Prognostic Usefulness of Insulin-Like Growth Factor-Binding Protein 7 in Heart Failure With Reduced Ejection Fraction: A Novel Biomarker of Myocardial Diastolic Function?
Abstract
Insulin-like growth factor-binding protein 7 (IGFBP7) is a biomarker that has recently been associated with heart failure and cardiac hypertrophy. The aim of this study was to examine IGFBP7 relative to echocardiographic abnormalities reflecting diastolic dysfunction. One hundred twenty-four patients with ambulatory heart failure with reduced ejection fraction and baseline detailed 2-dimensional echocardiograms were followed for a mean of 10 months. IGFBP7 was measured serially at each office visit; 108 patients underwent follow-up echocardiography. Echocardiographic parameters of diastolic function were compared at baseline and over time. IGFBP7 concentrations were not linked to left ventricular size or systolic function. In contrast, those with elevated baseline IGFBP7 concentrations were more likely to have abnormalities of parameters describing diastolic function, such as higher left atrial volume index, transmitral E/A ratio, E/E' ratio, and right ventricular systolic pressure. IGFBP7 was correlated with left atrial volume index (ρ = 0.237, p = 0.008), transmitral E/A ratio (ρ = 0.304, p = 0.001), E/E' ratio (ρ = 0.257, p = 0.005), and right ventricular systolic pressure (ρ = 0.316, p = 0.001). Furthermore, each was found to be independently predictive of IGFBP7 in adjusted analysis. In subjects with baseline and final echocardiograms, more time spent with elevated IGFBP7 concentrations in serial measurement was associated with worsening diastolic function and increasing left atrial volume index or right ventricular systolic pressure. IGFBP7 concentrations were predictive of an increased risk for cardiovascular events independent of echocardiographic measures of diastolic function (p = 0.006). In conclusion, IGFBP7 is a novel prognostic biomarker for heart failure with reduced ejection fraction and shows significant links to the presence and severity of echocardiographic parameters of abnormal diastolic function.
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The progression of DCM has been linked to cardiomyocyte hypertrophy and increased fibrosis.
“Structurally, the progression of DCM has been linked to cardiomyocyte hypertrophy and increased fibrosis [26-29].”
From Role of Serum Biomarkers in Early Detection of Diabetic Cardiomyopathy in the West Virginian Population (2016) · cites this paper as [28]
IGFBP7 is an established marker for diabetes and is associated with the severity of diastolic dysfunction.
“IGFBP7 is an established marker for diabetes, and is associated with the severity of diastolic dysfunction [28].”
From Role of Serum Biomarkers in Early Detection of Diabetic Cardiomyopathy in the West Virginian Population (2016) · cites this paper as [28]
IGFBP7 has been identified as a biomarker for diastolic dysfunction associated with cardiac hypertrophy, myocyte fibrosis, and vascular remodeling, and an association exists between serum IGFBP7 levels and echocardiographic abnormalities describing diastolic heart dysfunction independent of systolic function.
“IGFBP7 has been identified as a biomarker for diastolic dysfunction associated with cardiac hypertrophy, myocyte fibrosis, and vascular remodeling, and an association exists between serum IGFBP7 levels and echocardiographic abnormalities describing diastolic heart dysfunction independent of systolic function [28].”
From Role of Serum Biomarkers in Early Detection of Diabetic Cardiomyopathy in the West Virginian Population (2016) · cites this paper as [28]
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Insulin-Like Growth Factor-1 Bioregulation System Abnormalities
Tzanis, G. S., Philippou, Α., Dimopoulos, S. K., Koutsilieris, M., & Nanas, S. (2017) · JACC Heart Failure · doi:10.1016/j.jchf.2016.11.001 · Cited by 4 · see citing works
IGFBP7 as a preoperative predictor of congestive acute kidney injury after cardiac surgery
MacMillan, Y. S., Mamas, M. A., & Sun, L. Y. (2022) · Open Heart · doi:10.1136/openhrt-2022-002027 · Cited by 3 · see citing works
Effects of Empagliflozin in Heart Failure Patients with Type 2 Diabetes: A Biomarker Perspective
Elrakaybi, A., Zhou, Q., Päth, G., Hug, M. J., Seufert, J., & Laubner, K. (2025) · Experimental and Clinical Endocrinology & Diabetes · doi:10.1055/a-2722-8616 · Cited by 2 · see citing works
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Association between Insulin-Like Growth Factor Binding Protein-7 and Heart Failure
Ghasempour, P., Khanmohammadi, S., & Rezaei, N. (2025) · Current Medicinal Chemistry · doi:10.2174/0109298673346933241223063559 · Cited by 2 · see citing works
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DIA proteomics reveals potential biomarkers for T2DM in acute myocardial infarction patientsPreprint
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- Authors
- Gandhi, P. U., Gaggin, H. K., Sheftel, A. D., Belcher, A. M., Weiner, R. B., Baggish, A. L., Motiwala, S. R., Liu, P. P., & Januzzi, J. L.
- Affiliations
- Massachusetts General Hospital (US)
- University of Ottawa (CA)
- Corresponding author
- Januzzi, James L.
- Venue
- The American Journal of Cardiology
- Publisher
- Elsevier BV
- Published
- 2014-11
- Volume
- 114
- Issue
- 10
- Pages
- 1543-1549
- ISSN
- 0002-9149 (ISSN-L)
- OpenAlex
- W2162758488
- Cited by
- 72
- References
- 19
- Citations by year
- 2026: 3 · 2025: 5 · 2024: 3 · 2023: 10 · 2022: 5 · 2021: 9 · 2020: 12 · 2019: 5 · 2018: 8 · 2017: 6 · 2016: 6
- FWCI
- 2.56
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The American Journal of Cardiology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Singulex
- Sphingotec GmbH
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Failure Treatment and Management
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Fibrosis and Remodeling
- Keywords
- IGFBP7, heart failure with reduced ejection fraction, diastolic dysfunction, prognostic factors, left atrial volume index, E/e' ratio, right ventricular systolic pressure, cardiovascular events, serial biomarker measurement
- MeSH terms
- Female, Follow-Up Studies, Humans, Male, Middle Aged, Myocardial Contraction, Prognosis, Prospective Studies, Severity of Illness Index, Stroke Volume, Time Factors, Echocardiography, Doppler, Biomarkers, Ventricular Function, Left, Disease Progression, Insulin-Like Growth Factor Binding Proteins, Heart Failure, Diastolic
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