Cited by 102Lipoproteins and Cardiovascular HealthDiabetes, Cardiovascular Risks, and LipoproteinsLipid metabolism and disorders

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Relative Atherogenicity and Predictive Value of Non–High-Density Lipoprotein Cholesterol for Coronary Heart Disease

Miller, Michael, Ginsberg, Henry N., Schaefer, Ernst J.·2008·The American Journal of Cardiology

DOI 10.1016/j.amjcard.2007.11.046

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Abstract

Although low-density lipoprotein cholesterol (LDL-C) is a well-established atherogenic factor for coronary heart disease, it does not completely represent the risk associated with atherogenic lipoproteins in the presence of high triglyceride (TG) levels. Constituent lipoproteins constituting non-high-density lipoprotein cholesterol (non-HDL-C) include atherogenic TG-rich lipoproteins, cholesteryl ester-enriched remnants of TG-rich lipoproteins, and lipoprotein(a). Recent observational and intervention studies suggest that the predictive value of non-HDL-C for cardiovascular risk and mortality is better than low-density lipoprotein cholesterol and that non-HDL-C correlates highly with plasma apolipoprotein B levels. Currently, the National Cholesterol Education Program Adult Treatment Panel III guidelines identify non-HDL-C as a secondary target of therapy in patients with TG elevation (> or =200 mg/dl) after the attainment of LDL-C target goals. In patients with coronary heart disease or coronary heart disease risk equivalents, an optional non-HDL-C goal is <100 mg/dl. To achieve the non-HDL-C goal, statin therapy may be intensified or combined with ezetimibe, niacin, a fibrate, or omega-3 fatty acids. In conclusion, non-HDL-C remains an important target of therapy for patients with elevated TGs, although its widespread adoption has yet to gain a foothold among health care professionals treating patients with dyslipidemia.

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Authors: Miller, M., Ginsberg, H. N., & Schaefer, E. J.
Affiliations: University of Maryland Medical Center (US)
Columbia University (US)
Tufts University (US)
Corresponding author: Miller, Michael
ORCID: Miller, Michael
Ginsberg, Henry N.
Schaefer, Ernst J.
Venue: The American Journal of Cardiology
Publisher: Elsevier BV
Published: 2008-04
Volume: 101
Issue: 7
Pages: 1003-1008
ISSN: 0002-9149 (ISSN-L)
DOI: 10.1016/j.amjcard.2007.11.046
OpenAlex: W2027014777
Cited by: 102
References: 43
Citations by year: 2026: 1 · 2025: 2 · 2024: 1 · 2023: 4 · 2022: 2 · 2021: 2 · 2020: 9 · 2019: 4 · 2018: 4 · 2017: 5 · 2016: 2 · 2015: 12 · 2014: 6 · 2013: 3 · 2012: 3
FWCI: 2.38
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: The American Journal of Cardiology (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipoproteins and Cardiovascular Health
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipid metabolism and disorders
Keywords: non-HDL cholesterol, coronary artery disease, atherogenic lipoproteins, triglyceride-rich lipoproteins, lipoprotein(a), apolipoprotein B, cardiovascular risk prediction, dyslipidemia, statin therapy, ezetimibe, nicotinic acid, fibrates, omega-3 fatty acids, LDL cholesterol, NCEP ATP III guidelines, hypertriglyceridemia
MeSH terms: Apolipoproteins B, Coronary Disease, Humans, Cholesterol, LDL, Predictive Value of Tests, Triglycerides, Dyslipidemias, Atherosclerosis

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Relative Atherogenicity and Predictive Value of Non–High-Density Lipoprotein Cholesterol for Coronary Heart Disease

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