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Cited by 105Barrier Structure and Function StudiesNanoparticle-Based Drug DeliveryNanoplatforms for cancer theranostics

Reversibly Modulating the Blood–Brain Barrier by Laser Stimulation of Molecular-Targeted Nanoparticles

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Li, Xiaoqing, Vemireddy, Vamsidhara, Cai, Qi, Xiong, Hejian, Kang, Peiyuan, Li, Xiuying, Giannotta, Monica, Hayenga, Heather N. +9 more·2021·Nano Letters
DOI 10.1021/acs.nanolett.1c02996PMC PMC8616836
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Abstract

The blood-brain barrier (BBB) is highly selective and acts as the interface between the central nervous system and circulation. While the BBB is critical for maintaining brain homeostasis, it represents a formidable challenge for drug delivery. Here we synthesized gold nanoparticles (AuNPs) for targeting the tight junction specifically and demonstrated that transcranial picosecond laser stimulation of these AuNPs post intravenous injection increases the BBB permeability. The BBB permeability change can be graded by laser intensity, is entirely reversible, and involves increased paracellular diffusion. BBB modulation does not lead to significant disruption in the spontaneous vasomotion or the structure of the neurovascular unit. This strategy allows the entry of immunoglobulins and viral gene therapy vectors, as well as cargo-laden liposomes. We anticipate this nanotechnology to be useful for tissue regions that are accessible to light or fiberoptic application and to open new avenues for drug screening and therapeutic interventions in the central nervous system.

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  • BV11-modified gold nanoparticles cause no obvious disruptions in brain microvasculature dynamics or neuronal injury.

    “There were no obvious disruptions in vast dynamics or neuronal injury.”

    From The blood–brain barrier: Structure, regulation and drug delivery (2023) · cites this paper as [218]

    The Results section, “Effect of BBB Modulation on Vascular Dynamics and Brain Parenchyma” (page unavailable), reports no impairment of spontaneous vasomotion at low laser energy and no observed neuronal structural injury. But vasomotion was temporarily attenuated at higher laser energy, so the unqualified claim of no disruption overstates the findings. These observations concern laser stimulation of BV11-modified nanoparticles, not the nanoparticles alone. (LLM, conf=0.87)

    Experimental — accuracy not yet measured

  • After light stimulation of BV11-modified gold nanoparticles, tight junctions of BBB ameliorate, allowing macromolecules and virus to cross.

    “after light stimulation of BV11 modified gold nanoparticles, tight junctions of BBB ameliorated, allowing particles like macromolecules and virus to cross.”

    From The blood–brain barrier: Structure, regulation and drug delivery (2023) · cites this paper as [218]

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Sorted by citations

Authors
Li, X., Vemireddy, V., Cai, Q., Xiong, H., Kang, P., Li, X., Giannotta, M., Hayenga, H. N., Pan, E., Sirsi, S. R., Mateo, C., Kleinfeld, D., Greene, C., Campbell, M., Dejana, E., Bachoo, R., & Qin, Z.
Affiliations
  • The University of Texas at Dallas (US)
  • Harold C. Simmons Comprehensive Cancer Center (US)
  • IFOM (IT)
  • The University of Texas Southwestern Medical Center (US)
  • Department of Physics, University of California San Diego, La Jolla, California 92093, United States
  • University of California San Diego (US)
  • Trinity College Dublin (IE)
Corresponding author
  • Bachoo, Robert
  • Qin, Zhenpeng
ORCID
Venue
Nano Letters
Publisher
American Chemical Society (ACS)
Published
2021-09-13
Volume
21
Issue
22
Pages
9805-9815
ISSN
  • 1530-6984 (ISSN-L)
  • 1530-6992
DOI
10.1021/acs.nanolett.1c02996
PMC
PMC8616836
OpenAlex
W3200816532
Cited by
105
References
6
Citations by year
2026: 9 · 2025: 29 · 2024: 24 · 2023: 26 · 2022: 14 · 2021: 3
FWCI
6.71
Type
journal article
Language
en
Open access
Licence
Locations
  • Nano Letters (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • American Heart Association (19CSLOI34770004)
  • Fondazione Cariplo (2016-0461)
  • Cancer Prevention and Research Institute of Texas (RP160770, RP190278)
  • Office of the Director (1S10OD021685-01A1)
  • H2020 European Research Council (742922)
Topics
  • Life Sciences › Neuroscience › Neurology › Barrier Structure and Function Studies
  • Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
  • Physical Sciences › Engineering › Biomedical Engineering › Nanoplatforms for cancer theranostics
Keywords
blood-brain barrier, gold nanoparticles, paracellular diffusion, vasomotion, neurovascular unit, brain drug delivery, liposomal drug delivery, central nervous system
MeSH terms
Biological Transport, Blood-Brain Barrier, Gold, Lasers, Nanoparticles, Metal Nanoparticles

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