Exposure to cold airflow alters skin pH and epidermal filaggrin degradation products in children with atopic dermatitis
Open accessAbstract
BACKGROUND: We aimed to evaluate the influence of cold airflow from the air conditioner on skin barrier function and filaggrin degradation products (FDPs) in children with atopic deramtitis (AD). METHODS: In a case-control study, 28 children with AD and 12 normal children without AD were exposed to one of two air conditioner modes (conventional or wind-free) for 2 h. Skin temperature, transepidermal water loss (TEWL), and skin pH were measured on right cheek and forearm at pre- and post-exposure time points. We also measured filaggrin and FDPs from the volar surface of the forearm. RESULTS: In AD patients, skin temperature on the forearm decreased after exposure to the conventional and wind-free modes (P < 0.001 and P = 0.026), and TEWL on the cheek and the forearm decreased in the wind-free mode (P = 0.037 and 0.002). Skin pH on the cheek increased only after exposure to the conventional mode in AD group (P = 0.002). However, no changes in TEWL and skin pH were found after exposure to either the conventional or the wind-free mode in the control group. In AD children, the levels of pyrrolidone carboxylic acid (PCA) and cis-urocanic acid (UCA) were reduced only after exposure to the conventional mode (all P = 0.033). The percent changes of PCA and cis-UCA were higher in the AD group than those in the control group after exposure to conventional mode (P = 0.029 and 0.046). CONCLUSIONS: Skin barrier function in children with AD may be altered by the exposure to cold airflow from a conventional air conditioner.
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Cold and dry air do not change the levels of trans-UCA.
“This finding is consistent with a recent report that cold and dry air do not change the levels of trans-UCA (51).”
From Particulate matter causes skin barrier dysfunction. (2021) · cites this paper as [51]
The Results section, “Comparison of filaggrin, caspase-14, and filaggrin degradation products” (page unavailable), reports no significant change in trans-UCA in control children after either air-conditioner mode. The claim is broader than this two-hour cold-airflow experiment: humidity was held constant, so the paper did not test whether dry air changes trans-UCA levels. (LLM, conf=0.84)
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Particulate matter causes skin barrier dysfunction.
Kim, B. E., Kim, J., Goleva, E., Berdyshev, E., Lee, J., Vang, K. A., Lee, U. H., Han, S., Leung, S., Hall, C. F., et al. (2021) · JCI insight · doi:10.1172/jci.insight.145185 · Cited by 173 · see citing works
“This finding is consistent with a recent report that cold and dry air do not change the levels of transUCA (51).”
ResultSelf-citation
- Authors
- Jung, M., Kim, I., Lee, J. Y., Kim, H. M., Kwon, M., Kim, M., Lim, K.-M., Kim, P. S., Ahn, K., & Kim, J.
- Affiliations
- Kosin University Gospel Hospital (KR)
- Hallym University Hangang Sacred Heart Hospital (KR)
- Samsung Medical Center (KR)
- Ewha Womans University (KR)
- Colorado College (US)
- Corresponding author
- Kim, Jihyun
- ORCID
- Venue
- Allergology International
- Publisher
- Elsevier BV
- Published
- 2020-07
- Volume
- 69
- Issue
- 3
- Pages
- 429-436
- ISSN
- 1323-8930 (ISSN-L)
- OpenAlex
- W2997596797
- Cited by
- 11
- References
- 30
- Citations by year
- 2026: 2 · 2025: 1 · 2024: 3 · 2023: 1 · 2022: 3 · 2021: 1
- FWCI
- 1.01
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Allergology International (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- SMC Research and Development (#SMO 0170591)
- Topics
- Health Sciences › Medicine › Dermatology › Dermatology and Skin Diseases
- Health Sciences › Medicine › Dermatology › Contact Dermatitis and Allergies
- Health Sciences › Medicine › Physiology › Asthma and respiratory diseases
- Keywords
- atopic dermatitis, skin barrier function, skin pH, transepidermal water loss, pyrrolidone carboxylic acid, cis-urocanic acid, skin temperature, children
- MeSH terms
- Filaggrin Proteins, Child, Cold Temperature, Dermatitis, Atopic, Disease Susceptibility, Environmental Exposure, Epidermis, Humans, Hydrogen-Ion Concentration, Intermediate Filament Proteins, Skin, Skin Temperature, Biomarkers, Case-Control Studies
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