Tumor Endothelial Cells Acquire Drug Resistance by MDR1 Up-Regulation via VEGF Signaling in Tumor Microenvironment

Angiogenesis in cancer, vascular, rheumatoid and other disease

Folkman, J. (1995) · Nature Medicine · doi:10.1038/nm0195-27 · Cited by 7,627 · see citing works

Paclitaxel–Carboplatin Alone or with Bevacizumab for Non–Small-Cell Lung Cancer

Sandler, A., Gray, R., Perry, M. C., Brahmer, J., Schiller, J. H., Dowlati, A., Lilenbaum, R., & Johnson, D. H. (2006) · New England Journal of Medicine · doi:10.1056/nejmoa061884 · Cited by 5,761 · see citing works

Cancer genes and the pathways they control

Vogelstein, B., & Kinzler, K. W. (2004) · Nature Medicine · doi:10.1038/nm1087 · Cited by 4,245 · see citing works

Mesenchymal stem cells within tumour stroma promote breast cancer metastasis

Karnoub, A. E., Dash, A. B., Vo, A. P., Sullivan, A., Brooks, M. W., Bell, G. W., Richardson, A. L., Polyak, K., Tubo, R., & Weinberg, R. A. (2007) · Nature · doi:10.1038/nature06188 · Cited by 3,206 · see citing works

Paclitaxel plus Bevacizumab versus Paclitaxel Alone for Metastatic Breast Cancer

Miller, K. D., Wang, M., Gralow, J. R., Dickler, M. N., Cobleigh, M., Perez, E. A., Shenkier, T. N., Cella, D. F., & Davidson, N. E. (2007) · New England Journal of Medicine · doi:10.1056/nejmoa072113 · Cited by 3,077 · see citing works

Role of angiogenesis in tumor growth and metastasis

Folkman, J. (2002) · Seminars in Oncology · doi:10.1016/s0093-7754(02)70065-1 · Cited by 2,862 · see citing works

Molecular regulation of vessel maturation

Jain, R. K. (2003) · Nature Medicine · doi:10.1038/nm0603-685 · Cited by 2,515 · see citing works

Role of angiogenesis in tumor growth and metastasis

Folkman, J. (2002) · Seminars in Oncology · doi:10.1053/sonc.2002.37263 · Cited by 2,424 · see citing works

Genes Expressed in Human Tumor Endothelium

Croix, B. S., Rago, C., Velculescu, V. E., Traverso, G., Romans, K. E., Montgomery, E. A., Lal, A., Riggins, G. J., Christoph Lengauer, C., Vogelstein, B., et al. (2000) · Science · doi:10.1126/science.289.5482.1197 · Cited by 1,845 · see citing works

Antiangiogenic scheduling of chemotherapy improves efficacy against experimental drug-resistant cancer.

Browder, T. D., Butterfield, C., Kräling, B. M., Shi, B., Marshall, B., OʼReilly, M., & Folkman, J. (2000) · PubMed · Cited by 1,542 · see citing works

Abnormalities in Pericytes on Blood Vessels and Endothelial Sprouts in Tumors

Morikawa, S., Bałuk, P., Kaidoh, T., Haskell, A., Jain, R. K., & McDonald, D. M. (2002) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)64920-6 · Cited by 987 · see citing works

A Randomized Trial of Adjuvant Chemotherapy with Uracil–Tegafur for Adenocarcinoma of the Lung

Kato, H., Ichinose, Y., Ohta, M., Hata, E., Tsubota, N., Tada, H., Watanabe, Y., Wada, H., Tsuboi, M., Hamajima, N., et al. (2004) · New England Journal of Medicine · doi:10.1056/nejmoa032792 · Cited by 819 · see citing works

Human Multidrug Resistance ABCB and ABCG Transporters: Participation in a Chemoimmunity Defense System

Sarkadi, B., Homolya, L., Szakács, G., & Váradi, A. (2006) · Physiological Reviews · doi:10.1152/physrev.00037.2005 · Cited by 726 · see citing works

Metronomic chemotherapy: new rationale for new directions

Pasquier, E., Kavallaris, M., & André, N. (2010) · Nature Reviews Clinical Oncology · doi:10.1038/nrclinonc.2010.82 · Cited by 655 · see citing works

Tumor-Associated Endothelial Cells with Cytogenetic Abnormalities

Hida, K., Hida, Y., Amin, D. N., Flint, A., Panigrahy, D., Morton, C. C., & Klagsbrun, M. (2004) · Cancer Research · doi:10.1158/0008-5472.can-04-1567 · Cited by 470 · see citing works

Significance of blood vessel leakiness in cancer.

McDonald, D. M., & Bałuk, P. (2002) · PubMed · Cited by 462 · see citing works

Role of MicroRNA miR-27a and miR-451 in the regulation of MDR1/P-glycoprotein expression in human cancer cells

Hua Zhu, C., Wu, H., Liu, X., Evans, B. R., Medina, D. J., Liu, C., & Yang, J. (2008) · Biochemical Pharmacology · doi:10.1016/j.bcp.2008.06.007 · Cited by 457 · see citing works

Genes that Distinguish Physiological and Pathological Angiogenesis

Seaman, S., Stevens, J., Yang, M., Logsdon, D. L., Graff‐Cherry, C., & Croix, B. S. (2007) · Cancer Cell · doi:10.1016/j.ccr.2007.04.017 · Cited by 415 · see citing works

Apatinib (YN968D1) Reverses Multidrug Resistance by Inhibiting the Efflux Function of Multiple ATP-Binding Cassette Transporters

Mi, Y.-J., Liang, Y.-J., Huang, H.-B., Zhao, H.-Y., Wu, C.-P., Wang, F., Tao, L.-Y., Zhang, C.-Z., Dai, C.-L., Tiwari, A. K., et al. (2010) · Cancer Research · doi:10.1158/0008-5472.can-10-0111 · Cited by 337 · see citing works

Lymphoma-Specific Genetic Aberrations in Microvascular Endothelial Cells in B-Cell Lymphomas

Streubel, B., Chott, A., Huber, D., Exner, M., Jaeger, U., Wagner, O. F., & Schwarzinger, I. (2004) · New England Journal of Medicine · doi:10.1056/nejmoa033153 · Cited by 318 · see citing works

Antitumor effects in mice of low-dose (metronomic) cyclophosphamide administered continuously through the drinking water.

Man, S., Bocci, G., Francia, G., Green, S. K., Jothy, S., Hanahan, D., Böhlen, P., Hicklin, D. J., Bergers, G., & Kerbel, R. S. (2002) · PubMed · Cited by 314 · see citing works

Akt phosphorylates the Y-box binding protein 1 at Ser102 located in the cold shock domain and affects the anchorage-independent growth of breast cancer cells

Sutherland, B. W., Kucab, J. E., Wu, J., Lee, C., Cheang, M. C. U., Yorida, E., Turbin, D. A., Dedhar, S., Nelson, C. C., Pollak, M., et al. (2005) · Oncogene · doi:10.1038/sj.onc.1208590 · Cited by 299 · see citing works

Altered angiogenesis and survival in human tumor‐derived endothelial cells

Bussolati, B., Deambrosis, I., Russo, S., Deregibus, M. C., & Camussi, G. (2003) · The FASEB Journal · doi:10.1096/fj.02-0557fje · Cited by 285 · see citing works

Possible Mechanisms of Acquired Resistance to Anti-angiogenic Drugs: Implications for the Use of Combination Therapy Approaches

Kerbel, R. S., Yu, J., Tran, J., Man, S., Viloria‐Petit, A., Klement, G. L., Coomber, B. L., & Rak, J. W. (2001) · Cancer and Metastasis Reviews · doi:10.1023/a:1013172910858 · Cited by 236 · see citing works

A Human Melanoma Line Heterogeneous With Respect to Metastatic Capacity in Athymic Nude Mice 2 3 4

Kozlowski, J. M., Hart, I. R., Fidler, I. J., & Hanna, N. (1984) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/72.4.913 · Cited by 230 · see citing works

Tumor Endothelial Cells Express Epidermal Growth Factor Receptor (EGFR) but not ErbB3 and Are Responsive to EGF and to EGFR Kinase Inhibitors

Amin, D. N., Hida, K., Bielenberg, D. R., & Klagsbrun, M. (2006) · Cancer Research · doi:10.1158/0008-5472.can-05-3387 · Cited by 220 · see citing works

Curcumin down-regulates the multidrug-resistance mdr1b gene by inhibiting the PI3K/Akt/NFκB pathway

Choi, B. H., Kim, C. G., Lim, Y., Shin, S. Y., & Lee, Y. H. (2007) · Cancer Letters · doi:10.1016/j.canlet.2007.10.003 · Cited by 217 · see citing works

Human Hepatocellular Carcinoma Tumor–derived Endothelial Cells Manifest Increased Angiogenesis Capability and Drug Resistance Compared with Normal Endothelial Cells

Xiong, Y., Sun, H., Zhang, W., Zhu, X., Zhuang, P., Zhang, J., Wang, L., Wu, W., Qin, L., & Tang, Z. (2009) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-08-2780 · Cited by 214 · see citing works

Gene Alterations Identified by Expression Profiling in Tumor-Associated Endothelial Cells from Invasive Ovarian Carcinoma

Lü, C., Bonome, T., Li, Y., Kamat, A. A., Han, L. Y., Schmandt, R. E., Coleman, R. L., Gershenson, D. M., Jaffe, R. B., Birrer, M. J., et al. (2007) · Cancer Research · doi:10.1158/0008-5472.can-06-3700 · Cited by 185 · see citing works

Cytogenetic Abnormalities of Tumor-Associated Endothelial Cells in Human Malignant Tumors

Akino, T., Hida, K., Hida, Y., Tsuchiya, K., Freedman, D. A., Muraki, C., Ohga, N., Matsuda, K., Akiyama, K., Harabayashi, T., et al. (2009) · American Journal Of Pathology · doi:10.2353/ajpath.2009.090202 · Cited by 183 · see citing works

Y‐box factor YB‐1 predicts drug resistance and patient outcome in breast cancer independent of clinically relevant tumor biologic factors HER2, uPA and PAI‐1

Janz, M., Harbeck, N., Dettmar, P., Berger, U., Schmidt, A., Jürchott, K., Schmitt, M., & Royer, H. (2001) · International Journal of Cancer · doi:10.1002/ijc.1610 · Cited by 182 · see citing works

YB‐1 is upregulated during prostate cancer tumor progression and increases P‐glycoprotein activity

Gimenez‐Bonafé, P., Fedoruk, M., Whitmore, T. G., Akbari, M., Ralph, J., Ettinger, S., Gleave, M. E., & Nelson, C. C. (2004) · The Prostate · doi:10.1002/pros.20023 · Cited by 165 · see citing works

A New Perspective on Tumor Endothelial Cells: Unexpected Chromosome and Centrosome Abnormalities

Hida, K., & Klagsbrun, M. (2005) · Cancer Research · doi:10.1158/0008-5472.can-05-0002 · Cited by 160 · see citing works

The role of the organ microenvironment in the biology and therapy of cancer metastasis

Fidler, I. J., Kim, S., & Langley, R. R. (2006) · Journal of Cellular Biochemistry · doi:10.1002/jcb.21148 · Cited by 143 · see citing works

Angiogenesis Assays: Problems and Pitfalls

Auerbach, R., Akhtar, N., Lewis, R. L., & Shinners, B. L. (2000) · Cancer and Metastasis Reviews · doi:10.1023/a:1026574416001 · Cited by 141 · see citing works

Isolated tumor endothelial cells maintain specific character during long-term culture

Matsuda, K., Ohga, N., Hida, Y., Muraki, C., Tsuchiya, K., Kurosu, T., Akino, T., Shih, S., Totsuka, Y., Klagsbrun, M., et al. (2010) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2010.03.089 · Cited by 135 · see citing works

Understanding tumor endothelial cell abnormalities to develop ideal anti‐angiogenic therapies

Hida, K., Hida, Y., & Shindoh, M. (2008) · Cancer Science · doi:10.1111/j.1349-7006.2007.00704.x · Cited by 125 · see citing works

Phase II study of metronomic chemotherapy for recurrent malignant gliomas in adults

Kesari, S., Schiff, D., Doherty, L. M., Gigas, D. C., Batchelor, T. T., Muzikansky, A., O’Neill, A., Drappatz, J., Chen‐Plotkin, A. S., Ramakrishna, N. R., et al. (2007) · Neuro-Oncology · doi:10.1215/15228517-2007-006 · Cited by 120 · see citing works

Overexpression of VEGF 121 in Immortalized Endothelial Cells Causes Conversion to Slowly Growing Angiosarcoma and High Level Expression of the VEGF Receptors VEGFR-1 and VEGFR-2 in Vivo

Arbiser, J. L., Larsson, H., Claesson, L., Bai, X., LaMontagne, K. R., Weiss, S. W., Soker, S., Flynn, E. A., & Brown, L. F. (2000) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)65015-8 · Cited by 119 · see citing works

Role of single‐stranded DNA regions and Y‐box proteins in transcriptional regulation of viral and cellular genes

Swamynathan, S. K., Nambiar, A., & Guntaka, R. V. (1998) · The FASEB Journal · doi:10.1096/fasebj.12.7.515 · Cited by 117 · see citing works

HuR keeps an angiogenic switch on by stabilising mRNA of VEGF and COX-2 in tumour endothelium

Kurosu, T., Ohga, N., Hida, Y., Maishi, N., Akiyama, K., Kakuguchi, W., Kuroshima, T., Kondo, M., Akino, T., Totsuka, Y., et al. (2011) · British Journal of Cancer · doi:10.1038/bjc.2011.20 · Cited by 114 · see citing works

The basic and clinical implications of ABC transporters, Y‐box‐binding protein‐1 (YB‐1) and angiogenesis‐related factors in human malignancies

Kuwano, M., Uchiumi, T., Hayakawa, H., Ono, M., Wada, M., Izumi, H., & Kohno, K. (2003) · Cancer Science · doi:10.1111/j.1349-7006.2003.tb01344.x · Cited by 107 · see citing works

Rescue of paclitaxel sensitivity by repression of Prohibitin1 in drug-resistant cancer cells

Patel, N., Chatterjee, S. K., Vrbanac, V. D., Chung, I., Mu, C. J., Olsen, R. R., Waghorne, C. G., & Zetter, B. R. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0910649107 · Cited by 103 · see citing works

Inhibitory effects of epigallocatechin‐3 gallate, a polyphenol in green tea, on tumor‐associated endothelial cells and endothelial progenitor cells

Ohga, N., Hida, K., Hida, Y., Muraki, C., Tsuchiya, K., Matsuda, K., Ohiro, Y., Totsuka, Y., & Shindoh, M. (2009) · Cancer Science · doi:10.1111/j.1349-7006.2009.01255.x · Cited by 92 · see citing works

Chemoresistance of Endothelial Cells Induced by Basic Fibroblast Growth Factor Depends on Raf-1–Mediated Inhibition of the Proapoptotic Kinase, ASK1

Alavi, A., Acevedo, L. M., Wang, M., & Cheresh, D. A. (2007) · Cancer Research · doi:10.1158/0008-5472.can-06-3648 · Cited by 89 · see citing works

A human melanoma line heterogeneous with respect to metastatic capacity in athymic nude mice.

Kozlowski, J. M., Hart, I. R., Fidler, I. J., & Hanna, N. (1984) · The Mouseion at the JAXlibrary (Jackson Laboratory) · Cited by 87 · see citing works

Multidrug resistance in oral squamous cell carcinoma: The role of vacuolar ATPases

Pérez‐Sayáns, M., Martín, J. M. S., Barros, F., Díz, P., Rey, J. M. G., & Garcı́a, A. G. (2010) · Cancer Letters · doi:10.1016/j.canlet.2010.03.019 · Cited by 80 · see citing works

Isolation and characterization of human breast tumor-derived endothelial cells

Grange, C., Bussolati, B., Bruno, S., Fonsato, V., Sapino, A., & Camussi, G. (2006) · Oncology Reports · doi:10.3892/or.15.2.381 · Cited by 78 · see citing works

LY294,002, a specific inhibitor of PI3K/Akt kinase pathway, antagonizes P-glycoprotein-mediated multidrug resistance

Barančı́k, M., Boháčová, V., Sedlák, J., Sulová, Z., & Breier, A. (2006) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2006.08.006 · Cited by 77 · see citing works

A phase 2 pilot trial of low‐dose, continuous infusion, or “metronomic” paclitaxel and oral celecoxib in patients with metastatic melanoma

Bhatt, R. S., Merchan, J. R., Parker, R. A., Wu, H., Zhang, L., Seery, V. J., Heymach, J. V., Atkins, M. B., McDermott, D. F., & Sukhatme, V. P. (2010) · Cancer · doi:10.1002/cncr.24902 · Cited by 72 · see citing works

Hepatocyte Growth Factor and Inducible Nitric Oxide Synthase Are Involved in Multidrug Resistance–Induced Angiogenesis in Hepatocellular Carcinoma Cell Lines

Lasagna, N., Fantappiè, O., Solazzo, M., Morbidelli, L., Marchetti, S., Cipriani, G., Ziche, M., & Mazzanti, R. (2006) · Cancer Research · doi:10.1158/0008-5472.can-05-2290 · Cited by 58 · see citing works

Adrenomedullin antagonist suppresses tumor formation in renal cell carcinoma through inhibitory effects on tumor endothelial cells and endothelial progenitor mobilization

Hida (2010) · International Journal of Oncology · doi:10.3892/ijo_00000622 · Cited by 50 · see citing works

Inhibition of the Multidrug-Resistant Phenotype by Targeting YB-1 with a Conditionally Oncolytic Adenovirus: Implications for Combinatorial Treatment Regimen with Chemotherapeutic Agents

Mantwill, K., Köhler-Vargas, N., Bernshausen, A., Bieler, A., Lage, H., Kaszubiak, A., Surowiak, P., Dravits, T., Treiber, U., Härtung, R., et al. (2006) · Cancer Research · doi:10.1158/0008-5472.can-05-2339 · Cited by 49 · see citing works

Y‐box binding protein‐1 is a novel molecular target for tumor vessels

Takahashi, M., Shimajiri, S., Izumi, H., Hirano, G., Kashiwagi, E., Yasuniwa, Y., Wu, Y., Han, B., Akiyama, M., Nishizawa, S., et al. (2010) · Cancer Science · doi:10.1111/j.1349-7006.2010.01534.x · Cited by 46 · see citing works

Reversal of P‐glycoprotein‐mediated multi‐drug resistance by the E3 ubiquitin ligase Cbl‐b in human gastric adenocarcinoma cells

Zhang, Y., Qu, X., Hu, X., Yang, X., Hou, K., Teng, Y., Zhang, J., Sada, K., & Liu, Y. (2009) · The Journal of Pathology · doi:10.1002/path.2533 · Cited by 46 · see citing works

Co-expression of Y box-binding protein-1 and P-glycoprotein as a prognostic marker for survival in epithelial ovarian cancer

HUANG, X., Ushijima, K., KOMAI, K., TAKEMOTO, Y., Motoshima, S., Kamura, T., & Kohno, K. (2004) · Gynecologic Oncology · doi:10.1016/j.ygyno.2004.01.040 · Cited by 41 · see citing works

A phase II trial of continuous low-dose oral cyclophosphamide and celecoxib in patients with renal cell carcinoma

Krzyzanowska, M. K., Tannock, I. F., Lockwood, G. A., Knox, J. J., Moore, M. J., & Bjarnason, G. A. (2006) · Cancer Chemotherapy and Pharmacology · doi:10.1007/s00280-006-0347-x · Cited by 39 · see citing works

Metronomic Schedule of Paclitaxel Is Effective in Hormone Receptor–Positive and Hormone Receptor–Negative Breast Cancer

Mehta, R. S., Jackson, D., & Schubbert, T. (2009) · Journal of Clinical Oncology · doi:10.1200/jco.2009.22.9377 · Cited by 8 · see citing works

Microenvironmental regulation of tumour angiogenesis

De Palma, M., Biziato, D., & Petrova, T. V. (2017) · Nature Reviews Cancer · doi:10.1038/nrc.2017.51 · Cited by 1,847 · see citing works

Tumor microenvironment complexity and therapeutic implications at a glance

Baghban, R., Roshangar, L., Jahanban-Esfahlan, R., Seidi, K., Ebrahimi-Kalan, A., Jaymand, M., Kolahian, S., Javaheri, T., & Zare, P. (2020) · Cell Communication and Signaling · doi:10.1186/s12964-020-0530-4 · Cited by 1,784 · see citing works

Tumor microenvironment and therapeutic response

Wu, T., & Dai, Y. (2017) · Cancer Letters · doi:10.1016/j.canlet.2016.01.043 · Cited by 1,802 · see citing works

Endothelial Cell Metabolism

Eelen, G., de Zeeuw, P., Treps, L., Harjes, U., Wong, B. W., & Carmeliet, P. (2017) · Physiological Reviews · doi:10.1152/physrev.00001.2017 · Cited by 591 · see citing works

Eradication of Tumors through Simultaneous Ablation of CD276/B7-H3-Positive Tumor Cells and Tumor Vasculature

Seaman, S., Zhu, Z., Saha, S., Zhang, X. M., Yang, M., Hilton, M. B., Morris, K., Szot, C. S., Morris, H., Swing, D. A., et al. (2017) · Cancer Cell · doi:10.1016/j.ccell.2017.03.005 · Cited by 422 · see citing works

Tumor endothelial cells accelerate tumor metastasis

Maishi, N., & Hida, K. (2017) · Cancer Science · doi:10.1111/cas.13336 · Cited by 319 · see citing works

The role of tumor microenvironment in therapeutic resistance

Son, B., Lee, S., Youn, H., Kim, E., Kim, W., & Youn, B. (2016) · Oncotarget · doi:10.18632/oncotarget.13907 · Cited by 305 · see citing works

Contribution of Tumor Endothelial Cells in Cancer Progression

Hida, K., Maishi, N., Annan, D. A., & Hida, Y. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19051272 · Cited by 260 · see citing works

Overcoming ABC transporter-mediated multidrug resistance: The dual role of tyrosine kinase inhibitors as multitargeting agents

Beretta, G. L., Cassinelli, G., Pennati, M., Zuco, V., & Gatti, L. (2017) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2017.07.062 · Cited by 234 · see citing works

The Great Escape; the Hallmarks of Resistance to Antiangiogenic Therapy

B, J. R. V. B., Nowak-Sliwinska, P. M., Huijbers, E. J. M., Thijssen, V. L., & Griffioen, A. W. (2015) · Pharmacological Reviews · doi:10.1124/pr.114.010215 · Cited by 211 · see citing works

Nanoformulations for combination or cascade anticancer therapy

Miao, L., Guo, S., Lin, C. M., Liu, Q., & Huang, L. (2017) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2017.06.003 · Cited by 178 · see citing works

New insights into antiangiogenic therapy resistance in cancer: Mechanisms and therapeutic aspects

Huang, M., Lin, Y., Wang, C., Deng, L., Chen, M., Assaraf, Y. G., Chen, Z., Ye, W., & Zhang, D. (2022) · Drug Resistance Updates · doi:10.1016/j.drup.2022.100849 · Cited by 176 · see citing works

The Role of Tumor-Stroma Interactions in Drug Resistance Within Tumor Microenvironment

Ni, Y., Zhou, X., Yang, J., Shi, H., Li, H., Zhao, X., & Ma, X. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.637675 · Cited by 172 · see citing works

MicroRNA-19a/b regulates multidrug resistance in human gastric cancer cells by targeting PTEN

Wang, F., Li, T., Zhang, B., Li, H., Wu, Q., Li, Y., Nie, Y., Wu, K., Shi, Y., & Fan, D. (2013) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2013.04.010 · Cited by 171 · see citing works

Heparanase and the hallmarks of cancer

Jayatilleke, K. M., & Hulett, M. D. (2020) · Journal of Translational Medicine · doi:10.1186/s12967-020-02624-1 · Cited by 161 · see citing works

Tumor angiogenesis—characteristics of tumor endothelial cells

Hida, K., Maishi, N., Torii, C., & Hida, Y. (2016) · International Journal of Clinical Oncology · doi:10.1007/s10147-016-0957-1 · Cited by 156 · see citing works

Tumor Neovascularization and Developments in Therapeutics

Katayama, Y., Uchino, J., Chihara, Y., Tamiya, N., Kaneko, Y., Yamada, T., & Takayama, K. (2019) · Cancers · doi:10.3390/cancers11030316 · Cited by 146 · see citing works

Tumour endothelial cells in high metastatic tumours promote metastasis via epigenetic dysregulation of biglycan

Maishi, N., Ohba, Y., Akiyama, K., Ohga, N., Hamada, J., Nagao‐Kitamoto, H., Alam, M. T., Yamamoto, K., Kawamoto, T., Inoue, N., et al. (2016) · Scientific Reports · doi:10.1038/srep28039 · Cited by 139 · see citing works

Redox-sensitive nanoscale drug delivery systems for cancer treatment

Mirhadi, E., Mashreghi, M., Maleki, M. F., Alavizadeh, S. H., Arabi, L., Badiee, A., & Jaafari, M. R. (2020) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2020.119882 · Cited by 123 · see citing works

Limitations of Anti-Angiogenic Treatment of Tumors

Ribatti, D., Annese, T., Ruggieri, S., Tamma, R., & Enrico Crivellato, B. (2019) · Translational Oncology · doi:10.1016/j.tranon.2019.04.022 · Cited by 122 · see citing works

Heterogeneity of tumor endothelial cells and drug delivery

Hida, K., Maishi, N., Sakurai, Y., Hida, Y., & Harashima, H. (2015) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2015.11.008 · Cited by 116 · see citing works

Hypoxia-Induced Reactive Oxygen Species Cause Chromosomal Abnormalities in Endothelial Cells in the Tumor Microenvironment

Kondoh, M., Ohga, N., Akiyama, K., Hida, Y., Maishi, N., Towfik, A. M., Inoue, N., Shindoh, M., & Hida, K. (2013) · PLoS ONE · doi:10.1371/journal.pone.0080349 · Cited by 109 · see citing works

Targeting tumour microenvironment by tyrosine kinase inhibitor

Tan, H.-Y., Wang, N., Lam, W., Guo, W., Feng, Y., & Cheng, Y.-C. (2018) · Molecular Cancer · doi:10.1186/s12943-018-0800-6 · Cited by 107 · see citing works

Biglycan is a specific marker and an autocrine angiogenic factor of tumour endothelial cells

Yamamoto, K., Ohga, N., Hida, Y., Maishi, N., Kawamoto, T., Kitayama, K., Akiyama, K., Osawa, T., Kondoh, M., Matsuda, K., et al. (2012) · British Journal of Cancer · doi:10.1038/bjc.2012.59 · Cited by 107 · see citing works

Tumor Endothelial Heterogeneity in Cancer Progression

Maishi, N., Annan, D. A., Kikuchi, H., Hida, Y., & Hida, K. (2019) · Cancers · doi:10.3390/cancers11101511 · Cited by 103 · see citing works

Tumor microenvironment and nanotherapeutics.

Upreti, M., Jyoti, A., & Sethi, P. (2013) · PubMed · doi:10.3978/j.issn.2218-676x.2013.08.11 · Cited by 103 · see citing works

Metronomic chemotherapy for cancer treatment: a decade of clinical studies

Romiti, A., Cox, M. C., Sarcina, I., Rocco, R. D., D’Antonio, C., Barucca, V., & Marchetti, P. (2013) · Cancer Chemotherapy and Pharmacology · doi:10.1007/s00280-013-2125-x · Cited by 103 · see citing works

Role of the tumor stroma in resistance to anti-angiogenic therapy

Huijbers, E. J. M., B, J. R. V. B., Thijssen, V. L., Sabrkhany, S., Nowak-Sliwinska, P. M., & Griffioen, A. W. (2016) · Drug Resistance Updates · doi:10.1016/j.drup.2016.02.002 · Cited by 97 · see citing works

Alleviation of Multidrug Resistance by Flavonoid and Non-Flavonoid Compounds in Breast, Lung, Colorectal and Prostate Cancer

Costea, T., Vlad, O., Miclea, L. C., Ganea, C., Szöllõsi, J., & Mocanu, M. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21020401 · Cited by 92 · see citing works

Hypoxic Tumor-Derived Exosomal Circ0048117 Facilitates M2 Macrophage Polarization Acting as miR-140 Sponge in Esophageal Squamous Cell Carcinoma

Lu, Q., Wang, X., Zhu, J. J., Fei, X., Chen, H., & Li, C. G. (2020) · OncoTargets and Therapy · doi:10.2147/ott.s284192 · Cited by 83 · see citing works

Lysyl oxidase secreted by tumour endothelial cells promotes angiogenesis and metastasis

Osawa, T., Ohga, N., Akiyama, K., Hida, Y., Kitayama, K., Kawamoto, T., Yamamoto, K., Maishi, N., Kondoh, M., Onodera, Y., et al. (2013) · British Journal of Cancer · doi:10.1038/bjc.2013.535 · Cited by 84 · see citing works

Tumour Microenvironment Stress Promotes the Development of Drug Resistance

Seebacher, N. A., Krchniaková, M., Stacy, A. E., Skoda, J., & Jansson, P. J. (2021) · Antioxidants · doi:10.3390/antiox10111801 · Cited by 79 · see citing works

Amino acid transporter LAT1 in tumor-associated vascular endothelium promotes angiogenesis by regulating cell proliferation and VEGF-A-dependent mTORC1 activation

Quan, L., Ohgaki, R., Hara, S., Okuda, S., Wei, L., Okanishi, H., Nagamori, S., Endou, H., & Kanai, Y. (2020) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-020-01762-0 · Cited by 75 · see citing works

CXCL12–CXCR7 axis is important for tumor endothelial cell angiogenic property

Yamada, K., Maishi, N., Akiyama, K., Alam, M. T., Ohga, N., Kawamoto, T., Shindoh, M., Takahashi, N., Kamiyama, T., Hida, Y., et al. (2015) · International Journal of Cancer · doi:10.1002/ijc.29655 · Cited by 75 · see citing works

Heterogeneity of tumor endothelial cells

Hida, K., Ohga, N., Akiyama, K., Maishi, N., & Hida, Y. (2013) · Cancer Science · doi:10.1111/cas.12251 · Cited by 72 · see citing works

Tumour endothelial cells acquire drug resistance in a tumour microenvironment

Hida, K., Akiyama, K., Ohga, N., Maishi, N., & Hida, Y. (2013) · Journal of Biochemistry · doi:10.1093/jb/mvs152 · Cited by 68 · see citing works

Carbonic anhydrase 2 (CAII) supports tumor blood endothelial cell survival under lactic acidosis in the tumor microenvironment

Annan, D. A., Maishi, N., Soga, T., Dawood, R., Li, C., Kikuchi, H., Hojo, T., Morimoto, M., Kitamura, T., Alam, M. T., et al. (2019) · Cell Communication and Signaling · doi:10.1186/s12964-019-0478-4 · Cited by 67 · see citing works

Tumor endothelial expression of P-glycoprotein upon microvesicular transfer of TrpC5 derived from adriamycin-resistant breast cancer cells

Dong, Y., Pan, Q., Li, J., Chen, Z., Zhang, F.-F., Liu, Y., Xing, H., Shi, M., Li, J., Li, X., et al. (2014) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2014.02.076 · Cited by 63 · see citing works

Recent advances in tumor microenvironment-targeted nanomedicine delivery approaches to overcome limitations of immune checkpoint blockade-based immunotherapy.

Kim, J., Hong, J., Lee, J., Lahiji, S. F., & Kim, Y.-H. (2021) · Journal of Controlled Release · doi:10.1016/j.jconrel.2021.02.002 · Cited by 51 · see citing works

Epigenetic Crosstalk between the Tumor Microenvironment and Ovarian Cancer Cells: A Therapeutic Road Less Traveled

Klymenko, Y., & Nephew, K. P. (2018) · Cancers · doi:10.3390/cancers10090295 · Cited by 61 · see citing works

Concentration- and schedule-dependent effects of chemotherapy on the angiogenic potential and drug sensitivity of vascular endothelial cells

Pasquier, E., Tuset, M., Street, J. A., Sinnappan, S. M., MacKenzie, K. L., Braguer, D., André, N., & Kavallaris, M. (2012) · Angiogenesis · doi:10.1007/s10456-012-9321-x · Cited by 60 · see citing works

Identification of Tumor Endothelial Cells with High Aldehyde Dehydrogenase Activity and a Highly Angiogenic Phenotype

Ohmura, H., Akiyama, K., Maishi, N., Ohga, N., Hida, Y., Kawamoto, T., Iida, J., Shindoh, M., Tsuchiya, K., Shinohara, N., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0113910 · Cited by 57 · see citing works

Cancer Stem Cells in Ovarian Cancer—A Source of Tumor Success and a Challenging Target for Novel Therapies

Wilczyński, J. R., Wilczyński, M., & Paradowska, E. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23052496 · Cited by 58 · see citing works

Induction of acquired drug resistance in endothelial cells and its involvement in anticancer therapy

Huang, L., Perrault, C., Coelho-Martins, J., Hu, C., Dulong, C., Varna, M., Liu, J., Jin, J., Soria, C., Cazin, L., et al. (2013) · Journal of Hematology & Oncology · doi:10.1186/1756-8722-6-49 · Cited by 53 · see citing works

Building blood vessels in development and disease

Kushner, E. J., & Bautch, V. L. (2013) · Current Opinion in Hematology · doi:10.1097/moh.0b013e328360614b · Cited by 51 · see citing works

Chemotherapy-Induced IL8 Upregulates MDR1/ABCB1 in Tumor Blood Vessels and Results in Unfavorable Outcome

Kikuchi, H., Maishi, N., Annan, D. A., Alam, M. T., Dawood, R., Sato, M., Morimoto, M., Takeda, R., Ishizuka, K., Matsumoto, R., et al. (2020) · Cancer Research · doi:10.1158/0008-5472.can-19-3791 · Cited by 51 · see citing works

Tumor endothelial cells with high aldehyde dehydrogenase activity show drug resistance

Hida, K., Maishi, N., Akiyama, K., Ohmura‐Kakutani, H., Torii, C., Ohga, N., Osawa, T., Kikuchi, H., Morimoto, H., Morimoto, M., et al. (2017) · Cancer Science · doi:10.1111/cas.13388 · Cited by 48 · see citing works

ROS enhance angiogenic properties via regulation of NRF2 in tumor endothelial cells

Hojo, T., Maishi, N., Towfik, A. M., Akiyama, K., Ohga, N., Shindoh, M., Hida, Y., Minowa, K., Fujisawa, T., & Hida, K. (2017) · Oncotarget · doi:10.18632/oncotarget.17567 · Cited by 47 · see citing works

The Epigenetic Profile of Tumor Endothelial Cells. Effects of Combined Therapy with Antiangiogenic and Epigenetic Drugs on Cancer Progression

Ciesielski, O., Biesiekierska, M., Panthu, B., Vialichka, V., Pirola, L., & Balcerczyk, A. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21072606 · Cited by 47 · see citing works

Tumour associated endothelial cells: origin, characteristics and role in metastasis and anti-angiogenic resistance

Yao, X.-H., & Zeng, Y. (2023) · Frontiers in Physiology · doi:10.3389/fphys.2023.1199225 · Cited by 41 · see citing works

Hybrids from 4-anilinoquinazoline and hydroxamic acid as dual inhibitors of vascular endothelial growth factor receptor-2 and histone deacetylase

Peng, F.-W., Wu, T.-T., Ren, Z., Xue, J., & Shi, L. (2015) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2015.10.006 · Cited by 45 · see citing works

Identification of novel targets for antiangiogenic therapy by comparing the gene expressions of tumor and normal endothelial cells

Otsubo, T., Hida, Y., Ohga, N., Sato, H., Kai, T., Matsuki, Y., Takasu, H., Akiyama, K., Maishi, N., Kawamoto, T., et al. (2014) · Cancer Science · doi:10.1111/cas.12394 · Cited by 43 · see citing works

Antisense Oligonucleotides Targeting Y-Box Binding Protein-1 Inhibit Tumor Angiogenesis by Downregulating Bcl-xL-VEGFR2/-Tie Axes

Setoguchi, K., Cui, L., Hachisuka, N., Obchoei, S., Shinkai, K., Hyodo, F., Kato, K., Wada, F., Yamamoto, T., Harada‐Shiba, M., et al. (2017) · Molecular Therapy — Nucleic Acids · doi:10.1016/j.omtn.2017.09.004 · Cited by 42 · see citing works

Multiplicity of acquired cross-resistance in paclitaxel-resistant cancer cells is associated with feedback control of TUBB3 via FOXO3a-mediated ABCB1 regulation

Aldonza, M. B. D., Hong, J., Alinsug, M. V., Song, J., & Lee, S. K. (2016) · Oncotarget · doi:10.18632/oncotarget.9118 · Cited by 41 · see citing works

Suprabasin as a novel tumor endothelial cell marker

Alam, M. T., Nagao‐Kitamoto, H., Ohga, N., Akiyama, K., Maishi, N., Kawamoto, T., Shinohara, N., Taketomi, A., Shindoh, M., Hida, Y., et al. (2014) · Cancer Science · doi:10.1111/cas.12549 · Cited by 41 · see citing works

Prostacyclin receptor in tumor endothelial cells promotes angiogenesis in an autocrine manner

Osawa, T., Ohga, N., Hida, Y., Kitayama, K., Akiyama, K., Onodera, Y., Fujie, M., Shinohara, N., Shindoh, M., Nonomura, K., et al. (2012) · Cancer Science · doi:10.1111/j.1349-7006.2012.02261.x · Cited by 40 · see citing works

Stromal cells in breast cancer as a potential therapeutic target

Dykes, S. S., Hughes, V. S., Wiggins, J. M., Fasanya, H. O., Tanaka, M., & Siemann, D. W. (2018) · Oncotarget · doi:10.18632/oncotarget.25245 · Cited by 39 · see citing works

Resistance to metronomic chemotherapy and ways to overcome it

Martínez, M. C. R., Parra, K., Saluja, R., Francia, G., & Emmenegger, U. (2017) · Cancer Letters · doi:10.1016/j.canlet.2017.02.027 · Cited by 37 · see citing works

Tumor Endothelial Cell—A Biological Tool for Translational Cancer Research

Annan, D. A., Kikuchi, H., Maishi, N., Hida, Y., & Hida, K. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21093238 · Cited by 37 · see citing works

miRNA-1246 in extracellular vesicles secreted from metastatic tumor induces drug resistance in tumor endothelial cells

Torii, C., Maishi, N., Kawamoto, T., Morimoto, M., Akiyama, K., Yoshioka, Y., Minami, T., Tsumita, T., Alam, M. T., Ochiya, T., et al. (2021) · Scientific Reports · doi:10.1038/s41598-021-92879-5 · Cited by 37 · see citing works

Colchicine Binding Site Agent DJ95 Overcomes Drug Resistance and Exhibits Antitumor Efficacy

Arnst, K. E., Wang, Y., Lei, Z., Hwang, D., Kumar, G., Ma, D., Parke, D. N., Chen, Q., Yang, J., White, S. W., et al. (2019) · Molecular Pharmacology · doi:10.1124/mol.118.114801 · Cited by 35 · see citing works

AKT as locus of cancer multidrug resistance and fragility

Radisavljevic, Z. M. (2012) · Journal of Cellular Physiology · doi:10.1002/jcp.24176 · Cited by 34 · see citing works

Tumor microenvironment conditions alter Akt and Na+/H+ exchanger NHE1 expression in endothelial cells more than hypoxia alone: implications for endothelial cell function in cancer

Pedersen, A. K., de Melo, J. M. L., Mørup, N., Tritsaris, K., & Pedersen, S. F. (2017) · BMC Cancer · doi:10.1186/s12885-017-3532-x · Cited by 34 · see citing works

Development of an orally bioavailable mSWI/SNF ATPase degrader and acquired mechanisms of resistance in prostate cancer

He, T., Cheng, C., Qiao, Y., Cho, H., YOUNG, E. A., Mannan, R., Mahapatra, S., Miner, S. J., Zheng, Y., Kim, N. H., et al. (2024) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2322563121 · Cited by 32 · see citing works

Inhibition of Multidrug Transporter in Tumor Endothelial Cells Enhances Antiangiogenic Effects of Low-Dose Metronomic Paclitaxel

Akiyama, K., Maishi, N., Ohga, N., Hida, Y., Ohba, Y., Alam, M. T., Kawamoto, T., Ohmura, H., Yamada, K., Torii, C., et al. (2014) · American Journal Of Pathology · doi:10.1016/j.ajpath.2014.10.017 · Cited by 31 · see citing works

Extracellular galectin-3 programs multidrug resistance through Na+/K+-ATPase and P-glycoprotein signaling

Harazono, Y., Kho, D. H., Balan, V., Nakajima, K., Hogan, V. A., & Raz, A. (2015) · Oncotarget · doi:10.18632/oncotarget.4285 · Cited by 30 · see citing works

Cancer anti-angiogenesis vaccines: Is the tumor vasculature antigenically unique?

Wagner, S. C., Ichim, T. E., Ma, H., Szymanski, J., Perez, J. A., Lopez, J., Bogin, V., Patel, A. N., Marincola, F. M., & Kesari, S. (2015) · Journal of Translational Medicine · doi:10.1186/s12967-015-0688-5 · Cited by 28 · see citing works

Nanomedicine as a potent strategy in melanoma tumor microenvironment

Pautu, V., Leonetti, D., Lepeltier, É., Clere, N., & Passirani, C. (2017) · Pharmacological Research · doi:10.1016/j.phrs.2017.02.014 · Cited by 28 · see citing works

Recruited bone marrow derived cells, local stromal cells and IL-17 at the front line of resistance development to anti-VEGF targeted therapies

Darvishi, B., Majidzadeh‐A, K., Ghadirian, R., Mosayebzadeh, M., & Farahmand, L. (2018) · Life Sciences · doi:10.1016/j.lfs.2018.11.033 · Cited by 28 · see citing works

Contribution of tumor endothelial cells to drug resistance: anti-angiogenic tyrosine kinase inhibitors act as p-glycoprotein antagonists

Bani, M. R., Decio, A., Giavazzi, R., & Ghilardi, C. (2017) · Angiogenesis · doi:10.1007/s10456-017-9549-6 · Cited by 27 · see citing works

Endothelial Cells Promote Docetaxel Resistance of Prostate Cancer Cells by Inducing ERG Expression and Activating Akt/mTOR Signaling Pathway

Zhou, W., Su, Y., Zhang, Y., Han, B., Liu, H., & Wang, X. (2020) · Frontiers in Oncology · doi:10.3389/fonc.2020.584505 · Cited by 26 · see citing works

Role of tumor hypoxia in acquisition of resistance to microtubule-stabilizing drugs

Das, V., Štěpánková, J., Hajdúch, M., & Miller, J. H. (2015) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2015.02.001 · Cited by 26 · see citing works

Tumor–stromal interactions in breast tumor progression – significance of histological heterogeneity of tumor–stromal fibroblasts

Hasebe, T. (2013) · Expert Opinion on Therapeutic Targets · doi:10.1517/14728222.2013.757305 · Cited by 26 · see citing works

Novel human Ab against vascular endothelial growth factor receptor 2 shows therapeutic potential for leukemia and prostate cancer

Lu, R., Chiu, C., Liu, I.-J., Chang, Y., Liu, Y., & Wu, H. (2019) · Cancer Science · doi:10.1111/cas.14208 · Cited by 25 · see citing works

Growth-Factor-Driven Rescue to Receptor Tyrosine Kinase (RTK) Inhibitors through Akt and Erk Phosphorylation in Pediatric Low Grade Astrocytoma and Ependymoma

Sie, M., den Dunnen, W. F. A., Lourens, H. J., Boer, T. M.-D., Scherpen, F. J. G., Zomerman, W. W., Kampen, K. R., Hoving, E. W., & de Bont, E. S. J. M. (2015) · PLoS ONE · doi:10.1371/journal.pone.0122555 · Cited by 24 · see citing works

Cancer-Induced Metabolic Rewiring of Tumor Endothelial Cells

Lidonnici, J., Santoro, M. M., & Oberkersch, R. E. (2022) · Cancers · doi:10.3390/cancers14112735 · Cited by 22 · see citing works

ATP-binding cassette transporters in tumor endothelial cells and resistance to metronomic chemotherapy

Hida, K., Kikuchi, H., Maishi, N., & Hida, Y. (2017) · Cancer Letters · doi:10.1016/j.canlet.2017.02.006 · Cited by 22 · see citing works

mAb MDR1-modified chitosan nanoparticles overcome acquired EGFR-TKI resistance through two potential therapeutic targets modulation of MDR1 and autophagy

Zheng, Y., Su, C., Zhao, L., & Shi, Y. (2017) · Journal of Nanobiotechnology · doi:10.1186/s12951-017-0302-5 · Cited by 21 · see citing works

Hypoxia Induces Multidrug Resistance via Enhancement of Epidermal Growth Factor-Like Domain 7 Expression in Non-Small Lung Cancer Cells

Shen, X., Zhi, Q., Wang, Y., Li, Z., Zhou, J., & Huang, J. (2017) · Chemotherapy · doi:10.1159/000456066 · Cited by 20 · see citing works

Potential Therapeutic Strategies for Lung and Breast Cancers through Understanding the Anti-Angiogenesis Resistance Mechanisms

Ramadan, W. S. H., Zaher, D. M., Altaie, A. M., Talaat, I. M., & Elmoselhi, A. B. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21020565 · Cited by 20 · see citing works

Induction of multiple drug resistance in HMEC-1 endothelial cells after long-term exposure to sunitinib

Lu, H., Vannier, J., Huang, L., Hu, C., Liu, J., Wang, L., Jin, J., Janin, A., Li, H., Benedetto, M. D., et al. (2014) · OncoTargets and Therapy · doi:10.2147/ott.s67251 · Cited by 19 · see citing works

Systematic Analysis of the Transcriptome Profiles and Co-Expression Networks of Tumour Endothelial Cells Identifies Several Tumour-Associated Modules and Potential Therapeutic Targets in Hepatocellular Carcinoma

Mohr, T. T., Katz, S., Paulitschke, V., Aizarani, N., & Tolios, A. (2021) · Cancers · doi:10.3390/cancers13081768 · Cited by 18 · see citing works

Efficacy and safety of ramucirumab plus modified FOLFIRI for metastatic colorectal cancer

Yoshihiro, T., Kusaba, H., Makiyama, A., Kobayashi, K., Uenomachi, M., Ito, M., Doi, Y., Mitsugi, K., Aikawa, T., Takayoshi, K., et al. (2019) · International Journal of Clinical Oncology · doi:10.1007/s10147-018-01391-w · Cited by 19 · see citing works

Fluorescence‐based discrimination of breast cancer cells by direct exposure to 5‐aminolevulinic acid

Morita, M., Tanaka, H., Kumamoto, Y., Nakamura, A., Harada, Y., Ogata, T., Sakaguchi, K., Taguchi, T., & Takamatsu, T. (2019) · Cancer Medicine · doi:10.1002/cam4.2466 · Cited by 18 · see citing works

Aberrant tumor vasculature. Facts and pitfalls

Ribatti, D. (2024) · Frontiers in Pharmacology · doi:10.3389/fphar.2024.1384721 · Cited by 18 · see citing works

A New Antitumor Direction: Tumor-Specific Endothelial Cells

Liang, J., Wang, S., Zhang, G., He, B., Bie, Q., & Zhang, B. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.756334 · Cited by 18 · see citing works

Small Molecule Inhibitors of Multidrug Resistance Gene (MDR1) Expression: Preclinical Evaluation and Mechanisms of Action

Santos, S., & Paulo, A. (2013) · Current Cancer Drug Targets · doi:10.2174/15680096113139990082 · Cited by 18 · see citing works

Scaffold biomaterials for nano-pathophysiology

Yamamoto, M., Rafii, S., & Rabbany, S. Y. (2013) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2013.09.009 · Cited by 18 · see citing works

Abnormalities of tumor endothelial cells and cancer progression

Hida, K., & Maishi, N. (2017) · Oral Science International · doi:10.1016/s1348-8643(17)30041-1 · Cited by 18 · see citing works

Multi-omics dissection of tumor microenvironment-mediated drug resistance: mechanisms and therapeutic reprogramming

Chen, F., Fu, Y., Bai, G., Qiu, J., & Hua, K. (2025) · Frontiers in Pharmacology · doi:10.3389/fphar.2025.1634413 · Cited by 17 · see citing works

Cajanol Sensitizes A2780/Taxol Cells to Paclitaxel by Inhibiting the PI3K/Akt/NF-κB Signaling Pathway

Sui, M., Yang, H., Guo, M., Li, W., Gong, Z., Jiang, J., & Li, P. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.783317 · Cited by 17 · see citing works

Fibrocytes: A Novel Stromal Cells to Regulate Resistance to Anti-Angiogenic Therapy and Cancer Progression

Goto, H., & Nishioka, Y. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms19010098 · Cited by 16 · see citing works

The Roles of Tumor Endothelial Cells in Cancer Metastasis

Hida, K., Maishi, N., Takeda, R., & Hida, Y. (2022) · Exon Publications eBooks · doi:10.36255/exon-publications.metastasis.endothelial-cells · Cited by 16 · see citing works

The F ‐prostaglandin receptor is a novel marker for tumor endothelial cells in renal cell carcinoma

Akiyama, K., Ohga, N., Maishi, N., Hida, Y., Kitayama, K., Kawamoto, T., Osawa, T., Suzuki, Y., Shinohara, N., Nonomura, K., et al. (2013) · Pathology International · doi:10.1111/pin.12031 · Cited by 16 · see citing works

Acquisition of drug resistance in endothelial cells by tumor-derived extracellular vesicles and cancer progression

Morimoto, M., Maishi, N., & Hida, K. (2024) · Cancer Drug Resistance · doi:10.20517/cdr.2023.121 · Cited by 15 · see citing works

Prognostic role of YB-1 expression in breast cancer: a meta-analysis.

Wang, X., Guo, X., Shen, X., Zhou, H., Wan, D.-W., Xue, X., Han, Y., Yuan, B., Zhou, J., Zhao, H., et al. (2015) · PubMed Central · Cited by 15 · see citing works

Targeting angiogenesis in gastrointestinal tumors: current challenges

Nandikolla, A. G., & Rajdev, L. N. (2016) · Translational Gastroenterology and Hepatology · doi:10.21037/tgh.2016.08.04 · Cited by 15 · see citing works

Tubulin Beta3 Serves as a Target of HDAC3 and Mediates Resistance to Microtubule-Targeting Drugs

Kim, Y., Kim, H., & Jeoung, D. (2015) · Molecules and Cells · doi:10.14348/molcells.2015.0086 · Cited by 14 · see citing works

miR-1246 in tumor extracellular vesicles promotes metastasis via increased tumor cell adhesion and endothelial cell barrier destruction

Morimoto, M., Maishi, N., Tsumita, T., Alam, M. T., Kikuchi, H., Hida, Y., Yoshioka, Y., Ochiya, T., Annan, D. A., Takeda, R., et al. (2023) · Frontiers in Oncology · doi:10.3389/fonc.2023.973871 · Cited by 13 · see citing works

Beyond starving cancer: anti-angiogenic therapy

Hida, K., Maishi, N., Matsuda, A., & Yu, L. (2023) · Journal of Medical Ultrasonics · doi:10.1007/s10396-023-01310-1 · Cited by 13 · see citing works

Abstract 1370: Tumor endothelial cells acquire drug resistance by MDR1 upregulation via VEGF signaling in tumor microenvironment

Akiyama, K., Ohga, N., Hida, Y., Kawamoto, T., Sadamoto, Y., Ishikawa, S., Maishi, N., Akino, T., Kondoh, M., Matsuda, A., et al. (2012) · Cancer Research · doi:10.1158/1538-7445.am2012-1370

Tumour endothelial cells acquire drug resistance in a tumour microenvironment

Hida, K., Akiyama, K., Ohga, N., Maishi, N., & Hida, Y. (2013) · Journal of Biochemistry · doi:10.1093/jb/mvs152 · Cited by 68 · see citing works

Abstract 2376: Endothelial cells acquire abnormalities by factors from tumor cells

Akiyama, K., Ohga, N., Hida, Y., Akino, T., Hirata, N., Kurosu, T., Ishikawa, S., Kondo, M., Maishi, N., Kawamoto, T., et al. (2010) · Cancer Research · doi:10.1158/1538-7445.am10-2376

Multiple drug resistance phenotype of human endothelial cells induced by vascular endothelial growth factor 165.

Zhang, X., Zhu, X., Gao, J., Qian, C., Kuang, Z.-J., Liu, Z., & Zeng, Y. (2001) · PubMed · Cited by 13 · see citing works

Adaptive resistance of tumor cells to anti-vascular endothelial growth factor therapy: A reversible phenomenon

Wang, Z., Wang, M., Guo, J., Lu, Y., & Wei, P. (2024) · Cytokine · doi:10.1016/j.cyto.2024.156674 · Cited by 3 · see citing works