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Cited by 70Geriatric Care and Nursing HomesMental Health Treatment and AccessTreatment of Major Depression

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Prevalence and Predictors of Antidepressant Prescribing in Nursing Home Residents in the United States

Karkare, Swapna U., Bhattacharjee, Sandipan, Kamble, Pravin, Aparasu, Rajender·2011·The American Journal of Geriatric Pharmacotherapy
DOI 10.1016/j.amjopharm.2011.03.001
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Abstract

Background Late-life depression is a common psychiatric disorder associated with increased morbidity and mortality. Depression is often under-detected and undertreated in elderly nursing home residents. Objectives The aim of this study was to examine the prevalence of antidepressant drug use and to identify the factors associated with its use among elderly nursing home residents. Methods The study involved the analysis of a nationally representative sample of prescription and resident files from the 2004 National Nursing Home Survey (NNHS). The study sample included all elderly nursing home residents ≥65 years of age. The analysis focused on prescribing from any antidepressant class, including selective serotonin reuptake inhibitors (SSRIs), tricyclic antidepressants (TCAs), serotonin modulators, serotonin-norepinephrine reuptake inhibitors (SNRIs), monoamine oxidase inhibitors (MAOIs), and others. Descriptive weighted analysis was performed to examine antidepressant use prevalence patterns in elderly nursing home residents. Multiple logistic regression analysis within the conceptual framework of Anderson's behavioral model was used to examine the predisposing, enabling, and need characteristics associated with antidepressant use. Results According to the 2004 NNHS, overall prevalence of antidepressant use among elderly nursing home residents was 46.22% (95% CI, 45.16-47.27). Most antidepressant users were ≥85 years of age (49.7%), female (75.7%), non-Hispanic (96.4%), and wh…

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Research works printed but not linked: 58

  1. Kallenbach, 2006, Identification and management of depression in nursing facility residents, J Am Med Dir Assoc, 7, 448, 10.1016/j.jamda.2006.04.007 · DOI
  2. Jongenelis, 2004, Prevalence and risk indicators of depression in elderly nursing home patients: the AGED study, J Affect Disord, 83, 135, 10.1016/j.jad.2004.06.001 · DOI
  3. 2003, The American Geriatrics Society and American Association for Geriatric Psychiatry recommendations for policies in support of quality mental health care in US nursing homes, J Am Geriatr Soc, 51, 1299, 10.1046/j.1532-5415.2003.51416.x · DOI
  4. Kaldy, 2002, A clinical practice guideline approach to treating depression in long-term care, J Am Med Dir Assoc, 3, 103, 10.1016/S1525-8610(04)70422-3 · DOI
  5. Bruce, 2002, Psychosocial risk factors for depressive disorders in late life, Biol Psychiatry, 52, 175, 10.1016/S0006-3223(02)01410-5 · DOI
  6. Stek, 2004, Prevalence, correlates and recognition of depression in the oldest old: the Leiden 85-plus study, J Affect Disord, 78, 193, 10.1016/S0165-0327(02)00310-5 · DOI
  7. Blazer, 2003, Depression in late life: review and commentary, J Gerontol A Biol Sci Med Sci, 58, 249, 10.1093/gerona/58.3.M249 · DOI
  8. Murray, 1997, Alternative projections of mortality and disability by cause 1990-2020: global burden of disease study, Lancet., 349, 1498, 10.1016/S0140-6736(96)07492-2 · DOI
  9. Levin, 2007, Prevalence and treatment of diagnosed depression among elderly nursing home residents in Ohio, J Am Med Dir Assoc, 8, 585, 10.1016/j.jamda.2007.07.010 · DOI
  10. Jones, 2003, Prevalence and correlates of recognized depression in U.S. nursing homes, J Am Geriatr Soc, 51, 1404, 10.1046/j.1532-5415.2003.51458.x · DOI
  11. 1992, Diagnosis and treatment of depression in late life, JAMA, 268, 1018, 10.1001/jama.1992.03490080092032 · DOI
  12. Schnelle, 2001, Measurement sensitivity and the minimum data set depression quality indicator, Gerontologist, 41, 401, 10.1093/geront/41.3.401 · DOI
  13. Teresi, 2001, Prevalence of depression and depression recognition in nursing homes, Soc Psychiatry Psychiatr Epidemiol, 36, 613, 10.1007/s127-001-8202-7 · DOI
  14. 1992, Diagnosis and treatment of depression in late life, JAMA, 268, 1018, 10.1001/jama.1992.03490080092032 · DOI
  15. Brown, 2002, The management of depression in older nursing home residents, J Am Geriatr Soc, 50, 69, 10.1046/j.1532-5415.2002.50010.x · DOI
  16. Gallo, 1999, Attitudes, knowledge and behavior of family physicians regarding depression in late life, Arch Fam Med, 8, 249, 10.1001/archfami.8.3.249 · DOI
  17. 1987, Public Law No. 100-203, Omnibus Budget Reconciliation Act of 1987, 22 December 1987, Annu Rev Popul Law, 14, 473
  18. Hansen, 2007, Increased use of antidepressants at the end of life: population-based study among people aged 65 years and above, Age Ageing, 36, 449, 10.1093/ageing/afm056 · DOI
  19. Khawam, 2006, Side effects of antidepressants: an overview, Cleve Clin J Med, 73, 351, 10.3949/ccjm.73.4.351 · DOI
  20. Borson, 1997, The impact of OBRA-87 on psychotropic drug prescribing in skilled nursing facilities, Psych Services, 48, 1289, 10.1176/ps.48.10.1289 · DOI
  21. Garrard, 1995, The impact of the 1987 Federal Regulations on the use of psychotropic drugs in Minnesota nursing homes, Am J Public Health, 85, 771, 10.2105/AJPH.85.6.771 · DOI
  22. Hanlon, 2010, Antidepressant prescribing in U.S. nursing homes between 1996–2006 and its relationship to staffing patterns and use of other psychotropic medications, J Am Med Dir Assoc., 11, 320, 10.1016/j.jamda.2010.01.007 · DOI
  23. Foote, 2000, Increasing use of new prescription drugs: a case study, Health Aff (Millwood), 19, 165, 10.1377/hlthaff.19.4.165 · DOI
  24. Pollock, 1996, Adverse reactions of antidepressants in elderly patients, J Clin Psychiatry, 60, 4
  25. Draper, 2008, Tolerability of selective serotonin reuptake inhibitors: Issues relevant to the elderly, Drugs Aging, 25, 501, 10.2165/00002512-200825060-00004 · DOI
  26. Thapa, 1998, Antidepressants and risk of falls among nursing home residents, N Engl J Med, 339, 875, 10.1056/NEJM199809243391303 · DOI
  27. Liu, 1998, Use of selective serotonin-reuptake inhibitors or tricyclic antidepressants and risk of hip fractures in elderly people, Lancet, 351, 1303, 10.1016/S0140-6736(97)09528-7 · DOI
  28. Koch, 1982, The collection and processing of drug information: National Ambulatory Medical Care Survey - United States, 1980, Vital Health Stat., 2, 1
  29. Bhattacharjee, 2010, Datapoints: psychotropic drug utilization among elderly nursing home residents in the United States, Psychiatr Serv, 61, 655, 10.1176/appi.ps.61.7.655 · DOI
  30. Kamble, 2008, Antipsychotic drug use among elderly nursing home residents in the United States, Am J Geriatr Pharmacother, 6, 187, 10.1016/j.amjopharm.2008.10.002 · DOI
  31. Kamble, 2010, Off-label use of second-generation antipsychotic agents among elderly nursing home residents, Psychiatr Serv, 61, 130, 10.1176/appi.ps.61.2.130 · DOI
  32. Kamble, 2009, Use of antipsychotics among elderly nursing home residents with dementia in the US: an analysis of National Survey Data, Drugs Aging, 26, 483, 10.2165/00002512-200926060-00005 · DOI
  33. Arthur, 2002, Factors associated with antidepressant treatment in residential care: changes between 1990 and 1997, Int J Geriatr Psychiatry, 17, 54, 10.1002/gps.512 · DOI
  34. Nishtala, 2009, Determinants of antidepressant medication prescribing in elderly residents of aged care homes in Australia: a retrospective study, Am J Geriatr Pharmacother, 7, 210, 10.1016/j.amjopharm.2009.07.001 · DOI
  35. Burns, 1993, Mental health services use by the elderly in nursing homes, Am J Public Health, 83, 331, 10.2105/AJPH.83.3.331 · DOI
  36. Shea, 1994, Determinants of the use of specialist mental health services by nursing home residents, Health Serv Res, 29, 169
  37. Garrard, 1991, Evaluation of neuroleptic drug use by nursing home elderly under proposed Medicare and Medicaid regulations, JAMA, 265, 463, 10.1001/jama.1991.03460040039025 · DOI
  38. Harrington, 1992, Psychotropic drug use in long-term care facilities: a review of the literature, Gerontologist, 32, 822, 10.1093/geront/32.6.822 · DOI
  39. Borson, 2002, Antidepressant prescribing in nursing homes: is there a place for tricyclics?, Int J Geriatr Psychiatry, 17, 1140, 10.1002/gps.766 · DOI
  40. Lane, 1997, Selective Serotonin reuptake inhibitor-induced serotonin syndrome: review, J Clin Psychopharmacol, 17, 208, 10.1097/00004714-199706000-00012 · DOI
  41. Beers, 1991, Explicit criteria for determining inappropriate medication use in nursing home residents, Arch Intern Med, 151, 1825, 10.1001/archinte.1991.00400090107019 · DOI
  42. Beers, 1997, Explicit criteria for determining potentially inappropriate medication use by the elderly: an update, Arch Intern Med, 157, 1531, 10.1001/archinte.1997.00440350031003 · DOI
  43. Roose, 2003, Open-label study of mirtazapine orally disintegrating tablets in depressed patients in the nursing home, Curr Med Res Opin, 19, 737, 10.1185/030079903125002441 · DOI
  44. Gurvich, 2000, Appropriate use of psychotropic drugs in nursing homes, Am Fam Physician, 61, 1437
  45. Fawcett, 1998, Review of the results from clinical studies on the efficacy, safety and tolerability of mirtazapine for the treatment of patients with major depression, J Affect Disord, 51, 267, 10.1016/S0165-0327(98)00224-9 · DOI
  46. Gardner, 2004, Mirtazapine is associated with less anxiolytic use among elderly depressed patients in long-term care facilities, J Am Med Dir Assoc, 5, 101, 10.1016/S1525-8610(04)70063-8 · DOI
  47. Hosia-Randell, 2005, Use of psychotropic drugs in elderly nursing home residents with and without dementia in Helsinki, Finland, Drugs Aging, 22, 793, 10.2165/00002512-200522090-00008 · DOI
  48. Fick, 2008, Updating the Beers criteria for potentially inappropriate medication use in older adults: results of a US consensus panel of experts, Arch Intern Med, 163, 2716, 10.1001/archinte.163.22.2716 · DOI · Paper page
  49. McLeod, 1997, Defining inappropriate practices in prescribing for elderly people: a national consensus panel, CMAJ, 156, 385
  50. Chutka, 2004, Inappropriate medications for elderly patients, Mayo Clin Proc, 79, 122, 10.4065/79.1.122 · DOI
  51. Sørensen, 2001, Determinants for the use of psychotropics among nursing home residents, Int J Geriatr Psychiatry, 16, 147, 10.1002/1099-1166(200102)16:2<147::AID-GPS286>3.0.CO;2-4 · DOI
  52. Frank, 2003, Medicaid and mental health: be careful what you ask for, Health Affairs, 22, 101, 10.1377/hlthaff.22.1.101 · DOI
  53. Lapane, 2004, Which organizational characteristics are associated with increased management of depression using antidepressants in US nursing homes?, Med Care, 42, 992, 10.1097/00005650-200410000-00008 · DOI
  54. Lenze, 2000, Comorbid anxiety disorders in depressed elderly patients, Am J Psychiatry, 157, 722, 10.1176/appi.ajp.157.5.722 · DOI
  55. Flint, 1997, Anxious depression in elderly patients, Am J Geriatr Psychiatry, 5, 107
  56. Khawam, 2006, Side effects of antidepressants: an overview, Cleve Clin J Med, 73, 351, 10.3949/ccjm.73.4.351 · DOI
  57. Magaziner, 2007, Intervening to prevent falls and fractures in nursing homes: are we putting the cart before the horse?, J Am Geriatr Soc, 55, 464, 10.1111/j.1532-5415.2007.01088.x · DOI
  58. Ruthazer, 1993, Antidepressants and falls among elderly people in long-term care, Am J Public Health, 83;, 746, 10.2105/AJPH.83.5.746 · DOI

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Metadata

Authors
Karkare, S. U., Bhattacharjee, S., Kamble, P., & Aparasu, R.
Affiliations
Texas Medical Center (US)
Corresponding author
Aparasu, Rajender
ORCID
Venue
The American Journal of Geriatric Pharmacotherapy
Publisher
Elsevier BV
Published
2011-04
Volume
9
Issue
2
Pages
109-119
ISSN
1543-5946 (ISSN-L)
DOI
10.1016/j.amjopharm.2011.03.001
OpenAlex
W2063336333
Cited by
70
References
2
Citations by year
2026: 5 · 2025: 3 · 2024: 1 · 2023: 2 · 2022: 7 · 2021: 6 · 2020: 3 · 2019: 3 · 2018: 1 · 2017: 4 · 2016: 8 · 2015: 3 · 2014: 3 · 2013: 6 · 2012: 12
FWCI
6.28
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • The American Journal of Geriatric Pharmacotherapy (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Geriatrics and Gerontology › Geriatric Care and Nursing Homes
  • Health Sciences › Medicine › Psychiatry and Mental health › Mental Health Treatment and Access
  • Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
Keywords
antidepressant prescribing, nursing home residents, geriatric depression, older adults, selective serotonin reuptake inhibitors, tricyclic antidepressants, serotonin-norepinephrine reuptake inhibitors, monoamine oxidase inhibitors, citalopram, prescribing determinants, National Nursing Home Survey, undertreatment
MeSH terms
Age Factors, Aged, Aged, 80 and over, Antidepressive Agents, Anxiety, Depression, Female, Humans, Male, Nursing Homes, Practice Patterns, Physicians', United States, Prevalence, Logistic Models, Health Care Surveys

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