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Cited by 14Salivary Gland Disorders and FunctionsDysphagia Assessment and ManagementSensory Analysis and Statistical Methods

The DOI matches its Crossref record; 78 of the 78 references it cites were found in a registry or an index.

The relation between stimulated salivary flow and the temporal consumption experience of a liquid oral nutritional supplement

Open access
Lester, S., Hurst, K., Cornacchia, L., Kleijn, M., Ayed, C., Dinu, V., Taylor, M.A., Fisk, I.·2021·Appetite
DOI 10.1016/j.appet.2021.105325PMC PMC8385417
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Abstract

Use of oral nutritional supplements (ONS) in undernourished patients has proven clinical benefits, but this can be hampered by low adherence due to poor experience of palatability. Many patients, particularly older patients, experience hyposalivation which can cause taste changes and reduce the enjoyment of foods. The aim of this study was to investigate differences in the temporal consumption experience (comprising sensory perception, in-mouth aroma release and subjective appetite) of a clinically relevant portion of ONS, for groups differing in saliva flow rates (SFR). The SFR (mL/min) of thirty healthy individuals was measured on three occasions. This data was used to categorise individuals into three groups using quartile analysis: low flow (LF) (0.3-0.6 mL/min, n = 5), medium flow (MF) (0.7-1.2 mL/min, n = 16) and high flow (HF) (1.3-1.8 mL/min, n = 9). Over the consumption of eight 15 mL sips of ONS, individuals rated their sensory perception and subjective appetite perception using line scales. Additionally, in-mouth aroma release was measured for each sip, using atmospheric pressure chemical ionisation (APCI). Compared with the MF and HF group, the LF group reported a significantly greater increase of mouth-drying over increased sips (p = 0.02). The LF group also experienced significantly higher aftertaste perception (p < 0.001), and more intense in-mouth aroma release (p = 0.015), compared with the HF group. These findings occurred concurrently with relatively lower hunger sensations in the LF and MF group. Many patients who are prescribed ONS likely experience reduced salivary flow rates. The unique sensory experiences of these individuals should be considered in order to optimise palatability and nutritional intake.

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  • Based on reported target strain abundance in saliva (<10^7 cells/mL for each target species) and average saliva volume, the total amount of postbiotic cells required for efficient coaggregation was estimated to be 10^9 bacterial cells/g of product.

    “Based on the reported target strain abundance in saliva (<107 cells/mL saliva for each of the target species) [43–46] and the average saliva volume in the mouth under stimulated conditions [47,48], we estimated that the total amount of postbiotic cells required for efficient coaggregation would be 109 bacterial cells/g of product.”

    From Coaggregation of oral pathogens by postbiotic lactobacilli (2025) · cites this paper as [48]

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Research works printed but not linked: 4

  1. Aprea, 2006, Vol. 21, 53
  2. Bolhuis, 2011, Both longer oral sensory exposure to and higher intensity of saltiness decrease ad, Libitum Food Intake in Healthy Normal-Weight Men, 141, 2242
  3. Edgar, 2004, Vol. 146
  4. Odake, 1998, Effect of saliva dilution on the release of diacetyl and 2‐heptanone from cream style dressings, Food, 42, 385

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  • Coaggregation of oral pathogens by postbiotic lactobacilli

    Golletz, P., Jensen, S. D., Collignon, M., Hall, C., Khamas, A. B., Møllebjerg, A., Schlafer, S., Meyer, R. L., & Tykwinska, K. (2025) · Journal of oral microbiology · doi:10.1080/20002297.2025.2508483 · Cited by 10

    “…abundance in saliva ( 10 7 cells/mL saliva for each of the target species) [43–46] and the average saliva volume in the mouth under stimulated conditions [47,48], we estimated that the total amount of postbiotic cells required for efficient coaggregation would be 10 9 bacterial cells/g of product.”

Related

Metadata

Authors
Lester, S., Hurst, K., Cornacchia, L., Kleijn, M., Ayed, C., Dinu, V., Taylor, M. A., & Fisk, I.
Affiliations
  • University of Nottingham (GB)
  • Danone Nutricia Research (Netherlands) (NL)
Corresponding author
Fisk, I.
ORCID
Venue
Appetite
Publisher
Elsevier BV
Published
2021-11
Volume
166
Pages
105325
ISSN
0195-6663 (ISSN-L)
DOI
10.1016/j.appet.2021.105325
PMC
PMC8385417
OpenAlex
W3164827074
Cited by
14
References
78
Citations by year
2026: 3 · 2025: 1 · 2024: 4 · 2023: 3 · 2022: 3
FWCI
1.57
Type
journal article
Language
en
Open access
Licence
Locations
  • Appetite (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, other-oa)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • Repository@Nottingham (University of Nottingham) (submittedVersion, cc-by)
Funders
  • BBSRC
  • Danone Nutricia Medical Nutrition
Topics
  • Health Sciences › Medicine › Physiology (medical) › Salivary Gland Disorders and Functions
  • Health Sciences › Health Professions › Speech and Hearing › Dysphagia Assessment and Management
  • Life Sciences › Agricultural and Biological Sciences › Food Science › Sensory Analysis and Statistical Methods
Keywords
oral nutritional supplements, salivary flow rate, hyposalivation, palatability, sensory perception, aftertaste, subjective appetite, hunger, older adults
MeSH terms
Appetite, Humans, Hunger, Mouth, Dietary Supplements, Malnutrition

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