Pregnancy and infection: using disease pathogenesis to inform vaccine strategy
Open accessAbstract
Vaccination is the mainstay of preventative medicine for many infectious diseases. Pregnant women, unborn fetuses, and neonates represent three at-risk populations that can be simultaneously protected by strategic vaccination protocols. Because the pathogenesis of different infectious microbes varies based on tissue tropism, timing of infection, and host susceptibility, the goals of immunization are not uniform across all vaccines. Mechanistic understanding of infectious disease pathogenesis and immune responses is therefore essential to inform vaccine design and the implementation of appropriate immunization protocols that optimize protection of pregnant women, fetuses, and neonates.
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The dynamic nature of the immune system during pregnancy increases a person's susceptibility to infectious diseases.
“The dynamic nature of the immune system during pregnancy increases a person’s susceptibility to infectious diseases, and infection can have disastrous impacts on maternal health and fetal development219.”
From mRNA vaccines for infectious diseases: principles, delivery and clinical translation (2021) · cites this paper as [219]
Infection during pregnancy can have disastrous impacts on maternal health and fetal development.
“The dynamic nature of the immune system during pregnancy increases a person’s susceptibility to infectious diseases, and infection can have disastrous impacts on maternal health and fetal development219.”
From mRNA vaccines for infectious diseases: principles, delivery and clinical translation (2021) · cites this paper as [219]
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- Authors
- Vermillion, M. S., & Klein, S. L.
- Affiliations
- Johns Hopkins University (US)
- Corresponding author
- Klein, Sabra L.
- Venue
- npj Vaccines
- Published
- 2018-02-01
- Volume
- 3
- Issue
- 1
- Pages
- 6-6
- ISSN
- 2059-0105 (ISSN-L)
- PMC
- PMC5794984
- OpenAlex
- W2796627031
- Cited by
- 39
- References
- 178
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 3 · 2023: 7 · 2022: 6 · 2021: 7 · 2020: 5 · 2019: 4 · 2018: 4
- FWCI
- 0.51
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- npj Vaccines (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Funders
- Fisher Center for Alzheimer's Research Foundation
- Johns Hopkins University
- National Institutes of Health (T32OD011089)
- National Institute of General Medical Sciences (T32GM008752)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Immune responses and vaccinations
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Neonatal and Maternal Infections
- Life Sciences › Immunology and Microbiology › Microbiology › Bacterial Infections and Vaccines
- Keywords
- pregnancy, infection, vaccine design, pathogenesis, maternal immunization, fetal protection, neonatal protection, tissue tropism, timing of infection, host susceptibility, immune response, vaccination protocols
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