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Endothelial Cell Calcium Signaling during Barrier Function and Inflammation
Open accessAbstract
Calcium is an essential second messenger in endothelial cells and plays a pivotal role in regulating a number of physiological processes including cell migration, angiogenesis, barrier function, and inflammation. An increase in intracellular Ca2+ concentration can trigger a number of diverse signaling pathways under both physiologic and pathologic conditions. In this review we will specifically discuss how calcium signaling pathways in endothelial cells play an essential role in affecting barrier function and facilitating inflammation. Inflammatory mediators such as thrombin and histamine increase intracellular calcium levels. This calcium influx causes adherens junctions disassembly and cytoskeletal rearrangements to facilitate endothelial cell retraction and increased permeability. During inflammation endothelial cell calcium entry and the calcium-related signaling events also help facilitate several leukocyte-endothelial cell interactions such as leukocyte rolling, adhesion, and ultimately transendothelial migration.
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Clapham, D. E. (2007) · Cell · doi:10.1016/j.cell.2007.11.028 · Cited by 4,175
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Li, X., Vemireddy, V., Cai, Q., Xiong, H., Kang, P., Li, X., Giannotta, M., Hayenga, H. N., Pan, E., Sirsi, S. R., et al. (2021) · Nano Letters · doi:10.1021/acs.nanolett.1c02996 · Cited by 105
Metadata
- Authors
- Dalal, P. J., Muller, W. A., & Sullivan, D. P.
- Venue
- The American Journal of Pathology
- Publisher
- Elsevier BV
- Published
- 2020-03
- Volume
- 190
- Issue
- 3
- Pages
- 535-542
- ISSN
- 0002-9440 (ISSN-L)
- OpenAlex
- W2994635858
- Cited by
- 237
- References
- 1
- FWCI
- 11.45
- Type
- journal article
- Language
- en
- Open access
- bronze
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