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Cardiovascular Risk in Rheumatoid Arthritis: Comparing TNF-α Blockade with Nonbiologic DMARDs
Open accessAbstract
Background Elevated tumor necrosis factor (TNF)-α likely contributes to the excess cardiovascular risk observed in rheumatoid arthritis. We compared the cardiovascular risk in rheumatoid arthritis patients starting a TNF-α blocking agent versus a nonbiologic disease-modifying antirheumatic drug (nbDMARD).Methods Subjects with rheumatoid arthritis participating in several different US insurance programs between 1998 and 2007 who received methotrexate were eligible. Those who added a TNF-α blocking agent were compared with subjects who added a nbDMARD in Cox regression models stratified by propensity score decile and adjusted for oral glucocorticoid dosage. We examined the composite cardiovascular end point of myocardial infarction, stroke, or coronary re-vascularization after 6 months.Results We compared 8656 new users of a nbDMARD with 11,587 new users of a TNF-α blocking agent with similar baseline covariates. Incidence rates per 100 person-years for the composite cardiovascular end point were 3.05 (95% confidence interval [CI], 2.54-3.65) for nbDMARDs and 2.52 (95% CI, 2.12-2.98) for TNF-α blocking agents. The hazard ratio (HR) for the TNF-α blocking agent compared with nbDMARD carrying the first exposure forward was 0.80 (95%, CI 0.62-1.04), while the HR for the as-treated analysis was 0.71 (95% CI, 0.52-0.97). The potential cardiovascular benefit of TNF-α blocking agents was strongest among individuals ≥65 years of age (HR 0.52; 95% CI, 0.34 -0.77; P for interaction = 0.075).Conclusion Among subjects with rheumatoid arthritis, TNF-α blocking agents may be associated with a reduced risk of cardiovascular events compared with an nbDMARD. Randomized controlled clinical trials should be considered to test this hypothesis.
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“treatment with TNF inhibitors in rheumatoid arthritis, an overt inflammatory disease, is associated with a decreased risk of cardiovascular events”
From Inflammageing: chronic inflammation in ageing, cardiovascular disease, and frailty (2018) · cites this paper as [184]
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Cites
The central role of the propensity score in observational studies for causal effects
ROSENBAUM, P. R., & RUBIN, D. B. (1983) · Biometrika · doi:10.1093/biomet/70.1.41 · Cited by 31,241
Inflammation and Atherosclerosis
Libby, P., Ridker, P. M., & Maseri, A. (2002) · Circulation · doi:10.1161/hc0902.104353 · Cited by 7,724
Rosuvastatin to Prevent Vascular Events in Men and Women with Elevated C-Reactive Protein
Ridker, P. M., Danielson, E., Fonseca, F. A. H., Genest, J., Gotto, A. M., Kastelein, J. J. P., Koenig, W., Libby, P., Lorenzatti, A. J., MacFadyen, J. G., et al. (2008) · New England Journal of Medicine · doi:10.1056/nejmoa0807646 · Cited by 6,674
No adjustments are needed for multiple comparisons.
Rothman, K. J. (1990) · Epidemiology · doi:10.1097/00001648-199001000-00010 · Cited by 5,965
Inflammation, aspirin, and the risk of cardiovascular disease in apparently healthy men
Ridker, P. M., Cushman, M., Stampfer, M. J., Tracy, R. P., & Hennekens, C. H. (1997) · New England Journal of Medicine · doi:10.1056/nejm199704033361401 · Cited by 5,504
Rosuvastatin to Prevent Vascular Events in Men and Women With Elevated C-Reactive Protein
Ridker, P. M., Danielson, E., Fonseca, F. A. H., Genest, J. J., Gotto, A. M., Kastelein, J. J. P., Köenig, W., Libby, P., Lorenzatti, A. J., MacFadyen, J. G., et al. (2009) · Obstetrical & Gynecological Survey · doi:10.1097/01.ogx.0000344393.60303.0a · Cited by 3,641
ROLE OF CYTOKINES IN RHEUMATOID ARTHRITIS
Feldmann, M., Brennan, F. M., & Maini, R. N. (1996) · Annual Review of Immunology · doi:10.1146/annurev.immunol.14.1.397 · Cited by 2,507
Evaluating medication effects outside of clinical trials: new-user designs
Ray, W. A. (2003) · American Journal of Epidemiology · doi:10.1093/aje/kwg231 · Cited by 1,646
Aviña-Zubieta, J. A., Choi, H. K., Sadatsafavi, M., Etminan, M., Esdaile, J. M., & Lacaille, D. V. (2008) · Arthritis Care & Research · doi:10.1002/art.24092 · Cited by 1,461
Checking the Cox model with cumulative sums of martingale-based residuals
LIN, D. Y., WEI, L. J., & YING, Z. (1993) · Biometrika · doi:10.1093/biomet/80.3.557 · Cited by 1,432
Lee, D. M., & Weinblatt, M. E. (2001) · The Lancet · doi:10.1016/s0140-6736(01)06075-5 · Cited by 1,328
Cardiovascular Morbidity and Mortality in Women Diagnosed With Rheumatoid Arthritis
Solomon, D. H., Karlson, E. W., Rimm, E. B., Cannuscio, C. C., Mandl, L. A., Manson, J. E., Stampfer, M. J., & Curhan, G. C. (2003) · Circulation · doi:10.1161/01.cir.0000054612.26458.b2 · Cited by 1,251
Self-citationInflammatory Markers and Onset of Cardiovascular Events: Results From the Health ABC Study
Cesari, M., Penninx, B. W. J. H., Newman, A. B., Kritchevsky, S. B., Nicklas, B. J., Sutton-Tyrrell, K., Rubin, S. M., Ding, J., Simonsick, E. M., Harris, T. B., et al. (2003) · Circulation · doi:10.1161/01.cir.0000097109.90783.fc · Cited by 978
Ridker, P. M., Rifai, N., Pfeffer, M., Sacks, F., Lepage, S., & Braunwald, E. (2000) · Circulation · doi:10.1161/01.cir.101.18.2149 · Cited by 934
Ridker, P. M., Thuren, T., Zalewski, A., & Libby, P. (2011) · American Heart Journal · doi:10.1016/j.ahj.2011.06.012 · Cited by 799
Austin, P. C. (2009) · Biometrical Journal · doi:10.1002/bimj.200810488 · Cited by 769
Accuracy of ICD-9-CM Codes for Identifying Cardiovascular and Stroke Risk Factors
Birman-Deych, E., Waterman, A. D., Yan, Y., Nilasena, D. S., Radford, M. J., & Gage, B. F. (2005) · Medical Care · doi:10.1097/01.mlr.0000160417.39497.a9 · Cited by 723
Austin, P. (2010) · American Journal of Epidemiology · doi:10.1093/aje/kwq224 · Cited by 670
Hürlimann, D., Forster, A., Noll, G., Enseleit, F., Chenevard, R., Distler, O., Béchir, M., Spieker, L. E., Neidhart, M., Michel, B. A., et al. (2002) · Circulation · doi:10.1161/01.cir.0000037521.71373.44 · Cited by 577
Dixon, W. G., Watson, K. D., Lunt, M., Hyrich, K. L., Silman, A. J., & Symmons, D. P. M. (2007) · Arthritis & Rheumatism · doi:10.1002/art.22809 · Cited by 557
Jacobsson, L., Turesson, C., Gülfe, A., Kapetanovic, M. C., Petersson, I. F., Saxne, T., & Geborek, P. (2005) · PubMed · Cited by 533
Kiyota, Y., Schneeweiß, S., Glynn, R. J., Cannuscio, C. C., Avorn, J., & Solomon, D. H. (2004) · American Heart Journal · doi:10.1016/j.ahj.2004.02.013 · Cited by 533
Self-citationCardiovascular disease in patients with rheumatoid arthritis: results from the QUEST-RA study
Naranjo, A., Sokka, T., Descalzo, M. Á., Alén, J. C., Hørslev‐Petersen, K., Luukkainen, R., Combe, B. G., Burmester, G. R., Devlin, J., Ferraccioli, G., et al. (2008) · Arthritis Research & Therapy · doi:10.1186/ar2383 · Cited by 464
Kurrelmeyer, K. M., Michael, L. H., Baumgarten, G., Taffet, G. E., Peschon, J. J., Sivasubramanian, N., Entman, M. L., & Mann, D. L. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.070036297 · Cited by 440
TNFα in atherosclerosis, myocardial ischemia/reperfusion and heart failure
Kleinbongard, P., Heusch, G., & Schulz, R. (2010) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2010.05.002 · Cited by 415
Greenberg, J. D., Kremer, J. M., Curtis, J. R., Hochberg, M. C., Reed, G., Tsao, P., Farkouh, M. E., Nasir, A., Setoguchi, S., & Solomon, D. H. (2011) · Annals of the Rheumatic Diseases · doi:10.1136/ard.2010.129916 · Cited by 350
Self-citationCardiovascular disease in rheumatoid arthritis: state of the art and future perspectives
Kitas, G. D., & Gabriel, S. E. (2010) · Annals of the Rheumatic Diseases · doi:10.1136/ard.2010.142133 · Cited by 326
Solomon, D. H., Kremer, J. M., Curtis, J. R., Hochberg, M. C., Reed, G. W., Tsao, P., Farkouh, M. E., Setoguchi, S., & Greenberg, J. D. (2010) · Annals of the Rheumatic Diseases · doi:10.1136/ard.2009.122226 · Cited by 297
Self-citationJohnson, M. L., Crown, W., Martin, B. C., Dormuth, C. R., & Siebert, U. (2009) · Value in Health · doi:10.1111/j.1524-4733.2009.00602.x · Cited by 285
del Rincón, I., Freeman, G. L., Haas, R. W., O’Leary, D. H., & Escalante, A. (2005) · Arthritis & Rheumatism · doi:10.1002/art.21397 · Cited by 244
Carmona, L., Descalzo, M. Á., Pérez-Pampín, E. M., Ruiz-Montesinos, D., Erra, A., Cobo‐Ibáñez, T., & Gómez-Reino, J. J. (2007) · Annals of the Rheumatic Diseases · doi:10.1136/ard.2006.067660 · Cited by 231
Validation of rheumatoid arthritis diagnoses in health care utilization data
Kim, S. C., Servi, A. D., Polinski, J. M., Mogun, H., Weinblatt, M. E., Katz, J. N., & Solomon, D. H. (2011) · Arthritis Research & Therapy · doi:10.1186/ar3260 · Cited by 229
Self-citationDevelopments in Post-marketing Comparative Effectiveness Research
Schneeweiß, S. (2007) · Clinical Pharmacology & Therapeutics · doi:10.1038/sj.clpt.6100249 · Cited by 200
Antirheumatic drug use and the risk of acute myocardial infarction
Suissa, S., Bernatsky, S., & Hudson, M. (2006) · Arthritis Care & Research · doi:10.1002/art.22094 · Cited by 192
Solomon, D. H., Avorn, J., Katz, J. N., Weinblatt, M. E., Setoguchi, S., Levin, R., & Schneeweiß, S. (2006) · Arthritis & Rheumatism · doi:10.1002/art.22255 · Cited by 181
Self-citationFox, C. S., Evans, J. C., Larson, M. G., Lloyd‐Jones, D. M., O’Donnell, C. J., Sorlie, P. D., Manolio, T. A., Kannel, W. B., & Levy, D. A. (2005) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2004.12.011 · Cited by 75
Weisman, M. H., Paulus, H. E., Burch, F. X., Kivitz, A., Fierer, J., Dunn, M. E., Kerr, D. R., Tsuji, W., & Baumgartner, S. W. (2007) · Lara D. Veeken · doi:10.1093/rheumatology/kem033 · Cited by 65
A computer case definition for sudden cardiac death
Chung, C. P., Murray, K. T., Stein, C. M., Hall, K., & Ray, W. A. (2009) · Pharmacoepidemiology and Drug Safety · doi:10.1002/pds.1888 · Cited by 52
An algorithm to identify incident myocardial infarction using Medicaid data
Choma, N. N., Griffin, M. R., Huang, R. L., Mitchel, E. F., Kaltenbach, L. A., Gideon, P. S., Stratton, S. M., & Roumie, C. L. (2009) · Pharmacoepidemiology and Drug Safety · doi:10.1002/pds.1821 · Cited by 46
Self-citationSynthesis of TNFα and TGFβ mRNA in the different micro-environments within atheromatous plaques
Rayment, N. B., Moss, E., Faulkner, L., Brickell, P. M., DAVIES, M., Woolf, N., & Katz, D. R. (1996) · Cardiovascular Research · doi:10.1016/s0008-6363(96)00145-9 · Cited by 38
Rassen, J. A., Solomon, D. H., Curtis, J. R., Herrinton, L. J., & Schneeweiß, S. (2010) · Medical Care · doi:10.1097/mlr.0b013e3181d59541 · Cited by 37
Self-citationHerrinton, L. J., Curtis, J. R., Chen, L., Liu, L., Delzell, E., Lewis, J. D., Solomon, D. H., Griffin, M. R., Ouellet‐Hellstrom, R., Beukelman, T., et al. (2011) · Pharmacoepidemiology and Drug Safety · doi:10.1002/pds.2196 · Cited by 31
Self-citation
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Inflammageing: chronic inflammation in ageing, cardiovascular disease, and frailty
Ferrucci, L., & Fabbri, E. (2018) · Nature Reviews Cardiology · doi:10.1038/s41569-018-0064-2 · Cited by 3,690
Agca, R., Heslinga, S. C., Rollefstad, S., Heslinga, M., McInnes, I. B., Peters, M. J. L., Kvien, T. K., Dougados, M., Radner, H., Atzeni, F., et al. (2017) · Annals of the Rheumatic Diseases · doi:10.1136/annrheumdis-2016-209775 · Cited by 1,380
Roubille, C., Richer, V., Starnino, T., McCourt, C., McFarlane, A., Fleming, P., Siu, S., Kraft, J., Lynde, C., Pope, J., et al. (2015) · Annals of the Rheumatic Diseases · doi:10.1136/annrheumdis-2014-206624 · Cited by 907
Increased cardiovascular risk in rheumatoid arthritis: mechanisms and implications
England, B. R., Thiele, G. M., Anderson, D. R., & Mikuls, T. R. (2018) · BMJ · doi:10.1136/bmj.k1036 · Cited by 627
Mason, J. C., & Libby, P. (2015) · European Heart Journal · doi:10.1093/eurheartj/ehu403 · Cited by 420
Metadata
- Authors
- Solomon, D. H., Curtis, J. R., Saag, K. G., Lii, J., Chen, L., Harrold, L. R., Herrinton, L. J., Graham, D. J., Kowal, M. K., Kuriya, B., Liu, L., Griffin, M. R., Lewis, J. D., & Rassen, J. A.
- Affiliations
- Brigham and Women's Hospital (US)
- University of Alabama at Birmingham (US)
- University of Massachusetts Chan Medical School (US)
- Kaiser Permanente (US)
- United States Food and Drug Administration (US)
- University of Toronto (CA)
- Vanderbilt University (US)
- University of Pennsylvania (US)
- Corresponding author
- Solomon, Daniel H.
- ORCID
- Venue
- The American Journal of Medicine
- Publisher
- Elsevier BV
- Published
- 2013-08
- Volume
- 126
- Issue
- 8
- Pages
- 730.e9-730.e17
- ISSN
- 0002-9343 (ISSN-L)
- PMC
- PMC4674813
- OpenAlex
- W1995953874
- Cited by
- 111
- References
- 42
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 11 · 2023: 10 · 2022: 11 · 2021: 3 · 2020: 6 · 2019: 5 · 2018: 10 · 2017: 12 · 2016: 11 · 2015: 12 · 2014: 14 · 2013: 4
- FWCI
- 11.18
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- The American Journal of Medicine (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- U.S. Food and Drug Administration
- Agency for Healthcare Research and Quality
- U.S. Department of Health and Human Services (1U18 HSO17919-0)
- Topics
- Health Sciences › Medicine › Rheumatology › Rheumatoid Arthritis Research and Therapies
- Health Sciences › Medicine › Hematology › Autoimmune and Inflammatory Disorders Research
- Health Sciences › Medicine › Pharmacology (medical) › Inflammatory mediators and NSAID effects
- Keywords
- rheumatoid arthritis, cardiovascular risk, TNF-alpha blockade, methotrexate, myocardial infarction, stroke, coronary revascularization, cardiovascular events, older adults, propensity score matching
- MeSH terms
- Adult, Aged, Arthritis, Rheumatoid, Cardiovascular Diseases, Female, Humans, Male, Methotrexate, Middle Aged, Myocardial Infarction, Myocardial Revascularization, Retrospective Studies, Risk, Tumor Necrosis Factor-alpha, Cohort Studies, Proportional Hazards Models, Treatment Outcome, Antirheumatic Agents, Stroke, Kaplan-Meier Estimate
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