The DOI matches its Crossref record; 138 of the 138 references it cites were found in a registry or an index.
Resting Heart Rate: Risk Indicator and Emerging Risk Factor in Cardiovascular Disease
Abstract
Resting heart rate is central to cardiac output and is influenced by changes occurring in numerous diseases. It predicts longevity and cardiovascular diseases, and current evidence suggests that it is also an important marker of outcome in cardiovascular disease, including heart failure. Beta-blockers improve outcomes in heart failure; however, they have effects outside reducing heart rate. Ivabradine has demonstrated efficacy in reducing rehospitalizations and mortality in heart failure and in improving exercise tolerance and reducing angina attacks in patients with coronary artery disease, whereas selective heart rate reduction may also prove to be beneficial in therapeutic areas outside those in which ivabradine has already demonstrated clinical efficacy. This review provides an update on the associations between heart rate and cardiovascular outcomes in various conditions, the experimental effects of heart rate reduction with ivabradine, and the potential new indications in cardiovascular disease.
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“Increased heart rate is generally considered an adverse effect, associated with lower survival. 35”
From Healthy Weight Loss Maintenance with Exercise, Liraglutide, or Both Combined (2021) · cites this paper as [35]
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Self-citationEuropean Guidelines on cardiovascular disease prevention in clinical practice (version 2012)
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ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure 2012
Authors/Task Force Members, McMurray, J. J. V., Adamopoulos, S., Anker, S. D., Auricchio, A., Böhm, M., Dickstein, K., Falk, V., Filippatos, G., Fonseca, C., et al. (2012) · European Heart Journal · doi:10.1093/eurheartj/ehs104 · Cited by 6,879
Self-citationImpotence and Its Medical and Psychosocial Correlates: Results of the Massachusetts Male Aging Study
Feldman, H. A., Goldstein, I., Hatzichristou, D. G., Krane, R. J., & McKinlay, J. B. (1994) · Journal of Urology · doi:10.1016/s0022-5347(17)34871-1 · Cited by 5,074
2013 ESC guidelines on the management of stable coronary artery disease
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European guidelines on cardiovascular disease prevention in clinical practice: executive summary
Graham, I., Atar, D., Borch‐Johnsen, K., Boysen, G., Burell, G. K., Cífková, R., Dallongeville, J., Backer, G. D., Ebrahim, S. B. J., Gjelsvik, B., et al. (2007) · European Heart Journal · doi:10.1093/eurheartj/ehm316 · Cited by 3,865
Ivabradine and outcomes in chronic heart failure (SHIFT): a randomised placebo-controlled study
Swedberg, K., Komajda, M., Böhm, M., Borer, J. S., Ford, I., Dubost-Brama, A., Lerebours, G., & Tavazzi, L. (2010) · The Lancet · doi:10.1016/s0140-6736(10)61198-1 · Cited by 2,563
Self-citationGibbons, R. J., Abrams, J., Chatterjee, K., Daley, J., DEEDWANIA, P. C., Douglas, J. S., Ferguson, T. B., Fihn, S. D., Fraker, T. D., Gardin, J. M., et al. (2002) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(02)02848-6 · Cited by 1,685
Self-citationGraham (2007) · doi:10.1097/01.hjr.0000277983.23934.c9 · Cited by 1,647
Chatzizisis, Y. S., Coskun, A. U., Jonas, M., Edelman, E. R., Feldman, C. L., & Stone, P. H. (2007) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2007.02.059 · Cited by 1,483
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Filippatos, T. D., Panagiotopoulou, T. V., & Elisaf, M. S. (2014) · The Review of Diabetic Studies · Cited by 560
Healthy Weight Loss Maintenance with Exercise, Liraglutide, or Both Combined
Lundgren, J. R., Janus, C., Jensen, S. B. K., Juhl, C. R., Olsen, L. M., Christensen, R. M., Svane, M. S., Bandholm, T., Bojsen-Møller, K. N., Blond, M. B., et al. (2021) · New England Journal of Medicine · doi:10.1056/nejmoa2028198 · Cited by 536
Zhang, D., Shen, X., & Qi, X. (2015) · Canadian Medical Association Journal · doi:10.1503/cmaj.150535 · Cited by 329
Lyall, D. M., Celis-Morales, C., Ward, J., Iliodromiti, S., Anderson, J. J., Gill, J. M. R., Smith, D. J., Ntuk, U. E., Mackay, D. F., Holmes, M. V., et al. (2017) · JAMA Cardiology · doi:10.1001/jamacardio.2016.5804 · Cited by 235
Lip, G. Y. H., Coca, A., Kahan, T., Boriani, G., Manolis, A. S., Olsen, M. H., Oto, A., Potpara, T., Steffel, J., Marín, F. R., et al. (2017) · EP Europace · doi:10.1093/europace/eux091 · Cited by 233
Metadata
- Authors
- Böhm, M., Reil, J.-C., Deedwania, P., Kim, J. B., & Borer, J. S.
- Affiliations
- Universitätsklinikum des Saarlandes (DE)
- University of California, San Francisco (US)
- Amgen (United States) (US)
- Cornell University (US)
- Corresponding author
- Böhm, Michael
- Venue
- The American Journal of Medicine
- Publisher
- Elsevier BV
- Published
- 2015-03
- Volume
- 128
- Issue
- 3
- Pages
- 219-228
- ISSN
- 0002-9343 (ISSN-L)
- OpenAlex
- W2082410000
- Cited by
- 236
- References
- 138
- Citations by year
- 2026: 12 · 2025: 25 · 2024: 22 · 2023: 25 · 2022: 34 · 2021: 24 · 2020: 16 · 2019: 16 · 2018: 14 · 2017: 14 · 2016: 24 · 2015: 9
- FWCI
- 2.55
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The American Journal of Medicine (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Amgen
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart rate and cardiovascular health
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
- Health Sciences › Medicine › Physiology (medical) › Cardiovascular and exercise physiology
- Keywords
- resting heart rate, cardiovascular risk, heart failure, ivabradine, beta-blockers, heart rate reduction, cardiovascular outcomes, coronary artery disease, mortality, hospital readmission, angina pectoris, exercise tolerance
- MeSH terms
- Ivabradine, Benzazepines, Cardiovascular Agents, Cardiovascular Diseases, Heart Rate, Humans, Rest, Risk Factors, Treatment Outcome
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