Orthostatic Hypotension in the Elderly: Diagnosis and Treatment
Abstract
Orthostatic hypotension is a common problem among elderly patients, associated with significant morbidity and mortality. While acute orthostatic hypotension is usually secondary to medication, fluid or blood loss, or adrenal insufficiency, chronic orthostatic hypotension is frequently due to altered blood pressure regulatory mechanisms and autonomic dysfunction. The diagnostic evaluation requires a comprehensive history including symptoms of autonomic nervous system dysfunction, careful blood pressure measurement at various times of the day and after meals or medications, and laboratory studies. Laboratory investigation and imaging studies should be based upon the initial findings with emphasis on excluding diagnoses of neurodegenerative diseases, amyloidosis, diabetes, anemia, and vitamin deficiency as the cause. Whereas asymptomatic patients usually need no treatment, those with symptoms often benefit from a stepped approach with initial nonpharmacological interventions, including avoidance of potentially hypotensive medications and use of physical counter maneuvers. If these measures prove inadequate and the patient remains persistently symptomatic, various pharmacotherapeutic agents can be added, including fludrocortisone, midodrine, and nonsteroidal anti-inflammatory drugs. The goals of treatment are to improve symptoms and to make the patient as ambulatory as possible rather then trying to achieve arbitrary blood pressure goals. With proper evaluation and management, the occurrence of adverse events, including falls, fracture, functional decline, and myocardial ischemia, can be significantly reduced.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Preliminary evidence suggests that nocturnal HBPM can be used as an alternative to ABPM in the investigation of nocturnal BP in patients with sleep apnoea.
“Preliminary evidence suggests that nocturnal HBPM can be used as an alternative to ABPM in the investigation of nocturnal BP in patients with sleep apnoea [230,231].”
Cites
The Cardiovascular Health Study: design and rationale.
Fried, L. P., Borhani, N. O., Enright, P., Furberg, C. D., Gardin, J. M., Kronmal, R. A., Kuller, L. H., Manolio, T. A., Mittelmark, M. B., Newman, A., et al. (1991) · Annals of Epidemiology · doi:10.1016/1047-2797(91)90005-w · Cited by 3,652 · see citing works
The Consensus Committee of the American Autonomic Society and the American Academy of Neurology (1996) · Neurology · doi:10.1212/wnl.46.5.1470 · Cited by 1,238 · see citing works
Rutan, G. H., Hermanson, B., Bild, D. E., Kittner, S. J., LaBaw, F., & Tell, G. S. (1992) · Hypertension · doi:10.1161/01.hyp.19.6.508 · Cited by 607 · see citing works
Low, P. A. (1997) · JAMA · doi:10.1001/jama.1997.03540370036033 · Cited by 425 · see citing works
Orthostatic Hypotension in the Elderly
Desforges, J. F., & Lipsitz, L. A. (1989) · New England Journal of Medicine · doi:10.1056/nejm198910053211407 · Cited by 376 · see citing works
Self-citationTreatment of Orthostatic Hypotension with Erythropoietin
Hoeldtke, R. D., & Streeten, D. H. P. (1993) · New England Journal of Medicine · doi:10.1056/nejm199308263290904 · Cited by 226 · see citing works
TREATMENT OF IDIOPATHIC ORTHOSTATIC HYPOTENSION (SHY-DRAGER SYNDROME) WITH INDOMETHACIN
Ms, K., & Hd, I. (1978) · The Lancet · doi:10.1016/s0140-6736(78)90737-7 · Cited by 115 · see citing works
Fludrocortisone in the treatment of hypotensive disorders in the elderly.
Hussain, R. M., McIntosh, S. J., Lawson, J. J., & Kenny, R. A. (1996) · Heart · doi:10.1136/hrt.76.6.507 · Cited by 100 · see citing works
Postural Change in Blood Pressure Associated With Age and Systolic Blood Pressure
Harris, T. B., Lipsitz, L. A., Kleinman, J. C., & Cornoni‐Huntley, J. C. (1991) · Journal of Gerontology · doi:10.1093/geronj/46.5.m159 · Cited by 78 · see citing works
Self-citationChanges in frequency of orthostatic hypotension in elderly hypertensive patients under medications
Masuo, K. (1996) · American Journal of Hypertension · doi:10.1016/0895-7061(95)00348-7 · Cited by 75 · see citing works
Effects of postprandial walking exercise on meal-related hypotension in frail elderly patients
Oberman, A. S., Harada, R. K., Gagnon, M. M., Kiely, D. K., & Lipsitz, L. A. (1999) · The American Journal of Cardiology · doi:10.1016/s0002-9149(99)00520-2 · Cited by 36 · see citing works
Self-citation
Flagged first, then by citations
1 of the 12 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
PRACTICE GUIDELINE FOR THE Treatment of Patients With Major Depressive Disorder
Gelenberg, A. J., Freeman, P. B., Markowitz, J. C., Rosenbaum, J. F., Thase, M. E., Trivedi, M. H., & Rhoads, R. S. (2010) · Cited by 1,372 · see citing works
Paraneoplastic Syndromes: An Approach to Diagnosis and Treatment
Pelosof, L. C., & Gerber, D. E. (2010) · Mayo Clinic Proceedings · doi:10.4065/mcp.2010.0099 · Cited by 779 · see citing works
Revisions to the Canadian Emergency Department Triage and Acuity Scale (CTAS) Guidelines 2016
Bullard, M. J., Musgrave, E., Warren, D., Unger, B., Skeldon, T., Grierson, R., van der Linde, E., & Swain, J. (2017) · Canadian Journal of Emergency Medicine · doi:10.1017/cem.2017.365 · Cited by 497 · see citing works
2017 ACC/AHA/HRS Guideline for the Evaluation and Management of Patients With Syncope
Shen, W.-K., Sheldon, R. S., Benditt, D. G., Cohen, M. I., Forman, D. E., Goldberger, Z. D., Grubb, B. P., Hamdan, M. H., Krahn, A. D., Link, M. S., et al. (2017) · Heart Rhythm · doi:10.1016/j.hrthm.2017.03.004 · Cited by 484 · see citing works
Ricci, F., De Caterina, R., & Fedorowski, A. (2015) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2015.06.1084 · Cited by 472 · see citing works
Shen, W.-K., Sheldon, R. S., Benditt, D. G., Cohen, M. I., Forman, D. E., Goldberger, Z. D., Grubb, B. P., Hamdan, M. H., Krahn, A. D., Link, M. S., et al. (2017) · Circulation · doi:10.1161/cir.0000000000000499 · Cited by 453 · see citing works
Shen, W.-K., Sheldon, R. S., Benditt, D. G., Cohen, M. I., Forman, D. E., Goldberger, Z. D., Grubb, B. P., Hamdan, M. H., Krahn, A. D., Link, M. S., et al. (2017) · Circulation · doi:10.1161/cir.0000000000000498 · Cited by 408 · see citing works
Rethinking the Association of High Blood Pressure With Mortality in Elderly Adults
Odden, M. C., Peralta, C. A., Haan, M. N., & Covinsky, K. E. (2012) · Archives of Internal Medicine · doi:10.1001/archinternmed.2012.2555 · Cited by 359 · see citing works
Fedorowski, A., Stavenow, L., Hedblad, B., Berglund, G., Nilsson, P. M., & Melander, O. (2009) · European Heart Journal · doi:10.1093/eurheartj/ehp329 · Cited by 350 · see citing works
2017 ACC/AHA/HRS Guideline for the Evaluation and Management of Patients With Syncope
Shen, W.-K., Sheldon, R. S., Benditt, D. G., Cohen, M. I., Forman, D. E., Goldberger, Z. D., Grubb, B. P., Hamdan, M. H., Krahn, A. D., Link, M. S., et al. (2017) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2017.03.003 · Cited by 327 · see citing works
Gangavati, A., Hajjar, I. M., Quach, L., Jones, R. N., Kiely, D. K., Gagnon, P., & Lipsitz, L. A. (2011) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2011.03317.x · Cited by 328 · see citing works
Self-citationVital Signs in Older Patients: Age-Related Changes
Chester, J. G., & Rudolph, J. L. (2010) · Journal of the American Medical Directors Association · doi:10.1016/j.jamda.2010.04.009 · Cited by 239 · see citing works
Benarroch, E. E. (2008) · Neurology · doi:10.1212/01.wnl.0000335246.93495.92 · Cited by 209 · see citing works
Parati, G., Stergiou, G. S., Bilo, G., Kollias, A., Pengo, M., Ochoa, J. E., Agarwal, R., Asayama, K., Asmar, R., Burnier, M., et al. (2021) · Journal of Hypertension · doi:10.1097/hjh.0000000000002922 · Cited by 178 · see citing works
Dizziness: a diagnostic approach.
Post, R. E., & Dickerson, L. M. (2010) · PubMed · Cited by 169 · see citing works
Evaluation and management of orthostatic hypotension.
Lanier, J. B., Mote, M. B., & Clay, E. C. (2011) · PubMed · Cited by 152 · see citing works
Benvenuto, L. J., & Krakoff, L. R. (2010) · American Journal of Hypertension · doi:10.1038/ajh.2010.146 · Cited by 144 · see citing works
Fagard, R. H., & Cort, P. D. (2010) · Hypertension · doi:10.1161/hypertensionaha.110.151654 · Cited by 139 · see citing works
Bromfield, S. G., Ngameni, C.-A., Colantonio, L. D., Bowling, C. B., Shimbo, D., Reynolds, K., Safford, M. M., Banach, M., Toth, P. P., & Muntner, P. (2017) · Hypertension · doi:10.1161/hypertensionaha.116.09390 · Cited by 132 · see citing works
Orthostatic hypotension in genetically related hypertensive and normotensive individuals
Fedorowski, A., Burri, P., & Melander, O. (2009) · Journal of Hypertension · doi:10.1097/hjh.0b013e3283279860 · Cited by 128 · see citing works
Bhanu, C., Nimmons, D., Petersen, I., Orlu, M., Davis, D., Hussain, H., Magammanage, S., & Walters, K. (2021) · PLOS Medicine · doi:10.1371/journal.pmed.1003821 · Cited by 116 · see citing works
Mazzutti, S., Rodrigues, L. G. G., Mezzomo, N., Venturi, V., & Ferreira, S. R. S. (2017) · The Journal of Supercritical Fluids · doi:10.1016/j.supflu.2017.12.039 · Cited by 115 · see citing works
Denfeld, Q. E., Turrise, S. L., MacLaughlin, E. J., Chang, P., Clair, W. K., Lewis, E. F., Forman, D. E., & Goodlin, S. J. (2022) · Circulation Cardiovascular Quality and Outcomes · doi:10.1161/hcq.0000000000000108 · Cited by 112 · see citing works
<scp>ASH</scp> Position Paper: Evaluation and Treatment of Orthostatic Hypotension
Shibao, C., Lipsitz, L. A., & Biaggioni, I. (2013) · The Journal of Clinical Hypertension · doi:10.1111/jch.12062 · Cited by 110 · see citing works
Self-citationHiitola, P. K., Enlund, H., Kettunen, R., Sulkava, R. O., & Hartikainen, S. A. (2008) · Journal of Human Hypertension · doi:10.1038/jhh.2008.81 · Cited by 101 · see citing works
Evaluation and treatment of orthostatic hypotension
Shibao, C. A., Lipsitz, L. A., & Biaggioni, I. (2013) · Journal of the American Society of Hypertension · doi:10.1016/j.jash.2013.04.006 · Cited by 97 · see citing works
Self-citationClinical validation of a wearable ultrasound sensor of blood pressure
Zhou, S., Park, G., Longardner, K., Lin, M., Qi, B., Yang, X., Gao, X., Huang, H., Chen, X., Bian, Y., et al. (2024) · Nature Biomedical Engineering · doi:10.1038/s41551-024-01279-3 · Cited by 96 · see citing works
Efficacy of treatments for orthostatic hypotension: a systematic review
Logan, I., & Witham, M. D. (2012) · Age and Ageing · doi:10.1093/ageing/afs061 · Cited by 93 · see citing works
Shimbo, D., Bowling, C. B., Levitan, E. B., Deng, L., Sim, J. J., Huang, L., Reynolds, K., & Muntner, P. (2016) · Circulation Cardiovascular Quality and Outcomes · doi:10.1161/circoutcomes.115.002524 · Cited by 88 · see citing works
Orthostatic Changes in Blood Pressure and Mortality in the Elderly: The Pro.V.A Study
Veronese, N., RUI, M. D., Bolzetta, F., Zambon, S., Corti, M. C., Baggio, G., Toffanello, E. D., Maggi, S., Crepaldi, G., Perissinotto, E., et al. (2015) · American Journal of Hypertension · doi:10.1093/ajh/hpv022 · Cited by 87 · see citing works
Shaw, B. H., Borrel, D., Sabbaghan, K., Kum, C., Yang, Y., Robinovitch, S. N., & Claydon, V. E. (2019) · BMC Geriatrics · doi:10.1186/s12877-019-1082-6 · Cited by 83 · see citing works
Amyloidosis—the Diagnosis and Treatment of an Underdiagnosed Disease
Ihne-Schubert, S. M., Morbach, C., Sommer, C., Geier, A., Knop, S. T., & Störk, S. (2020) · Deutsches Ärzteblatt international · doi:10.3238/arztebl.2020.0159 · Cited by 80 · see citing works
Aerobic Training and Mobilization Early Post-stroke: Cautions and Considerations
Marzolini, S., Robertson, A. D., OH, P. I., Goodman, J. M., Corbett, D., Du, X., & MacIntosh, B. J. (2019) · Frontiers in Neurology · doi:10.3389/fneur.2019.01187 · Cited by 81 · see citing works
The relationship between orthostatic hypotension and falling in older adults
Shaw, B. H., & Claydon, V. E. (2013) · Clinical Autonomic Research · doi:10.1007/s10286-013-0219-5 · Cited by 77 · see citing works
Luo, F., Wang, Y., Wang, X., Sun, K., Zhou, X., & Hui, R. (2009) · Hypertension · doi:10.1161/hypertensionaha.109.135103 · Cited by 75 · see citing works
Mussi, C., Ungar, A., Salvioli, G., Menozzi, C., Bartoletti, A., Giada, F., Lagi, A., Ponassi, I., Re, G., Furlan, R., et al. (2009) · The Journals of Gerontology Series A · doi:10.1093/gerona/glp028 · Cited by 70 · see citing works
High Prevalence of Orthostatic Hypotension in Mild Dementia
Sønnesyn, H., Nilsen, D. W. T., Rongve, A., Nore, S. P., Ballard, C. G., Tysnes, O., & Aarsland, D. (2009) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000247586 · Cited by 66 · see citing works
Blood pressure and falls in community-dwelling people aged 60 years and older in the VHM&PP cohort
Klein, D., Nagel, G., Kleiner, A., Ulmer, H., Rehberger, B., Concin, H., & Rapp, K. (2013) · BMC Geriatrics · doi:10.1186/1471-2318-13-50 · Cited by 65 · see citing works
Arterial-cardiac baroreflex function: insights from repeated squat-stand maneuvers
Zhang, R., Claassen, J. A. H. R., Shibata, S., Kılıç, S., Martin‐Cook, K., Diaz-Arrastia, R. R., & Levine, B. D. (2009) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.90977.2008 · Cited by 58 · see citing works
Fedorowski, A., Stavenow, L., Hedblad, B., Berglund, G. L., Nilsson, P. M., & Melander, O. (2010) · Journal of Hypertension · doi:10.1097/hjh.0b013e3283350e8c · Cited by 57 · see citing works
Orthostatic hypotension (OH) and mortality in relation to age, blood pressure and frailty
Rockwood, M. R. H., Howlett, S. E., & Rockwood, K. J. (2012) · Archives of Gerontology and Geriatrics · doi:10.1016/j.archger.2011.12.009 · Cited by 55 · see citing works
Suri, J. S., Paul, S., Maindarkar, M. A., Puvvula, A., Saxena, S., Saba, L., Turk, M., Laird, J. R., Khanna, N. N., Višković, K., et al. (2022) · Metabolites · doi:10.3390/metabo12040312 · Cited by 58 · see citing works
Current Concepts in Orthostatic Hypotension Management
Arnold, A. C., & Shibao, C. A. (2013) · Current Hypertension Reports · doi:10.1007/s11906-013-0362-3 · Cited by 56 · see citing works
Mattioli, P., Pardini, M., Famà, F., Girtler, N. G., Brugnolo, A., Orso, B., Meli, R., Filippi, L., Grisanti, S. G., Massa, F., et al. (2021) · European Journal of Nuclear Medicine and Molecular Imaging · doi:10.1007/s00259-021-05205-6 · Cited by 53 · see citing works
Aydın, A. E., Soysal, P., & Işık, A. T. (2017) · Clinical Interventions in Aging · doi:10.2147/cia.s129868 · Cited by 53 · see citing works
What is the relationship between frailty and orthostatic hypotension in older adults?
Koçyiğit, S. E., Soysal, P., Bulut, E. A., Aydın, A. E., Dokuzlar, Ö., & Işık, A. T. (2019) · PubMed Central · doi:10.11909/j.issn.1671-5411.2019.03.005 · Cited by 53 · see citing works
Tratamiento de la diabetes mellitus tipo 2 en el paciente anciano
Gómez‐Huelgas, R., Peralta, F. G., Rodríguez‐Mañas, L., Formiga, F., Puig‐Domingo, M., Bravo, J. J. M., Miranda, C., & Ena, J. (2018) · Revista Clínica Española · doi:10.1016/j.rce.2017.12.003 · Cited by 53 · see citing works
Harbison, J. A., Walsh, S., & Kenny, R. A. (2008) · QJM · doi:10.1093/qjmed/hcn146 · Cited by 51 · see citing works
Fludrocortisone for orthostatic hypotension
Veazie, S., Peterson, K., Ansari, Y., Chung, K. A., Gibbons, C. H., Raj, S. R., & Helfand, M. (2021) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd012868.pub2 · Cited by 51 · see citing works
Orthostatic hypotension and cognition in older adults: A systematic review and meta-analysis
Iseli, R. K., Nguyen, V., Sharmin, S., Reijnierse, E. M., Lim, W. K., & Maier, A. B. (2019) · Experimental Gerontology · doi:10.1016/j.exger.2019.02.017 · Cited by 51 · see citing works
El‐Dokla, A., Mohamed‐Hussein, A. A., Fouad, A., Abdelnasser, M. G., Ali, S. T., Makhlouf, N. A., Sayed, I. G., Makhlouf, H. A., Shah, J., & Aiash, H. (2022) · Annals of Clinical and Translational Neurology · doi:10.1002/acn3.51557 · Cited by 50 · see citing works
New developments in diagnosis, risk assessment and management in systemic amyloidosis
Vaxman, I., Dispenzieri, A. A., Muchtar, E., & Gertz, M. A. (2019) · Blood Reviews · doi:10.1016/j.blre.2019.100636 · Cited by 50 · see citing works
Early postural blood pressure response and cause-specific mortality among middle-aged adults
Fedorowski, A., Hedblad, B., & Melander, O. (2011) · European Journal of Epidemiology · doi:10.1007/s10654-011-9578-1 · Cited by 48 · see citing works
Orthostatic Changes in Blood Pressure and Cognitive Status in the Elderly
Curreri, C., Giantin, V., Veronese, N., Trevisan, C., Sartori, L., Musacchio, E., Zambon, S., Maggi, S., Perissinotto, E., Corti, M. C., et al. (2016) · Hypertension · doi:10.1161/hypertensionaha.116.07334 · Cited by 49 · see citing works
The Treatment of Primary Orthostatic Hypotension
Hale, G. M., Valdes, J., & Brenner, M. J. (2017) · Annals of Pharmacotherapy · doi:10.1177/1060028016689264 · Cited by 49 · see citing works
Treatment of type 2 diabetes mellitus in elderly patients
Gómez‐Huelgas, R., Peralta, F. G., Rodríguez‐Mañas, L., Formiga, F., Puig‐Domingo, M., Bravo, J. J. M., Miranda, C., & Ena, J. (2018) · Revista Clínica Española (English Edition) · doi:10.1016/j.rceng.2017.12.004 · Cited by 47 · see citing works
Orthostatic Hypotension in the Elderly: A Marker of Clinical Frailty?
Liguori, I., Russo, G., Coscia, V., Aran, L., Bulli, G., Curcio, F., Della‐Morte, D., Gargiulo, G., Testa, G., Cacciatore, F., et al. (2018) · Journal of the American Medical Directors Association · doi:10.1016/j.jamda.2018.04.018 · Cited by 47 · see citing works
Pharmacotherapy of heart failure in the elderly: adverse events
Rich, M. W. (2011) · Heart Failure Reviews · doi:10.1007/s10741-011-9263-1 · Cited by 45 · see citing works
Does vitamin D deficiency increase orthostatic hypotension risk in the elderly patients?
Soysal, P., Yay, A., & Işık, A. T. (2014) · Archives of Gerontology and Geriatrics · doi:10.1016/j.archger.2014.03.008 · Cited by 42 · see citing works
Diffuse alveolar hemorrhage in lupus nephritis.
Lee, J. G., Joo, K. W., Chung, W. K., Jung, Y., Zheung, S. H., Yoon, H., Kim, Y. S., Ahn, C., Han, J. S., Kim, S., et al. (2001) · PubMed · Cited by 41 · see citing works
Tratamiento de la diabetes mellitus tipo 2 en el paciente anciano
Gómez‐Huelgas, R., Peralta, F. G., Rodríguez‐Mañas, L., Formiga, F., Puig‐Domingo, M., Bravo, J. J. M., Miranda, C., & Ena, J. (2018) · Revista Española de Geriatría y Gerontología · doi:10.1016/j.regg.2017.12.003 · Cited by 40 · see citing works
Morbidity and mortality in orthostatic hypotension
Farrell, M., & Shibao, C. A. (2020) · Autonomic Neuroscience · doi:10.1016/j.autneu.2020.102717 · Cited by 39 · see citing works
Orthostatic Hypotension and Incident Heart Failure in Community-Dwelling Older Adults
Alagiakrishnan, K., Patel, K., Desai, R. V., Ahmed, M. B., Fonarow, G. C., Forman, D. E., White, M., Aban, I., Love, T. E., Aronow, W. S., et al. (2013) · The Journals of Gerontology Series A · doi:10.1093/gerona/glt086 · Cited by 38 · see citing works
Johnsson, K. M., JOHNSSON, E. K., Mansfield, T. A., Yavin, Y., Ptaszynska, A., & Parikh, S. J. (2016) · Postgraduate Medicine · doi:10.1080/00325481.2016.1153941 · Cited by 38 · see citing works
Ungvari, Z. I., Tarantini, S., Yabluchanskiy, A., & Csiszár, A. (2019) · Frontiers in Genetics · doi:10.3389/fgene.2019.00898 · Cited by 38 · see citing works
Raber, I., Belanger, M. J., Farahmand, R., Aggarwal, R., Chiu, N., Rifai, M. A., Jacobsen, A. P., Lipsitz, L. A., & Juraschek, S. P. (2022) · Hypertension · doi:10.1161/hypertensionaha.122.18557 · Cited by 39 · see citing works
Self-citationWilliams, E. L., Raj, S. R., Schondorf, R., Shen, W.-K., Wieling, W., & Claydon, V. E. (2021) · Autonomic Neuroscience · doi:10.1016/j.autneu.2021.102906 · Cited by 36 · see citing works
Hypovitaminosis D and orthostatic hypotension
Ometto, F., Stubbs, B., Annweiler, C., Duval, G. T., Jang, W., Kim, H.-T., McCarroll, K. G., Cunningham, C. J., Soysal, P., Işık, A. T., et al. (2016) · Journal of Hypertension · doi:10.1097/hjh.0000000000000907 · Cited by 36 · see citing works
Vitamin D and orthostatic hypotension
McCarroll, K. G., Robinson, D. J., Coughlan, A., Healy, M., Kenny, R. A., & Cunningham, C. M. (2012) · Age and Ageing · doi:10.1093/ageing/afs088 · Cited by 35 · see citing works
Briggs, R., Carey, D., McNicholas, T., Claffey, P., Nolan, H., Kennelly, S., & Kenny, R. A. (2018) · Journal of the American Society of Hypertension · doi:10.1016/j.jash.2018.06.002 · Cited by 35 · see citing works
Fedorowski, A., Franceschini, N., Brody, J. A., Liu, C., Verwoert, G. C., Boerwinkle, E., Couper, D. J., Rice, K. M., Rotter, J. I., Mattace-Raso, F. U. S., et al. (2012) · European Heart Journal · doi:10.1093/eurheartj/ehs058 · Cited by 35 · see citing works
Peeters, L. E. J., Kester, M. P., Feyz, L., van den Bemt, P. M. L. A., Koch, B. C. P., van Gelder, T., & Versmissen, J. (2019) · Expert Opinion on Drug Metabolism & Toxicology · doi:10.1080/17425255.2019.1588249 · Cited by 34 · see citing works
Prevalence of initial orthostatic hypotension in older adults: a systematic review and meta-analysis
Tran, J., Hillebrand, S. L., Meskers, C. G. M., Iseli, R. K., & Maier, A. B. (2021) · Age and Ageing · doi:10.1093/ageing/afab090 · Cited by 37 · see citing works
Musculoskeletal diseases as a causal factor of cervical vertigo
Morinaka, S. (2009) · Auris Nasus Larynx · doi:10.1016/j.anl.2009.04.009 · Cited by 33 · see citing works
Orthostatic hypotension and associated conditions in geriatric inpatients
Jodaïtis, L., Vaillant, F., Snacken, M., Boland, B. B., Spinewine, A., Dalleur, O., Gilles, C., Petrovic, M., & Pepersack, T. (2015) · Acta Clinica Belgica · doi:10.1179/2295333715y.0000000006 · Cited by 32 · see citing works
Menant, J. C., Wong, A. K. W., Trollor, J. N., Close, J., & Lord, S. R. (2016) · Journal of the American Geriatrics Society · doi:10.1111/jgs.14104 · Cited by 32 · see citing works
Hypotensive Syndromes Are Not Associated With Cognitive Impairment in Geriatric Patients
Schoon, Y., Lagró, J., Verhoeven, Y., Rikkert, M. G. M. O., & Claassen, J. A. H. R. (2012) · American Journal of Alzheimer s Disease & Other Dementias® · doi:10.1177/1533317512466692 · Cited by 31 · see citing works
Orthostatic Hypotension Associated With Baroreceptor Dysfunction: Treatment Approaches
Briasoulis, Α., Silver, A. J., Yano, Y., & Bakris, G. L. (2014) · Journal of Clinical Hypertension · doi:10.1111/jch.12258 · Cited by 31 · see citing works
Goyal, P., & Maurer, M. S. (2016) · PubMed Central · doi:10.11909/j.issn.1671-5411.2016.05.002 · Cited by 33 · see citing works
Vitamin D deficiency is associated with orthostatic hypotension in oldest‐old women
Annweiler, C., Schott, A., Rolland, Y., & Beauchet, O. (2014) · Journal of Internal Medicine · doi:10.1111/joim.12201 · Cited by 29 · see citing works
Blood pressure and all-cause mortality: a prospective study of nursing home residents
Rådholm, K., Festin, K., Falk, M., Midlöv, P., Mölstad, S., & Östgren, C. J. (2016) · Age and Ageing · doi:10.1093/ageing/afw122 · Cited by 28 · see citing works
Bullard, M. J., Melady, D., Émond, M., members of the CTAS National working group:, Musgrave, E., Unger, B., van der Linde, E., Grierson, R., Skeldon, T., Warren, D., et al. (2017) · Canadian Journal of Emergency Medicine · doi:10.1017/cem.2017.363 · Cited by 28 · see citing works
When should orthostatic blood pressure changes be evaluated in elderly: 1st, 3rd or 5th minute?
Soysal, P., Aydın, A. E., Okudur, S. K., & Işık, A. T. (2016) · Archives of Gerontology and Geriatrics · doi:10.1016/j.archger.2016.03.022 · Cited by 27 · see citing works
New Horizons in orthostatic hypotension: Table 1.
Frith, J., & Parry, S. W. (2016) · Age and Ageing · doi:10.1093/ageing/afw211 · Cited by 27 · see citing works
Potentially inappropriate prescribing in older adults with advanced chronic kidney disease
Molnar, A. O., Bota, S. E., Jeyakumar, N., McArthur, E., Battistella, M., Garg, A. X., Sood, M. M., & Brimble, K. S. (2020) · PLoS ONE · doi:10.1371/journal.pone.0237868 · Cited by 26 · see citing works
Steinman, M. A., Lund, B. C., Miao, Y., Boscardin, W. J., & Kaboli, P. J. (2011) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2011.03331.x · Cited by 27 · see citing works
Haubrich, C., Pies, K., Dafotakis, M., Block, F., Klötzsch, C., & Diehl, R. R. (2010) · Ultrasound in Medicine & Biology · doi:10.1016/j.ultrasmedbio.2010.06.016 · Cited by 27 · see citing works
Vitamin D deficiency in Parkinson's disease patients with orthostatic hypotension
Jang, W., Park, J., Kim, J. S., Youn, J., Oh, E., Kwon, K. Y., Jo, K. D., Lee, M. K., & Kim, H.-T. (2015) · Acta Neurologica Scandinavica · doi:10.1111/ane.12390 · Cited by 26 · see citing works
New Developments in the Management of Neurogenic Orthostatic Hypotension
Biaggioni, I. (2014) · Current Cardiology Reports · doi:10.1007/s11886-014-0542-z · Cited by 26 · see citing works
Pharmacogenomic Implications of Variants of Monoaminergic-Related Genes in Geriatric Psychiatry
Shiroma, P. R., Geda, Y. E., & Mrazek, D. A. (2010) · Pharmacogenomics · doi:10.2217/pgs.10.118 · Cited by 26 · see citing works
Orthostatic hypotension among outpatients with ischemic stroke
Phipps, M., Schmid, A. A., Kapoor, J. R., Peixoto, A. J., Williams, L. S., & Bravata, D. M. (2011) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2011.10.031 · Cited by 26 · see citing works
Lim, P. K., Ng, S., Jassim, W. A., Redmond, S. J., Zilany, M. S. A., Avolio, A. P., Lim, E., Tan, M. P., & Lovell, N. H. (2015) · Sensors · doi:10.3390/s150614142 · Cited by 26 · see citing works
Bionic Baroreceptor Corrects Postural Hypotension in Rats With Impaired Baroreceptor
Hosokawa, K., Ide, T., Tobushi, T., Sakamoto, K., Onitsuka, K., Sakamoto, T., Fujino, T., Saku, K., & Sunagawa, K. (2012) · Circulation · doi:10.1161/circulationaha.112.108357 · Cited by 25 · see citing works
Torres, R. V., Elias, M. F., Crichton, G. E., Dore, G. A., & Davey, A. (2017) · Journal of Clinical Hypertension · doi:10.1111/jch.13095 · Cited by 24 · see citing works
Anatomical observations of the caudal vestibulo-sympathetic pathway
Holstein, G. R., Martinelli, G. P., & Friedrich, V. L. (2011) · Journal of Vestibular Research · doi:10.3233/ves-2011-0395 · Cited by 24 · see citing works
Application of the Sit-Up Test for orthostatic hypotension in individuals with stroke
Tang, A., Eng, J. J., & Krassioukov, A. V. (2012) · Autonomic Neuroscience · doi:10.1016/j.autneu.2012.02.002 · Cited by 24 · see citing works
Klanbut, S., Phattanarudee, S., Wongwiwatthananukit, S., Suthisisang, C. C., & Bhidayasiri, R. (2017) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2017.12.037 · Cited by 23 · see citing works
Orthostatic hypotension and health outcomes: an umbrella review of observational studies
The Special Interest Groups in Systematic Reviews and Meta-analyses for Healthy Ageing, A. C. M. O. T. E. S. O. G. M. (., Soysal, P., Veronese, N., Smith, L., Torbahn, G., Jackson, S. E., Yang, L., Ungar, A., Rivasi, G., Rafanelli, M., et al. (2019) · European Geriatric Medicine · doi:10.1007/s41999-019-00239-4 · Cited by 23 · see citing works
Treatment of Older Parkinson's Disease
Lenka, A., Padmakumar, C., & Pal, P. K. (2017) · International review of neurobiology · doi:10.1016/bs.irn.2017.01.005 · Cited by 23 · see citing works
Sachse, C., Trozić, I., Brix, B., Roessler, A., & Goswami, N. (2019) · Physiology International · doi:10.1556/2060.106.2019.16 · Cited by 23 · see citing works
- Authors
- Gupta, V., & Lipsitz, L. A.
- Affiliations
- Beth Israel Deaconess Medical Center (US)
- Corresponding author
- Lipsitz, Lewis A.
- ORCID
- Lipsitz, Lewis A.
- Venue
- The American Journal of Medicine
- Publisher
- Elsevier BV
- Published
- 2007-10
- Volume
- 120
- Issue
- 10
- Pages
- 841-847
- ISSN
- 0002-9343 (ISSN-L)
- OpenAlex
- W2022065142
- Cited by
- 388
- References
- 12
- Citations by year
- 2026: 3 · 2025: 11 · 2024: 29 · 2023: 25 · 2022: 21 · 2021: 20 · 2020: 26 · 2019: 29 · 2018: 27 · 2017: 32 · 2016: 22 · 2015: 18 · 2014: 26 · 2013: 20 · 2012: 23
- FWCI
- 11.65
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The American Journal of Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Surgery › Cardiovascular Syncope and Autonomic Disorders
- Health Sciences › Health Professions › Physical Therapy, Sports Therapy and Rehabilitation › Balance, Gait, and Falls Prevention
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
- Keywords
- orthostatic hypotension, older adults, autonomic dysfunction, blood pressure regulation, fludrocortisone, midodrine, nonsteroidal anti-inflammatory drugs, non-pharmacological treatment, falls, ambulatory function, differential diagnosis
- MeSH terms
- Adrenergic alpha-Agonists, Aged, Aged, 80 and over, Aging, Central Nervous System Stimulants, Anti-Inflammatory Agents, Blood Pressure Determination, Caffeine, Dose-Response Relationship, Drug, Erythropoietin, Fludrocortisone, Geriatrics, Humans, Hypotension, Orthostatic, Midodrine, Posture, Prostaglandin Antagonists, United States, Prevalence, Risk Reduction Behavior
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
