The DOI matches its Crossref record; 33 of the 33 references it cites were found in a registry or an index.
Phenotypic Transitions of Macrophages Orchestrate Tissue Repair
Open accessAbstract
Macrophages are essential for the efficient healing of numerous tissues, and they contribute to impaired healing and fibrosis. Tissue repair proceeds through overlapping phases of inflammation, proliferation, and remodeling, and macrophages are present throughout this progression. Macrophages exhibit transitions in phenotype and function as tissue repair progresses, although the precise factors regulating these transitions remain poorly defined. In efficiently healing injuries, macrophages present during a given stage of repair appear to orchestrate transition into the next phase and, in turn, can promote debridement of the injury site, cell proliferation and angiogenesis, collagen deposition, and matrix remodeling. However, dysregulated macrophage function can contribute to failure to heal or fibrosis in several pathological situations. This review will address current knowledge of the origins and functions of macrophages during the progression of tissue repair, with emphasis on skin and skeletal muscle. Dysregulation of macrophages in disease states and therapies targeting macrophage activation to promote tissue repair are also discussed.
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Cites
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Cited by
From Monocytes to M1/M2 Macrophages: Phenotypical vs. Functional Differentiation
Italiani, P., & Boraschi, D. (2014) · Frontiers in Immunology · doi:10.3389/fimmu.2014.00514 · Cited by 2,067
Microglia in the TBI brain: The good, the bad, and the dysregulated
Loane, D. J., & Kumar, A. (2016) · Experimental Neurology · doi:10.1016/j.expneurol.2015.08.018 · Cited by 802
Macrophage activation and its role in repair and pathology after spinal cord injury
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Macrophage polarization in pathology
Sica, A., Erreni, M., Allavena, P., & Porta, C. (2015) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-015-1995-y · Cited by 673
Tumors: Wounds That Do Not Heal—Redux
Dvorak, H. F. (2015) · Cancer Immunology Research · doi:10.1158/2326-6066.cir-14-0209 · Cited by 592
Metadata
- Authors
- Novak, M. L., & Koh, T. J.
- Venue
- The American Journal of Pathology
- Publisher
- Elsevier BV
- Published
- 2013-11
- Volume
- 183
- Issue
- 5
- Pages
- 1352-1363
- ISSN
- 0002-9440 (ISSN-L)
- OpenAlex
- W2006960578
- Cited by
- 350
- References
- 33
- FWCI
- 28.10
- Type
- journal article
- Language
- en
- Open access
- hybrid
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