Cited by 107Blood Pressure and Hypertension StudiesCardiovascular Function and Risk FactorsCardiovascular Health and Risk Factors

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Left Ventricular Hypertrophy and Cardiovascular Mortality by Race and Ethnicity

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Havranek, Edward P., Froshaug, Desiree B., Emserman, Caroline D.B., Hanratty, Rebecca, Krantz, Mori J., Masoudi, Frederick A., Dickinson, L. Miriam, Steiner, John F.·2008·The American Journal of Medicine

DOI 10.1016/j.amjmed.2008.05.034PMC PMC2574427

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Abstract

Background Left ventricular hypertrophy is a major independent risk factor for cardiovascular mortality. The contribution of left ventricular hypertrophy to racial and ethnic differences in cardiovascular mortality is poorly understood.Methods We used data from the Third National Health and Nutrition Examination Survey and from the National Death Index to compare mortality for those with an electrocardiographic (ECG) diagnosis of left ventricular hypertrophy to those without left ventricular hypertrophy separately for whites, African Americans, and Latinos. We used Cox proportional hazards regression to control for other known prognostic factors.Results ECG left ventricular hypertrophy was significantly associated with 10-year cardiovascular mortality in all 3 racial/ethnic groups, both unadjusted and adjusted for other known prognostic factors. The hazard ratio for this association was significantly greater for African Americans (2.31; 95% confidence interval [CI], 1.55-3.42) than for whites and Latinos (1.32; 95% CI, 1.14-1.76 and 2.11; 95% CI, 1.35-3.30, respectively), independent of systolic blood pressure.Conclusions ECG left ventricular hypertrophy contributes more to the risk of cardiovascular mortality in African Americans than it does in whites. Using regression of ECG left ventricular hypertrophy as a goal of therapy might be a means to reduce racial differences in cardiovascular mortality; prospective validation is required.

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Authors: Havranek, E. P., Froshaug, D. B., Emserman, C. D. B., Hanratty, R., Krantz, M. J., Masoudi, F. A., Dickinson, L. M., & Steiner, J. F.
Affiliations: Denver Health Medical Center (US)
University of Colorado Denver (US)
ORCID: Havranek, Edward P.
Hanratty, Rebecca
Krantz, Mori J.
Masoudi, Frederick A.
Dickinson, L. Miriam
Steiner, John F.
Venue: The American Journal of Medicine
Publisher: Elsevier BV
Published: 2008-10
Volume: 121
Issue: 10
Pages: 870-875
ISSN: 0002-9343 (ISSN-L)
DOI: 10.1016/j.amjmed.2008.05.034
PMC: PMC2574427
OpenAlex: W2064635885
Cited by: 107
References: 27
Citations by year: 2026: 1 · 2025: 4 · 2024: 1 · 2023: 5 · 2022: 2 · 2021: 10 · 2020: 5 · 2019: 3 · 2018: 6 · 2017: 6 · 2016: 2 · 2015: 1 · 2014: 7 · 2013: 12 · 2012: 13
FWCI: 6.31
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: The American Journal of Medicine (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: U.S. Public Health Service (HP00054 5 D12)
National Heart, Lung, and Blood Institute (U01HL079160)
Topics: Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Risk Factors
Keywords: left ventricular hypertrophy, cardiovascular mortality, racial and ethnic disparities, African Americans, Hispanic Americans, white, electrocardiographic diagnosis, systolic blood pressure, cardiovascular risk factors
MeSH terms: Aged, Black or African American, Electrocardiography, Female, Hispanic or Latino, Humans, Male, Middle Aged, Nutrition Surveys, United States, Proportional Hazards Models, Hypertrophy, Left Ventricular

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Left Ventricular Hypertrophy and Cardiovascular Mortality by Race and Ethnicity

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