The DOI matches its Crossref record; 47 of the 47 references it cites were found in a registry or an index.
The broad spectrum antiviral ivermectin targets the host nuclear transport importin α/β1 heterodimer
Abstract
Infection by RNA viruses such as human immunodeficiency virus (HIV)-1, influenza, and dengue virus (DENV) represent a major burden for human health worldwide. Although RNA viruses replicate in the infected host cell cytoplasm, the nucleus is central to key stages of the infectious cycle of HIV-1 and Influenza, and an important target of DENV nonstructural protein 5 (NS5) in limiting the host antiviral response. We previously identified the small molecule ivermectin as an inhibitor of HIV-1 integrase nuclear entry, subsequently showing ivermectin could inhibit DENV NS5 nuclear import, as well as limit infection by viruses such as HIV-1 and DENV. We show here that ivermectin's broad spectrum antiviral activity relates to its ability to target the host importin (IMP) α/β1 nuclear transport proteins responsible for nuclear entry of cargoes such as integrase and NS5. We establish for the first time that ivermectin can dissociate the preformed IMPα/β1 heterodimer, as well as prevent its formation, through binding to the IMPα armadillo (ARM) repeat domain to impact IMPα thermal stability and α-helicity. We show that ivermectin inhibits NS5-IMPα interaction in a cell context using quantitative bimolecular fluorescence complementation. Finally, we show for the first time that ivermectin can limit infection by the DENV-related West Nile virus at low (μM) concentrations. Since it is FDA approved for parasitic indications, ivermectin merits closer consideration as a broad spectrum antiviral of interest.
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Cites
The global distribution and burden of dengue
Bhatt, S., Gething, P. W., Brady, O. J., Messina, J. P., Farlow, A. W., Moyes, C. L., Drake, J. M., Brownstein, J. S., Hoen, A. G., Sankoh, O., et al. (2013) · Nature · doi:10.1038/nature12060 · Cited by 10,037
Schuck, P. (2000) · Biophysical Journal · doi:10.1016/s0006-3495(00)76713-0 · Cited by 3,868
Analytical ultracentrifugation in biochemistry and polymer science
(1995) · Analytica Chimica Acta · doi:10.1016/0003-2670(95)90401-8 · Cited by 1,980
Refining the Global Spatial Limits of Dengue Virus Transmission by Evidence-Based Consensus
Brady, O. J., Gething, P. W., Bhatt, S., Messina, J. P., Brownstein, J. S., Hoen, A. G., Moyes, C. L., Farlow, A. W., Scott, T. W., & Hay, S. I. (2012) · PLoS Neglected Tropical Diseases · doi:10.1371/journal.pntd.0001760 · Cited by 1,864
Hu, C.-D., Chinenov, Y., & Kerppola, T. K. (2002) · Molecular Cell · doi:10.1016/s1097-2765(02)00496-3 · Cited by 1,549
Nair, H., Brooks, W. A., Katz, M., Roca, A., Berkley, J. A., Madhi, S. A., Simmerman, J. M., Gordon, A., Sato, M., Howie, S., et al. (2011) · The Lancet · doi:10.1016/s0140-6736(11)61051-9 · Cited by 1,006
Kerppola, T. K. (2008) · Annual Review of Biophysics · doi:10.1146/annurev.biophys.37.032807.125842 · Cited by 709
Evaluation of fluorescence-based thermal shift assays for hit identification in drug discovery
Lo, M.-C., Aulabaugh, A., Jin, G., Cowling, R., Bard, J., Malamas, M., & Ellestad, G. (2004) · Analytical Biochemistry · doi:10.1016/j.ab.2004.04.031 · Cited by 684
Wagstaff, K. M., Sivakumaran, H., Heaton, S. M., Harrich, D., & Jans, D. A. (2012) · Biochemical Journal · doi:10.1042/bj20120150 · Cited by 680
Self-citationWang, H., Wolock, T. M., Carter, A., Nguyen, G., Kyu, H. H., Gakidou, E., Hay, S. I., Mills, E. J., Trickey, A., Msemburi, W., et al. (2016) · The Lancet HIV · doi:10.1016/s2352-3018(16)30087-x · Cited by 613
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The FDA-approved drug ivermectin inhibits the replication of SARS-CoV-2 in vitro.
Caly, L., Druce, J. D., Catton, M. G., Jans, D. A., & Wagstaff, K. M. (2020) · Antiviral Research · doi:10.1016/j.antiviral.2020.104787 · Cited by 2,179
Self-citationKory, P., Meduri, G. U., Varon, J., Iglesias, J., & Marik, P. E. (2021) · American Journal of Therapeutics · doi:10.1097/mjt.0000000000001377 · Cited by 203
Ivermectin for preventing and treating COVID-19
Popp, M., Reis, S., Schießer, S., Hausinger, R. I., Stegemann, M., Metzendorf, M.-I., Kranke, P., Meybohm, P., Skoetz, N., & Weibel, S. (2022) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd015017.pub3 · Cited by 169
Ivermectin for preventing and treating COVID-19
Popp, M., Stegemann, M., Metzendorf, M.-I., Kranke, P., Meybohm, P., Skoetz, N., & Weibel, S. (2021) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd015017 · Cited by 31
ADAP restraint of STAT1 signaling regulates macrophage phagocytosis in immune thrombocytopenia
Xiong, Y., Li, Y., Cui, X., Zhang, L., Yang, X., & Liu, H. (2022) · Cellular & Molecular Immunology · doi:10.1038/s41423-022-00881-2 · Cited by 27
Metadata
- Authors
- Yang, S. N. Y., Atkinson, S. C., Wang, C., Lee, A., Bogoyevitch, M. A., Borg, N. A., & Jans, D. A.
- Venue
- Antiviral Research
- Publisher
- Elsevier BV
- Published
- 2020-05
- Volume
- 177
- Pages
- 104760
- ISSN
- 0166-3542 (ISSN-L)
- OpenAlex
- W3009301311
- Cited by
- 322
- References
- 47
- FWCI
- 46.81
- Type
- journal article
- Language
- en
- Open access
- closed
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- Yang, S. N. Y., Atkinson, S. C., Wang, C., Lee, A., Bogoyevitch, M. A., Borg, N. A., & Jans, D. A. (2020). The broad spectrum antiviral ivermectin targets the host nuclear transport importin α/β1 heterodimer. Antiviral Research. https://doi.org/10.1016/j.antiviral.2020.104760
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