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Natural and unnatural anthraquinones isolated from the ethanol extract of the roots of Knoxia valerianoides
Open accessAbstract
Eight new 9,10-anthraquinones (1–8) including three acetonide derivatives of 3-hydroxy-2-hydroxymethyl-9,10-anthraquinones (6–8) were isolated from an ethanol extract of the roots of Knoxia valerianoides. On the basis of chemical transformation reactions of the co-occurring 14 and 15 combined with HPLC–DAD–ESI–MS analysis of the extracts, the previously and newly isolated 2-methoxymethyl- and 2-ethoxymethyl-9,10-anthraquinones (4, 5, and 9–13), as well as the 3-hydroxy-2-hydroxymethyl-9,10-anthraquinone acetonide derivatives (6–8), were shown to be solvolytic artifacts. In the in vitro assays, compound 4 was active to protect hepatocyte (WB-F344) damage.
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“However, extracting anthraquinones at temperatures above 65 °C or over 78 °C in methanol or ethanol based solvents, respectively, for prolonged periods (> 9 h) can result in the formation of artefacts, such as 2-ethoxyethyl or 2-ethoxymethyl groups [33,110].”
From Natural Quinone Dyes: A Review on Structure, Extraction Techniques, Analysis and Application Potential (2021) · cites this paper as [110]
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Research works printed but not linked: 19
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Dulo, B., Phan, K., Githaiga, J., Raes, K., & De Meester, S. (2021) · Waste and Biomass Valorization · doi:10.1007/s12649-021-01443-9 · Cited by 181
“However, extracting anthraquinones at temperatures above 65 °C or over 78 °C in methanol or ethanol based solvents, respectively, for prolonged periods (> 9 h) can result in the formation of artefacts, such as 2-ethoxyethyl or 2-ethoxymethyl groups [33, 110].”
Background
Metadata
- Authors
- Zhao, F., Wang, S., Lin, S., Zhu, C., Yue, Z., Yu, Y., Liu, B., Wu, X., Yang, Y., Li, Y., & Shi, J.
- Affiliations
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Corresponding author
- Wang, Sujuan
- Venue
- Acta Pharmaceutica Sinica B
- Publisher
- Elsevier BV
- Published
- 2012-06
- Volume
- 2
- Issue
- 3
- Pages
- 260-266
- ISSN
- 2211-3835 (ISSN-L)
- OpenAlex
- W1982607381
- Cited by
- 21
- References
- 0
- Citations by year
- 2024: 2 · 2022: 1 · 2021: 3 · 2020: 2 · 2019: 1 · 2018: 1 · 2017: 1 · 2016: 2 · 2015: 6 · 2014: 1 · 2012: 1
- FWCI
- 2.92
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Acta Pharmaceutica Sinica B (publishedVersion, cc-by-nc-nd)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- National Natural Sciences Foundation of China (30825044, 20932007)
- National Science and Technology Project of China (2009ZX09311-004)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Phytochemistry and biological activity of medicinal plants
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Phytochemistry and Biological Activities
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Phytochemistry and Bioactivity Studies
- Keywords
- 9,10-anthraquinone, natural product isolation, hepatoprotection, root extract
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- CoChat. (2026). Citation check: Natural and unnatural anthraquinones isolated from the ethanol extract of the roots of Knoxia valerianoides. https://app.cochat.ai/papers/10.1016/j.apsb.2012.03.004
- The paper
- Zhao, F., Wang, S., Lin, S., Zhu, C., Yue, Z., Yu, Y., Liu, B., Wu, X., Yang, Y., Li, Y., & Shi, J. (2012). Natural and unnatural anthraquinones isolated from the ethanol extract of the roots of Knoxia valerianoides. Acta Pharmaceutica Sinica B. https://doi.org/10.1016/j.apsb.2012.03.004
