Neuroimmune mechanisms of type 2 inflammation in the skin and lung

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Two Phase 3 Trials of Dupilumab versus Placebo in Atopic Dermatitis

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The Sensory Neurons of Touch

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Dupilumab Treatment in Adults with Moderate-to-Severe Atopic Dermatitis

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Sensory Neurons Co-opt Classical Immune Signaling Pathways to Mediate Chronic Itch

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Type 2 innate lymphoid cells control eosinophil homeostasis

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Tezepelumab in Adults and Adolescents with Severe, Uncontrolled Asthma

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Interleukin 31, a cytokine produced by activated T cells, induces dermatitis in mice

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The Epithelial Cell-Derived Atopic Dermatitis Cytokine TSLP Activates Neurons to Induce Itch

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Bacteria activate sensory neurons that modulate pain and inflammation

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A sensory neuron–expressed IL-31 receptor mediates T helper cell–dependent itch: Involvement of TRPV1 and TRPA1

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Atopic Dermatitis

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TSLP Elicits IL-33–Independent Innate Lymphoid Cell Responses to Promote Skin Inflammation

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Atopic dermatitis: New insights and opportunities for therapeutic intervention

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Neuronal Control of Skin Function: The Skin as a Neuroimmunoendocrine Organ

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The neuropeptide NMU amplifies ILC2-driven allergic lung inflammation

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Tralokinumab for moderate‐to‐severe atopic dermatitis: results from two 52‐week, randomized, double‐blind, multicentre, placebo‐controlled phase III trials (ECZTRA 1 and ECZTRA 2)*

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Mepolizumab for chronic rhinosinusitis with nasal polyps (SYNAPSE): a randomised, double-blind, placebo-controlled, phase 3 trial

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Application of moisturizer to neonates prevents development of atopic dermatitis

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Neuronal regulation of type 2 innate lymphoid cells via neuromedin U

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The neuropeptide neuromedin U stimulates innate lymphoid cells and type 2 inflammation

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Sensing the outside world: TSLP regulates barrier immunity

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Vagal Afferent Innervation of the Airways in Health and Disease

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Type 2 immunity in the skin and lungs

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Dupilumab in Adults and Adolescents with Eosinophilic Esophagitis

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Cutaneous immunosurveillance and regulation of inflammation by group 2 innate lymphoid cells

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Efficacy and safety of lebrikizumab in patients with uncontrolled asthma (LAVOLTA I and LAVOLTA II): replicate, phase 3, randomised, double-blind, placebo-controlled trials

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Silencing Nociceptor Neurons Reduces Allergic Airway Inflammation

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An Atlas of Vagal Sensory Neurons and Their Molecular Specialization

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Blocking Neuronal Signaling to Immune Cells Treats Streptococcal Invasive Infection

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The atopic march

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Pulmonary neuroendocrine cells amplify allergic asthma responses

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Tissue signals imprint ILC2 identity with anticipatory function

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β 2 -adrenergic receptor–mediated negative regulation of group 2 innate lymphoid cell responses

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Cutaneous TRPV1+ Neurons Trigger Protective Innate Type 17 Anticipatory Immunity

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Blocking IL-25 prevents airway hyperresponsiveness in allergic asthma

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Two Phase 3 Trials of Lebrikizumab for Moderate-to-Severe Atopic Dermatitis

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Allergic Rhinitis

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House dust mites activate nociceptor–mast cell clusters to drive type 2 skin inflammation

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Anti‐IL‐5 recombinant humanized monoclonal antibody (Mepolizumab) for the treatment of atopic dermatitis

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Efficacy and safety of benralizumab in chronic rhinosinusitis with nasal polyps: A randomized, placebo-controlled trial

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Efficacy and safety of gefapixant, a P2X3 receptor antagonist, in refractory chronic cough and unexplained chronic cough (COUGH-1 and COUGH-2): results from two double-blind, randomised, parallel-group, placebo-controlled, phase 3 trials

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Neuropeptide CGRP Limits Group 2 Innate Lymphoid Cell Responses and Constrains Type 2 Inflammation

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Basophil-Derived Interleukin-4 Controls the Function of Natural Helper Cells, a Member of ILC2s, in Lung Inflammation

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Substance P Release by Sensory Neurons Triggers Dendritic Cell Migration and Initiates the Type-2 Immune Response to Allergens

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Sensory neurons and circuits mediating itch

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An Interleukin-33-Mast Cell-Interleukin-2 Axis Suppresses Papain-Induced Allergic Inflammation by Promoting Regulatory T Cell Numbers

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Transcriptional Atlas of Intestinal Immune Cells Reveals that Neuropeptide α-CGRP Modulates Group 2 Innate Lymphoid Cell Responses

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Calcitonin Gene-Related Peptide Negatively Regulates Alarmin-Driven Type 2 Innate Lymphoid Cell Responses

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The Itch–Scratch Cycle: A Neuroimmune Perspective

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Dupilumab in patients with prurigo nodularis: two randomized, double-blind, placebo-controlled phase 3 trials

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Candida albicans morphology and dendritic cell subsets determine T helper cell differentiation

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A multidimensional coding architecture of the vagal interoceptive system

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Epidemiology of Chronic Rhinosinusitis: Prevalence and Risk Factors

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Phase 3 Trial of Nemolizumab in Patients with Prurigo Nodularis

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