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Cited by 146Connective tissue disorders researchMusculoskeletal pain and rehabilitationFibromyalgia and Chronic Fatigue Syndrome Research

Disability in Adolescents and Adults Diagnosed With Hypermobility-Related Disorders: A Meta-Analysis

Scheper, Mark C., Juul-Kristensen, Birgit, Rombaut, Lies, Rameckers, Eugene A., Verbunt, Jeanine, Engelbert, Raoul H.·2016·Archives of Physical Medicine and Rehabilitation
DOI 10.1016/j.apmr.2016.02.015
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Abstract

Objective To (1) establish the association of the most common reported symptoms on disability; and (2) study the effectiveness of treatment on disability in patients with Ehlers-Danlos syndrome-hypermobility type (EDS-HT)/hypermobility syndrome (HMS). Data sources An electronic search (Medical Subject Headings and free-text terms) was conducted in bibliographic databases CENTRAL/MEDLINE. Study selection Comparative, cross-sectional, longitudinal cohort studies and (randomized) controlled trials including patients with HMS/EDS-HT aged ≥17 years were considered for inclusion. A class of symptoms was included when 5 publications were available. In regards to treatment (physical, cognitive interventions), only (randomized) controlled trials were considered. Surgical and medicinal interventions were excluded. Data extraction Bias was assessed according to the methodological scoring tools of the Cochrane collaboration. Z-score transformations were applied to classify the extent of disability in comparison with healthy controls and to ensure comparability between studies. Data synthesis Initially, the electronic search yielded 714 publications, and 21 articles remained for analysis after selection. The following symptoms were included for meta-analysis: pain (n=12), fatigue (n=6), and psychological distress (n=7). Pain (r=.64, P=.021), fatigue (r=.91, P=.011), and psychological distress (r=.86, P=.018) had a significant impact on disability. Regarding treatment, a significant pain r…

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  • To improve, treat and prevent musculoskeletal manifestations of joint hypermobility, education, active participation and active physical therapy intervention are recommended.

    “Generally, to improve, treat and prevent musculoskeletal manifestations of joint hypermobility, the facets of education, active participation and active physical therapy intervention are recommended. [23, 24, 40–43].”

    From Are patients with hypermobile Ehlers–Danlos syndrome or hypermobility spectrum disorder so different? (2021) · cites this paper as [42]

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References 51 · Cited by 146

Authors
Scheper, M. C., Juul-Kristensen, B., Rombaut, L., Rameckers, E. A., Verbunt, J., & Engelbert, R. H.
Affiliations
  • Amsterdam UMC Location University of Amsterdam (NL)
  • Ghent University (BE)
  • Avans University of Applied Sciences (NL)
  • Maastricht University Medical Centre (NL)
Corresponding author
Scheper, Mark C.
ORCID
Venue
Archives of Physical Medicine and Rehabilitation
Publisher
Elsevier BV
Published
2016-12
Volume
97
Issue
12
Pages
2174-2187
ISSN
0003-9993 (ISSN-L)
DOI
10.1016/j.apmr.2016.02.015
OpenAlex
W2293816428
Cited by
146
References
51
Citations by year
2026: 13 · 2025: 17 · 2024: 12 · 2023: 21 · 2022: 11 · 2021: 26 · 2020: 17 · 2019: 10 · 2018: 5 · 2017: 10 · 2016: 3
FWCI
1.25
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Archives of Physical Medicine and Rehabilitation (publishedVersion)
  • PubMed (publishedVersion)
  • University of Southern Denmark Research Portal (University of Southern Denmark) (publishedVersion)
  • Data Archiving and Networked Services (DANS) (submittedVersion)
  • Ghent University Academic Bibliography (Ghent University) (submittedVersion)
  • Research Publications (Maastricht University) (submittedVersion)
  • Pure Amsterdam UMC (submittedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Connective tissue disorders research
  • Health Sciences › Medicine › Pharmacology › Musculoskeletal pain and rehabilitation
  • Health Sciences › Medicine › Psychiatry and Mental health › Fibromyalgia and Chronic Fatigue Syndrome Research
Keywords
Ehlers-Danlos syndrome hypermobility type, hypermobility syndrome, disability, pain, fatigue, psychological distress, physiotherapy, cognitive intervention, adolescents and adults
MeSH terms
Adolescent, Adult, Ehlers-Danlos Syndrome, Fatigue, Persons with Disabilities, Disabled Persons, Humans, Joint Instability, Pain, Stress, Psychological, Syndrome, Observer Variation, Mobility Limitation

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