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Cited by 12Regulation of Appetite and ObesityNeuropeptides and Animal PhysiologyNeuroscience of respiration and sleep

Control of water intake by a pathway from the nucleus of the solitary tract to the paraventricular hypothalamic nucleus

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Volcko, K.L., Brakey, D.J., McNamara, T.E., Meyer, M.J., McKay, N.J., Santollo, J., Daniels, D.·2022·Appetite
DOI 10.1016/j.appet.2022.105943PMC PMC9903207
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Abstract

Several brain areas have been shown to participate in thirst and control of fluid intake. An understanding of how these circuits interact, and their roles in the activation, maintenance, and termination of fluid intake remains incomplete. Central glucagon-like peptide-1 (GLP-1) receptor activation appears to be an important part of the termination of drinking, but the site(s) of action for this suppression has not yet been determined. In an attempt to use GLP-1 responsiveness as a means to screen targets of hindbrain cells that participate in the termination of thirst and the resultant water intake, we injected the GLP-1 receptor agonist exendin-4 (Ex-4) into three brain areas known to express GLP-1 receptors, and measured subsequent water intake. Ex-4 reduced water consumption when injected into the paraventricular hypothalamic nucleus (PVH) and nucleus of the solitary tract (NTS), but not when injected into the nucleus accumbens (NAc). Using the effective response after injection into the PVH as a guide, we examined the connection between the NTS - the site of endogenous central GLP-1 production - and the PVH. Retrograde tracing combined with Fos immunohistochemistry suggested intake-induced activity in PVH-projecting NTS cells. To test the hypothesis that this pathway is important in the termination of drinking, we chemogenetically activated PVH-projecting hindbrain cells. Interestingly, activation of this population of cells increased water intake, calling into question the heterogeneity of the pathway with respect to the control of fluid intake. Taken together, we conclude that the PVH is a site of action for GLP-1 receptor activation in the inhibition of water intake, but suspect that endogenous GLP-1 in NTS-to-PVH projections may be counterbalanced by a parallel pathway that either activates or maintains already activated water intake.

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  • Semaglutide's effects in suppressing consummatory behaviors are not specific to alcohol and might be driven by its ability to reduce appetite and thirst, palatability for sweet, and/or metabolic energy needs and calorie intake.

    “From a mechanistic standpoint, these results suggest that semaglutide’s effects in suppressing consummatory behaviors are not specific to alcohol and might be driven by its ability to reduce appetite and thirst, such as the need for general fluid intake (55–60), palatability for sweet (taste) (61–64), and/or metabolic energy needs and calorie intake (24, 65–68).”

    From The glucagon-like peptide-1 (GLP-1) analogue semaglutide reduces alcohol drinking and modulates central GABA neurotransmission (2023) · cites this paper as [55]

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Authors
Volcko, K. L., Brakey, D. J., McNamara, T. E., Meyer, M. J., McKay, N. J., Santollo, J., & Daniels, D.
Affiliations
  • Buffalo State University (US)
  • University of Kentucky (US)
  • University at Buffalo, State University of New York (US)
Corresponding author
Daniels, D.
ORCID
Venue
Appetite
Publisher
Elsevier BV
Published
2022-05
Volume
172
Pages
105943
ISSN
0195-6663 (ISSN-L)
DOI
10.1016/j.appet.2022.105943
PMC
PMC9903207
OpenAlex
W4210708066
Cited by
12
References
36
Citations by year
2026: 3 · 2025: 4 · 2024: 3 · 2023: 2
FWCI
1.19
Type
journal article
Language
en
Open access
Licence
Locations
  • Appetite (acceptedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
National Institute of Diabetes and Digestive and Kidney Diseases (R01DK107500)
Topics
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroscience of respiration and sleep
Keywords
water intake, thirst, nucleus tractus solitarius, paraventricular nucleus, GLP-1 receptor, exendin-4, retrograde tracing, Fos expression, chemogenetic activation, nucleus accumbens, hindbrain
MeSH terms
Glucagon-Like Peptide-1 Receptor, Drinking, Humans, Paraventricular Hypothalamic Nucleus, Solitary Nucleus, Glucagon-Like Peptide 1

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