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Cited by 12,591Cardiovascular Health and Risk FactorsHealthcare Systems and Public HealthAcute Ischemic Stroke Management

Heart Disease and Stroke Statistics—2017 Update: A Report From the American Heart Association

Benjamin, Emelia J., Blaha, Michael J., Chiuve, Stephanie E., Cushman, Mary, Das, Sandeep R., Deo, Rajat, de Ferranti, Sarah D., Floyd, James +37 more·2017·Circulation
DOI 10.1161/cir.0000000000000485PMC PMC5408160
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  • Approximately half of treated patients do not have adequate blood pressure or glycemic control.

    “Despite the widespread availability of effective treatments, approximately half of treated patients do not have adequate blood pressure (BP) or glycemic control [4,6,7].”

    From Effectiveness of Digital Medicines to Improve Clinical Outcomes in Patients with Uncontrolled Hypertension and Type 2 Diabetes: Prospective, Open-Label, Cluster-Randomized Pilot Clinical Trial (2017) · cites this paper as [4]

    In ‘High Blood Pressure > Awareness, Treatment, and Control’ (page unavailable), the report says 70.4% of US adults taking antihypertensive medication had controlled BP—about 30%, not half, lacked control. Its diabetes discussion reports poor glycemic control in children receiving monotherapy, but does not establish the claimed proportion for treated patients generally. (LLM, conf=0.83)

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  • Hypertension and diabetes mellitus are major risk factors for cardiac diseases, stroke, and kidney diseases.

    “Hypertension (HTN) and diabetes mellitus are major risk factors for cardiac diseases, stroke, and kidney diseases [1-5].”

    From Effectiveness of Digital Medicines to Improve Clinical Outcomes in Patients with Uncontrolled Hypertension and Type 2 Diabetes: Prospective, Open-Label, Cluster-Randomized Pilot Clinical Trial (2017) · cites this paper as [4]

    The High Blood Pressure ‘Aftermath’ section reports higher risks of heart disease and stroke with elevated blood pressure, and the ‘Prehypertension’ section reports an association with end-stage renal disease; page numbers were not available in our copy. The retrieved Diabetes Mellitus passages do not establish diabetes as a risk factor for the three disease categories, so the full claim is not supported by the passages found. (LLM, conf=0.82)

    Experimental — accuracy not yet measured

  • Ischemic stroke is most prevalent in older individuals and is strongly linked to systemic diseases such as hypertension, hypercholesterolemia, obesity, and diabetes mellitus.

    “despite the fact that ischemic stroke is most prevalent in older individuals [24, 95] and is strongly linked to systemic diseases, such as hypertension, hypercholesterolemia, obesity, and diabetes mellitus [14].”

    From Microglia and monocytes in inflammatory CNS disease: integrating phenotype and function (2022) · cites this paper as [24]

    The cited paper’s Overweight and Obesity > Complications section reports higher ischemic-stroke risk in overweight and obese individuals, and High Blood Pressure > Aftermath links hypertension to stroke risk generally. The passages found do not establish the claimed links between ischemic stroke and hypercholesterolemia or diabetes mellitus specifically. The older-age clause has separate citations, so it is not judged against this source. (LLM, conf=0.83)

    Experimental — accuracy not yet measured

  • Atherosclerosis is the most likely cause of myocardial infarction and stroke.

    “Atherosclerosis is the most likely cause of MI and stroke [12–15].”

    From Cardiovascular disease models: A game changing paradigm in drug discovery and screening (2019) · cites this paper as [12]

  • Cardiovascular disease is a leading cause of death globally, with an estimated 17 million deaths annually.

    “Cardiovascular disease is the leading cause of death worldwide.”

    From Cardiovascular disease models: A game changing paradigm in drug discovery and screening (2019) · cites this paper as [12]

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Research works printed but not linked: 93

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Authors
Benjamin, E. J., Blaha, M. J., Chiuve, S. E., Cushman, M., Das, S. R., Deo, R., de Ferranti, S. D., Floyd, J., Fornage, M., Gillespie, C., Isasi, C. R., Jiménez, M. C., Jordan, L. C., Judd, S. E., Lackland, D., Lichtman, J. H., Lisabeth, L., Liu, S., Longenecker, C. T., Mackey, R. H., Matsushita, K., Mozaffarian, D., Mussolino, M. E., Nasir, K., Neumar, R. W., Palaniappan, L., Pandey, D. K., Thiagarajan, R. R., Reeves, M. J., Ritchey, M., Rodriguez, C. J., Roth, G. A., Rosamond, W. D., Sasson, C., Towfighi, A., Tsao, C. W., Turner, M. B., Virani, S. S., Voeks, J. H., Willey, J. Z., Wilkins, J. T., Wu, J. H., Alger, H. M., Wong, S. S., & Muntner, P.
Affiliations
Johns Hopkins University (US)
ORCID
Venue
Circulation
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2017-03-07
Volume
135
Issue
10
ISSN
  • 0009-7322 (ISSN-L)
  • 1524-4539
DOI
10.1161/cir.0000000000000485
PMC
PMC5408160
OpenAlex
W2580792129
Cited by
12,591
References
2,095
Citations by year
2026: 163 · 2025: 504 · 2024: 709 · 2023: 945 · 2022: 1198 · 2021: 1492 · 2020: 1897 · 2019: 2020 · 2018: 2300 · 2017: 1023 · 2016: 167 · 2015: 14 · 2014: 16 · 2013: 17 · 2012: 49
FWCI
279.28
Type
journal article
Language
en
Update notices
Open access
closed
Locations
  • Circulation (publishedVersion)
  • eCommons - AKU (Aga Khan University) (submittedVersion)
Funders
  • National Institutes of Health (CC999999)
  • Eunice Kennedy Shriver National Institute of Child Health and Human Development (U54HD083211)
Topics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Risk Factors
  • Health Sciences › Medicine › Epidemiology › Healthcare Systems and Public Health
  • Health Sciences › Medicine › Epidemiology › Acute Ischemic Stroke Management
Keywords
heart disease, stroke, cardiovascular disease epidemiology, cardiovascular disease statistics, cardiovascular mortality, cardiovascular disease prevalence

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