The DOI matches its Crossref record; 29 of the 29 references it cites were found in a registry or an index.
Meta-Analysis of Cohort and Case–Control Studies of Type 2 Diabetes Mellitus and Risk of Atrial Fibrillation
Open accessAbstract
Atrial fibrillation (AF) is one of the most clinically diagnosed cardiac disturbances but little is known about its risk factors. Previous epidemiological studies have reported on the association between diabetes mellitus (DM) and subsequent risk of AF with inconsistent results. The aim of this study was to conduct a meta-analysis of published studies to reliably determine the direction and magnitude of any association between DM and AF. A systematic review and meta-analysis was conducted. PUBMED and EMBASE were searched to identify prospective cohort and case-control studies that had reported on the association between DM and other measures of glucose homeostasis with incident AF by April 2010. Studies conducted in primarily high-risk populations and participants in randomized controlled trials were excluded. Seven prospective cohort studies and four case-control studies with information on 108,703 cases of AF among 1,686,097 individuals contributed to this analysis. The summary estimate indicated that individuals with DM had an approximate 40% greater risk of AF compared with unaffected individuals: RR 1.39 (95% Confidence Intervals: 1.10 – 1.75; p for heterogeneity <0.001). After correcting for publication bias the RR was XXXXXXX. Studies that had adjusted for multiple risk factors reported a smaller effect estimate compared with age-adjusted studies: RR 1.24 (95% Confidence Intervals: 1.06 – 1.44) versus 1.70 (1.29 – 2.22); p for heterogeneity = 0.053. The population attributable fraction of AF due to DM was 2.5% (95% CI: 0.1 – 3.9%). In conclusion, DM is associated with an increased risk of subsequent AF but the mechanisms that may underpin the relation between DM and AF remain speculative.
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Meta-analysis of Observational Studies in Epidemiology<SUBTITLE>A Proposal for Reporting</SUBTITLE>
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Heart Disease and Stroke Statistics—2015 Update: A Report From the American Heart Association
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Metadata
- Authors
- Huxley, R. R., Filion, K. B., Konety, S., & Alonso, A.
- Venue
- The American Journal of Cardiology
- Publisher
- Elsevier BV
- Published
- 2011-07
- Volume
- 108
- Issue
- 1
- Pages
- 56-62
- ISSN
- 0002-9149 (ISSN-L)
- OpenAlex
- W2166966803
- Cited by
- 561
- References
- 29
- FWCI
- 3.01
- Type
- journal article
- Language
- en
- Open access
- green
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- Huxley, R. R., Filion, K. B., Konety, S., & Alonso, A. (2011). Meta-Analysis of Cohort and Case–Control Studies of Type 2 Diabetes Mellitus and Risk of Atrial Fibrillation. The American Journal of Cardiology. https://doi.org/10.1016/j.amjcard.2011.03.004
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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