · 2023: 8 · 2022: 6 · 2021: 17 · 2020: 4 · 2019: 16 · 2018: 28 · 2017: 15 · 2016: 20 · 2015: 19 · 2014: 31 · 2013: 23 · 2012: 20
- FWCI
- 24.24
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Obstetrics and Gynecology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Immunology and Microbiology › Microbiology › Bacterial Infections and Vaccines
- Health Sciences › Medicine › Infectious Diseases › Diphtheria, Corynebacterium, and Tetanus
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Neonatal and Maternal Infections
- Keywords
- maternal immunization, Tdap vaccine, pregnancy, neonatal pertussis, passive immunity, umbilical cord blood, maternal serum antibodies, diphtheria antitoxin, pertussis toxin, filamentous hemagglutinin, pertactin
- MeSH terms
- Antibodies, Bacterial Outer Membrane Proteins, Diphtheria Antitoxin, Female, Humans, Infant, Newborn, Virulence Factors, Bordetella, Pregnancy, Tetanus Antitoxin, Diphtheria-Tetanus-Pertussis Vaccine, Adhesins, Bacterial, Fimbriae Proteins, Pertussis Toxin
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