The DOI matches its Crossref record; 25 of the 25 references it cites were found in a registry or an index.
Relation of Vigorous Exercise to Risk of Atrial Fibrillation
Open accessAbstract
Limited data suggest that athletes may have a higher risk of developing atrial fibrillation (AF); however, there has been no large prospective assessment of the relation between vigorous exercise and AF. Logistic regression analyses stratified by time were used to assess the association between frequency of vigorous exercise and risk of developing AF in 16,921 apparently healthy men in the Physicians' Health Study. During 12 years of follow-up, 1,661 men reported developing AF. With increasing frequency of vigorous exercise (0, 1, 1 to 2, 3 to 4, 5 to 7 days/week), multivariate relative risks for the full cohort were 1.0 (referent), 0.90, 1.09, 1.04, and 1.20 (p = 0.04). This risk was not significantly increased when exercise habits were updated or in models excluding variables that may be in the biological pathway through which exercise influences AF risk. In subgroup analyses, this increased risk was observed only in men <50 years of age (1.0, 0.94, 1.20, 1.05, 1.74, p <0.01) and joggers (1.0, 0.91, 1.03, 1.30, 1.53, p <0.01), where risks remained increased in all analyses. In conclusion, frequency of vigorous exercise was associated with an increased risk of developing AF in young men and joggers. This risk decreased as the population aged and was offset by known beneficial effects of vigorous exercise on other AF risk factors.
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“Habitual vigorous exercise 214 Non-exercisers < 1 day/week 1-2 days/week 3-4 days/week 5-7 days/week RR: 1.00 (reference) 0.90 (95% CI 0.68 -1.20) 1.09 (95% CI 0.95-1.26) 1.04 (95% CI 0.91-1.19) 1.20 (95% CI 1.02-1.41”
From 2016 ESC Guidelines for the management of atrial fibrillation developed in collaboration with EACTS (2016) · cites this paper as [214]
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“This results in a U-shaped relationship of physical activity and incident AF. 214,898,902,905,906”
From 2016 ESC Guidelines for the management of atrial fibrillation developed in collaboration with EACTS (2016) · cites this paper as [214]
In the citing paper
“In men, a U-shaped association has been reported, in which sedentary lifestyle and vigorous exercise both are associated with increased AF risk,41,44,45 whereas moderate activity is protective.46”
From Atrial fibrillation in women: epidemiology, pathophysiology, presentation, and prognosis (2016) · cites this paper as [45]
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Citations
Cites
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Prevalence and Clinical Significance of Left Atrial Remodeling in Competitive Athletes
Pelliccia, A., Maron, B. J., Di Paolo, F. M., Biffi, A., Quattrini, F. M., Pisicchio, C., Roselli, A., Caselli, S., & Culasso, F. (2005) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2005.04.052 · Cited by 443
Catheter Ablation of Cardiac Autonomic Nerves for Prevention of Vagal Atrial Fibrillation
SCHAUERTE, P. N., Scherlag, B. J., Pitha, J. V., Scherlag, M. A., REYNOLDS, D. W., Lazzara, R., & Jackman, W. M. (2000) · Circulation · doi:10.1161/01.cir.102.22.2774 · Cited by 378
Sinus node disease and arrhythmias in the long-term follow-up of former professional cyclists
Baldesberger, S., Bauersfeld, U., CANDINAS, R., Seifert, B., Zuber, M., Ritter, M., Jenni, R., Oechslin, E. N., Luthi, P., Scharf, C., et al. (2007) · European Heart Journal · doi:10.1093/eurheartj/ehm555 · Cited by 352
Long-lasting sport practice and lone atrial fibrillation
Mont, L. (2002) · European Heart Journal · doi:10.1053/euhj.2001.2802 · Cited by 331
Lone atrial fibrillation in vigorously exercising middle aged men: case-control study
Karjalainen, J., Kujala, U. M., Kaprio, J., Sarna, S., & Viitasalo, M. (1998) · BMJ · doi:10.1136/bmj.316.7147.1784 · Cited by 326
A MAIL SURVEY OF PHYSICAL ACTIVITY HABITS AS RELATED TO MEASURED PHYSICAL FITNESS
Kohl, H. W., Blair, S. N., Paffenbarger, R. S., MACERA, C. A., & Kronenfeld, J. J. (1988) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a114915 · Cited by 325
A Mail Survey of Physical Activity Habits as Related to Measured Physical Fitness
Kohl, H. W., Blair, S. N., Paffenbarger, R. S., Macera, C. A., & Kronenfeld, J. J. (1988) · Journal of Cardiopulmonary Rehabilitation · doi:10.1097/00008483-198810000-00012 · Cited by 298
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Hindricks, G., Potpara, T., Dagres, N., Arbelo, E., Bax, J. J., Blomström‐Lundqvist, C., Boriani, G., Castella, M., Dan, G.-A., Dilaveris, P., et al. (2020) · European Heart Journal · doi:10.1093/eurheartj/ehaa612 · Cited by 10,550
Heart Disease and Stroke Statistics—2012 Update: A Report From the American Heart Association
Writing Group Members, Roger, V. L., Go, A. S., Lloyd-Jones, D. M., Benjamin, E. J., Berry, J. D., Borden, W. B., Bravata, D. M., Dai, S., Ford, E. S., et al. (2012) · Circulation · doi:10.1161/cir.0b013e31823ac046 · Cited by 7,333
2014 AHA/ACC/HRS Guideline for the Management of Patients With Atrial Fibrillation
January, C. T., Wann, L. S., Alpert, J. S., Calkins, H. G., Cigarroa, J. E., Cleveland, J. C., CONTI, J. B., Ellinor, P. T., Ezekowitz, M. D., Field, M. E., et al. (2014) · Circulation · doi:10.1161/cir.0000000000000041 · Cited by 7,145
2016 ESC Guidelines for the management of atrial fibrillation developed in collaboration with EACTS
Kirchhof, P. F., Benussi, S., Kotecha, D., Ahlsson, A., Atar, D., Casadei, B., Castellà, M., Diener, H., Heidbüchel, H., Hendriks, J., et al. (2016) · EP Europace · doi:10.1093/europace/euw295 · Cited by 6,438
2016 ESC Guidelines for the management of atrial fibrillation developed in collaboration with EACTS
Kirchhof, P., Benussi, S., Kotecha, D., Ahlsson, A., Atar, D., Casadei, B., Castella, M., Diener, H.-C., Heidbuchel, H., Hendriks, J., et al. (2016) · European Heart Journal · doi:10.1093/eurheartj/ehw210 · Cited by 6,418
Metadata
- Authors
- Aizer, A., Gaziano, J. M., Cook, N. R., Manson, J. E., Buring, J. E., & Albert, C. M.
- Affiliations
- Brigham and Women's Hospital (US)
- Corresponding author
- Aizer, Anthony
- ORCID
- Venue
- The American Journal of Cardiology
- Publisher
- Elsevier BV
- Published
- 2009-06
- Volume
- 103
- Issue
- 11
- Pages
- 1572-1577
- ISSN
- 0002-9149 (ISSN-L)
- PMC
- PMC2687527
- OpenAlex
- W2070824750
- Cited by
- 383
- References
- 25
- Citations by year
- 2026: 9 · 2025: 12 · 2024: 17 · 2023: 37 · 2022: 19 · 2021: 21 · 2020: 32 · 2019: 23 · 2018: 31 · 2017: 21 · 2016: 30 · 2015: 22 · 2014: 24 · 2013: 23 · 2012: 22
- FWCI
- 13.42
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- The American Journal of Cardiology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (5r01hl043851-10)
- National Heart, Lung, and Blood Institute (HL-34595, HL 26490, R01‐HL043851, R01HL034595)
- National Cancer Institute (R01CA040360, CA 34944, CA-097193, R01CA097193, CA 40360, R01CA047988)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Effects of Exercise
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Atrial Fibrillation Management and Outcomes
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Physical Activity and Health
- Keywords
- atrial fibrillation, high-intensity exercise, exercise frequency, joggers, young men, aging, risk factors, Physicians' Health Study
- MeSH terms
- Adult, Age Factors, Aged, Aged, 80 and over, Atrial Fibrillation, Humans, Life Style, Male, Middle Aged, Prospective Studies, Exercise, Effect Modifier, Epidemiologic, Body Mass Index, Logistic Models, Risk Assessment
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