Effects of leptin on intake of specific micro- and macronutrients in a woman with leptin gene deficiency studied off and on leptin at stable body weight.
Open accessAbstract
In this report, we examine the effects of leptin on the intake of specific macro- and micronutrients in a female patient with leptin gene deficiency. The patient was studied off and on leptin at stable body weight, within the normal to mildly overweight range. The data were obtained by detailed dietary assessments, measuring dietary intakes by weighed food and fluid consumption records, and analyzed using nutrition analysis software. Overall, significant differences were found in the off versus on leptin treatment periods in the following categories: (i) macronutrients: kilocalories, protein, carbohydrates, monounsaturated fats, MFA 18:1 oleic and total fiber; (ii) vitamins: vitamin C, pyridoxine and pantothenic acid; (iii) minerals: potassium, magnesium, copper and chromium; and amino acids: threonine, lysine and histidine. The nutritional data from this study indicates a direct link between the effects of leptin and ingestion of several specific micronutrients. The mechanisms underlying these effects warrant further investigation and study.
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Normal individuals typically show this activity only in the starved state and do not show this response after eating.
“Normal individuals typically show this activity only in the starved state and do not show this response after eating.”
From Leptin at 14 y of age: an ongoing story (2009) · cites this paper as [54]
Leptin-deficient patients show markedly different food preferences and perception of food than do normal individuals.
“In addition, leptin-deficient patients show markedly different food preferences and perception of food than do normal individuals (52)(53)(54).”
From Leptin at 14 y of age: an ongoing story (2009) · cites this paper as [54]
In leptin-deficient subjects, functional magnetic resonance imaging reveals a marked increase in activity in the nucleus accumbens in response to images of food even after eating.
“Consistent with this, functional magnetic resonance imaging of leptin-deficient subjects has revealed a marked increase in activity in the nucleus accumbens in response to images of food even after eating (52)(53)(54).”
From Leptin at 14 y of age: an ongoing story (2009) · cites this paper as [54]
Leptin therapy normalizes the increased accumbens activity after eating in leptin-deficient patients.
“The activity that is seen in the accumbens in leptin-deficient patients after eating was normalized by the use of leptin therapy (52)(53)(54).”
From Leptin at 14 y of age: an ongoing story (2009) · cites this paper as [54]
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Leptin at 14 y of age: an ongoing story
Friedman, J. M. (2009) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.2008.26788b · Cited by 272 · see citing works
- Authors
- Licinio, J., Milane, M., Thakur, S., Whelan, F., Yildiz, B. O., Delibasi, T., de Miranda, P. B., Ozata, M., Bolu, E., DePaoli, A., & Wong, M.-L.
- Affiliations
- University of California, Los Angeles (US)
- Amgen (United States) (US)
- University of Miami (US)
- Venue
- Appetite
- Publisher
- Elsevier BV
- Published
- 2007-11
- Volume
- 49
- Issue
- 3
- Pages
- 594-599
- ISSN
- 0195-6663 (ISSN-L)
- PMC
- PMC2194812
- OpenAlex
- W2059973387
- Cited by
- 22
- References
- 23
- Citations by year
- 2019: 2 · 2016: 1 · 2015: 1 · 2014: 3 · 2013: 2 · 2012: 2
- FWCI
- 0.68
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Appetite (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Hacettepe University Institutional Repository (hacettepe.edu.tr) (submittedVersion, other-oa)
- Funders
- National Heart, Lung, and Blood Institute (K30HL004526, HL04526)
- National Institute of Mental Health (R21MH062777, MH-062777)
- National Human Genome Research Institute (R03HG002500, HG002500)
- National Institute of Diabetes and Digestive and Kidney Diseases (R01DK063240, DK-063240, R01DK058851, DK-58851)
- National Center for Research Resources (RR000865, RR-16996, K24RR017365, M01RR000865, K24RR016996, RR017365)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Social Sciences › Psychology › Clinical Psychology › Eating Disorders and Behaviors
- Keywords
- leptin, dietary intake, macronutrient intake, micronutrient intake, leptin replacement therapy, body weight, women, protein intake, dietary fiber intake, vitamins, minerals, amino acids
- MeSH terms
- Energy Intake, Dietary Carbohydrates, Dietary Fats, Dietary Fiber, Dietary Proteins, Female, Humans, Satiation, Micronutrients, Leptin
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