The DOI matches its Crossref record; 15 of the 15 references it cites were found in a registry or an index.
Detrimental Effects of Energy Drink Consumption on Platelet and Endothelial Function
Abstract
Background Energy drink consumption has been anecdotally linked with sudden cardiac death and, more recently, myocardial infarction. As myocardial infarction is strongly associated with both platelet and endothelial dysfunction, we tested the hypothesis that energy drink consumption alters platelet and endothelial function.Methods Fifty healthy volunteers (34 male, aged 22+/-2 years) participated in the study. Platelet aggregation and endothelial function were tested before, and 1 hour after, the consumption of 250 mL (1 can) of a sugar-free energy drink. Platelet function was assessed by adenosine diphosphate-induced (1 micromol/L) optical aggregometry in platelet-rich plasma. Endothelial function was assessed via changes in peripheral arterial tonometry and expressed as the reactive hyperemia index (RHI).Results Compared with baseline values, there was a significant increase in platelet aggregation following energy drink consumption, while no change was observed with control (13.7+/-3.7% vs 0.3+/-0.8% aggregation, respectively, P <.01). Similarly, RHI decreased following energy drink consumption (-0.33+/-0.13 vs 0.07+/-0.12 RHI [control], P <.05). Mean arterial pressure significantly increased following energy drink consumption, compared with control (P <.05). Heart rate was unaffected by energy drink consumption.Conclusion Energy drink consumption acutely increases platelet aggregation and decreases endothelial function in healthy young adults.
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“a study of 50 young adults found that consuming a sugar-free energy drink containing 80 mg of caffeine (slightly less than the caffeine contained in one cup of coffee) was associated with changes in platelet and endothelial function great enough to increase the risk for severe cardiac events in susceptible individuals (193).”
From The Safety of Ingested Caffeine: A Comprehensive Review (2017) · cites this paper as [193]
Citations
Cites
Schächinger, V., Britten, M. B., & Zeiher, A. M. (2000) · Circulation · doi:10.1161/01.cir.101.16.1899 · Cited by 2,589
Assessment of peripheral vascular endothelial function with finger arterial pulse wave amplitude
Kuvin, J. T., Patel, A. R., Sliney, K. A., Pandian, N. G., Sheffy, J., Schnall, R. P., Karas, R. H., & Udelson, J. E. (2003) · American Heart Journal · doi:10.1016/s0002-8703(03)00094-2 · Cited by 772
A survey of energy drink consumption patterns among college students
Malinauskas, B. M., Aeby, V. G., Overton, R. F., Carpenter-Aeby, T., & Heidal, K. (2007) · Nutrition Journal · doi:10.1186/1475-2891-6-35 · Cited by 661
Wright, C. E., Tallan, H. H., Lin, Y. Y., & Gaull, G. E. (1986) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.55.070186.002235 · Cited by 575
Cardiac arrest in a young man following excess consumption of caffeinated “energy drinks”
Berger, A., & Alford, K. (2009) · The Medical Journal of Australia · doi:10.5694/j.1326-5377.2009.tb02263.x · Cited by 222
The Relationship of Coffee Consumption with Mortality
López‐García, E., van Dam, R. M., Li, T. Y., Rodriguez-Artalejo, F., & Hu, F. B. (2008) · Annals of Internal Medicine · doi:10.7326/0003-4819-148-12-200806170-00003 · Cited by 201
Effects of Acute Administration of Caffeine on Vascular Function
Umemura, T., Ueda, K., Nishioka, K., Hidaka, T., Takemoto, H., Nakamura, S., Jitsuiki, D., Soga, J., Goto, C., Chayama, K., et al. (2006) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2006.06.058 · Cited by 189
Worthley, M. I., Holmes, A. S., Willoughby, S. R., Kucia, A. M., Heresztyn, T., Stewart, S., Chirkov, Y. Y., Zeitz, C. J., & Horowitz, J. D. (2007) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2006.08.053 · Cited by 188
Self-citationSteinke, L., Lanfear, D. E., Dhanapal, V., & Kalus, J. S. (2009) · Annals of Pharmacotherapy · doi:10.1345/aph.1l614 · Cited by 139
The health effects of stimulant drinks
Finnegan, D. (2003) · Nutrition Bulletin · doi:10.1046/j.1467-3010.2003.00345.x · Cited by 131
Taurine and Vitamin C Modify Monocyte and Endothelial Dysfunction in Young Smokers
Fennessy, F. M., Moneley, D., Wang, J. H., Kelly, C. J., & Bouchier‐Hayes, D. J. (2003) · Circulation · doi:10.1161/01.cir.0000046447.72402.47 · Cited by 113
Effect of coffee drinking on platelets: inhibition of aggregation and phenols incorporation
Natella, F., Nardini, M., Belelli, F., Pignatelli, P., Santo, S. D., Ghiselli, A., Violi, F., & Scaccini, C. (2008) · British Journal Of Nutrition · doi:10.1017/s0007114508981459 · Cited by 96
Platelet Nitric Oxide Responsiveness
Willoughby, S. R., Stewart, S., Holmes, A. S., Chirkov, Y. Y., & Horowitz, J. D. (2005) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000193622.77294.57 · Cited by 75
Self-citationWiklund, U., Karlsson, M., Öström, M., & Messner, T. (2009) · Clinical Physiology and Functional Imaging · doi:10.1111/j.1475-097x.2008.00837.x · Cited by 58
Willoughby, S. (2002) · European Heart Journal · doi:10.1053/euhj.2002.3296 · Cited by 50
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Health effects of energy drinks on children, adolescents, and young adults
Seifert, S. M., Schaechter, J. L., Hershorin, E. R., & Lipshultz, S. E. (2011) · Pediatrics · doi:10.1542/peds.2009-3592 · Cited by 893
Caffeine: Cognitive and Physical Performance Enhancer or Psychoactive Drug?
Cappelletti, S., Daria, P., Sani, G., & Aromatario, M. (2015) · Current Neuropharmacology · doi:10.2174/1570159x13666141210215655 · Cited by 631
“Finally, extensive studies performed in cohorts of both healthy and diabetic subjects have demonstrated minimal or no effect of caffeine on coronary artery disease, myocardial infarction, and stroke [100-102].”
BackgroundScientific Opinion on the safety of caffeine
EFSA Panel on Dietetic Products, N. A. A. (. (2015) · EFSA Journal · doi:10.2903/j.efsa.2015.4102 · Cited by 613
“In 2009, the Panel on Food Additives and Nutrient Sources Added to Food (ANS Panel) concluded that exposure to taurine and D-glucurono-γ-lactone at levels commonly used in “energy drinks” was not of safety concern, even for consumers of high levels (EFSA (European Food Safety Authority), EFSA Journal 2015;13(5):4102 1…”
BackgroundInfluentialThe Safety of Ingested Caffeine: A Comprehensive Review
Temple, J. L., Bernard, C., Lipshultz, S. E., Czachor, J. D., Westphal, J. A., & Mestre, M. A. (2017) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2017.00080 · Cited by 557
Caffeine Consumption through Coffee: Content in the Beverage, Metabolism, Health Benefits and Risks
DePaula, J., & Farah, A. (2019) · Beverages · doi:10.3390/beverages5020037 · Cited by 258
Metadata
- Authors
- Worthley, M. I., Prabhu, A., De Sciscio, P., Schultz, C., Sanders, P., & Willoughby, S. R.
- Affiliations
- Royal Adelaide Hospital (AU)
- Corresponding author
- Willoughby, Scott R.
- Venue
- The American Journal of Medicine
- Publisher
- Elsevier BV
- Published
- 2010-02
- Volume
- 123
- Issue
- 2
- Pages
- 184-187
- ISSN
- 0002-9343 (ISSN-L)
- OpenAlex
- W2074640646
- Cited by
- 179
- References
- 15
- Citations by year
- 2026: 10 · 2025: 2 · 2024: 7 · 2023: 15 · 2022: 4 · 2021: 8 · 2020: 5 · 2019: 10 · 2018: 14 · 2017: 14 · 2016: 14 · 2015: 16 · 2014: 19 · 2013: 17 · 2012: 16
- FWCI
- 9.62
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The American Journal of Medicine (publishedVersion)
- PubMed (publishedVersion)
- Adelaide Research & Scholarship (AR&S) (University of Adelaide) (submittedVersion)
- Topics
- Health Sciences › Medicine › Pharmacology (medical) › Coffee research and impacts
- Health Sciences › Medicine › Hematology › Platelet Disorders and Treatments
- Health Sciences › Medicine › Physiology (medical) › Nitric Oxide and Endothelin Effects
- Keywords
- energy drinks, platelet aggregation, endothelial function, reactive hyperemia index, sudden cardiac death, myocardial infarction, mean arterial pressure, cardiovascular risk
- MeSH terms
- Central Nervous System Stimulants, Beverages, Caffeine, Endothelium, Vascular, Female, Glucuronates, Humans, Male, Platelet Aggregation, Taurine, Cohort Studies, Young Adult
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