Demonstration of anatomic reentrant circuit in verapamil-sensitive atrial tachycardia originating from the atrioventricular annulus other than the vicinity of the atrioventricular node
Abstract
The mechanism and tachycardia circuit of verapamil-sensitive atrial tachycardia originating from the atrioventricular annulus (AVA-AT) other than the atrioventricular node vicinity are not well clarified. In 23 patients, we examined the mechanism and anatomic tachycardia circuit of AVA-AT. While recording the atrial electrogram at the earliest atrial activation site (EAAS) during tachycardia, rapid atrial pacing at a rate 5 beats/min faster than the tachycardia rate was delivered from multiple sites of the right atrium (RA) to demonstrate manifest entrainment and define the direction of proximity of slow conduction area (SCA) of reentry circuit. When EAAS was orthodromically captured, radiofrequency energy was delivered starting at a site 2 cm away from the EAAS in the direction of entrainment pacing site. Then application site was gradually advanced toward the EAAS until termination of tachycardia to define the entrance of SCA of reentry circuit. Manifest entrainment was demonstrated in all AVA-ATs. The EAAS, distributed along the tricuspid annulus from 3- to the 12-o'clock position, was orthodromically captured by pacing delivered from high anterolateral RA (n = 6), high anteroseptal RA (n = 7), high posteroseptal RA (n = 3), low anterolateral RA (n = 6), and coronary sinus ostium (n = 1). Radiofrequency energy delivery to the site, 10.4 ± 2.4 mm proximal to the EAAS where the atrial electrogram was observed 13.9 ± 5.7 ms later than the EAAS, terminated AVA-AT immediately after the onset of energy delivery (2.9 ± 1.1 seconds). In conclusion, it was shown that the AVA-AT is organized as reentry involving the verapamil-sensitive SCA with its entrance and exit at different distinct locations.
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Beta blockers and calcium-channel blockers may be effective for chronic AT with low risk of side effects.
“Beta blockers and calcium-channel blockers may be effective and there is a low risk of side effects.113,114”
From European Heart Rhythm Association (EHRA) consensus document on the management of supraventricular arrhythmias, endorsed by Heart Rhythm Society (HRS), Asia-Pacific Heart Rhythm Society (APHRS), and Sociedad Latinoamericana de Estimulacion Cardiaca y Electrofisiologia (SOLAECE) (2017) · cites this paper as [114]
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- Authors
- Yamabe, H., Okumura, K., Koyama, J., Kanazawa, H., Hoshiyama, T., & Ogawa, H.
- Affiliations
- Kumamoto University (JP)
- Hirosaki University (JP)
- Corresponding author
- Yamabe, Hiroshige
- Venue
- The American Journal of Cardiology
- Publisher
- Elsevier BV
- Published
- 2014-06
- Volume
- 113
- Issue
- 11
- Pages
- 1822-1828
- ISSN
- 0002-9149 (ISSN-L)
- OpenAlex
- W2046770586
- Cited by
- 26
- References
- 20
- Citations by year
- 2026: 2 · 2024: 3 · 2023: 1 · 2022: 4 · 2021: 1 · 2020: 4 · 2019: 4 · 2018: 2 · 2017: 2 · 2016: 3
- FWCI
- 1.14
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The American Journal of Cardiology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Ministry of Education, Culture, Sports, Science and Technology
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Arrhythmias and Treatments
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac electrophysiology and arrhythmias
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac pacing and defibrillation studies
- Keywords
- reentrant circuit, atrial electrograms, radiofrequency ablation, tricuspid annulus, atrioventricular node
- MeSH terms
- Adult, Aged, Aged, 80 and over, Anti-Arrhythmia Agents, Atrioventricular Node, Cardiac Pacing, Artificial, Female, Heart Atria, Heart Conduction System, Heart Rate, Humans, Male, Middle Aged, Tachycardia, Atrioventricular Nodal Reentry, Verapamil, Treatment Outcome, Catheter Ablation, Electrophysiologic Techniques, Cardiac
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