Multinational experience with hypersensitivity drug reactions in Latin America.
Abstract
Background Epidemiologic drug allergy data from Latin America are scarce, and there are no studies on specific procedures focusing on this topic in Latin America.Objective To assess the clinical characteristics and management of hypersensitivity drug reactions in different Latin American countries.Methods An European Network of Drug Allergy questionnaire survey was implemented in 22 allergy units in 11 Latin American countries to report on consecutive patients who presented with a suspected hypersensitivity drug reaction. Each unit used its own protocols to investigate patients.Results Included were 868 hypersensitivity drug reactions in 862 patients (71% of adults and elderly patients were women and 51% of children were girls, P = .0001). Children presented with less severe reactions than adults and elderly patients (P < .0001). Urticaria and angioedema accounted for the most frequent clinical presentations (71%), whereas anaphylaxis was present in 27.3% of cases. There were no deaths reported. Nonsteroidal anti-inflammatory drugs (52.3%), β-lactam antibiotics (13.8%), and other antibiotics (10.1%) were the drugs used most frequently. Skin prick tests (16.7%) and provocation tests (34.2%) were the study procedures most commonly used. A large proportion of patients were treated in the emergency department (62%) with antihistamines (68%) and/or corticosteroids (53%). Only 22.8% of patients presenting with anaphylaxis received epinephrine.Conclusion Nonsteroidal anti-inflammatory drugs and antibiotics were the drugs used in at least 75% of patients. More than half the reactions were treated in the emergency department, whereas epinephrine was administered in fewer than 25% of patients with anaphylaxis. Dissemination of guidelines for anaphylaxis among primary and emergency department physicians should be encouraged.
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The prevalence of reported penicillin allergy in low-income countries is unknown; however, limited data indicate that penicillin is one of the most frequently reported antibiotic allergies.
“The prevalence of reported penicillin allergy in low-income countries is unknown; however, limited data indicate that penicillin is one of the most frequently reported antibiotic allergies (661).”
From Sexually Transmitted Infections Treatment Guidelines, 2021 (2021) · cites this paper as [661]
Cites
Sampson, H. A., Muñoz‐Furlong, A., Campbell, R. L., Adkinson, N. F., Bock, S. A., Branum, A. M., Brown, S. G. A., Camargo, C. A., Cydulka, R. K., Galli, S. J., et al. (2006) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2005.12.1303 · Cited by 2,308 · see citing works
Preventability and severity assessment in reporting adverse drug reactions
Hartwig, S. C., Siegel, J., & Schneider, P. J. (1992) · American Journal of Health-System Pharmacy · doi:10.1093/ajhp/49.9.2229 · Cited by 929 · see citing works
Complement activation-related pseudoallergy: A new class of drug-induced acute immune toxicity
Szebeni, J. (2005) · Toxicology · doi:10.1016/j.tox.2005.07.023 · Cited by 610 · see citing works
2015 update of the evidence base: World Allergy Organization anaphylaxis guidelines
Simons, F. E. R., Ebisawa, M., Sánchez‐Borges, M., Thong, B. Y., Worm, M., Tanno, L. K., Lockey, R. F., El‐Gamal, Y., Brown, S. G. A., Park, H., et al. (2015) · World Allergy Organization Journal · doi:10.1186/s40413-015-0080-1 · Cited by 591 · see citing works
Self-citationWorld Allergy Organization anaphylaxis guidelines: Summary
Simons, F. E. R., Ardusso, L., Bilò, M. B., El‐Gamal, Y., Ledford, D. K., Ring, J., Sánchez‐Borges, M., Senna, G., Sheikh, A., & Thong, B. Y. (2011) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2011.01.038 · Cited by 565 · see citing works
Self-citationAnaphylaxis during anesthesia in France: An 8-year national survey
Mertès, P., Alla, F., Tréchot, P., Auroy, Y., & Jougla, É. (2011) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2011.03.003 · Cited by 395 · see citing works
Epidemiology and risk factors for drug allergy
Thong, B. Y., & Tan, T. C. (2010) · British Journal of Clinical Pharmacology · doi:10.1111/j.1365-2125.2010.03774.x · Cited by 393 · see citing works
Drug-Induced Cutaneous Reactions
Bigby, M. E. (1986) · JAMA · doi:10.1001/jama.1986.03380240052027 · Cited by 366 · see citing works
Caubet, J., Kaiser, L., Lemaître, B., Fellay, B., Gervaix, A., & Eigenmann, P. (2010) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2010.08.025 · Cited by 343 · see citing works
Self-reported antibiotic allergy incidence and prevalence: age and sex effects.
Macy, E., & Poon K-Y, T. (2009) · The American Journal of Medicine · doi:10.1016/j.amjmed.2009.01.034 · Cited by 313 · see citing works
Messaad, D., Sahla, H., Benahmed, S., Godard, P., Bousquet, J., & Demoly, P. M. (2004) · Annals of Internal Medicine · doi:10.7326/0003-4819-140-12-200406150-00009 · Cited by 298 · see citing works
Incidence and Characteristics of Angioedema Associated With Enalapril
Kostis, J. B., Kim, H. J., Rusnak, J., Casale, T., Kaplan, A., Corren, J., & Levy, E. (2005) · Archives of Internal Medicine · doi:10.1001/archinte.165.14.1637 · Cited by 291 · see citing works
Drug hypersensitivity: questionnaire
Demoly, P. M., Kropf, R., Pichler, W. J., et al. (1999) · Allergy · doi:10.1034/j.1398-9995.1999.00247.x · Cited by 280 · see citing works
World Allergy Organization Anaphylaxis Guidelines: 2013 update of the evidence base
Simons, F. E. R., Ardusso, L. R. F., Dimov, V., Ebisawa, M., El-Gamal, Y. M., Lockey, R. F., Sanchez-Borges, M., Senna, G. E., Sheikh, A., Thong, B. Y., et al. (2013) · International Archives of Allergy and Immunology · doi:10.1159/000354543 · Cited by 269 · see citing works
Doña, I., Blanca‐López, N., Torres, M. J., García-Campos, J., García-Núñez, I., Gómez, F., Salas, M. L., Rondón, C., Canto, M. G., & Blanca, M. (2012) · PubMed · Cited by 263 · see citing works
Simons, F. E. R., Ardusso, L., Bilò, M. B., Dimov, V. V., Ebisawa, M., El‐Gamal, Y., Ledford, D. K., Lockey, R. F., Ring, J., Sánchez‐Borges, M., et al. (2012) · Current Opinion in Allergy and Clinical Immunology · doi:10.1097/aci.0b013e328355b7e4 · Cited by 259 · see citing works
Self-citationBSACI guidelines for the management of drug allergy
Mirakian, R. M., Ewan, P. W., Durham, S. R., Youlten, L. J. F., Dugué, P., Friedmann, P. S., English, J. S. C., Huber, P. A. J., & Nasser, S. M. (2009) · Clinical & Experimental Allergy · doi:10.1111/j.1365-2222.2008.03155.x · Cited by 240 · see citing works
Angioedema Incidence in US Veterans Initiating Angiotensin-Converting Enzyme Inhibitors
Miller, D. R., Oliveria, S. A., Berlowitz, D. R., Fincke, B. G., Stang, P., & Lillienfeld, D. E. (2008) · Hypertension · doi:10.1161/hypertensionaha.108.110270 · Cited by 238 · see citing works
Doña, I., Blanca‐López, N., Cornejo-García, J. A., Torres, M. J., Laguna, J. J., Fernández, J., Rosado, A., Rondón, C., Campo, P., Agúndez, J. A. G., et al. (2010) · Clinical & Experimental Allergy · doi:10.1111/j.1365-2222.2010.03651.x · Cited by 224 · see citing works
Drug allergy claims in children: from self‐reporting to confirmed diagnosis
Gomes, E. R., Fonseca, J., Araújo, L. M., et al. (2007) · Clinical & Experimental Allergy · doi:10.1111/j.1365-2222.2007.02870.x · Cited by 178 · see citing works
Zuraw, B. L., Bernstein, J. A., Lang, D. M., Craig, T., Dreyfus, D. H., Hsieh, F. H., Khan, D. A., Sheikh, J. K., Weldon, D., Bernstein, D. I., et al. (2013) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2013.03.034 · Cited by 171 · see citing works
Self-citationAdverse Drug Reactions Among Children Over a 10-Year Period
Lê, J., Nguyen, T., Law, A. V., & Hodding, J. (2006) · PEDIATRICS · doi:10.1542/peds.2005-2429 · Cited by 166 · see citing works
Torres, M. J., Ariza, A., Mayorga, C., Doña, I., Blanca‐López, N., Rondón, C., & Blanca, M. (2010) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2009.11.032 · Cited by 146 · see citing works
Renaudin, J., Beaudouin, É., Ponvert, C., et al. (2013) · Allergy · doi:10.1111/all.12168 · Cited by 138 · see citing works
Results of drug hypersensitivity evaluations in a large group of children and adults
Rubio, M., Bousquet, P., Gomes, E. R., Romano, A. G., & Demoly, P. M. (2011) · Clinical & Experimental Allergy · doi:10.1111/j.1365-2222.2011.03887.x · Cited by 126 · see citing works
Adkinson, N. F., Essayan, D. M., Gruchalla, R. S., Haggerty, H. G., Kawabata, T. T., Sandler, J. D., Updyke, L. W., Shear, N. H., & Wierda, D. (2002) · Journal of Allergy and Clinical Immunology · doi:10.1067/mai.2002.122214 · Cited by 87 · see citing works
Raja, A. S., Lindsell, C. J., Bernstein, J. A., Codispoti, C. D., & Moellman, J. J. (2009) · Annals of Emergency Medicine · doi:10.1016/j.annemergmed.2008.12.034 · Cited by 84 · see citing works
Self-citationBanerji, A., Rudders, S. A., Clark, S., et al. (2013) · The Journal of Allergy and Clinical Immunology In Practice · doi:10.1016/j.jaip.2013.08.012 · Cited by 83 · see citing works
Classification and epidemiology of hypersensitivity drug reactions
Demoly, P. M., & Hillaire‐Buys, D. (2004) · Immunology and Allergy Clinics of North America · doi:10.1016/j.iac.2004.03.010 · Cited by 75 · see citing works
Consumption of medicines among adolescent students: a concern
da Silva, C. H., & Giugliani, E. R. J. (2004) · Jornal de Pediatria · doi:10.2223/jped.1208 · Cited by 69 · see citing works
Angiotensin-Converting Enzyme Inhibitors and Angioedema
Sánchez‐Borges, M., & González-Aveledo, L. (2010) · Allergy Asthma and Immunology Research · doi:10.4168/aair.2010.2.3.195 · Cited by 67 · see citing works
Self-citationGamboa, P. M. (2009) · PubMed · Cited by 66 · see citing works
General and epidemiological aspects of allergic drug reactions.
Barranco, P., & Mc, L.-S. (1998) · PubMed · Cited by 61 · see citing works
Thong, B. Y., Mirakian, R. M., Castells, M., Pichler, W. J., Romano, A. G., Bonadonna, P., Deleanu, D. M., Kowalski, M. L., Yáñez, A., Lleonart, R., et al. (2011) · World Allergy Organization Journal · doi:10.1097/wox.0b013e31823dc02c · Cited by 59 · see citing works
Self-citationAdverse effects of orally administered ampicillin
Bass, J. W., Crowley, D. M., Steele, R. W., et al. (1973) · The Journal of Pediatrics · doi:10.1016/s0022-3476(73)80328-2 · Cited by 54 · see citing works
Challenge-proven nonsteroidal anti-inflammatory drug hypersensitivity in children
Yılmaz, Ö., Karagöl, İ. H. E., Bakırtaş, A., et al. (2013) · Allergy · doi:10.1111/all.12266 · Cited by 52 · see citing works
Risk of skin reactions when using ibuprofen-based medicines
Sánchez‐Borges, M., Capriles-Hulett, A., & Caballero-Fonseca, F. (2005) · Expert Opinion on Drug Safety · doi:10.1517/14740338.4.5.837 · Cited by 44 · see citing works
Self-citationOutcomes and safety of drug provocation tests
Aun, M. V., Bisaccioni, C., Garro, L. S., et al. (2011) · Allergy and Asthma Proceedings · doi:10.2500/aap.2011.32.3450 · Cited by 33 · see citing works
Adverse drug effects and angioedema hospitalizations in the United States from 2000 to 2009
Lin, R. Y.-W., Levine, R. J., & Lin, H. K. (2013) · Allergy and Asthma Proceedings · doi:10.2500/aap.2013.34.3618 · Cited by 26 · see citing works
Droste, J. C., & Narayan, N. (2012) · PubMed · Cited by 25 · see citing works
Usefulness of drug provocation tests in children with a history of adverse drug reaction
Na, H. R., Lee, J. M., Jung, J. W., & Lee, S. (2011) · Korean Journal of Pediatrics · doi:10.3345/kjp.2011.54.7.304 · Cited by 20 · see citing works
Çelík, G., Karakaya, G., Öztürk, A. B., et al. (2013) · Allergologia et Immunopathologia · doi:10.1016/j.aller.2013.07.007 · Cited by 19 · see citing works
Betancourt, B. Y., Marrero-Miragaya, M. A., Jiménez-López, G., et al. (2005) · BMC Clinical Pharmacology · doi:10.1186/1472-6904-5-5 · Cited by 18 · see citing works
Reasons for outpatient consultation in allergy/immunology
Dietrich, J. J., Quinn, J. M., & England, R. W. (2009) · Allergy and Asthma Proceedings · doi:10.2500/aap.2009.30.3195 · Cited by 15 · see citing works
Drug hypersensitivity in students from São Paulo, Brazil
Ensina, L. F., Amigo, M. H. L., Koch, T., et al. (2010) · Clinics · doi:10.1590/s1807-59322010001000014 · Cited by 11 · see citing works
Self-citationManagement of acute food allergic reactions by general practitioners.
Klemans, R. J. B., Le, T.-M., Sigurdsson, V., et al. (2013) · PubMed · Cited by 10 · see citing works
Epidemiology of Drug Hypersensitivity Reactions in an Allergy Service
Kilimajer, J., Alava, C., Herrero, T., et al. (2011) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2010.12.1004 · Cited by 1 · see citing works
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Sexually Transmitted Infections Treatment Guidelines, 2021
Workowski, K. A., Bachmann, L. H., Chan, P. A., Johnston, C. M., Muzny, C. A., Park, I., Reno, H., Zenilman, J. M., & Bolan, G. A. (2021) · MMWR. Recommendations and Reports · doi:10.15585/mmwr.rr7004a1 · Cited by 2,759 · see citing works
- Authors
- Jares, E. J., Sánchez-Borges, M., Cardona-Villa, R., Ensina, L. F., Arias-Cruz, A., Gómez, M., Barayazarra, S., Bernstein, J. A., Serrano, C. D., Cuello, M. N., Morfin-Maciel, B. M., De Falco, A., & Cherrez-Ojeda, I.
- Affiliations
- University of Cincinnati (US)
- Fundación Valle del Lili (CO)
- Corresponding author
- Jares, Edgardo José
- Venue
- Annals of Allergy, Asthma & Immunology
- Publisher
- Elsevier BV
- Published
- 2014-09
- Volume
- 113
- Issue
- 3
- Pages
- 282-289
- ISSN
- 1081-1206 (ISSN-L)
- OpenAlex
- W2070045958
- Cited by
- 48
- References
- 48
- Citations by year
- 2025: 1 · 2024: 1 · 2023: 2 · 2022: 7 · 2021: 4 · 2020: 4 · 2019: 3 · 2018: 9 · 2017: 3 · 2016: 6 · 2015: 5 · 2013: 2
- FWCI
- 3.40
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Annals of Allergy Asthma & Immunology (publishedVersion)
- PubMed (publishedVersion)
- UNIFESP Institutional Repository (Universidade Federal de São Paulo) (submittedVersion)
- Funders
- Universidad Autónoma de Nuevo León
- Universidad de León
- Topics
- Health Sciences › Medicine › Pharmacology › Drug-Induced Adverse Reactions
- Health Sciences › Medicine › Immunology and Allergy › Food Allergy and Anaphylaxis Research
- Health Sciences › Medicine › Dermatology › Contact Dermatitis and Allergies
- Keywords
- anaphylaxis, urticaria, angioedema, nonsteroidal anti-inflammatory drugs, beta-lactam antibiotics, antibiotic allergy, skin testing, provocation tests, epinephrine, emergency department management, Latin America
- MeSH terms
- Adolescent, Adult, Aged, Aged, 80 and over, Child, Child, Preschool, Cross-Sectional Studies, Drug Hypersensitivity, Female, Humans, Hypersensitivity, Infant, Latin America, Male, Middle Aged, Severity of Illness Index, Young Adult
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