Bifidobacterium spp. influences the production of autoinducer-2 and biofilm formation by Escherichia coli O157:H7
Abstract
The effect of Bifidobacterium spp. on the production of quorum-sensing (QS) signals and biofilm formation by enterohemorrhagic Escherichia coli (EHEC) O157:H7 was investigated. In an AI-2 bioassay, cell extracts of Bifidobacterium longum ATCC 15707 resulted in a 98-fold reduction in AI-2 activity in EHEC O157:H7 as well as in the Vibrio harveyi reporter strain, even though they did not inhibit the growth of EHEC O157:H7. In addition, they resulted in a 36% reduction in biofilm formation by the organism. Consistently, the virulence of EHEC O157:H7 was significantly attenuated by the presence of cell extracts of B. longum ATCC 15707 in the Caenorhabditis elegans nematode in vivo model. By a proteome analysis using two dimensional electrophoresis (2-DE), we determined that seven proteins including formation of iron-sulfur protein (NifU), thiol:disulfide interchange protein (DsbA), and flagellar P-ring protein (FlgI) were differentially regulated in the EHEC O157:H7 when supplemented with cell extracts of B. longum ATCC 15707. Taken together, these findings propose a novel function of a dairy adjunct in repressing the virulence of EHEC O157:H7.
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Numerous in vitro studies have demonstrated that bifidobacteria can inhibit pathogens through the production of organic acids, antibacterial peptides, quorum-sensing inhibitors, or immune stimulation among other mechanisms.
“Numerous in vitro studies have demonstrated that bifidobacteria can inhibit pathogens through the production of organic acids (38), antibacterial peptides (39), quorum-sensing inhibitors (40, 41), or immune stimulation (42) among other mechanisms, providing molecular clues of their capacity to prevent certain infections.”
From Bifidobacteria and Their Health-Promoting Effects (2017) · cites this paper as [41]
Cites
Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method
Livak, K. J., & Schmittgen, T. D. (2001) · Methods · doi:10.1006/meth.2001.1262 · Cited by 180,860 · see citing works
Miller, M. B., & Bassler, B. L. (2001) · Annual Review of Microbiology · doi:10.1146/annurev.micro.55.1.165 · Cited by 5,127 · see citing works
Diarrheagenic Escherichia coli
Nataro, J. P., & Kaper, J. B. (1998) · Clinical Microbiology Reviews · doi:10.1128/cmr.11.1.142 · Cited by 5,109 · see citing works
Pratt, L. A., & Kolter, R. (1998) · Molecular Microbiology · doi:10.1046/j.1365-2958.1998.01061.x · Cited by 1,641 · see citing works
Bacterial Quorum Sensing in Pathogenic Relationships
de Kievit, T. R., & Iglewski, B. H. (2000) · Infection and Immunity · doi:10.1128/iai.68.9.4839-4849.2000 · Cited by 1,114 · see citing works
Tan, M., Mahajan‐Miklos, S., & Ausubel, F. M. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.2.715 · Cited by 1,008 · see citing works
Bacterial bioluminescence: Isolation and genetic analysis of functions from Vibrio fischeri
Engebrecht, J., Nealson, K. H., & Silverman, M. R. (1983) · Cell · doi:10.1016/0092-8674(83)90063-6 · Cited by 907 · see citing works
LuxS quorum sensing: more than just a numbers game
Xavier, K. B., & Bassler, B. L. (2003) · Current Opinion in Microbiology · doi:10.1016/s1369-5274(03)00028-6 · Cited by 750 · see citing works
Parsek, M. R., & Greenberg, E. P. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.16.8789 · Cited by 652 · see citing works
Quorum sensing in Escherichia coli and Salmonella typhimurium
Surette, M. G., & Bassler, B. L. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.12.7046 · Cited by 642 · see citing works
Antimicrobial substance from a human Lactobacillus strain
Silva, M., Jacobus, N. V., Deneke, C. F., & Gorbach, S. L. (1987) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.31.8.1231 · Cited by 558 · see citing works
Sperandio, V., Mellies, J. L., Nguyen, W., Shin, S., & Kaper, J. B. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.26.15196 · Cited by 515 · see citing works
Global impact of mature biofilm lifestyle on Escherichia coli K‐12 gene expression
Beloin, C., Valle, J., Latour‐Lambert, P., Fauré, P., Kzreminski, M., Balestrino, D., Haagensen, J. A. J., Molin, S., Prensier, G., Arbeille, B., et al. (2003) · Molecular Microbiology · doi:10.1046/j.1365-2958.2003.03865.x · Cited by 478 · see citing works
CELL-CELL COMMUNICATION IN GRAM-POSITIVE BACTERIA
Dunny, G. M., & Buttaro, B. A. (1997) · Annual Review of Microbiology · doi:10.1146/annurev.micro.51.1.527 · Cited by 454 · see citing works
Irazoqui, J. E., Troemel, E. R., Feinbaum, R. L., Luhachack, L. G., Cezairliyan, B. O., & Ausubel, F. M. (2010) · PLoS Pathogens · doi:10.1371/journal.ppat.1000982 · Cited by 382 · see citing works
Killing of Caenorhabditis elegans by Cryptococcus neoformans as a model of yeast pathogenesis
Mylonakis, E. E., Ausubel, F. M., Perfect, J. R., Heitman, J., & Calderwood, S. B. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.232568599 · Cited by 330 · see citing works
Ren, D., Sims, J. J., & Wood, T. K. (2001) · Environmental Microbiology · doi:10.1046/j.1462-2920.2001.00249.x · Cited by 327 · see citing works
Kim, Y., Oh, S., & Kim, S. H. (2008) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2008.12.053 · Cited by 276 · see citing works
Self-citationRen, D., Zuo, R., Barrios, A. F. G., Bedzyk, L. A., Eldridge, G. R., Pasmore, M. E., & Wood, T. K. (2005) · Applied and Environmental Microbiology · doi:10.1128/aem.71.7.4022-4034.2005 · Cited by 235 · see citing works
Probiotics Affect Virulence-Related Gene Expression in Escherichia coli O157:H7
Medellin-Peña, M. J., Wang, H., Johnson, R. P., Anand, S. K., & Griffiths, M. W. (2007) · Applied and Environmental Microbiology · doi:10.1128/aem.00159-07 · Cited by 228 · see citing works
Self-citationRen, D., Bedzyk, L. A., Ye, R. W., Thomas, S. M., & Wood, T. K. (2004) · Biotechnology and Bioengineering · doi:10.1002/bit.20259 · Cited by 220 · see citing works
Quantifying Protein in 2-D PAGE Solubilization Buffers
Ramagli, L. S. (2003) · Humana Press eBooks · doi:10.1385/1-59259-584-7:99 · Cited by 199 · see citing works
McKee, M. L., Melton‐Celsa, A. R., Moxley, R. A., Francis, D. H., & O’Brien, A. D. (1995) · Infection and Immunity · doi:10.1128/iai.63.9.3739-3744.1995 · Cited by 198 · see citing works
Quorum-sensing blockade as a strategy for enhancing host defences against bacterial pathogens
Bjarnsholt, T., & Givskov, M. (2007) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2007.2046 · Cited by 187 · see citing works
Ueda, A., Attila, C., Whiteley, M., & Wood, T. K. (2008) · Microbial Biotechnology · doi:10.1111/j.1751-7915.2008.00060.x · Cited by 174 · see citing works
Kim, Y., & Mylonakis, E. E. (2012) · Infection and Immunity · doi:10.1128/iai.06350-11 · Cited by 158 · see citing works
Self-citationTranscriptional regulation of flhDC by QseBC and σ 28 (FliA) in enterohaemorrhagic Escherichia coli
Clarke, M. B., & Sperandio, V. (2005) · Molecular Microbiology · doi:10.1111/j.1365-2958.2005.04792.x · Cited by 156 · see citing works
Medellin-Peña, M. J., & Griffiths, M. W. (2008) · Applied and Environmental Microbiology · doi:10.1128/aem.01651-08 · Cited by 139 · see citing works
Self-citationEnumeration of bifidobacteria in dairy products
Σαμωνά, Α., & Robinson, R. K. (1991) · International Journal of Dairy Technology · doi:10.1111/j.1471-0307.1991.tb00639.x · Cited by 135 · see citing works
DsbA of Pseudomonas aeruginosa Is Essential for Multiple Virulence Factors
Ha, U., Wang, Y., & Jin, S. (2003) · Infection and Immunity · doi:10.1128/iai.71.3.1590-1595.2003 · Cited by 113 · see citing works
Meurman, J. H., Antila, H., Korhonen, A., & Salminen, S. (1995) · European Journal Of Oral Sciences · doi:10.1111/j.1600-0722.1995.tb00169.x · Cited by 112 · see citing works
Autoinducer-2–like Activity Associated with Foods and Its Interaction with Food Additives
Lu, L., Hume, M. E., & Pillai, S. D. (2004) · Journal of Food Protection · doi:10.4315/0362-028x-67.7.1457 · Cited by 109 · see citing works
Rader, B. A., Campagna, S. R., Semmelhack, M. F., Bassler, B. L., & Guillemin, K. J. (2007) · Journal of Bacteriology · doi:10.1128/jb.00246-07 · Cited by 106 · see citing works
Kim, Y., Lee, Y., Kim, S. H., Yeom, J., Yeom, S., Kim, B. S., Oh, S., Park, S., Jeon, C. O., & Park, W. (2006) · PROTEOMICS · doi:10.1002/pmic.200600320 · Cited by 82 · see citing works
Self-citationInvolvement of LuxS in the Regulation of Motility and Flagella Biogenesis inVibrio alginolyticus
Tian, Y. M., Wang, Q., Liu, Q., Ma, Y., Cao, X., Guan, L., & Zhang, Y. (2008) · Bioscience Biotechnology and Biochemistry · doi:10.1271/bbb.70812 · Cited by 48 · see citing works
Ling, H., Kang, A., Tan, M. H., Qi, X., & Chang, M. W. (2010) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2010.09.080 · Cited by 44 · see citing works
Lee, Y., Kim, Y., Yeom, S., Kim, S. H., Park, S., Jeon, C. O., & Park, W. (2008) · FEMS Microbiology Letters · doi:10.1111/j.1574-6968.2007.00993.x · Cited by 38 · see citing works
Self-citationKaravolos, M. H., Bulmer, D. M., Winzer, K., Wilson, M., Mastroeni, P., Williams, P. M., & Khan, C. M. A. (2007) · Journal of Bacteriology · doi:10.1128/jb.01253-07 · Cited by 37 · see citing works
Kim, Y., Oh, S., Park, S., Seo, J. B., & Kim, S. H. (2007) · Food Control · doi:10.1016/j.foodcont.2007.10.014 · Cited by 30 · see citing works
Self-citationKim, Y., Oh, S., Ahn, E. Y., Imm, J., Oh, S., Park, S., & Kim, S. H. (2007) · Journal of Food Protection · doi:10.4315/0362-028x-70.2.300 · Cited by 28 · see citing works
Self-citationBardiau, M., Labrozzo, S., & Mainil, J. G. (2011) · BMC Microbiology · doi:10.1186/1471-2180-11-124 · Cited by 7 · see citing works
Stress Tolerance of Bifidobacterium infantis ATCC 27920 to Mild-heat Adaptation
Kang, S., Kim, Y., Cho, I., Kang, J., Chung, I., Kim, K., & Oh, S. (2009) · Food Science and Biotechnology · Cited by 1 · see citing works
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Prazdnova, E. V., Gorovtsov, A. V., Vasilchenko, N., Kulikov, M. P., Statsenko, V. N., Bogdanova, A. A., Refeld, A. G., Brislavskiy, Y., Chistyakov, V. A., & Chikindas, M. L. (2022) · Microorganisms · doi:10.3390/microorganisms10020350 · Cited by 131 · see citing works
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Yun, B., Oh, S., & Griffiths, M. W. (2014) · Journal of Dairy Science · doi:10.3168/jds.2014-7921 · Cited by 102 · see citing works
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Anti-Quorum Sensing Activity of Probiotics: The Mechanism and Role in Food and Gut Health
Salman, M. K., Abuqwider, J., & Mauriello, G. (2023) · Microorganisms · doi:10.3390/microorganisms11030793 · Cited by 79 · see citing works
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Ha, N. M., Tran, S. H., Shim, Y., & Kang, K. (2022) · Applied Biological Chemistry · doi:10.1186/s13765-022-00685-y · Cited by 66 · see citing works
Yang, Z., Zhou, Y., Han, Z., He, K., Zhang, Y., Wu, D., & Chen, H. (2024) · Scientific Reports · doi:10.1038/s41598-024-59399-4 · Cited by 62 · see citing works
Pathogenic Biofilm Formation in the Food Industry and Alternative Control Strategies
Giaouris, E. E., & Simões, M. V. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-811444-5.00011-7 · Cited by 56 · see citing works
Oloketuyi, S., & Khan, F. (2017) · Current Microbiology · doi:10.1007/s00284-017-1314-y · Cited by 43 · see citing works
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Chen, G., Yang, L., Liu, K., Shen, S., Zhang, Q., Li, H., & Cheng, Y. (2021) · Medical Science Monitor · doi:10.12659/msm.928467 · Cited by 21 · see citing works
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Algburi, A., Zehm, S., Netrebov, V., Weeks, R. M., Zubovskiy, K., & Chikindas, M. L. (2018) · Infectious Diseases in Obstetrics and Gynecology · doi:10.1155/2018/1426109 · Cited by 18 · see citing works
Ding, T., Li, X., Zhan, H., Li, Y., Li, Z., & Deng, Y. (2024) · Food Science and Human Wellness · doi:10.26599/fshw.2024.9250337 · Cited by 12 · see citing works
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Li, H., He, B., Ma, N., Liu, C., Cai, K., Zhang, X., & Ma, X. (2025) · Microbiological Research · doi:10.1016/j.micres.2025.128102 · Cited by 12 · see citing works
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Aljohani, A. M., Chami, C. E., Alhubail, M., Ledder, R. G., O’Neill, C. A., & McBain, A. J. (2023) · Frontiers in Microbiology · doi:10.3389/fmicb.2023.1108273 · Cited by 11 · see citing works
Roy, A., Varshney, U., & Pal, D. (2014) · Journal of Biosciences · doi:10.1007/s12038-014-9453-9 · Cited by 3 · see citing works
Yang, H., Zhu, L., Zhi, J., & Zhong, Q. (2026) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.5c17992 · Cited by 2 · see citing works
Chaichana, N., Sukpondma, Y., Sermwittayawong, D., & Sermwittayawong, N. (2024) · Sains Malaysiana · doi:10.17576/jsm-2024-5312-13 · Cited by 2 · see citing works
Strategies to Combat Microbial Hazards Associated with Fresh Produce
Ölmez, H. (2015) · Cited by 2 · see citing works
Probiotics: multifunctional microorganisms for human health and biotechnological applications
Ali, M., Srivastava, A., & Arora, P. K. (2026) · Frontiers in Microbiology · doi:10.3389/fmicb.2026.1847515 · Cited by 1 · see citing works
Săndulescu, O., Streinu‐Cercel, A., Săndulescu, M., & Streinu‐Cercel, A. (2019) · Springer eBooks · doi:10.1007/978-3-030-19958-6_11
Vijayan, N. K., Tanimu, H., & Sukumaran, B. O. (2025) · Folia Microbiologica · doi:10.1007/s12223-025-01395-w
Chen, Y., Zheng, H., Huang, W., Chen, S., Jiang, Y., Zhang, S., & Liu, P. (2026) · Frontiers in Microbiology · doi:10.3389/fmicb.2026.1953186
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Obry, L., & Brosse, A. (2026) · Anaerobe · doi:10.1016/j.anaerobe.2026.103085
- Authors
- Kim, Y., Lee, J. W., Kang, S.-G., Oh, S., & Griffiths, M. W.
- Affiliations
- Jeonbuk National University (KR)
- Chonnam National University (KR)
- Corresponding author
- Oh, Sejong
- Venue
- Anaerobe
- Publisher
- Elsevier BV
- Published
- 2012-10
- Volume
- 18
- Issue
- 5
- Pages
- 539-545
- ISSN
- 1075-9964 (ISSN-L)
- OpenAlex
- W2041438860
- Cited by
- 41
- References
- 45
- Citations by year
- 2026: 4 · 2025: 3 · 2024: 5 · 2023: 3 · 2022: 4 · 2021: 3 · 2019: 3 · 2018: 3 · 2017: 5 · 2015: 3 · 2014: 2 · 2013: 3
- FWCI
- 1.61
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Anaerobe (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Endocrinology › Escherichia coli research studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bacterial biofilms and quorum sensing
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
- Keywords
- Bifidobacterium longum, Escherichia coli O157:H7, autoinducer-2, quorum sensing, biofilm formation, enterohemorrhagic Escherichia coli, virulence attenuation, Caenorhabditis elegans, proteomics, NifU, DsbA
- MeSH terms
- Adult, Animals, Anti-Bacterial Agents, Bifidobacterium, Disease Models, Animal, Escherichia coli Infections, Homoserine, Humans, Infant, Lactones, Vibrio, Survival Analysis, Caenorhabditis elegans, Biofilms, Escherichia coli O157, Proteome, Escherichia coli Proteins, Microbial Interactions
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