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Ethanol treatment of lymphoblastoid cell lines from alcoholics and non-alcoholics causes many subtle changes in gene expression

McClintick, Jeanette N., Brooks, Andrew I., Deng, Li, Liang, Li, Wang, Jen C., Kapoor, Manav, Xuei, Xiaoling, Foroud, Tatiana +2 more·2014·Alcohol
DOI 10.1016/j.alcohol.2014.07.004PMC PMC4730944
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  • Intersection of the microglia signature gene list with 46 publicly available data sets for differentially regulated genes in neurodegenerative and behavioral disorders revealed significant enrichment or depletion of microglia signature genes in 28 of the 46 data sets.

    “We then intersected this gene list with 46 publicly available data sets for differentially regulated genes in neurodegenerative and behavioral disorders derived from microarray or RNA-seq analysis of intact tissue (39–53). Two-sided Fisher’s exact tests revealed significant enrichment or depletion of microglia signature genes in 28 of the 46 data sets (Table S3).”

    From An environment-dependent transcriptional network specifies human microglia identity (2017) · cites this paper as [44]

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Cited by

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Authors
McClintick, J. N., Brooks, A. I., Deng, L., Liang, L., Wang, J. C., Kapoor, M., Xuei, X., Foroud, T., Tischfield, J. A., & Edenberg, H. J.
Venue
Alcohol
Publisher
Elsevier BV
Published
2014-09
Volume
48
Issue
6
Pages
603-610
ISSN
0741-8329
DOI
10.1016/j.alcohol.2014.07.004
PMC
PMC4730944
Cited by
27
References
3
Language
en
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Funders
  • Indiana Genomics Initiative of Indiana University
  • The Lilly Endowment, Inc
  • National Institutes of Health (U10AA008401)
  • National Institute on Alcohol Abuse and Alcoholism
  • National Institute on Drug Abuse
  • National Health and Medical Research Council
  • The University of Sydney
  • Prince of Wales Medical Research Institute
  • Neuroscience Institute of Schizophrenia and Allied Disorders
  • National Institute of Alcohol Abuse and Alcoholism (R01 AA12725)
  • NSW Department of Health

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