The DOI matches its Crossref record; 31 of the 31 references it cites were found in a registry or an index.
Approaches to establish Q-markers for the quality standards of traditional Chinese medicines
Open accessAbstract
Traditional Chinese medicine (TCM) has played a pivotal role in maintaining the health of Chinese people and is now gaining increasing acceptance around the global scope. However, TCM is confronting more and more concerns with respect to its quality. The intrinsic "multicomponent and multitarget" feature of TCM necessitates the establishment of a unique quality and bioactivity evaluation system, which is different from that of the Western medicine. However, TCM is investigated essentially as "herbal medicine" or "natural product", and the pharmacopoeia quality monographs are actually chemical-markers-based, which can ensure the consistency only in the assigned chemical markers, but, to some extent, have deviated from the basic TCM theory. A concept of "quality marker" (Q-marker), following the "property-effect-component" theory, is proposed. The establishment of Q-marker integrates multidisciplinary technologies like natural products chemistry, analytical chemistry, bionics, chemometrics, pharmacology, systems biology, and pharmacodynamics, etc. Q-marker-based fingerprint and multicomponent determination conduce to the construction of more scientific quality control system of TCM. This review delineates the background, definition, and properties of Q-marker, and the associated technologies applied for its establishment. Strategies and approaches for establishing Q-marker-based TCM quality control system are presented and highlighted with a few TCM examples.
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Cites
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Metadata
- Authors
- Yang, W., Zhang, Y., Wu, W., Huang, L., Guo, D., & Liu, C.
- Venue
- Acta Pharmaceutica Sinica B
- Publisher
- Elsevier BV
- Published
- 2017-07
- Volume
- 7
- Issue
- 4
- Pages
- 439-446
- ISSN
- 2211-3835 (ISSN-L)
- OpenAlex
- W2619968329
- Cited by
- 267
- References
- 31
- FWCI
- 28.19
- Type
- journal article
- Language
- en
- Open access
- gold
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- Yang, W., Zhang, Y., Wu, W., Huang, L., Guo, D., & Liu, C. (2017). Approaches to establish Q-markers for the quality standards of traditional Chinese medicines. Acta Pharmaceutica Sinica B. https://doi.org/10.1016/j.apsb.2017.04.012
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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