Association of brain metabolism with sulcation and corpus callosum development assessed by MRI in late-onset small fetuses.
Abstract
Objective We sought to determine the relationship between fetal brain metabolism and microstructure expressed by brain sulcation, and corpus callosum (CC) development assessed by fetal brain magnetic resonance (MR) imaging and proton MR spectroscopy ((1)H-MRS).Study design A total of 119 fetuses, 64 that were small for gestational age (estimated fetal weight <10th centile and normal umbilical artery Doppler) and 55 controls underwent a 3T MR imaging/(1)H-MRS exam at 37 weeks. Anatomical T2-weighted images were obtained in the 3 orthogonal planes and long echo time (TE) (1)H-MRS acquired from the frontal lobe. Head biometrics, cortical fissure depths (insula, Sylvian, parietooccipital, cingulate, and calcarine), and CC area and biometries were blindly performed by manual and semiautomated delineation using Analyze software and corrected creating ratios for biparietal diameter and frontooccipital diameter, respectively, for group comparison. Spectroscopic data were processed using LCModel software and analyzed as metabolic ratios of N-acetylaspartate (NAA) to choline (Cho), Cho to creatine (Cr), and myo-inositol (Ino) to Cho. Differences between cases and controls were assessed. To test for the association between metabolic ratios and microstructural parameters, bivariate correlation analyses were performed.Results Spectroscopic findings showed decreased NAA/Cho and increased Cho/Cr ratios in small fetuses. They also presented smaller head biometrics, shorter and smaller CC, and greater insular and cingulate depths. Frontal lobe NAA/Cho significantly correlated with biparietal diameter (r = 0.268; P = .021), head circumference (r = 0.259; P = .026), CC length (r = 0.265; P = .026), CC area (r = 0.317; P = .007), and the area of 6 from the 7 CC subdivisions. It did not correlate with any of the cortical sulcation parameters evaluated. None of the other metabolic ratios presented significant correlations with cortical development or CC parameters.Conclusion Frontal lobe NAA/Cho levels-which are considered a surrogate marker of neuronal activity-show a strong association with CC development. These results suggest that both metabolic and callosal alterations may be part of the same process of impaired brain development associated with intrauterine growth restriction.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Advanced MRI and 1H-MRS techniques can be successfully applied to the living fetus.
“The successful applications of advanced magnetic resonance imaging (MRI) and proton magnetic resonance spectroscopy (1H-MRS) techniques to the living fetus30,31,32 provide an unprecedented opportunity to study the association between maternal psychological distress and human fetal brain development.”
From Association of prenatal maternal psychological distress with fetal brain growth, metabolism, and cortical maturation. (2020) · cites this paper as [31]
Cites
Estimation of metabolite concentrations from localized in vivo proton NMR spectra
Provencher, S. W. (1993) · Magnetic Resonance in Medicine · doi:10.1002/mrm.1910300604 · Cited by 3,659 · see citing works
Brain injury in premature infants: a complex amalgam of destructive and developmental disturbances
Volpe, J. J. (2008) · The Lancet Neurology · doi:10.1016/s1474-4422(08)70294-1 · Cited by 2,420 · see citing works
Automatic quantitation of localized in vivo1H spectra with LCModel
Provencher, S. W. (2001) · NMR in Biomedicine · doi:10.1002/nbm.698 · Cited by 1,640 · see citing works
WITELSON, S. F. (1989) · Brain · doi:10.1093/brain/112.3.799 · Cited by 1,424 · see citing works
A CRITICAL EVALUATION OF SONAR “CROWN‐RUMP LENGTH” MEASUREMENTS
Robinson, H. P., & Fleming, J. E. E. (1975) · BJOG An International Journal of Obstetrics & Gynaecology · doi:10.1111/j.1471-0528.1975.tb00710.x · Cited by 1,413 · see citing works
N-Acetylaspartate in the CNS: From neurodiagnostics to neurobiology
MOFFETT, J., Ross, B., Arun, P., Madhavarao, C. N., & Namboodiri, A. M. (2007) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2006.12.003 · Cited by 1,413 · see citing works
Lorek, A., Takei, Y., Cady, E. B., Wyatt, J. S., Penrice, J., Edwards, A. D., Peebles, D., Wylezinska, M., Owen-Reece, H., Kirkbride, V., et al. (1994) · Pediatric Research · doi:10.1203/00006450-199412000-00003 · Cited by 560 · see citing works
Organization of visceral and limbic connections in the insular cortex of the rat
Allen, G. V., Saper, C. B., Hurley, K. M., & Cechetto, D. F. (1991) · The Journal of Comparative Neurology · doi:10.1002/cne.903110102 · Cited by 501 · see citing works
Primary cortical folding in the human newborn: an early marker of later functional development
Dubois, J., Benders, M. J. N. L., Borradori-Tolsa, C., Cachia, A., Lazeyras, F., Leuchter, R. H., Sizonenko, S. V., Warfield, S. K., Mangin, J., & Hüppi, P. S. (2008) · Brain · doi:10.1093/brain/awn137 · Cited by 490 · see citing works
Arduini, D., & Rizzo, G. (1990) · Journal of Perinatal Medicine · doi:10.1515/jpme.1990.18.3.165 · Cited by 480 · see citing works
The developing oligodendrocyte: key cellular target in brain injury in the premature infant
Volpe, J. J., Kinney, H. C., Jensen, F. E., & Rosenberg, P. A. (2011) · International Journal of Developmental Neuroscience · doi:10.1016/j.ijdevneu.2011.02.012 · Cited by 394 · see citing works
N-Acetylaspartate in the Vertebrate Brain: Metabolism and Function
Baslow, M. H. (2003) · Neurochemical Research · doi:10.1023/a:1023250721185 · Cited by 393 · see citing works
Customized birthweight standards for a Spanish population
Figueras, F., Meler, E., Iraola, A., Eixarch, E., Coll, O., Figueras, J., Francis, A., Gratacós, E., & Gardosi, J. O. (2007) · European Journal of Obstetrics & Gynecology and Reproductive Biology · doi:10.1016/j.ejogrb.2006.12.015 · Cited by 387 · see citing works
Immunohistochemical localization of N-acetylaspartate in rat brain
Moffett, J. R., Namboodiri, M. A. A., Cangro, C. B., & Neale, J. H. (1991) · Neuroreport · doi:10.1097/00001756-199103000-00005 · Cited by 335 · see citing works
N-ACETYL-l-ASPARTIC ACID IN BRAIN
Tallan, H. H., Moore, S., & Stein, W. H. (1956) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)65789-8 · Cited by 328 · see citing works
Quality Initiatives: Guidelines for Use of Medical Imaging during Pregnancy and Lactation
Tremblay, É., Thérasse, É., Thomassin‐Naggara, I., & Trop, I. (2012) · Radiographics · doi:10.1148/rg.323115120 · Cited by 294 · see citing works
Patel, T. B., & Clark, J. B. (1979) · Biochemical Journal · doi:10.1042/bj1840539 · Cited by 293 · see citing works
Fetal cerebral cortex: normal gestational landmarks identified using prenatal MR imaging.
Garel, C., Chantrel, E., Brisse, H. J., Elmaleh, M., Luton, D., Oury, J., Sebag, G. H., & Hassan, M. (2001) · PubMed Central · Cited by 286 · see citing works
Paul, L. K. (2010) · Journal of Neurodevelopmental Disorders · doi:10.1007/s11689-010-9059-y · Cited by 259 · see citing works
Geva, R., Eshel, R., Leitner, Y., Valevski, A. F., & Harel, S. (2006) · PEDIATRICS · doi:10.1542/peds.2005-2343 · Cited by 252 · see citing works
Severi, F. M., Bocchi, C., Visentin, A., Falco, P., Cobellis, L., Florio, P., Zagonari, S., & Pilu, G. (2002) · Ultrasound in Obstetrics & Gynecology · doi:10.1046/j.1469-0705.2002.00652.x · Cited by 248 · see citing works
Bhakoo, K. K., & Pearce, D. (2000) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2000.0740254.x · Cited by 236 · see citing works
The biological basis of injury and neuroprotection in the fetal and neonatal brain
Rees, S. M., Harding, R., & Walker, D. W. (2011) · International Journal of Developmental Neuroscience · doi:10.1016/j.ijdevneu.2011.04.004 · Cited by 203 · see citing works
Perinatal mortality and fetal growth restriction
Kady, S. M., & Gardosi, J. O. (2004) · Best Practice & Research Clinical Obstetrics & Gynaecology · doi:10.1016/j.bpobgyn.2004.02.009 · Cited by 198 · see citing works
Scherjon, S. A., Briët, J. M., Oosting, H., & Kok, J. H. (2000) · PEDIATRICS · doi:10.1542/peds.105.2.385 · Cited by 187 · see citing works
Batallé, D., Eixarch, E., Figueras, F., Muñoz‐Moreno, E., Bargalló, N., Illa, M., Acosta‐Rojas, R., Amat‐Roldan, I., & Gratacós, E. (2012) · NeuroImage · doi:10.1016/j.neuroimage.2012.01.059 · Cited by 162 · see citing works
A Longitudinal Proton Magnetic Resonance Spectroscopy Study of Mild Traumatic Brain Injury
Yeo, R. A., Gasparovic, C., Merideth, F. L., Ruhl, D. A., Doezema, D., & Mayer, A. R. (2010) · Journal of Neurotrauma · doi:10.1089/neu.2010.1578 · Cited by 157 · see citing works
Savchev, S., Cortés, M. S., Cruz-Martínez, R., Arranz, Á., Botet, F., Gratacós, E., & Figueras, F. (2013) · Ultrasound in Obstetrics and Gynecology · doi:10.1002/uog.12391 · Cited by 152 · see citing works
Neurobehavior in Term, Small-for-Gestational Age Infants With Normal Placental Function
Figueras, F., Oros, D., Cruz-Martínez, R., Padilla, N., Hernandez‐Andrade, E. A., Botet, F., Moragas, C. C. I., & Gratacós, E. (2009) · PEDIATRICS · doi:10.1542/peds.2008-3346 · Cited by 133 · see citing works
Hernandez‐Andrade, E. A., Horacio Figueroa, D., Jansson, T. T., Rangel-Nava, H. A., & Gratacós, E. (2008) · Ultrasound in Obstetrics and Gynecology · doi:10.1002/uog.5377 · Cited by 129 · see citing works
Figueras, F., Eixarch, E., Meler, E., Iraola, A., Figueras, J., Puerto, B., & Gratacos, E. (2008) · European Journal of Obstetrics & Gynecology and Reproductive Biology · doi:10.1016/j.ejogrb.2007.02.016 · Cited by 121 · see citing works
Egaña‐Ugrinovic, G., Cortés, M. S., Figueras, F., Bargalló, N., & Gratacós, E. (2013) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2013.04.008 · Cited by 121 · see citing works
Self-citationOutcome in Prenatally Diagnosed Fetal Agenesis of the Corpus callosum
Goodyear, P. W. A., Bannister, C. M., Russell, S. S., & Rimmer, S. (2001) · Fetal Diagnosis and Therapy · doi:10.1159/000053898 · Cited by 112 · see citing works
Small for gestational age is not a diagnosis
SOOTHILL, P. W., Bobrow, C. S., & Holmes, R. P. (1999) · Ultrasound in Obstetrics and Gynecology · doi:10.1046/j.1469-0705.1999.13040225.x · Cited by 111 · see citing works
McCowan, L. M. E., Pryor, J. E., & Harding, J. E. (2002) · American Journal of Obstetrics and Gynecology · doi:10.1067/mob.2002.122292 · Cited by 94 · see citing works
Cortés, M. S., Figueras, F., Bargalló, N., Padilla, N., Amat‐Roldan, I., & Gratacós, E. (2010) · Ultrasound in Obstetrics and Gynecology · doi:10.1002/uog.7724 · Cited by 81 · see citing works
Subfield‐specific Loss of Hippocampal N‐acetyl Aspartate in Temporal Lobe Epilepsy
Vielhaber, S., Niessen, H. G., Dębska–Vielhaber, G., Kudin, A. P., Wellmer, J., Kaufmann, J., Schönfeld, M. A., Fendrich, R., Willker, W., Leibfritz, D., et al. (2007) · Epilepsia · doi:10.1111/j.1528-1167.2007.01280.x · Cited by 73 · see citing works
Cerebral Maturation in IUGR and Appropriate for Gestational Age Preterm Babies
Ramenghi, L. A., Martinelli, A., Carli, A. D., Brusati, V., Mandia, L., Fumagalli, M., Triulzi, F. M., Mosca, F., & Cetin, I. (2011) · Reproductive Sciences · doi:10.1177/1933719110388847 · Cited by 68 · see citing works
Egaña‐Ugrinovic, G., Cortés, M. S., Couve‐Pérez, C., Figueras, F., & Gratacós, E. (2014) · Prenatal Diagnosis · doi:10.1002/pd.4381 · Cited by 62 · see citing works
Self-citationStory, L., Damodaram, M. S., Allsop, J. M., McGuinness, A. E., Patel, A., Wylezinska, M., Hagberg, H., Kumar, S., & Rutherford, M. (2011) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2011.06.032 · Cited by 60 · see citing works
Egaña‐Ugrinovic, G., Cortés, M. S., Figueras, F., Couve‐Pérez, C., & Gratacós, E. (2014) · Ultrasound in Obstetrics and Gynecology · doi:10.1002/uog.13360 · Cited by 58 · see citing works
Self-citationJohnson, B., Zhang, K., Gay, M., Neuberger, T., Horovitz, S. G., Hallett, M., Sebastianelli, W. J., & Slobounov, S. (2011) · Neuroscience Letters · doi:10.1016/j.neulet.2011.11.013 · Cited by 58 · see citing works
Cortés, M. S., Egaña‐Ugrinovic, G., Zupan, R., Figueras, F., & Gratacós, E. (2013) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2013.12.008 · Cited by 58 · see citing works
Self-citationCortés, M. S., Figueras, F., Bonet-Carné, E., Padilla, N., Tenorio, V., Bargalló, N., Amat‐Roldan, I., & Gratacós, E. (2013) · Fetal Diagnosis and Therapy · doi:10.1159/000346566 · Cited by 50 · see citing works
Bapat, R. V., Narayana, P. A., Zhou, Y., & Parikh, N. A. (2014) · Pediatric Neurology · doi:10.1016/j.pediatrneurol.2014.03.011 · Cited by 48 · see citing works
Cortés, M. S., Simoes, R. V., Bargalló, N., Masoller, N., Figueras, F., & Gratacós, E. (2014) · Fetal Diagnosis and Therapy · doi:10.1159/000365102 · Cited by 34 · see citing works
Self-citationProton magnetic resonance spectroscopy in the fetus
Story, L., Damodaram, M. S., Allsop, J. M., McGuinness, A. E., Wylezinska, M., Kumar, S., & Rutherford, M. (2010) · European Journal of Obstetrics & Gynecology and Reproductive Biology · doi:10.1016/j.ejogrb.2010.03.003 · Cited by 33 · see citing works
Habek, D., Salihagić, A., Jugović, D., & Herman, R. (2007) · Fetal Diagnosis and Therapy · doi:10.1159/000106354 · Cited by 31 · see citing works
Proton MR Spectroscopy of the Brain with a Focus on Chemical Issues
Imamura, K. (2003) · Magnetic Resonance in Medical Sciences · doi:10.2463/mrms.2.117 · Cited by 31 · see citing works
Cortés, M. S., Ratta, G. A., Figueras, F., Bonet-Carné, E., Padilla, N., Arranz, Á., Bargalló, N., & Gratacós, E. (2013) · PLoS ONE · doi:10.1371/journal.pone.0069595 · Cited by 29 · see citing works
Egaña‐Ugrinovic, G., Savchev, S., Bazán-Arcos, C., Puerto, B., Gratacós, E., & Cortés, M. S. (2015) · Fetal Diagnosis and Therapy · doi:10.1159/000366160 · Cited by 23 · see citing works
Self-citation
Flagged first, then by citations
Cited by
Sorted by citations
Diagnosis and surveillance of late-onset fetal growth restriction
Figueras, F., Caradeux, J., Crispi, F., Eixarch, E., Peguero, A., & Gratacos, E. (2018) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2017.12.003 · Cited by 300 · see citing works
Wu, Y., Lu, Y.-C., Jacobs, M., Pradhan, S., Kapse, K., Zhao, L., Niforatos-Andescavage, N., Vezina, G., du Plessis, A. J., & Limperopoulos, C. (2020) · JAMA Network Open · doi:10.1001/jamanetworkopen.2019.19940 · Cited by 218 · see citing works
The hemodynamics of late-onset intrauterine growth restriction by MRI
Zhu, M. Y., Milligan, N., Keating, S. J., Windrim, R. C., Keunen, J., Thakur, V., Ohman, A., Portnoy, S., Sled, J. G., Kelly, E., et al. (2015) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2015.10.004 · Cited by 149 · see citing works
Kadji, C., Cannie, M., Resta, S., Guez, D., Abi-Khalil, F., Angelis, R. D., & Jani, J. C. (2018) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2018.12.031 · Cited by 68 · see citing works
Fetal cerebral redistribution: a marker of compromise regardless of fetal size
Morales‐Roselló, J., & Khalil, A. A. (2015) · Ultrasound in Obstetrics and Gynecology · doi:10.1002/uog.15664 · Cited by 66 · see citing works
Detection and assessment of brain injury in the growth-restricted fetus and neonate
Malhotra, A. K., Ditchfield, M. R., Fahey, M. C., Castillo-Meléndez, M., Allison, B. J., Polglase, G. R., Wallace, E. M., Hodges, R. J., Jenkin, G., & Miller, S. (2017) · Pediatric Research · doi:10.1038/pr.2017.37 · Cited by 66 · see citing works
Motor and cortico-striatal-thalamic connectivity alterations in intrauterine growth restriction
Eixarch, E., Muñoz‐Moreno, E., Bargalló, N., Batallé, D., & Gratacós, E. (2015) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2015.12.028 · Cited by 47 · see citing works
Benítez-Marín, M. J., Marín-Clavijo, J., Blanco-Elena, J. A., López, J. S. J., & González‐Mesa, E. (2021) · Children · doi:10.3390/children8090745 · Cited by 46 · see citing works
Hobbins, J. C., Gumina, D. L., Zaretsky, M. V., Driver, C., Wilcox, A., & DeVore, G. R. (2019) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2019.06.008 · Cited by 43 · see citing works
Muñoz‐Moreno, E., Fischi-Gómez, E., Batallé, D., Borradori-Tolsa, C., Eixarch, E., Thiran, J., Gratacós, E., & Hüppi, P. S. (2016) · Frontiers in Neuroscience · doi:10.3389/fnins.2016.00560 · Cited by 39 · see citing works
Simoes, R. V., Muñoz‐Moreno, E., Cruz-Lemini, M., Eixarch, E., Bargalló, N., Cortés, M. S., & Gratacós, E. (2016) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2016.09.089 · Cited by 33 · see citing works
Self-citationConde, J. R. C., Campo, C. G., González, N. L. G., Millán, B. R., Barrios, D. G., Jiménez, A., & Fuentes, I. Q. (2019) · Pediatric Research · doi:10.1038/s41390-019-0693-0 · Cited by 32 · see citing works
Basso, A., Youssef, L., Nakaki, A., Paulés, C., Miranda, J., Casu, G., Salazar, L., Gratacós, E., Eixarch, E., Crispi, F., et al. (2022) · Ultrasound in Obstetrics and Gynecology · doi:10.1002/uog.24853 · Cited by 31 · see citing works
Brain Development in Fetuses of Mothers with Diabetes: A Case-Control MR Imaging Study
Denison, F. C., Macnaught, G., Semple, S. I. K., Terris, G., Walker, J., Anblagan, D., Serag, A., Reynolds, R. M., & Boardman, J. P. (2017) · American Journal of Neuroradiology · doi:10.3174/ajnr.a5118 · Cited by 24 · see citing works
Spinelli, M., Sica, C., Ghezzi, F., Cromi, A., Surbek, D., & Raio, L. (2018) · Fetal Diagnosis and Therapy · doi:10.1159/000490242 · Cited by 22 · see citing works
Zheng, W., Zhang, X., Feng, Y., Liu, B., Zhu, J., Zou, Y., Qin, J., & Li, B. (2022) · JAMA Network Open · doi:10.1001/jamanetworkopen.2022.26696 · Cited by 22 · see citing works
Asis‐Cruz, J. D., & Limperopoulos, C. (2022) · Biological Psychiatry · doi:10.1016/j.biopsych.2022.11.019 · Cited by 22 · see citing works
Fetal brain development in fetal growth restriction using MRI: a systematic review
Meijerink, L., van Ooijen, I. M., Alderliesten, T., Terstappen, F., Benders, M. J. N. L., & Bekker, M. N. (2025) · BMC Pregnancy and Childbirth · doi:10.1186/s12884-024-07124-4 · Cited by 17 · see citing works
Kadji, C., Bevilacqua, E., Hurtado, I., Carlin, A., Cannie, M., & Jani, J. C. (2017) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2017.10.009 · Cited by 15 · see citing works
Reduced gyrification in fetal growth restriction with prenatal magnetic resonance images
Yehuda, B., Rabinowich, A., Zilberman, A., Wexler, Y., Haratz, K. K., Miller, E., Ben‐Sira, L., Hiersch, L., & Bashat, D. B. (2024) · Cerebral Cortex · doi:10.1093/cercor/bhae250 · Cited by 14 · see citing works
Cárdenas, A. M., Whitehead, M. T., & Bulas, D. (2020) · Seminars in Pediatric Neurology · doi:10.1016/j.spen.2020.100801 · Cited by 14 · see citing works
Similarity network fusion to identify phenotypes of small-for-gestational-age fetuses
Miranda, J., Paulés, C., Noell, G. G., Youssef, L., Paternina-Caicedo, Á. J., Crovetto, F., Cañellas, N., García‐Martín, M. L., Amigó, N., Eixarch, E., et al. (2023) · iScience · doi:10.1016/j.isci.2023.107620 · Cited by 12 · see citing works
Self-citationThe Role of Proton Magnetic Resonance Spectroscopy in Neonatal and Fetal Brain Research
Hui, S. C. N., Andescavage, N. N., & Limperopoulos, C. (2025) · Journal of Magnetic Resonance Imaging · doi:10.1002/jmri.29709 · Cited by 11 · see citing works
Brain Outcomes in Runted Piglets: A Translational Model of Fetal Growth Restriction
Chand, K. K., Pannek, K., Colditz, P. B., & Wixey, J. A. (2022) · Developmental Neuroscience · doi:10.1159/000523995 · Cited by 11 · see citing works
Corpus callosum–fastigium and tectal lengths in late‐onset small fetuses
Lip‐Sosa, D. L., Pérez‐Cruz, M., Ahumada‐Droguett, P., Ribas‐Prats, T., Puertollano, M., García‐Gómez, M. A., Mazarico, E., Eixarch, E., Escera, C., & Gómez‐Roig, M. D. (2023) · Ultrasound in Obstetrics and Gynecology · doi:10.1002/uog.26169 · Cited by 11 · see citing works
England-Mason, G., Reardon, A. J. F., Reynolds, J. E., Grohs, M. N., MacDonald, A. M., Kinniburgh, D. W., Martin, J. W., Lebel, C. A., & Dewey, D. (2024) · Environmental Research · doi:10.1016/j.envres.2024.120638 · Cited by 10 · see citing works
Lamon, S., de Dumast, P., Sanchez, T., Dunet, V., Pomar, L., Vial, Y., Koob, M., & Cuadra, M. B. (2024) · Frontiers in Neurology · doi:10.3389/fneur.2024.1358741 · Cited by 8 · see citing works
Prediction Model of Late Fetal Growth Restriction with Machine Learning Algorithms
Lee, S. U., Choi, S. K., Jo, Y. S., Wie, J. H., Shin, J. E., Kim, Y. H., Kil, K., & Ko, H. S. (2024) · Life · doi:10.3390/life14111521 · Cited by 7 · see citing works
Protein S100β in Late-Pregnancy Fetuses with Low Birth Weight and Abnormal Cerebroplacental Ratio
Morales‐Roselló, J., Khalil, A. A., Alba-Redondo, A., Martinez-Triguero, L., Akhoundova, F., Alfredo Perales, M., & Thilaganathan, B. (2016) · Fetal Diagnosis and Therapy · doi:10.1159/000445114 · Cited by 7 · see citing works
Urbanik, A., Cichocka, M., Kozub, J., Karcz, P., & Herman‐Sucharska, I. (2018) · The Journal of Maternal-Fetal & Neonatal Medicine · doi:10.1080/14767058.2018.1439009 · Cited by 6 · see citing works
Does the Blood–Brain Barrier Integrity Change in Regard to the Onset of Fetal Growth Restriction?
Misan, N., Michalak, S., Kapska, K., Osztynowicz, K., Ropacka‐Lesiak, M., & Kawka‐Paciorkowska, K. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24031965 · Cited by 5 · see citing works
Benítez-Marín, M. J., Alonso, M. B., de Fonseca, F. R., López, J. S. J., Rivera, P., & González‐Mesa, E. (2024) · Acta Paediatrica · doi:10.1111/apa.17521 · Cited by 4 · see citing works
Yakoub, N., Reinelt, T., & Natalucci, G. (2023) · BMJ Open · doi:10.1136/bmjopen-2023-074417 · Cited by 2 · see citing works
Peng, R., Yin, X., Liu, Y., He, M., Wu, H., & Xie, H. (2023) · Quantitative Imaging in Medicine and Surgery · doi:10.21037/qims-23-786 · Cited by 1 · see citing works
Neurosonographic assessments of corpus callosum related structures in growth‐restricted fetuses
Yakıştıran, B., Altınboğa, O., Öztürk, F. H., Erol, S. A., Canpolat, F. E., & Yücel, A. (2021) · Journal of Clinical Ultrasound · doi:10.1002/jcu.23052 · Cited by 1 · see citing works
İşgüder, Ç. K., Unlu, N., Ayvacı, H., Pektas, M. K., Kurt, D., & Tuğ, N. (2024) · Research Square · doi:10.21203/rs.3.rs-5401584/v1
Huang, S., Lin, Y., Su, H., Liu, X., Su, Y., Lin, Y.-T., Huang, M., Hong, L., Wang, Y.-Q., Lin, J., et al. (2026) · BMC Pregnancy and Childbirth · doi:10.1186/s12884-026-09051-y
- Authors
- Sanz-Cortes, M., Egaña-Ugrinovic, G., Simoes, R. V., Vazquez, L., Bargallo, N., & Gratacos, E.
- Affiliations
- Universitat de Barcelona (ES)
- Hospital Italiano de Buenos Aires (AR)
- ORCID
- Simoes, Rui V.
- Venue
- American Journal of Obstetrics and Gynecology
- Publisher
- Elsevier BV
- Published
- 2015-06
- Volume
- 212
- Issue
- 6
- Pages
- 804.e1-804.e8
- ISSN
- 0002-9378 (ISSN-L)
- OpenAlex
- W1991134303
- Cited by
- 38
- References
- 51
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 6 · 2023: 6 · 2022: 4 · 2021: 2 · 2020: 2 · 2019: 2 · 2018: 4 · 2017: 3 · 2016: 3 · 2015: 3
- FWCI
- 4.31
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- American Journal of Obstetrics and Gynecology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Fetal and Pediatric Neurological Disorders
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced MRI Techniques and Applications
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Neonatal and fetal brain pathology
- Keywords
- fetal brain metabolism, corpus callosum development, small for gestational age, 1H NMR, fetal brain MRI, neuronal activity, fetal growth restriction, fetal brain development, frontal lobe
- MeSH terms
- Adult, Brain, Corpus Callosum, Female, Fetal Growth Retardation, Humans, Magnetic Resonance Imaging, Pregnancy, Prospective Studies, Proton Magnetic Resonance Spectroscopy
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review