CoChat
Sign Up
Cited by 313Drug-Induced Adverse ReactionsPharmacovigilance and Adverse Drug ReactionsAntibiotic Use and Resistance

The DOI matches its Crossref record; 31 of the 32 references it cites were found in a registry or an index.

Self-reported antibiotic allergy incidence and prevalence: age and sex effects.

Macy, Eric, Poon K-Y, T.·2009·The American Journal of Medicine
DOI 10.1016/j.amjmed.2009.01.034
Open this paper in CoChat — free account

Abstract

Background Data on the prevalence and incidence of adverse reactions to antibiotics in outpatient populations are rare. These events are commonly called "allergy" when noted in the medical record.Objectives Determine the prevalence and incidence of allergy, as recorded in the medical record, to the most commonly used antibiotic classes in a large outpatient population using health care in the United States during 2007.Methods Data for drug allergy and antibiotic use were extracted from the electronic health records of 411,543 patients cared for by Kaiser Permanente in San Diego County who had at least one outpatient visit during 2007. Outpatient antibiotic utilization data was obtained for each year between 1995 and 2007. Penicillins, sulfas, cephalosporins, tetracyclines, macrolides, and quinolones were the classes of antibiotics evaluated.Results Antibiotics account for a majority of drug allergy entries. Antibiotic classes with higher historical use have higher allergy prevalence. Female patients use more antibiotics than males, and have higher allergy prevalence rates for all classes of antibiotics. There is a steady increase in antibiotic allergy prevalence with aging for both sexes. Females have higher allergy incidence rates for all classes of antibiotics. Antibiotic allergy incidence in female patients is highest for sulfas, 3.4%, compared with 1%-1.5% for all other classes of antibiotics. Antibiotic allergy incidence in males also is highest for sulfas, 2.2%, compared with 1.1% for penicillins and 0.5%-0.6% for all other classes of antibiotics.Conclusions Female sex, use, and increasing age are the primary factors that account for higher antibiotic allergy prevalence. Antibiotic allergy incidence is highest with sulfa class antibiotics.

Overview

Integrity signals

Registry

Crossref · 10.1016/j.amjmed.2009.01.034

Cites

31 of 31 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Citations

Cites

Show all 32 references

Research works printed but not linked: 1

  1. Dykewicz, 1996, Drug allergy, Compr Ther, 22, 353

Cited by

Sorted by citations

Items 201–300 of 313

Related

See all

Metadata

Authors
Macy, E., & Poon K-Y, T.
Affiliations
Kaiser Permanente (US)
Corresponding author
Macy, Eric
ORCID
Macy, Eric
Venue
The American Journal of Medicine
Publisher
Elsevier BV
Published
2009-08
Volume
122
Issue
8
Pages
778.e1-778.e7
ISSN
0002-9343 (ISSN-L)
DOI
10.1016/j.amjmed.2009.01.034
OpenAlex
W2026427547
Cited by
313
References
32
Citations by year
2026: 13 · 2025: 18 · 2024: 25 · 2023: 20 · 2022: 26 · 2021: 32 · 2020: 26 · 2019: 23 · 2018: 20 · 2017: 29 · 2016: 10 · 2015: 15 · 2014: 17 · 2013: 12 · 2012: 7
FWCI
6.23
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • The American Journal of Medicine (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Pharmacology (medical) › Drug-Induced Adverse Reactions
  • Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Toxicology › Pharmacovigilance and Adverse Drug Reactions
  • Health Sciences › Medicine › Infectious Diseases › Antibiotic Use and Resistance
Keywords
antibiotic allergy, sex differences, age effects, sulfonamides, penicillin, cephalosporins, tetracycline, macrolides, quinolones, outpatient antibiotic use, electronic health records
MeSH terms
Adolescent, Adult, Aged, Anti-Bacterial Agents, California, Child, Child, Preschool, Drug Hypersensitivity, Female, Humans, Infant, Male, Middle Aged, Incidence, Prevalence, Young Adult

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review