Potential association of mast cells with coronavirus disease 2019
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TMPRSS2 is also required for SARS-CoV and Middle Eastern respiratory syndrome coronavirus viral entry.
“TMPRSS2 is also required for SARS-CoV and Middle Eastern respiratory syndrome coronavirus viral entry.”
From COVID-19, Myocarditis and Pericarditis (2023) · cites this paper as [10]
In the main text (page unavailable), the paper says TMPRSS2 is required for coronavirus spike-protein priming in its discussion of SARS-CoV-2. It does not say that TMPRSS2 is required for SARS-CoV or Middle East respiratory syndrome coronavirus entry; searches for those viruses found no such passage. (LLM, conf=0.84)
Experimental — accuracy not yet measuredTMPRSS2 is also expressed on endothelial cells and pericytes.
“TMPRSS2 is also expressed on endothelial cells and pericytes.”
From COVID-19, Myocarditis and Pericarditis (2023) · cites this paper as [10]
The main text says mast cells express TMPRSS2, but does not say endothelial cells or pericytes express it. A separate passage mentions endothelial cells only in relation to their communication with mast cells. Searches for TMPRSS2 with endothelial cells and pericytes found no passage addressing the claimed expression in those cells; page numbers were not available in our copy. (LLM, conf=0.74)
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Cites
Multisystem Inflammatory Syndrome in U.S. Children and Adolescents
Feldstein, L. R., Rose, E. B., Horwitz, S. M., Collins, J. P., Newhams, M. M., Son, M. B. F., Newburger, J. W., Kleinman, L. C., Heidemann, S. M., Martin, A., et al. (2020) · New England Journal of Medicine · doi:10.1056/nejmoa2021680 · Cited by 2,660 · see citing works
Mast cell activation syndrome: Proposed diagnostic criteria
Akin, C., Valent, P., & Metcalfe, D. D. (2010) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2010.08.035 · Cited by 327 · see citing works
COVID ‐19, pulmonary mast cells, cytokine storms, and beneficial actions of luteolin
Theoharides, T. C. (2020) · BioFactors · doi:10.1002/biof.1633 · Cited by 139 · see citing works
Self-citationMotta, J. D. S., Miggiolaro, A. F. R. D. S., Nagashima, S., de Paula, C. B. V., Baena, C. P., Scharfstein, J., & de Noronha, L. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.574862 · Cited by 107 · see citing works
Ciprandi, G., Licari, A., Filippelli, G., et al. (2020) · Annals of Allergy Asthma & Immunology · doi:10.1016/j.anai.2020.06.001 · Cited by 27 · see citing works
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COVID-19, Myocarditis and Pericarditis
Fairweather, D., Beetler, D. J., Di Florio, D. N., Musigk, N., Heidecker, B., & Cooper, L. T. (2023) · Circulation Research · doi:10.1161/circresaha.123.321878 · Cited by 181 · see citing works
- Authors
- Theoharides, T. C.
- Affiliations
- Tufts University (US)
- Corresponding author
- Theoharides, Theoharis C.
- Venue
- Annals of Allergy, Asthma & Immunology
- Publisher
- Elsevier BV
- Published
- 2021-03
- Volume
- 126
- Issue
- 3
- Pages
- 217-218
- ISSN
- 1081-1206 (ISSN-L)
- PMC
- PMC7644430
- OpenAlex
- W3094895445
- Cited by
- 87
- References
- 5
- Citations by year
- 2026: 7 · 2025: 5 · 2024: 7 · 2023: 24 · 2022: 14 · 2021: 29 · 2020: 1
- FWCI
- 5.95
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Annals of Allergy Asthma & Immunology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Mast cells and histamine
- Health Sciences › Medicine › Infectious Diseases › COVID-19 Clinical Research Studies
- Health Sciences › Medicine › Physiology › Asthma and respiratory diseases
- Keywords
- mast cells, COVID-19 pandemic, SARS-CoV-2, pulmonary sequelae, systemic symptoms
- MeSH terms
- COVID-19, SARS-CoV-2, COVID-19 Drug Treatment, Cell Communication, Cholecalciferol, Cyproheptadine, Cromolyn Sodium, Histamine, Histamine Antagonists, Humans, Lung, Macrophages, Mast Cells, Severity of Illness Index, Substance P, Famotidine, Cytokines, Luteolin
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