Relation of Biomarkers and Cardiac Magnetic Resonance Imaging After Marathon Running
Abstract
Although previous studies including endurance athletes after marathon running have demonstrated biochemical evidence of cardiac injury and have correlated these findings with echocardiographic evidence of cardiac dysfunction, particularly of the right ventricle, a study of marathon athletes incorporating biomarkers, echocardiography, and cardiac magnetic resonance (CMR) imaging has not been performed to date. The aim of this study was to demonstrate the cardiac changes associated with participation in a marathon using serial cardiac biomarkers, echocardiography, and CMR imaging. Fourteen participants (mean age 33 +/- 6 years, 8 men) completed the full marathon. Myoglobin, creatine kinase, and troponin T were elevated in all athletes after the race. There was a strong linear correlation between right ventricular (RV) fractional area change as assessed by echocardiography and the RV ejection fraction as assessed by CMR imaging (r = 0.96) after the marathon. RV function, using echocardiography, transiently decreased from before to after the race (RV fractional area change 43 +/- 4% vs 33 +/- 5%, p <0.05). There were also postrace changes in left ventricular and RV diastolic filling. Although RV systolic changes were transient, left ventricular and RV diastolic abnormalities persisted up to 1 week after the marathon. No evidence of delayed enhancement of the left ventricular myocardium was found on CMR imaging, suggesting that the increase in cardiac biomarkers after the marathon…
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Right ventricular function may be more profoundly affected by intense endurance exercise than left ventricular function.
“However, right ventricular (RV) function may be more profoundly affected by intense endurance exercise 6 -10”
From Exercise-induced right ventricular dysfunction and structural remodelling in endurance athletes (2012) · cites this paper as [8]
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- Authors
- Mousavi, N., Czarnecki, A., Kumar, K., Fallah-Rad, N., Lytwyn, M., Han, S.-Y., Francis, A., Walker, J. R., Kirkpatrick, I. D. C., Neilan, T. G., Sharma, S., & Jassal, D. S.
- Affiliations
- University of Manitoba (CA)
- St. Boniface Hospital (CA)
- Harvard University (US)
- Corresponding author
- Jassal, Davinder S.
- Venue
- The American Journal of Cardiology
- Publisher
- Elsevier BV
- Published
- 2009-05
- Volume
- 103
- Issue
- 10
- Pages
- 1467-1472
- ISSN
- 0002-9149 (ISSN-L)
- OpenAlex
- W2086948724
- Cited by
- 190
- References
- 2
- Citations by year
- 2026: 7 · 2025: 5 · 2024: 3 · 2023: 6 · 2022: 12 · 2021: 8 · 2020: 11 · 2019: 6 · 2018: 6 · 2017: 9 · 2016: 14 · 2015: 11 · 2014: 20 · 2013: 16 · 2012: 23
- FWCI
- 11.86
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The American Journal of Cardiology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Effects of Exercise
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Takotsubo Cardiomyopathy and Associated Phenomena
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Cardiac Imaging and Diagnostics
- Keywords
- marathon running, endurance athletes, cardiac injury, right ventricular dysfunction, cardiac biomarkers, troponin T, creatine kinase, myoglobin, cardiac magnetic resonance imaging, right ventricular ejection fraction, diastolic dysfunction, myocardial necrosis, late gadolinium enhancement, exercise-induced cardiac changes
- MeSH terms
- Adult, Creatine Kinase, Echocardiography, Female, Humans, Magnetic Resonance Imaging, Male, Myoglobin, Physical Endurance, Prospective Studies, Running, Troponin, Biomarkers, Ventricular Function, Right
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