Absence of Cross-Reactivity between Sulfonamide Antibiotics and Sulfonamide Nonantibiotics
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BACKGROUND: The safety of sulfonamide nonantibiotics is unclear in patients with prior allergic reactions to sulfonamide antibiotics. METHODS: We conducted a retrospective cohort study using the General Practice Research Database in the United Kingdom, examining the risk of allergic reactions within 30 days after the receipt of a sulfonamide nonantibiotic. Patients with evidence of prior hypersensitivity after the receipt of a sulfonamide antibiotic were compared with those without such evidence. Similar analyses were also performed with the use of penicillins instead of sulfonamides, to determine whether any risk was specific to sulfonamide cross-reactivity. RESULTS: Of 969 patients with an allergic reaction after a sulfonamide antibiotic, 96 (9.9 percent) had an allergic reaction after subsequently receiving a sulfonamide nonantibiotic. Of 19,257 who had no allergic reaction after a sulfonamide antibiotic, 315 (1.6 percent) had an allergic reaction after receiving a sulfonamide nonantibiotic (adjusted odds ratio, 2.8; 95 percent confidence interval, 2.1 to 3.7). However, the risk of allergic reactions was even greater after the receipt of a penicillin among patients with a prior hypersensitivity reaction to a sulfonamide antibiotic, as compared with patients with no such history (adjusted odds ratio, 3.9; 95 percent confidence interval, 3.5 to 4.3). Furthermore, among those with a prior hypersensitivity reaction after the receipt of a sulfonamide antibiotic, the risk of an allergic reaction after the subsequent receipt of a sulfonamide nonantibiotic was lower than the risk of an allergic reaction after the subsequent receipt of a penicillin (adjusted odds ratio, 0.7; 95 percent confidence interval, 0.5 to 0.9). Finally, the risk of an allergic reaction after the receipt of a sulfonamide nonantibiotic was lower among patients with a history of hypersensitivity to sulfonamide antibiotics than among patients with a history of hypersensitivity to penicillins (adjusted odds ratio, 0.6; 95 percent confidence interval, 0.5 to 0.8). CONCLUSIONS: There is an association between hypersensitivity after the receipt of sulfonamide antibiotics and a subsequent allergic reaction after the receipt of a sulfonamide nonantibiotic, but this association appears to be due to a predisposition to allergic reactions rather than to cross-reactivity with sulfonamide-based drugs.
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Most allergy alerts were triggered by narcotic allergies or by cross-reactions of unknown significance.
“Most of our allergy alerts were triggered by narcotic allergies, or by cross-reactions of unknown significance [29,30].”
From Drug interaction alert override rates in the Meaningful Use era: No evidence of progress (2014) · cites this paper as [30]
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- Authors
- Strom, B. L., Schinnar, R., Apter, A. J., Margolis, D. J., Lautenbach, E., Hennessy, S., Bilker, W. B., & Pettitt, D.
- Affiliations
- University of Pennsylvania (US)
- Pfizer (United States) (US)
- ORCID
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 2003-10-23
- Volume
- 349
- Issue
- 17
- Pages
- 1628-1635
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2099552063
- Cited by
- 349
- References
- 34
- Citations by year
- 2026: 14 · 2025: 11 · 2024: 15 · 2023: 8 · 2022: 13 · 2021: 8 · 2020: 13 · 2019: 18 · 2018: 17 · 2017: 18 · 2016: 12 · 2015: 12 · 2014: 12 · 2013: 23 · 2012: 14
- FWCI
- 12.30
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- New England Journal of Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pharmacology › Drug-Induced Adverse Reactions
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Toxicology › Pharmacovigilance and Adverse Drug Reactions
- Health Sciences › Medicine › Dermatology › Contact Dermatitis and Allergies
- Keywords
- sulfonamide antibiotics, drug cross-reactivity, drug hypersensitivity, allergic reactions, penicillin allergy, general practice patients, drug allergy testing
- MeSH terms
- Anti-Bacterial Agents, Cross Reactions, Diuretics, Drug Hypersensitivity, Humans, Retrospective Studies, Sulfonamides, Cohort Studies, Databases, Factual
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