Cited by 349Cardiac Health and Mental HealthHeart Rate Variability and Autonomic ControlCardiovascular Health and Risk Factors

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Meta-Analysis of Perceived Stress and Its Association With Incident Coronary Heart Disease

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Richardson, Safiya, Shaffer, Jonathan A., Falzon, Louise, Krupka, David, Davidson, Karina W., Edmondson, Donald·2012·The American Journal of Cardiology

DOI 10.1016/j.amjcard.2012.08.004PMC PMC3511594

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Abstract

Most studies examining potential associations between psychological factors and cardiovascular outcomes have focused on either depression or anxiety. The effect of perceived stress on incident coronary heart disease (CHD) has yet to be reviewed systematically. We conducted a systematic review and meta-analysis of the association between perceived stress and incident CHD. Ovid MEDLINE and PsycINFO were searched as data sources. Prospective observational cohort studies were selected that measured self-reported perceived stress and assessed incident CHD at minimum of 6 months later. We extracted study characteristics and estimates of the risk of incident CHD associated with high perceived stress vs. low perceived stress. We identified 23 potentially relevant articles, of which 6 met our criteria (N = 118,696). Included studies measured perceived stress with both validated measures and non-validated simple self-report surveys. Incident CHD was defined as new diagnosis of, hospitalization for, or mortality secondary to CHD. Meta-analysis yielded an aggregate risk ratio of 1.27 (95% confidence interval 1.12 – 1.45) for the magnitude of the relation between high perceived stress and incident CHD. In conclusion this meta-analysis suggests that high perceived stress is associated with a moderately increased risk of incident CHD.

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Authors: Richardson, S., Shaffer, J. A., Falzon, L., Krupka, D., Davidson, K. W., & Edmondson, D.
Affiliations: Columbia University Irving Medical Center (US)
Corresponding author: Edmondson, Donald
ORCID: Richardson, Safiya
Shaffer, Jonathan A.
Falzon, Louise
Davidson, Karina W.
Edmondson, Donald
Venue: The American Journal of Cardiology
Publisher: Elsevier BV
Published: 2012-12
Volume: 110
Issue: 12
Pages: 1711-1716
ISSN: 0002-9149 (ISSN-L)
DOI: 10.1016/j.amjcard.2012.08.004
PMC: PMC3511594
OpenAlex: W2125315255
Semantic Scholar: 071040f82c0994a6069523d431dae51245242878
Cited by: 349
References: 28
Citations by year: 2026: 20 · 2025: 24 · 2024: 31 · 2023: 28 · 2022: 52 · 2021: 29 · 2020: 18 · 2019: 29 · 2018: 21 · 2017: 25 · 2016: 19 · 2015: 25 · 2014: 17 · 2013: 10
FWCI: 2.74
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: The American Journal of Cardiology (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Columbia Academic Commons (Columbia University)
Funders: National Institutes of Health (UL1RR024156)
Topics: Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Health and Mental Health
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Risk Factors
Keywords: perceived stress, coronary artery disease, incident coronary heart disease, psychological stress, cardiovascular risk, self-reported stress, relative risk
MeSH terms: Coronary Disease, Humans, Perception, Risk Factors, Stress, Psychological

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Meta-Analysis of Perceived Stress and Its Association With Incident Coronary Heart Disease

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