Neuroimmune signaling: a key component of alcohol abuse

From inflammation to sickness and depression: when the immune system subjugates the brain

Dantzer, R., O'Connor, J. C., Freund, G. G., Johnson, R. W., & Kelley, K. W. (2008) · Nature Reviews Neuroscience · doi:10.1038/nrn2297 · Cited by 7,395 · see citing works

The Danger Model: A Renewed Sense of Self

Matzinger, P. (2002) · Science · doi:10.1126/science.1071059 · Cited by 4,205 · see citing works

Mechanisms underlying inflammation in neurodegeneration

Glass, C. K., Saijo, K., Winner, B., Marchetto, M. C., & Gage, F. H. (2010) · Cell · doi:10.1016/j.cell.2010.02.016 · Cited by 3,580 · see citing works

Systemic LPS causes chronic neuroinflammation and progressive neurodegeneration

Qin, L., Wu, X., Block, M. L., Liu, Y., Breese, G. R., Hong, J., Knapp, D. J., & Crews, F. T. (2007) · Glia · doi:10.1002/glia.20467 · Cited by 2,144 · see citing works

Toll‐like Receptor and RIG‐1‐like Receptor Signaling

Kawai, T., & Akira, S. (2008) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1443.020 · Cited by 985 · see citing works

Pivotal role for neuronal Toll-like receptors in ischemic brain injury and functional deficits

Tang, S.-C., Arumugam, T. V., Xu, X., Cheng, A., Mughal, M. R., Jo, D. G., Lathia, J. D., Siler, D. A., Chigurupati, S., Ouyang, X., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0702553104 · Cited by 672 · see citing works

Innate immunity and neuroinflammation in the CNS: The role of microglia in Toll‐like receptor‐mediated neuronal injury

Lehnardt, S. (2009) · Glia · doi:10.1002/glia.20928 · Cited by 596 · see citing works

Pivotal role of TLR4 receptors in alcohol-induced neuroinflammation and brain damage

Alfonso-Loeches, S., Pascual-Lucas, M., Blanco, A. M., Sanchez-Vera, I., & Guerri, C. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.0976-10.2010 · Cited by 579 · see citing works

Topiramate for Treating Alcohol Dependence<SUBTITLE>A Randomized Controlled Trial</SUBTITLE>

Johnson, B. A. (2007) · JAMA · doi:10.1001/jama.298.14.1641 · Cited by 542 · see citing works

Increased systemic and brain cytokine production and neuroinflammation by endotoxin following ethanol treatment

Qin, L., He, J., Hanes, R. N., Pluzarev, O., Hong, J.-S., & Crews, F. T. (2008) · Journal of Neuroinflammation · doi:10.1186/1742-2094-5-10 · Cited by 532 · see citing works

Increased MCP-1 and microglia in various regions of the human alcoholic brain

He, J., & Crews, F. T. (2007) · Experimental Neurology · doi:10.1016/j.expneurol.2007.11.017 · Cited by 516 · see citing works

Toll-like receptor signaling in neural plasticity and disease

Okun, E., Griffioen, K. J. S., & Mattson, M. P. (2011) · Trends in Neurosciences · doi:10.1016/j.tins.2011.02.005 · Cited by 513 · see citing works

Signalling pathways in alcohol-induced liver inflammation

Mandrekar, P., & Szabó, G. (2009) · Journal of Hepatology · doi:10.1016/j.jhep.2009.03.007 · Cited by 499 · see citing works

Exploring the Neuroimmunopharmacology of Opioids: An Integrative Review of Mechanisms of Central Immune Signaling and Their Implications for Opioid Analgesia

Hutchinson, M. R., Shavit, Y., Grace, P. M., Rice, K. C., Maier, S. F., & Watkins, L. R. (2011) · Pharmacological Reviews · doi:10.1124/pr.110.004135 · Cited by 397 · see citing works

Intermittent ethanol exposure induces inflammatory brain damage and causes long‐term behavioural alterations in adolescent rats

Pascual, M., Blanco, A. M., Cauli, O., Miñarro, J., & Guerri, C. (2007) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2006.05298.x · Cited by 385 · see citing works

Gene Coexpression Networks in Human Brain Identify Epigenetic Modifications in Alcohol Dependence

Ponomarev, I., Wang, S., Zhang, L., Harris, R. A., & Mayfield, R. D. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.3136-11.2012 · Cited by 377 · see citing works

Critical role of TLR4 response in the activation of microglia induced by ethanol

Fernandez-Lizarbe, S., Pascual, M., & Guerri, C. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0803590 · Cited by 373 · see citing works

Neuroplastic changes in depression: A role for the immune system

Eyre, H., & Baune, B. T. (2012) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2012.03.019 · Cited by 319 · see citing works

Induction of innate immune genes in brain create the neurobiology of addiction

Crews, F. T., Zou, J., & Qin, L. (2011) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2011.03.003 · Cited by 313 · see citing works

Role of intestinal permeability and inflammation in the biological and behavioral control of alcohol-dependent subjects

Leclercq, S., Cani, P. D., Neyrinck, A. M., Stärkel, P., Jamar, F., Mikolajczak, M., Delzenne, N. M., & de Timary, P. (2012) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2012.04.001 · Cited by 310 · see citing works

High Mobility Group Box 1/Toll-like Receptor Danger Signaling Increases Brain Neuroimmune Activation in Alcohol Dependence

Crews, F. T., Qin, L., Sheedy, D. L., Vetreno, R. P., & Zou, J. (2012) · Biological Psychiatry · doi:10.1016/j.biopsych.2012.09.030 · Cited by 295 · see citing works

NADPH oxidase and reactive oxygen species contribute to alcohol-induced microglial activation and neurodegeneration

Qin, L., & Crews, F. T. (2012) · Journal of Neuroinflammation · doi:10.1186/1742-2094-9-5 · Cited by 290 · see citing works

The role of the innate immune system in psychiatric disorders

Jones, K. A., & Thomsen, C. (2013) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2012.10.002 · Cited by 274 · see citing works

Involvement of TLR4/type I IL-1 receptor signaling in the induction of inflammatory mediators and cell death induced by ethanol in cultured astrocytes

Blanco, A. M., Vallés, S. L., Pascual, M., & Guerri, C. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.175.10.6893 · Cited by 258 · see citing works

Patterns of Gene Expression in the Frontal Cortex Discriminate Alcoholic from Nonalcoholic Individuals

Liu, J., Lewohl, J. M., Harris, R. A., Iyer, V. R., Dodd, P. R., Randall, P. K., & Mayfield, R. D. (2005) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300947 · Cited by 254 · see citing works

Neuroimmune regulation of alcohol consumption: behavioral validation of genes obtained from genomic studies

Blednov, Y. A., Ponomarev, I., Geil, C., Bergeson, S., Koob, G. F., & Harris, R. A. (2012) · Addiction Biology · doi:10.1111/j.1369-1600.2010.00284.x · Cited by 251 · see citing works

Activation of inflammatory signaling by lipopolysaccharide produces a prolonged increase of voluntary alcohol intake in mice

Blednov, Y. A., Benavidez, J. M., Geil, C., Perra, S., Morikawa, H., & Harris, R. A. (2011) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2011.01.008 · Cited by 240 · see citing works

How does peripheral lipopolysaccharide induce gene expression in the brain of rats?

Singh, A. K., & Jiang, Y. (2004) · Toxicology · doi:10.1016/j.tox.2004.04.015 · Cited by 223 · see citing works

Impact of TLR4 on behavioral and cognitive dysfunctions associated with alcohol-induced neuroinflammatory damage

Pascual, M., Baliño, P., Alfonso-Loeches, S., Aragón, C. M. G., & Guerri, C. (2011) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2011.02.012 · Cited by 213 · see citing works

Activation of Toll-like receptor 4 signaling contributes to hippocampal neuronal death following global cerebral ischemia/reperfusion

Hua, F., Ma, J., Ha, T., Xia, Y., Kelley, J., Williams, D. L., Kao, R. L., Browder, I. W., Schweitzer, J. B., Kalbfleisch, J. H., et al. (2007) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2007.08.014 · Cited by 200 · see citing works

Up-Regulation of MicroRNAs in Brain of Human Alcoholics

Lewohl, J. M., Núnez, Y. O., Dodd, P. R., Tiwari, G. R., Harris, R. A., & Mayfield, R. D. (2011) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2011.01544.x · Cited by 192 · see citing works

Chronic ethanol increases systemic TLR3 agonist-induced neuroinflammation and neurodegeneration

Qin, L., & Crews, F. T. (2012) · Journal of Neuroinflammation · doi:10.1186/1742-2094-9-130 · Cited by 192 · see citing works

Implications of central immune signaling caused by drugs of abuse: Mechanisms, mediators and new therapeutic approaches for prediction and treatment of drug dependence

Coller, J. K., & Hutchinson, M. R. (2012) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2012.01.008 · Cited by 186 · see citing works

Adolescent binge drinking increases expression of the danger signal receptor agonist HMGB1 and toll-like receptors in the adult prefrontal cortex

Vetreno, R. P., & Crews, F. T. (2012) · Neuroscience · doi:10.1016/j.neuroscience.2012.08.046 · Cited by 183 · see citing works

Induction of Innate Immune Gene Expression Cascades in Brain Slice Cultures by Ethanol: Key Role of NF‐κB and Proinflammatory Cytokines

Zou, J., & Crews, F. T. (2010) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2010.01150.x · Cited by 158 · see citing works

Binge alcohol drinking is associated with GABA _A α2-regulated Toll-like receptor 4 (TLR4) expression in the central amygdala

Liu, J., Yang, A. R., Kelly, T., Puche, A., Esoga, C., June, H. L., Elnabawi, A., Merchenthaler, I., Sieghart, W., June, H. L., et al. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1019020108 · Cited by 152 · see citing works

Neuronal toll-like receptor 4 signaling induces brain endothelial activation and neutrophil transmigration in vitro

Leow‐Dyke, S., Allen, C., Dénes, Á., Nilsson, O., Maysami, S., Bowie, A., Rothwell, N. J., & Pinteaux, E. (2012) · Journal of Neuroinflammation · doi:10.1186/1742-2094-9-230 · Cited by 145 · see citing works

Alcoholism and inflammation: Neuroimmunology of behavioral and mood disorders

Kelley, K. W., & Dantzer, R. (2010) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2010.12.013 · Cited by 143 · see citing works

Molecular mechanisms of alcoholic fatty liver: role of peroxisome proliferator-activated receptor alpha

Crabb, D. W., Galli, A., Fischer, M., & You, M. (2004) · Alcohol · doi:10.1016/j.alcohol.2004.07.005 · Cited by 143 · see citing works

Minocycline reduces ethanol drinking

Agrawal, R. G., Hewetson, A., George, C. M., Syapin, P. J., & Bergeson, S. E. (2011) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2011.03.002 · Cited by 142 · see citing works

Activation of Nuclear PPARγ Receptors by the Antidiabetic Agent Pioglitazone Suppresses Alcohol Drinking and Relapse to Alcohol Seeking

Stopponi, S., Somaini, L., Cippitelli, A., Cannella, N., Braconi, S., Kallupi, M., Ruggeri, B., Heilig, M. A., Demopulos, G. A., Gaitanaris, G., et al. (2011) · Biological Psychiatry · doi:10.1016/j.biopsych.2010.12.010 · Cited by 134 · see citing works

Microglia are required for astroglial toll‐like receptor 4 response and for optimal TLR2 and TLR3 response

Holm, T. H., Dræby, D., & Owens, T. (2012) · Glia · doi:10.1002/glia.22296 · Cited by 130 · see citing works

Inflammasome-IL-1β Signaling Mediates Ethanol Inhibition of Hippocampal Neurogenesis

Zou, J., & Crews, F. T. (2012) · Frontiers in Neuroscience · doi:10.3389/fnins.2012.00077 · Cited by 124 · see citing works

Effects of Topiramate on Urge to Drink and the Subjective Effects of Alcohol: A Preliminary Laboratory Study

Miranda, R., MacKillop, J. M., Monti, P. M., Rohsenow, D. J., Tidey, J. W., Gwaltney, C. J., Swift, R. M., Ray, L. A., & McGeary, J. E. (2008) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2007.00592.x · Cited by 115 · see citing works

Ethanol‐Regulated Genes That Contribute to Ethanol Sensitivity and Rapid Tolerance in Drosophila

Kong, E. C., Allouche, L., Chapot, P. A., VRANIZAN, K. M., Moore, M. S., Heberlein, U., & Wolf, F. W. (2009) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2009.01093.x · Cited by 113 · see citing works

Association of NFKB1, which encodes a subunit of the transcription factor NF- B, with alcohol dependence

Edenberg, H. J., Xuei, X., Wetherill, L. F., Bierut, L., Bucholz, K., Dick, D. M., Hesselbrock, V., Kuperman, S., Porjesz, B., Schuckit, M. A., et al. (2007) · Human Molecular Genetics · doi:10.1093/hmg/ddm368 · Cited by 89 · see citing works

Neuroadaptations in Human Chronic Alcoholics: Dysregulation of the NF-κB System

Ökvist, A., Johansson, S., Kuzmin, A., Bazov, I., Merino-Martinez, R., Ponomarev, I., Mayfield, R. D., Harris, R. A., Sheedy, D., Garrick, T., et al. (2007) · PLoS ONE · doi:10.1371/journal.pone.0000930 · Cited by 84 · see citing works

Attenuation of microglial and IL-1 signaling protects mice from acute alcohol-induced sedation and/or motor impairment

Wu, Y. H., Lousberg, E. L., Moldenhauer, L. M., Hayball, J. D., Robertson, S. A., Coller, J. K., Watkins, L. R., Somogyi, A. A., & Hutchinson, M. R. (2011) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2011.01.012 · Cited by 78 · see citing works

Inhibiting the TLR4‐MyD88 signalling cascade by genetic or pharmacological strategies reduces acute alcohol‐induced sedation and motor impairment in mice

Wu, Y. H., Lousberg, E. L., Moldenhauer, L. M., Hayball, J. D., Coller, J. K., Rice, K. C., Watkins, L. R., Somogyi, A. A., & Hutchinson, M. R. (2011) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2011.01572.x · Cited by 76 · see citing works

Novel Use of a Lipid-Lowering Fibrate Medication to Prevent Nicotine Reward and Relapse: Preclinical Findings

Panlilio, L. V., Justinová, Z., Mascia, P., Pistis, M., Luchicchi, A., Lecca, S., Barnes, C., Redhi, G. H., Adair, J. E., Heishman, S. J., et al. (2012) · Neuropsychopharmacology · doi:10.1038/npp.2012.31 · Cited by 67 · see citing works

Cytochrome P4502E1 primes macrophages to increase TNF-α production in response to lipopolysaccharide

Cao, Q., Mak, K. M., & Lieber, C. S. (2005) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00383.2004 · Cited by 64 · see citing works

Protracted abstinence from distinct drugs of abuse shows regulation of a common gene network

Merrer, J. L., Befort, K., Gardon, O., Filliol, D., Darcq, E., Dembélé, D., Becker, J. A. J., & Kieffer, B. L. (2011) · Addiction Biology · doi:10.1111/j.1369-1600.2011.00365.x · Cited by 58 · see citing works

Unique aspects of transcriptional regulation in neurons - nuances in NFkappaB and Sp1-related factors

Mao, X. R., Moerman-Herzog, A. M., Chen, Y., & Barger, S. W. (2009) · Journal of Neuroinflammation · doi:10.1186/1742-2094-6-16 · Cited by 54 · see citing works

Effect of topiramate treatment on ethanol consumption in rats

Breslin, F. J., Johnson, B. A., & Lynch, W. J. (2009) · Psychopharmacology · doi:10.1007/s00213-009-1683-4 · Cited by 43 · see citing works

Behavioral actions of alcohol: phenotypic relations from multivariate analysis of mutant mouse data

Blednov, Y. A., Mayfield, R. D., Belknap, J. K., & Harris, R. A. (2012) · Genes Brain & Behavior · doi:10.1111/j.1601-183x.2012.00780.x · Cited by 38 · see citing works

The Blood–Brain Barrier in Psychoneuroimmunology

Banks, W. A. (2009) · Immunology and Allergy Clinics of North America · doi:10.1016/j.iac.2009.02.001 · Cited by 37 · see citing works

Neural-Immune Interactions in Brain Function and Alcohol Related Disorders

Cui, C.-H., Grandison, L., & Noronha, A. (2013) · Springer US · doi:10.1007/978-1-4614-4729-0 · Cited by 35 · see citing works

The Investigation into CYP2E1 in Relation to the Level of Response to Alcohol Through a Combination of Linkage and Association Analysis

Webb, A., Lind, P. A., Kalmijn, J. A., Feiler, H. S., Smith, T. L., Schuckit, M. A., & Wilhelmsen, K. C. (2010) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2010.01317.x · Cited by 34 · see citing works

Severity of drinking as a predictor of efficacy of the combination of ondansetron and topiramate in rat models of ethanol consumption and relapse

Lynch, W. J., Bond, C. W., Breslin, F. J., & Johnson, B. A. (2011) · Psychopharmacology · doi:10.1007/s00213-011-2253-0 · Cited by 32 · see citing works

Polymorphism in the Interleukin‐1 Receptor Antagonist Gene Is Associated With Alcoholism in Spanish Men

Pastor, I., Laso, F. J., Ávila, J. J. G., Rodrı́guez, R. E., & González‐Sarmiento, R. (2000) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2000.tb04563.x · Cited by 29 · see citing works

Association of Inflammation Genes with Alcohol Dependence/Abuse: A Systematic Review and a Meta-Analysis

Kébir, O., Gorsane, M.-A., Blecha, L., Krebs, M., Reynaud, M., & Benyamina, A. (2011) · European Addiction Research · doi:10.1159/000324849 · Cited by 22 · see citing works

The effect of doxycycline on alcohol consumption and sensitivity: consideration for inducible transgenic mouse models

McIver, S. R., Muccigrosso, M. M., & Haydon, P. G. (2012) · Experimental Biology and Medicine · doi:10.1258/ebm.2012.012029 · Cited by 21 · see citing works

Neuroimmune Genes and Alcohol Drinking Behavior

Harris, R. A., & Blednov, Y. A. (2012) · Springer eBooks · doi:10.1007/978-1-4614-4729-0_13 · Cited by 20 · see citing works

Polymorphisms of the IL‐1 Gene Complex Are Associated With Alcohol Dependence in Spanish Caucasians: Data From an Association Study

Sáiz, P. A., García‐Portilla, M. P., Flórez, G., Corcoran, P. E., Arango, C., Morales, B., Leza, J. C., Álvarez, S., Mesa, E. M. D., Álvarez, V., et al. (2009) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2009.01058.x · Cited by 20 · see citing works

Effect of repeated treatment with topiramate on voluntary alcohol intake and beta-endorphin plasma level in Warsaw alcohol high-preferring rats

Zalewska-Kaszubska, J., Bajer, B., Górska, D., Andrzejczak, D., Dyr, W., & Bieńkowski, P. (2012) · Psychopharmacology · doi:10.1007/s00213-012-2812-z · Cited by 18 · see citing works

Time-Course Alterations of Toll-Like Receptor 4 and NF-κB p65, and Their Co-Expression in the Gerbil Hippocampal CA1 Region After Transient Cerebral Ischemia

Yoo, K., Yoo, D. Y., Hwang, I. K., Park, J. H., Lee, C. H., Choi, J. H., Kwon, S., Her, S., Lee, Y. L., & Won, M. (2011) · Neurochemical Research · doi:10.1007/s11064-011-0569-0 · Cited by 16 · see citing works

Relation of tumor necrosis factor (TNF) gene polymorphisms with serum concentrations and in vitro production of TNF-alpha and interleukin-8 in heavy drinkers

González‐Quintela, A., Domínguez‐Santalla, M. J., Loidi, L., Quinteiro, C., & Perez, L. F. (2004) · Alcohol · doi:10.1016/j.alcohol.2004.06.011 · Cited by 12 · see citing works

Psychedelics as Medicines: An Emerging New Paradigm

Nichols, D. E., Johnson, M., & Nichols, C. (2016) · Clinical Pharmacology & Therapeutics · doi:10.1002/cpt.557 · Cited by 373 · see citing works

The role of neuroimmune signaling in alcoholism

Crews, F. T., Lawrimore, C. J., Walter, T. J., & Coleman, L. G. (2017) · Neuropharmacology · doi:10.1016/j.neuropharm.2017.01.031 · Cited by 321 · see citing works

Mechanisms of neuroimmune gene induction in alcoholism

Crews, F. T., & Vetreno, R. P. (2016) · Psychopharmacology · doi:10.1007/s00213-015-3906-1 · Cited by 232 · see citing works

Neuroimmune signaling in alcohol use disorder

Erickson, E. K., Grantham, E. K., Warden, A. S., & Harris, R. A. (2018) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2018.12.007 · Cited by 224 · see citing works

Cytokines and chemokines as biomarkers of ethanol-induced neuroinflammation and anxiety-related behavior: Role of TLR4 and TLR2

Pascual, M., Baliño, P., Aragón, C. M. G., & Guerri, C. (2014) · Neuropharmacology · doi:10.1016/j.neuropharm.2014.10.014 · Cited by 201 · see citing works

Impact of the Innate Immune Response in the Actions of Ethanol on the Central Nervous System

Montesinos, J., Alfonso‐Loeches, S., & Guerri, C. (2016) · Alcoholism Clinical and Experimental Research · doi:10.1111/acer.13208 · Cited by 184 · see citing works

Ethanol and its metabolites: update on toxicity, benefits, and focus on immunomodulatory effects

Daré, B. L., Lagente, V., & Gicquel, T. (2019) · Drug Metabolism Reviews · doi:10.1080/03602532.2019.1679169 · Cited by 183 · see citing works

Neuroinflammation in addiction: A review of neuroimaging studies and potential immunotherapies

Kohno, M., Link, J., Dennis, L. E., McCready, H. D., Huckans, M. S., Hoffman, W. F., & Loftis, J. M. (2019) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2019.01.007 · Cited by 168 · see citing works

Alcohol Use Disorder, Neurodegeneration, Alzheimer’s and Parkinson’s Disease: Interplay Between Oxidative Stress, Neuroimmune Response and Excitotoxicity

Kamal, H., Tan, G. C., Ibrahim, S. F., Shaikh, M. F., Mohamed, I. N., Mohamed, R. M. P., Hamid, A. A., Ugusman, A., & Kumar, J. (2020) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2020.00282 · Cited by 164 · see citing works

Neuroimmune Mechanisms of Alcohol and Drug Addiction

Cui, C., Shurtleff, D., & Harris, R. A. (2014) · International review of neurobiology · doi:10.1016/b978-0-12-801284-0.00001-4 · Cited by 163 · see citing works

Toll-like receptor signaling and stages of addiction

Crews, F. T., Walter, T. J., Coleman, L. G., & Vetreno, R. P. (2017) · Psychopharmacology · doi:10.1007/s00213-017-4560-6 · Cited by 159 · see citing works

TLR4 elimination prevents synaptic and myelin alterations and long-term cognitive dysfunctions in adolescent mice with intermittent ethanol treatment

Montesinos, J., Pascual, M., Pla, A., Maldonado, C., Rodríguez‐Arias, M., Miñarro, J., & Guerri, C. (2014) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2014.11.015 · Cited by 146 · see citing works

Involvement of TLR4 in the long-term epigenetic changes, rewarding and anxiety effects induced by intermittent ethanol treatment in adolescence

Montesinos, J., Pascual, M., Rodríguez‐Arias, M., Miñarro, J., & Guerri, C. (2015) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2015.12.006 · Cited by 141 · see citing works

Development of the Neuroimmune Modulator Ibudilast for the Treatment of Alcoholism: A Randomized, Placebo-Controlled, Human Laboratory Trial

Ray, L. A., Bujarski, S., Shoptaw, S., Roche, D. J., Heinzerling, K., & Miotto, K. (2017) · Neuropsychopharmacology · doi:10.1038/npp.2017.10 · Cited by 118 · see citing works

Stress–response pathways are altered in the hippocampus of chronic alcoholics

McClintick, J. N., Xuei, X., Tischfield, J. A., Goate, A., Foroud, T., Wetherill, L., Ehringer, M. A., & Edenberg, H. J. (2013) · Alcohol · doi:10.1016/j.alcohol.2013.07.002 · Cited by 105 · see citing works

Neuroimmune Pathways in Alcohol Consumption: Evidence from Behavioral and Genetic Studies in Rodents and Humans

Robinson, G., Most, D., Ferguson, L. B., Mayfield, J., Harris, R. A., & Blednov, Y. A. (2014) · International review of neurobiology · doi:10.1016/b978-0-12-801284-0.00002-6 · Cited by 96 · see citing works

Peroxisome Proliferator‐Activated Receptorsαandγare Linked with Alcohol Consumption in Mice and Withdrawal and Dependence in Humans

Blednov, Y. A., Benavidez, J. M., Black, M., Ferguson, L. B., Schoenhard, G. L., Goate, A., Edenberg, H. J., Wetherill, L. F., HESSELBROCK, V. M., Foroud, T., et al. (2014) · Alcoholism Clinical and Experimental Research · doi:10.1111/acer.12610 · Cited by 96 · see citing works

Analysis of whole genome-transcriptomic organization in brain to identify genes associated with alcoholism

Kapoor, M., Wang, J.-C., Farris, S. P., Liu, Y., McClintick, J., Gupta, I., Meyers, J. L., Bertelsen, S., Chao, M., Nurnberger, J., et al. (2019) · Translational Psychiatry · doi:10.1038/s41398-019-0384-y · Cited by 92 · see citing works

Neuroimmune mechanisms of psychostimulant and opioid use disorders

Hofford, R. S., Russo, S. J., & Kiraly, D. D. (2018) · European Journal of Neuroscience · doi:10.1111/ejn.14143 · Cited by 92 · see citing works

Innate Immune Signaling and Alcohol Use Disorders

Coleman, L. G., & Crews, F. T. (2018) · Handbook of experimental pharmacology · doi:10.1007/164_2018_92 · Cited by 90 · see citing works

The emerging tale of microglia in psychiatric disorders

Rahimian, R., Wakid, M., O’Leary, L. A., & Mechawar, N. (2021) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2021.09.023 · Cited by 91 · see citing works

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N-acetylcysteine Prevents Alcohol Related Neuroinflammation in Rats

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Cold-Inducible RNA-Binding Protein Is an Important Mediator of Alcohol-Induced Brain Inflammation

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Probiotics-Based Treatment as an Integral Approach for Alcohol Use Disorder in Alcoholic Liver Disease

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Chronic Drinking During Adolescence Predisposes the Adult Rat for Continued Heavy Drinking: Neurotrophin and Behavioral Adaptation after Long-Term, Continuous Ethanol Exposure

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TRAIL Mediates Neuronal Death in AUD: A Link between Neuroinflammation and Neurodegeneration

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Chronic Ethanol Consumption Profoundly Alters Regional Brain Ceramide and Sphingomyelin Content in Rodents

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Mechanistic insights into epigenetic modulation of ethanol consumption

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Biogenesis, physiological functions and potential applications of extracellular vesicles in substance use disorders

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Investigating the Relationships Between Alcohol Consumption, Cannabis Use, and Circulating Cytokines: A Preliminary Analysis

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Networking in Biology: The Hybrid Rat Diversity Panel

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Role of MyD88 in IL-1β and Ethanol Modulation of GABAergic Transmission in the Central Amygdala

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Ethanol induces interferon expression in neurons via TRAIL: role of astrocyte-to-neuron signaling

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Cerebral Hemorrhage and Alcohol Exposure: A Review

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Ethanol treatment of lymphoblastoid cell lines from alcoholics and non-alcoholics causes many subtle changes in gene expression

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Imaging Biomarkers of the Neuroimmune System among Substance Use Disorders: A Systematic Review

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Selective Inhibition of PDE4B Reduces Binge Drinking in Two C57BL/6 Substrains

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