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Anaphylaxis caused by lipid transfer proteins: an unpredictable clinical syndrome

Mota, Inês, Gaspar, Ângela, Benito-Garcia, Filipe, Correia, Magna, Arêde, Cristina, Piedade, Susana, Sampaio, Graça, Pires, Graça, Santa-Marta, Cristina, Borrego, Luís-Miguel, Morais-Almeida, Mário·2018·Allergologia et Immunopathologia
DOI 10.1016/j.aller.2018.04.002
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Abstract

Introduction Lipid transfer proteins (LTPs) are panallergens found in many plant foods. They are a common cause of food-induced anaphylaxis (FIA) in adults living in the Mediterranean area. LTPs have also been proposed as a main cause of food-dependent exercise-induced anaphylaxis (FDEIA). Objectives Describe clinical characteristics and allergen sensitization profiles in patients with FIA related to LTP. Materials and methods Forty-three patients were included, aged 3-52 years with a clinical history of FIA and proven sensitization to LTP. Patients were tested with a multiple plant food and pollen panel and specific IgE to LTP allergens. LTP sensitization was assessed by in vivo (Pru p 3, LTP extract) and/or by in vitro tests (specific IgE, ImmunoCAP/ISAC ® ). Results Median age of first anaphylactic episode was 24 years (range 2-51), 44% had asthma, 74% were atopic and 42% had pollinosis (olive, mugwort, plane tree, wall pellitory and cypress). Co-sensitization to profilins was found in 22%. Overall in our center, LTP-induced anaphylaxis represents 17% of all causes of FIA. Foods implicated in anaphylactic reactions were: fresh fruits 51%, tree nuts 42%, vegetables (including peanut) 40% and seeds 14%. Seven patients had FDEIA. Conclusions LTPs are important allergens of FIA in Portugal. Clinical reactivity to several taxonomically unrelated plant foods may raise suspicion toward LTP sensitization. The association of LTP-induced anaphylaxis with pollinosis is relevant in ou…

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Research works printed but not linked: 25

  1. Asero, 2013, Anaphylaxis to plant-foods and pollen allergens in patients with lipid transfer protein syndrome, Curr Opin Allergy Clin Immunol, 13, 379, 10.1097/ACI.0b013e32835f5b07 · DOI
  2. Van Winkle, 2014, The biochemical basis and clinical evidence of food allergy due to lipid transfer proteins: a comprehensive review, Clin Rev Allergy Immunol, 46, 211, 10.1007/s12016-012-8338-7 · DOI
  3. Asero, 2009, EpidemAAITO—features of food allergy in Italian adults attending allergy clinics: a multi-centre study, Clin Exp Allergy, 39, 547, 10.1111/j.1365-2222.2008.03167.x · DOI
  4. Romano, 2012, Lipid transfer proteins: the most frequent sensitizer in Italian subjects with food-dependent exercise-induced anaphylaxis, Clin Exp Allergy, 42, 1643, 10.1111/cea.12011 · DOI
  5. Sánchez-López, 2011, Cupressus arizonica pollen: a new pollen involved in the lipid transfer protein syndrome?, J Investig Allergol Clin Immunol, 21, 522
  6. Fernandez-Rivas, 2015, Fruit and vegetable allergy, Chem Immunol Allergy, 101, 162, 10.1159/000375469 · DOI
  7. Fernández-Rivas, 2009, Food allergy in Alergológica-2005, J Investig Allergol Clin Immunol, 19, 37
  8. Pastorello, 2011, Pru p 3-sensitised Italian peach-allergic patients are less likely to develop severe symptoms when also presenting IgE antibodies to Pru p 1 and Pru p 4, Int Arch Allergy Immunol, 156, 362, 10.1159/000324440 · DOI
  9. Arena, 2010, Anaphylaxis to apple: is fasting a risk factor for LTP-allergic patients?, Eur Ann Allergy Clin Immunol, 42, 155
  10. Egger, 2010, The role of lipid transfer proteins in allergic diseases, Curr Allergy Asthma Rep, 10, 326, 10.1007/s11882-010-0128-9 · DOI
  11. Pascal, 2012, Lipid transfer protein syndrome: clinical pattern, cofactor effect and profile of molecular sensitization to plant-foods and pollens, Clin Exp Allergy, 42, 1529, 10.1111/j.1365-2222.2012.04071.x · DOI
  12. Fernandez-Rivas, 2006, Apple allergy across Europe: how allergen sensitization profiles determine the clinical expression of allergies to plant foods, J Allergy Clin Immunol, 118, 481, 10.1016/j.jaci.2006.05.012 · DOI
  13. Asero, 2009, Causes of food-induced anaphylaxis in Italian adults: a multi-centre study, Int Arch Allergy Immunol, 150, 271, 10.1159/000222679 · DOI
  14. Feldweg, 2017, Food-dependent exercise-induced anaphylaxis: diagnosis and management in the outpatient setting, J Allergy Clin Immunol Pract, 5, 283, 10.1016/j.jaip.2016.11.022 · DOI
  15. Gomulka, 2017, Food-dependent, exercise-induced anaphylaxis triggered by co-incidence of culprit food, physical effort and a very high dose of ibuprofen or menstruation: a case report, Postepy Dermatol Alergol, 34, 87, 10.5114/ada.2017.65629 · DOI
  16. Minty, 2017, Food-dependent exercise-induced anaphylaxis, Can Fam Physician, 63, 42
  17. Harada, 2001, Aspirin enhances the induction of type I allergic symptoms when combined with food and exercise in patients with food-dependent exercise-induced anaphylaxis, Br J Dermatol, 145, 336, 10.1046/j.1365-2133.2001.04329.x · DOI
  18. Munoz-Garcia, 2016, Lettuce allergy is a lipid transfer syndrome-related food allergy with high risk of severe reactions, J Investig Allergol Clin Immunol, 27, 98, 10.18176/jiaci.0110 · DOI
  19. Bianchi, 2011, Rosaceae-associated exercise-induced anaphylaxis with positive SPT and negative IgE reactivity to Pru p 3, Eur Ann Allergy Clin Immunol, 43, 122
  20. Pascal, 2016, sensitisation is common in plant-food allergic children from the Northeast of Spain, Allergol Immunopathol (Madr), 44, 351, 10.1016/j.aller.2015.10.003 · DOI
  21. Vassilopoulou, 2007, Severe immediate allergic reactions to grapes: part of a lipid transfer protein-associated clinical syndrome, Int Arch Allergy Immunol, 143, 92, 10.1159/000098657 · DOI
  22. Garrido-Fernández, 2014, Are basophil activation and sulphidoleukotriene determination useful tests for monitoring patients with peach allergy receiving sublingual immunotherapy with a Pru p 3-enriched peach extract?, J Investig Allergol Clin Immunol, 24, 106
  23. Fernández-Rivas, 2009, Randomized double-blind, placebo-controlled trial of sublingual immunotherapy with a Pru p 3 quantified peach extract, Allergy, 64, 876, 10.1111/j.1398-9995.2008.01921.x · DOI
  24. Pereira, 2009, Specific sublingual immunotherapy with peach LTP (Pru p 3) One year treatment: a case report, Cases J, 2, 6553, 10.1186/1757-1626-0002-0000006553 · DOI
  25. Costa, 2015, Efficacy and tolerance of sublingual immunotherapy with Pru p 3 in patients with peach severe allergy—clinical and immunological follow-up during 12 months, Rev Port Imunoalergologia, 23, 11

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Metadata

Authors
Mota, I., Gaspar, Â., Benito-Garcia, F., Correia, M., Arêde, C., Piedade, S., Sampaio, G., Pires, G., Santa-Marta, C., Borrego, L.-M., & Morais-Almeida, M.
Venue
Allergologia et Immunopathologia
Publisher
Codon Publications
Published
2018-11
Volume
46
Issue
6
Pages
565-570
ISSN
0301-0546
DOI
10.1016/j.aller.2018.04.002
Cited by
23
References
0
Language
en
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)

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