The DOI matches its Crossref record; 27 of the 27 references it cites were found in a registry or an index.
Network Pharmacology: A Rosetta Stone for Traditional Chinese Medicine
Abstract
Preclinical Research Network pharmacology, based on the theory of systems biology, is a new discipline that analyzes the biological network and screens out the nodes of particular interest, with the aim of designing poly‐target drug molecule. It emphasizes maximizing drug efficacy and minimizing adverse effect via the multiple regulation of the signaling pathway. Coincidentally, almost all traditional C hinese medicine (TCM) and worldwide ethnomedicine exert therapeutic effect by targeting multiple molecules of the human body. In this overview, we offer a critique on the present perception of TCM and network pharmacology; illustrate the utility of network pharmacology in the study of single herb, medicine pair, and TCM formula; and summarize the recent progress of TCM‐based drug discovery inspired by network pharmacology. Network pharmacology could be of great help in decreasing drug attrition rate and thus is essential in rational and cost‐effective drug development. We also pinpoint the current TCM issues that could be tackled by the flexible combined use of network pharmacology and relevant disciplines.
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1 retracted
RETRACTED: Identification of Potent EGFR Inhibitors from TCM Database@Taiwan
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RetractedCytoscape: A software Environment for integrated models of biomolecular interaction networks
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Quantifying the chemical beauty of drugs
Bickerton, G. R., Paolini, G. V., Besnard, J., Muresan, S., & Hopkins, A. L. (2012) · Nature Chemistry · doi:10.1038/nchem.1243 · Cited by 2,242
Liu, X., Ouyang, S., Yu, B., Liu, Y., Huang, K., Gong, J., Zheng, S., Li, Z., Li, H., & Jiang, H. (2010) · Nucleic Acids Research · doi:10.1093/nar/gkq300 · Cited by 967
Chen, C. Y.-C. (2011) · PLoS ONE · doi:10.1371/journal.pone.0015939 · Cited by 806
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TCMID: traditional Chinese medicine integrative database for herb molecular mechanism analysis
Xue, R., Fang, Z., Zhang, M., Yi, Z., Wen, C., & Shi, T. (2012) · Nucleic Acids Research · doi:10.1093/nar/gks1100 · Cited by 617
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Update of TTD: Therapeutic Target Database
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Cited by
Approaches to establish Q-markers for the quality standards of traditional Chinese medicines
Yang, W., Zhang, Y., Wu, W., Huang, L., Guo, D., & Liu, C. (2017) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2017.04.012 · Cited by 267
Metadata
- Authors
- Hao, D. C., & Xiao, P. G.
- Venue
- Drug Development Research
- Publisher
- Wiley
- Published
- 2014-08
- Volume
- 75
- Issue
- 5
- Pages
- 299-312
- ISSN
- 0272-4391 (ISSN-L)
- 1098-2299
- OpenAlex
- W1685675634
- Cited by
- 277
- References
- 27
- FWCI
- 8.37
- Type
- journal article
- Language
- en
- Open access
- closed
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
