The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.
Is Age Really a Non-Modifiable Cardiovascular Risk Factor?
Open accessOverview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Ageing has a strong residual effect on CVD that cannot be simply explained by longer exposure to classical risk factors.
“However, ageing has a strong residual effect that cannot be simply explained by longer exposure to classical risk factors. Only 11.9% and 40.3% of the effect of age can be attributed to longer exposure to risk factors in men and women, respectively.123”
From Senescence-induced inflammation: an important player and key therapeutic target in atherosclerosis (2020) · cites this paper as [123]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
General Cardiovascular Risk Profile for Use in Primary Care: The Framingham Heart Study
D’Agostino, R. B., Vasan, R. S., Pencina, M. J., Wolf, P. A., Cobain, M., Massaro, J. M., & Kannel, W. B. (2008) · Circulation · doi:10.1161/circulationaha.107.699579 · Cited by 7,491
Self-citationPrediction of lifetime risk for cardiovascular disease by risk factor burden at 50 years of age
Lloyd-Jones, D. M., Leip, E. P., Larson, M. G., D’Agostino, R. B., Beiser, A., Wilson, P. W. F., Wolf, P. A., & Levy, D. (2006) · Circulation · doi:10.1161/circulationaha.105.548206 · Cited by 1,298
Lifetime risk of developing coronary heart disease
Lloyd‐Jones, D. M., Larson, M. G., Beiser, A., & Levy, D. A. (1999) · The Lancet · doi:10.1016/s0140-6736(98)10279-9 · Cited by 943
Seshadri, S. S., Beiser, A., Kelly‐Hayes, M., Kase, C. S., Au, R., Kannel, W. B., & Wolf, P. A. (2006) · Stroke · doi:10.1161/01.str.0000199613.38911.b2 · Cited by 711
Self-citationMidlife Risk Factors and Healthy Survival in Men
Willcox, B. J., He, Q., Chen, R., Yano, K., Masaki, K., Grove, J., Donlon, T. A., Willcox, D. C., & Curb, J. D. (2006) · JAMA · doi:10.1001/jama.296.19.2343 · Cited by 247
Age as a modifiable risk factor for cardiovascular disease
Sniderman, A. D., & Furberg, C. D. (2008) · The Lancet · doi:10.1016/s0140-6736(08)60313-x · Cited by 187
Terry, D. F., Pencina, M. J., Vasan, R. S., Murabito, J. M., Wolf, P. A., Kelly‐Hayes, M., Levy, D. A., D’Agostino, R. B., & Benjamin, E. J. (2005) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2005.00465.x · Cited by 142
Self-citationGoldberg, R. J. (1996) · Archives of Internal Medicine · doi:10.1001/archinte.156.5.505 · Cited by 125
Factors Associated With Survival to 75 Years of Age in Middle-aged Men and Women
Goldberg, R. J. (1996) · Archives of Internal Medicine · doi:10.1001/archinte.1996.00440050051006 · Cited by 82
Yashin, A. I., Akushevich, I. V., Arbeev, K. G., Akushevich, L., Ukraintseva, S. V., & Kulminski, A. (2006) · AGE · doi:10.1007/s11357-006-9023-7 · Cited by 54
Flagged first, then by citations
Cited by
Sorted by citations
Age and Age-Related Diseases: Role of Inflammation Triggers and Cytokines
Rea, I. M., Gibson, D. S., McGilligan, V., McNerlan, S. E., Alexander, H. D., & Ross, O. A. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.00586 · Cited by 1,267
Zhu, X., Chen, Z., Shen, W., Huang, G., Sedivy, J. M., Wang, H., & Ju, Z. (2021) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-021-00646-9 · Cited by 417
Dhingra, R., & Vasan, R. S. (2011) · Medical Clinics of North America · doi:10.1016/j.mcna.2011.11.003 · Cited by 331
Self-citationAdverse childhood experiences and the onset of chronic disease in young adulthood
Sonu, S. C., Post, S. L., & Feinglass, J. M. (2019) · Preventive Medicine · doi:10.1016/j.ypmed.2019.03.032 · Cited by 298
Cellular Senescence, Vascular Disease, and Aging
Kovacic, J. C., Moreno, P., Nabel, E. G., Hachinski, V., & Fuster, V. (2011) · Circulation · doi:10.1161/circulationaha.110.009118 · Cited by 223
Cellular Senescence, Vascular Disease, and Aging
Kovacic, J. C., Moreno, P., Hachinski, V., Nabel, E. G., & Fuster, V. (2011) · Circulation · doi:10.1161/circulationaha.110.007021 · Cited by 209
Senescence-induced inflammation: an important player and key therapeutic target in atherosclerosis
Stojanović, S. D., Fiedler, J., Bauersachs, J., Thum, T., & Sedding, D. G. (2020) · European Heart Journal · doi:10.1093/eurheartj/ehz919 · Cited by 188
Somatic Mutations and Clonal Hematopoiesis
Fuster, J. J., & Walsh, K. X. (2018) · Circulation Research · doi:10.1161/circresaha.117.312115 · Cited by 164
Cobo, I., Tanaka, T. N., Mangalhara, K. C., Lana, A. J., Yeang, C., Han, C. Z., Schlachetzki, J. C. M., Challcombe, J., Fixsen, B. R., Sakai, M., et al. (2022) · Immunity · doi:10.1016/j.immuni.2022.06.022 · Cited by 117
Association of Coronary Artery Calcium Score vs Age With Cardiovascular Risk in Older Adults
Yano, Y., O’Donnell, C. J., Kuller, L. H., Kavousi, M., Erbel, R., Ning, H., D’Agostino, R. B., Newman, A. B., Nasir, K., Albert Hofman, D., et al. (2017) · JAMA Cardiology · doi:10.1001/jamacardio.2017.2498 · Cited by 113
Prevalence of hypertension and its determinants in Ethiopia: A systematic review and meta-analysis
Tiruneh, S. A., Bukayaw, Y. A., Yigizaw, S. T., & Angaw, D. A. (2020) · PLoS ONE · doi:10.1371/journal.pone.0244642 · Cited by 83
Cobo, I., Tanaka, T. N., Glass, C. K., & Yeang, C. (2021) · Current Opinion in Hematology · doi:10.1097/moh.0000000000000688 · Cited by 90
Choudhury, S., Huang, A. Y., Kim, J., Zhou, Z., Morillo, K. S., Maury, E. A., Tsai, J. W., Miller, M. B., Lodato, M. A., Araten, S., et al. (2022) · Nature Aging · doi:10.1038/s43587-022-00261-5 · Cited by 76
van Bussel, E. F., Hoevenaar‐Blom, M. P., Poortvliet, R. K. E., Gussekloo, J., van Dalen, J. W., van Gool, W. A., Richard, E., & van Charante, E. P. M. (2020) · Preventive Medicine · doi:10.1016/j.ypmed.2020.105986 · Cited by 70
Integrating Health into Cognitive Aging: Toward a Preventive Cognitive Neuroscience of Aging
Spiro, A., & Brady, C. B. (2011) · The Journals of Gerontology Series B · doi:10.1093/geronb/gbr018 · Cited by 53
Natural products targeting inflammation-related metabolic disorders: A comprehensive review
Nainu, F., Frediansyah, A., Mamada, S. S., Permana, A. D., Salampe, M., Chandran, D., Emran, T. B., & Simal‐Gándara, J. (2023) · Heliyon · doi:10.1016/j.heliyon.2023.e16919 · Cited by 48
The ageing cardiovascular system
Bolton, E., & Rajkumar, C. (2011) · Reviews in Clinical Gerontology · doi:10.1017/s0959259810000389 · Cited by 42
Differences in Risk Factors for Coronary Atherosclerosis According to Sex
Kim, H. (2024) · Journal of Lipid and Atherosclerosis · doi:10.12997/jla.2024.13.2.97 · Cited by 39
Köbe, T., Binette, A. P., Vogel, J. W., Meyer, P., Breitner, J. C. S., Poirier, J., & Villeneuve, S. (2021) · NeuroImage · doi:10.1016/j.neuroimage.2021.117832 · Cited by 30
Anti-senescence therapies: a new concept to address cardiovascular disease
Stojanović, S. D., Thum, T., & Bauersachs, J. K. (2025) · Cardiovascular Research · doi:10.1093/cvr/cvaf030 · Cited by 31
Tegegne, K. D., Adella, G. A., Kassie, G. A., Mengstie, M. A., Seid, M. A., Zemene, M. A., Feleke, S. F., Dejenie, T. A., Abebe, E. C., Anley, D. T., et al. (2023) · BMC Infectious Diseases · doi:10.1186/s12879-023-08679-x · Cited by 20
da Silva, R. P., Martinez, D., Ramos, J. M. U., Martins, E. F., Silva, L. M. T., López, P., & Cadore, E. L. (2022) · Sleep Medicine · doi:10.1016/j.sleep.2022.04.014 · Cited by 21
Sex differences in coronary atherogenesis: a narrative review
Kim, H. (2024) · Ewha Medical Journal · doi:10.12771/emj.2024.e15 · Cited by 15
Harb, S. C., Cremer, P. C., Wu, Y., Xu, B., Cho, L., Menon, V., & Jaber, W. A. (2019) · European Journal of Preventive Cardiology · doi:10.1177/2047487319826400 · Cited by 11
Genetics of age-related clonal hematopoiesis and atherosclerotic cardiovascular disease
Jung, C. H., Evans, M. A., & Walsh, K. X. (2020) · Current Opinion in Cardiology · doi:10.1097/hco.0000000000000726 · Cited by 11
Amyloid cardiomyopathy in a large integrated health care system
Czobor, P., Hung, Y., Baer, D. M., McGlothlin, D. P., Weisshaar, D., & Zaroff, J. G. (2019) · American Heart Journal · doi:10.1016/j.ahj.2019.06.008 · Cited by 11
Kong, N., Sakhuja, S., Colantonio, L. D., Levitan, E. B., Lloyd‐Jones, D. M., Cushman, M., Muntner, P., & Polonsky, T. S. (2023) · American Journal of Preventive Cardiology · doi:10.1016/j.ajpc.2023.100612 · Cited by 9
CHIP-ping Away at Atherosclerosis
Keaney, J. F. (2017) · New England Journal of Medicine · doi:10.1056/nejme1706173 · Cited by 9
Machine Learning based Predictors of Cardiovascular Disease among Young Adults
Shetty, D. K., Rodrigues, L. L. R., Shetty, A. K., & Nair, G. (2022) · Engineered Science · doi:10.30919/es8d627 · Cited by 8
Yesmin, M., Ali, M., & Saha, S. (2023) · BMC Public Health · doi:10.1186/s12889-023-16090-z · Cited by 7
Can Resistance Training Play a Role in the Prevention or Treatment of Hypertension?
Hurley, B. F., & Gillin, A. R. (2015) · Molecular and translational medicine · doi:10.1007/978-3-319-17076-3_2 · Cited by 7
Amorós-Pérez, M., Monte-Monge, A. D., Gonzalo, P., Andrés‐Manzano, M. J., Rius, C., Fanjul, V., González‐Gómez, C., Moreno, G., Benguría, A., Dopazo, A., et al. (2025) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.124.322893 · Cited by 6
Jenkins, N. D. M., Banks, N. F., Rogers, E. M., Sciarrillo, C. M., Koemel, N. A., Colquhoun, R. J., & Emerson, S. R. (2020) · Nutrition Research · doi:10.1016/j.nutres.2020.08.012 · Cited by 4
Tsialtas, D., Bolognesi, M. G., Assimopoulos, S., Aldigeri, R., Volpi, R., & Bolognesi, R. (2019) · Gerontology · doi:10.1159/000497812 · Cited by 4
Walsh, C. A., Choudhury, S., Huang, A. Y., Kim, J. J., Morillo, K. S., Maury, E. A., Zhou, Z., Kenny, C. J., Lee, E., & Chen, M. H. (2020) · Research Square · doi:10.21203/rs.3.rs-84503/v1 · Cited by 4
The fat‐heart entanglement and the role of ‘osteopontin mechanics’ in cardiometabolic senescence
Michelauz, C., Montecucco, F., Liberale, L., & Carbone, F. (2026) · European Journal of Clinical Investigation · doi:10.1111/eci.70181 · Cited by 2
Alvani, M. S., Karimi, K., Khosravi, S., Naderian, M., Azizpour, Y., Golestani, A., Payab, M., Selk-Ghaffari, M., Ejtahed, H., Takian, A., et al. (2026) · Journal of Diabetes & Metabolic Disorders · doi:10.1007/s40200-026-01992-7 · Cited by 2
Geltore, T. E., Alemu, S., Ersado, T. L., Uliso, T. B., Anshebo, A. A., & Foto, L. L. (2025) · Frontiers in Global Women s Health · doi:10.3389/fgwh.2025.1571052 · Cited by 2
Empirical Evaluation of Ensemble Approach for Diagnostic Knowledge Management
Ha, S.-H., & Zhang, Z. (2011) · The Journal of Information Systems · doi:10.5859/kais.2011.20.3.237 · Cited by 1
Iqbal, A., Rahman, M., Bashar, M. I., Ahmed, A., Khan, S., Ahmed, N., Hasan, M. M., & Haider, M. M. (2024) · Research Square · doi:10.21203/rs.3.rs-4296649/v1 · Cited by 1
Clinical Decision Support For Disease Classification Based On The Tests Association
Ha, S. H., Joo, S. H., & Kwon, E. K. (2012) · Zenodo (CERN European Organization for Nuclear Research) · doi:10.5281/zenodo.1082984
Age-related Disease: A Revolution Is Coming.
Bland, J. S. (2018) · Europe PMC (PubMed Central)
Assessment on Factors That Affect the Cardiovascular Patients Using Cox Ph ModelPreprint
Hirbo, H. G., Kuse, K. A., Hola, R. N., & Oromo, H. H. (2023) · Research Square · doi:10.21203/rs.3.rs-3809090/v1
Risk management of patients with multiple CVDs: what are the best practices?
Harky, A., Patel, R. S. K., Yien, M., Khaled, A., Nguyen, D. H., Roy, S., & Zeinah, M. (2024) · Expert Review of Cardiovascular Therapy · doi:10.1080/14779072.2024.2427634
Tegegne, K. D., Adela, G. A., Kassie, G. A., Mengstie, M. A., Seid, M. A., Zemene, M. A., Feleke, S. F., Dejenie, T. A., Abebe, E. C., Anley, D. T., et al. (2023) · Figshare · doi:10.6084/m9.figshare.24439291
Tegegne, K. D., Adela, G. A., Kassie, G. A., Mengstie, M. A., Seid, M. A., Zemene, M. A., Feleke, S. F., Dejenie, T. A., Abebe, E. C., Anley, D. T., et al. (2024) · Figshare · doi:10.6084/m9.figshare.24439495
Yesmin, M., Ali, M., & Saha, S. (2024) · Figshare · doi:10.6084/m9.figshare.26598284
Watabe, H., Ishibashi, Y., Go, K., Nakajima, K., Tanabe, Y., Akashi, Y. J., Kadono, T., & Miyagaki, T. (2026) · The Journal of Dermatology · doi:10.1111/1346-8138.70133
A Review of Traditional and Non-Traditional Cardiovascular Risk Factors in Women
Vasanthakumar, S. A., Paleri, S., Aldous, E., Khanna, S., Nandurkar, R., Davis, E., Lin, A., & Nerlekar, N. (2026) · International Journal of Women s Health · doi:10.2147/ijwh.s574244
Epidemiology of Cardiovascular disease and associated risk factors in Gaza Strip- Palestine
Jamee, A. (2019) · theses.fr (ABES) · doi:10.70675/f3c10b16z6420z46b0z81b5z75ec59d4399e
A Machine Learning Driven Approach to Quantifying Coronary Artery Tortuosity
Ayala, J. R. T., Supriami, K., Swaroop, S., Friedman, S. F., Ünlü, O., Halford, J. L., Maddah, M., Abou-Karam, R., Pomerantsev, E. V., Ellinor, P. T., et al. (2026) · JACC Advances · doi:10.1016/j.jacadv.2026.102829
Metadata
- Authors
- Kannel, W. B., & Vasan, R. S.
- Affiliations
- Boston University (US)
- Venue
- The American Journal of Cardiology
- Publisher
- Elsevier BV
- Published
- 2009-11
- Volume
- 104
- Issue
- 9
- Pages
- 1307-1310
- ISSN
- 0002-9149 (ISSN-L)
- PMC
- PMC3760670
- OpenAlex
- W2048987084
- Cited by
- 51
- References
- 10
- Citations by year
- 2026: 5 · 2025: 3 · 2024: 6 · 2023: 6 · 2022: 4 · 2021: 3 · 2020: 5 · 2019: 6 · 2018: 3 · 2017: 2 · 2015: 1 · 2012: 1
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- The American Journal of Cardiology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (n01hc25195-41-0-1)
- National Heart, Lung, and Blood Institute (N01‐HC25195, N01-HC-025195)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Risk Factors
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Disease Prevention
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipoproteins and Cardiovascular Health
- Keywords
- aging, cardiovascular risk factors, modifiable risk factors, atherosclerosis, cardiovascular disease incidence, Framingham Heart Study
- MeSH terms
- Aging, Cardiovascular Diseases, Humans, Risk Factors, Survival Analysis
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
