Cited by 38Fetal and Pediatric Neurological DisordersAdvanced MRI Techniques and ApplicationsNeonatal and fetal brain pathology

Association of brain metabolism with sulcation and corpus callosum development assessed by MRI in late-onset small fetuses.

Sanz-Cortes, Magdalena, Egaña-Ugrinovic, Gabriela, Simoes, Rui V., Vazquez, Lucia, Bargallo, Nuria, Gratacos, Eduard·2015·American Journal of Obstetrics and Gynecology

Abstract

Objective We sought to determine the relationship between fetal brain metabolism and microstructure expressed by brain sulcation, and corpus callosum (CC) development assessed by fetal brain magnetic resonance (MR) imaging and proton MR spectroscopy ((1)H-MRS).Study design A total of 119 fetuses, 64 that were small for gestational age (estimated fetal weight <10th centile and normal umbilical artery Doppler) and 55 controls underwent a 3T MR imaging/(1)H-MRS exam at 37 weeks. Anatomical T2-weighted images were obtained in the 3 orthogonal planes and long echo time (TE) (1)H-MRS acquired from the frontal lobe. Head biometrics, cortical fissure depths (insula, Sylvian, parietooccipital, cingulate, and calcarine), and CC area and biometries were blindly performed by manual and semiautomated delineation using Analyze software and corrected creating ratios for biparietal diameter and frontooccipital diameter, respectively, for group comparison. Spectroscopic data were processed using LCModel software and analyzed as metabolic ratios of N-acetylaspartate (NAA) to choline (Cho), Cho to creatine (Cr), and myo-inositol (Ino) to Cho. Differences between cases and controls were assessed. To test for the association between metabolic ratios and microstructural parameters, bivariate correlation analyses were performed.Results Spectroscopic findings showed decreased NAA/Cho and increased Cho/Cr ratios in small fetuses. They also presented smaller head biometrics, shorter and smaller CC, and greater insular and cingulate depths. Frontal lobe NAA/Cho significantly correlated with biparietal diameter (r = 0.268; P = .021), head circumference (r = 0.259; P = .026), CC length (r = 0.265; P = .026), CC area (r = 0.317; P = .007), and the area of 6 from the 7 CC subdivisions. It did not correlate with any of the cortical sulcation parameters evaluated. None of the other metabolic ratios presented significant correlations with cortical development or CC parameters.Conclusion Frontal lobe NAA/Cho levels-which are considered a surrogate marker of neuronal activity-show a strong association with CC development. These results suggest that both metabolic and callosal alterations may be part of the same process of impaired brain development associated with intrauterine growth restriction.

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Crossref · 10.1016/j.ajog.2015.01.041

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Authors
Sanz-Cortes, M., Egaña-Ugrinovic, G., Simoes, R. V., Vazquez, L., Bargallo, N., & Gratacos, E.
Affiliations
  • Universitat de Barcelona (ES)
  • Hospital Italiano de Buenos Aires (AR)
Venue
American Journal of Obstetrics and Gynecology
Publisher
Elsevier BV
Published
2015-06
Volume
212
Issue
6
Pages
804.e1-804.e8
ISSN
0002-9378 (ISSN-L)
OpenAlex
W1991134303
Cited by
38
References
51
Citations by year
2026: 1 · 2025: 2 · 2024: 6 · 2023: 6 · 2022: 4 · 2021: 2 · 2020: 2 · 2019: 2 · 2018: 4 · 2017: 3 · 2016: 3 · 2015: 3
FWCI
4.31
Type
journal article
Language
en
Open access
closed
Locations
  • American Journal of Obstetrics and Gynecology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Fetal and Pediatric Neurological Disorders
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced MRI Techniques and Applications
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Neonatal and fetal brain pathology
Keywords
fetal brain metabolism, corpus callosum development, small for gestational age, 1H NMR, fetal brain MRI, neuronal activity, fetal growth restriction, fetal brain development, frontal lobe
MeSH terms
Adult, Brain, Corpus Callosum, Female, Fetal Growth Retardation, Humans, Magnetic Resonance Imaging, Pregnancy, Prospective Studies, Proton Magnetic Resonance Spectroscopy

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