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Cited by 248Influenza Virus Research StudiesRespiratory viral infections researchVaccine Coverage and Hesitancy

Impact of maternal immunization on influenza hospitalizations in infants

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Poehling, Katherine A., Szilagyi, Peter G., Staat, Mary A., Snively, Beverly M., Payne, Daniel C., Bridges, Carolyn B., Chu, Susan Y., Light, Laney S. +4 more·2011·American Journal of Obstetrics and Gynecology
DOI 10.1016/j.ajog.2011.02.042PMC PMC3111909
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Abstract

We sought to determine whether maternal vaccination during pregnancy was associated with a reduced risk of laboratory-confirmed influenza hospitalizations in infants <6 months old. Active population-based, laboratory-confirmed influenza surveillance was conducted in children hospitalized with fever and/or respiratory symptoms in 3 US counties from November through April during the 2002 through 2009 influenza seasons. The exposure, influenza vaccination during pregnancy, and the outcome, positive/negative influenza testing among their hospitalized infants, were compared using logistic regression analyses. Among 1510 hospitalized infants <6 months old, 151 (10%) had laboratory-confirmed influenza and 294 (19%) mothers reported receiving influenza vaccine during pregnancy. Eighteen (12%) mothers of influenza-positive infants and 276 (20%) mothers of influenza-negative infants were vaccinated (unadjusted odds ratio, 0.53; 95% confidence interval, 0.32-0.88 and adjusted odds ratio, 0.52; 95% confidence interval, 0.30-0.91). Infants of vaccinated mothers were 45-48% less likely to have influenza hospitalizations than infants of unvaccinated mothers. Our results support the current influenza vaccination recommendation for pregnant women.

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  • Infants of influenza-vaccinated mothers were 45-63% less likely to have episodes of proven influenza illness in early infancy (4-6 months of age).

    “infants of influenza vaccinated mothers were 45–63% less likely to have episodes of proven influenza illness in early infancy (4–6 months of age).”

    From Factors Affecting the FcRn-Mediated Transplacental Transfer of Antibodies and Implications for Vaccination in Pregnancy (2017) · cites this paper as [14]

    The Results and Comment sections report that infants of vaccinated mothers were 45%–48% less likely to have laboratory-confirmed influenza hospitalizations. The Comment also reports a 63% effectiveness estimate from a separate trial, but this paper does not establish a 45%–63% reduction in influenza illness specifically at ages 4–6 months; its own study concerned hospitalized infants younger than 6 months. (LLM, conf=0.88)

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  • Maternal vaccination is a highly effective approach to protect infants from infection.

    “Maternal vaccination is a highly effective approach to protect infants from infection.”

    From Factors Affecting the FcRn-Mediated Transplacental Transfer of Antibodies and Implications for Vaccination in Pregnancy (2017) · cites this paper as [14]

    The Abstract Conclusion reports that infants of mothers vaccinated against influenza were 45%–48% less likely to be hospitalized with influenza. The Introduction and Comment also describe protection against influenza in young infants. The claim is broader than the evidence: it does not specify influenza, and the paper's own result concerns hospitalizations in infants under six months rather than infection generally. (LLM, conf=0.86)

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Research works printed but not linked: 1

  1. [45]Hamilton BE Martin JA Ventura SJ Births: Preliminary Data for 2008 National Vital Statistics Report 2010 58 16 Available at http://www.cdc.gov/nchs/data/nvsr/nvsr58/nvsr58_16.pdf 25073731

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Authors
Poehling, K. A., Szilagyi, P. G., Staat, M. A., Snively, B. M., Payne, D. C., Bridges, C. B., Chu, S. Y., Light, L. S., Prill, M. M., Finelli, L., Griffin, M. R., & Edwards, K. M.
Affiliations
  • Wake Forest University Health Sciences (US)
  • University of Rochester Medicine (US)
  • Cincinnati Children's Hospital Medical Center (US)
  • Centers for Disease Control and Prevention (US)
  • Vanderbilt University Medical Center (US)
ORCID
Venue
American Journal of Obstetrics and Gynecology
Publisher
Elsevier BV
Published
2011-06
Volume
204
Issue
6
Pages
S141-S148
ISSN
0002-9378 (ISSN-L)
DOI
10.1016/j.ajog.2011.02.042
PMC
PMC3111909
OpenAlex
W2095886071
Cited by
248
References
50
Citations by year
2026: 3 · 2025: 2 · 2024: 3 · 2023: 5 · 2022: 11 · 2021: 10 · 2020: 19 · 2019: 24 · 2018: 19 · 2017: 20 · 2016: 25 · 2015: 18 · 2014: 25 · 2013: 19 · 2012: 31
FWCI
20.64
Type
journal article
Language
en
Open access
Licence
Locations
  • American Journal of Obstetrics and Gynecology (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Institute of Allergy and Infectious Diseases (K23 AI065805)
  • Centers for Disease Control and Prevention
Topics
  • Health Sciences › Medicine › Epidemiology › Influenza Virus Research Studies
  • Health Sciences › Medicine › Epidemiology › Respiratory viral infections research
  • Social Sciences › Health › Vaccine Coverage and Hesitancy
Keywords
maternal immunization, influenza vaccination during pregnancy, laboratory-confirmed influenza, infants, mother-to-child transmission, influenza vaccine recommendations
MeSH terms
Female, Hospitalization, Humans, Immunity, Maternally-Acquired, Infant, Influenza, Human, Influenza Vaccines, Population Surveillance, Pregnancy, Pregnancy Complications, Infectious, Risk, United States, Practice Guidelines as Topic

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