The DOI matches its Crossref record; 144 of the 144 references it cites were found in a registry or an index.
Human ovarian follicular development: From activation of resting follicles to preovulatory maturation
Abstract
By integrating morphometrical and endocrinological data, as well as biological effects of various molecules synthesized by the human follicle, we propose a dynamic view of the follicle growth within the human ovary. Folliculogenesis starts with entry of resting follicles into the growth phase, a process where the kit system plays a key role. Several months are required for a new growing follicle to reach the preantral stage (0.15mm), then 70 additional days to reach the size of 2mm. Early growing follicle growth is regulated by subtle interactions between follicle-stimulating hormone (FSH) and local factors produced by theca and granulosa cells (GCs), as well as the oocyte. From the time they enter the selectable stage during the late luteal phase, follicles become sensitive to cyclic changes of FSH in terms of granulosa cell proliferation. During the early follicular phase, the early selected follicle grows very quickly and estradiol is present in the follicular fluid. However, the total steroid production remains moderate. From the mid-follicular phase, the preovulatory follicle synthesizes high quantities of estradiol, then after the mid-cycle gonadotropin surge, very large amounts of progesterone. At this stage of development, the responsiveness of the follicle to gonadotropins is maximum, especially to luteinizing hormone (LH) that triggers granulosa wall dissociation and cumulus expansion as well as oocyte nuclear maturation. Thus, as the follicle develops, its responsiveness to gonadotropins progressively increases under the control of local factors acting in an autocrine/paracrine fashion.
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“FSHB encodes the beta polypeptide of FSH, a glycoprotein hormone that plays a central role in ovarian folliculogenesis46.”
From Meta-analysis identifies five novel loci associated with endometriosis highlighting key genes involved in hormone metabolism (2017) · cites this paper as [46]
In the citing paper
“They both play central roles in regulating follicle development in the ovary, influencing oestradiol release during the proliferative phase of the cycle46 and contributing to a role for estradiol in endometriosis risk.”
From Meta-analysis identifies five novel loci associated with endometriosis highlighting key genes involved in hormone metabolism (2017) · cites this paper as [46]
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Cites
Growth differentiation factor-9 is required during early ovarian folliculogenesis
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Livebirth after orthotopic transplantation of cryopreserved ovarian tissue
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Regulation of ovarian follicular development in primates: facts and hypotheses
GOUGEON, A. (1996) · Endocrine Reviews · doi:10.1210/edrv-17-2-121 · Cited by 1,497
Self-citationAccelerated disappearance of ovarian follicles in mid-life: implications for forecasting menopause
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Self-citationFollicle stimulating hormone is required for ovarian follicle maturation but not male fertility
Kumar, T. R., Wang, Y., Lu, N., & Matzuk, M. M. (1997) · Nature Genetics · doi:10.1038/ng0297-201 · Cited by 1,351
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A quantitative and cytological study of germ cells in human ovaries
Baker, T. G. (1963) · Proceedings of the Royal Society B Biological Sciences · doi:10.1098/rspb.1963.0055 · Cited by 1,094
EGF-Like Growth Factors As Mediators of LH Action in the Ovulatory Follicle
Park, J.-Y., Su, Y., Ariga, M., Law, E. C., Jin, S.-L. C., & Conti, M. (2004) · Science · doi:10.1126/science.1092463 · Cited by 1,047
Suppression of Ovarian Follicle Activation in Mice by the Transcription Factor Foxo3a
Castrillón, D. H., Miao, L., Kollipara, R., Horner, J. W., & DePinho, R. A. (2003) · Science · doi:10.1126/science.1086336 · Cited by 984
The Mammalian Ovary from Genesis to Revelation
Edson, M. A., Nagaraja, A. K., & Matzuk, M. M. (2009) · Endocrine Reviews · doi:10.1210/er.2009-0012 · Cited by 869
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Ovarian antral folliculogenesis during the human menstrual cycle: A review
Baerwald, A. R., Adams, G. P., & Pierson, R. A. (2012) · Human Reproduction Update · doi:10.1093/humupd/dmr039 · Cited by 487
Sapkota, Y., Steinthorsdottir, V., Morris, A. P., Fassbender, A., Rahmioglu, N., De Vivo, I., Buring, J. E., Zhang, F., Edwards, T. L., Jones, S., et al. (2017) · Nature Communications · doi:10.1038/ncomms15539 · Cited by 344
The genetic basis of endometriosis and comorbidity with other pain and inflammatory conditions
Rahmioğlu, N., Mortlock, S., Ghiasi, M., Møller, P. L., Stefánsdóttir, L., Galarneau, G., Turman, C., Danning, R., Law, M. H., Sapkota, Y., et al. (2023) · Nature Genetics · doi:10.1038/s41588-023-01323-z · Cited by 319
Autophagy in ovary and polycystic ovary syndrome: role, dispute and future perspective
Kumariya, S., Ubba, V., Jha, R. K., & Gayen, J. R. (2021) · Autophagy · doi:10.1080/15548627.2021.1938914 · Cited by 306
Modeling menopause: The utility of rodents in translational behavioral endocrinology research
Koebele, S. V., & Bimonte‐Nelson, H. A. (2016) · Maturitas · doi:10.1016/j.maturitas.2016.01.015 · Cited by 296
Metadata
- Authors
- Gougeon, A.
- Affiliations
- Inserm (FR)
- Corresponding author
- Gougeon, A.
- Venue
- Annales d'Endocrinologie
- Publisher
- Elsevier BV
- Published
- 2010-05
- Volume
- 71
- Issue
- 3
- Pages
- 132-143
- ISSN
- 0003-4266 (ISSN-L)
- OpenAlex
- W2120987058
- Cited by
- 257
- References
- 144
- Citations by year
- 2026: 9 · 2025: 25 · 2024: 35 · 2023: 18 · 2022: 24 · 2021: 20 · 2020: 18 · 2019: 15 · 2018: 11 · 2017: 14 · 2016: 8 · 2015: 8 · 2014: 8 · 2013: 12 · 2012: 17
- FWCI
- 13.62
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Annales d Endocrinologie (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Reproductive Biology and Fertility
- Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
- Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Reproductive Physiology in Livestock
- Keywords
- folliculogenesis, follicle activation, KIT signaling, follicle-stimulating hormone, luteinizing hormone, granulosa cell proliferation, estradiol, progesterone, cumulus expansion, oocyte nuclear maturation, follicle selection, autocrine and paracrine regulation, gonadotropins, follicle morphometry
- MeSH terms
- Aging, Cell Differentiation, Cell Division, Female, Follicle Stimulating Hormone, Ovarian Follicle, Granulosa Cells, Humans, Menstrual Cycle, Oocytes, Ovary, Ovulation, Anti-Mullerian Hormone
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