The DOI matches its Crossref record; 144 of the 147 references it cites were found in a registry or an index.
Fibromyalgia: An Overview
Abstract
Fibromyalgia is the diagnosis given to individuals with chronic widespread musculoskeletal pain for which no alternative cause, such as tissue inflammation or damage, can be identified. Fibromyalgia is now believed to be, at least in part, a disorder of central pain processing that produces heightened responses to painful stimuli (hyperalgesia) and painful responses to nonpainful stimuli (allodynia). Aberrations in central pain processing may also be partly responsible for symptoms experienced in several chronic pain disorders that coaggregate with fibromyalgia, which is itself a product of genetic and environmental factors. Thus, aberrational central pain processing is implicated in irritable bowel syndrome, temporomandibular disorder, chronic low back pain, and certain other chronic pain disorders. Fibromyalgia and related disorders appear to reflect deficiencies in serotonergic and noradrenergic, but not opioidergic, transmission in the central nervous system. The heightened state of pain transmission may also be owing to increases in pronociceptive neurotransmitters such as glutamate and substance P. In some cases, psychological and behavioral factors are also in play. Although the overlapping symptomatology between fibromyalgia and related disorders may present diagnostic challenges, proper examination and observation can help clinicians make an accurate diagnosis. In recent years, the vastly improved understanding of the mechanism underlying fibromyalgia and the related spectrum of diseases has fostered rapid advances in the therapy of these chronic pain disorders by both pharmacologic and nonpharmacologic interventions.
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“Hence, it provides a unifying explanation for the supposed multifactorial origin of the disease [1], by making a variety of triggering events upstream HPA and HPG axes to converge to a common neuroendocrine mechanism.”
From Fibromyalgia pathogenesis explained by a neuroendocrine multistable model (2024) · cites this paper as [1]
In the citing paper
“Although it is not clear how these physiologic alterations are generated, there is a wide agreement that FMS should be considered as a CPSS [9,10,11,32,33,34].”
From Effectiveness of acceptance and commitment therapy in central pain sensitization syndromes: A systematic review (2021) · cites this paper as [32]
Citations
Cites
3 retracted
Anticonvulsant drugs for acute and chronic pain
Wiffen, P. J., Collins, S., McQuay, H. J., Carroll, D., Jadad, A. R., & Moore, R. A. (2005) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd001133.pub2 · Cited by 409
RetractedAnticonvulsant drugs for acute and chronic pain
Wiffen, P. J., Collins, S., McQuay, H. J., Carroll, D., Jadad, A. R., & Moore, R. A. (2010) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd001133.pub3 · Cited by 153
RetractedAnticonvulsant drugs for acute and chronic pain
Wiffen, P. J., Collins, S., McQuay, H. J., Carroll, D., Jadad, A. R., & Moore, A. (2000) · doi:10.1002/14651858.cd001133 · Cited by 129
RetractedThe american college of rheumatology 1990 criteria for the classification of fibromyalgia
Wolfe, F., Smythe, H. A., Yunus, M. B., Bennett, R. M., Bombardier, C., Goldenberg, D. L., Tugwell, P., Campbell, S. M., Abeles, M., Clark, P., et al. (1990) · Arthritis & Rheumatism · doi:10.1002/art.1780330203 · Cited by 9,563
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Functional magnetic resonance imaging evidence of augmented pain processing in fibromyalgia
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Self-citationSleep hygiene and melatonin treatment for children and adolescents with ADHD and initial insomnia.
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Cited by
Sorted by citations
Multimorbidity patterns: a systematic review
Prados‐Torres, A., Calderón‐Larrañaga, A., Hancco-Saavedra, J. A., Poblador‐Plou, B., & van den Akker, M. (2014) · Journal of Clinical Epidemiology · doi:10.1016/j.jclinepi.2013.09.021 · Cited by 806
Fibromyalgia Syndrome: Etiology, Pathogenesis, Diagnosis, and Treatment
Bellato, E., Marini, E., Castoldi, F., Barbasetti, N., Mattei, L., Bonasia, D. E., & Blonna, D. (2012) · Pain Research and Treatment · doi:10.1155/2012/426130 · Cited by 389
Central sensitization in fibromyalgia? A systematic review on structural and functional brain MRI
Cagnie, B. J., Coppieters, I., Denecker, S., Six, J., Danneels, L. A., & Meeus, M. (2014) · Seminars in Arthritis and Rheumatism · doi:10.1016/j.semarthrit.2014.01.001 · Cited by 380
Pathophysiology of Fibromyalgia
Bradley, L. A. (2009) · The American Journal of Medicine · doi:10.1016/j.amjmed.2009.09.008 · Cited by 366
O’Brien, A. T., Deitos, A., Pego, Y. T., Fregni, F., & Carrillo‐de‐la‐Peña, M. T. (2018) · Journal of Pain · doi:10.1016/j.jpain.2018.01.010 · Cited by 225
Metadata
- Authors
- Clauw, D. J.
- Affiliations
- University of Michigan (US)
- Corresponding author
- Clauw, Daniel J.
- ORCID
- Clauw, Daniel J.
- Venue
- The American Journal of Medicine
- Publisher
- Elsevier BV
- Published
- 2009-12
- Volume
- 122
- Issue
- 12
- Pages
- S3-S13
- ISSN
- 0002-9343 (ISSN-L)
- OpenAlex
- W2024269125
- Cited by
- 350
- References
- 147
- Citations by year
- 2026: 13 · 2025: 14 · 2024: 13 · 2023: 12 · 2022: 22 · 2021: 29 · 2020: 17 · 2019: 15 · 2018: 13 · 2017: 17 · 2016: 16 · 2015: 18 · 2014: 38 · 2013: 34 · 2012: 39
- FWCI
- 3.16
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The American Journal of Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Fibromyalgia and Chronic Fatigue Syndrome Research
- Health Sciences › Medicine › Physiology (medical) › Pain Mechanisms and Treatments
- Health Sciences › Health Professions › Physical Therapy, Sports Therapy and Rehabilitation › Myofascial pain diagnosis and treatment
- Keywords
- fibromyalgia, central sensitization, hyperalgesia, allodynia, chronic widespread pain, irritable bowel syndrome, temporomandibular disorders, chronic low back pain, serotonergic neurotransmission, noradrenergic neurotransmission, glutamate, substance P, psychosocial factors, fibromyalgia diagnosis, fibromyalgia treatment
- MeSH terms
- Analgesics, Antidepressive Agents, Brain, Fibromyalgia, Humans, Magnetic Resonance Imaging, Neurosecretory Systems, Pain, Sleep Wake Disorders, Stress, Physiological, Tomography, Emission-Computed, Single-Photon
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