Recent progress in drug delivery
Open accessAbstract
Drug delivery systems (DDS) are defined as methods by which drugs are delivered to desired tissues, organs, cells and subcellular organs for drug release and absorption through a variety of drug carriers. Its usual purpose to improve the pharmacological activities of therapeutic drugs and to overcome problems such as limited solubility, drug aggregation, low bioavailability, poor biodistribution, lack of selectivity, or to reduce the side effects of therapeutic drugs. During 2015-2018, significant progress in the research on drug delivery systems has been achieved along with advances in related fields, such as pharmaceutical sciences, material sciences and biomedical sciences. This review provides a concise overview of current progress in this research area through its focus on the delivery strategies, construction techniques and specific examples. It is a valuable reference for pharmaceutical scientists who want to learn more about the design of drug delivery systems.
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There are four kinds of light sensitive groups: photocleavage group, photoisomerization group, photo-induced rearrangement group, and photocrosslinking group.
“According to the different light response mechanism, there are four kinds of light sensitive groups: 1) photocleavage group, such as o-nitrobenzyl and coumarin-based groups, etc. 2) photoisomerization group, such as azobenzenes and spiropyran. 3) photo-induced rearrangement group, such as 2-diazo-1,2-naphthoquinone. 4) photocrosslinking group, such as coumarin, cinnamoyl, anthracene, etc.175,176”
From Smart nanoparticles for cancer therapy (2023) · cites this paper as [175]
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References 225 · Cited by 818
- Authors
- Li, C., Wang, J., Wang, Y., Gao, H., Wei, G., Huang, Y., Yu, H., Gan, Y., Wang, Y., Mei, L., Chen, H., Hu, H., Zhang, Z., & Jin, Y.
- Affiliations
- Southwest University (CN)
- Peking University (CN)
- Shenyang Pharmaceutical University (CN)
- Sichuan University (CN)
- Fudan University (CN)
- Chinese Academy of Sciences (CN)
- Sun Yat-sen University (CN)
- Soochow University (CN)
- Huazhong University of Science and Technology (CN)
- Corresponding author
- Wang, Jiancheng
- ORCID
- Venue
- Acta Pharmaceutica Sinica B
- Publisher
- Elsevier BV
- Published
- 2019-11
- Volume
- 9
- Issue
- 6
- Pages
- 1145-1162
- ISSN
- 2211-3835 (ISSN-L)
- PMC
- PMC6900554
- OpenAlex
- W2969375616
- Cited by
- 818
- References
- 225
- Citations by year
- 2026: 59 · 2025: 104 · 2024: 113 · 2023: 140 · 2022: 143 · 2021: 145 · 2020: 108 · 2019: 5 · 2014: 1
- FWCI
- 6.39
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Acta Pharmaceutica Sinica B (publishedVersion, cc-by-nc-nd)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Funders
- National Natural Science Foundation of China (81773650, 81673376, 81690264)
- Topics
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Drug Solubulity and Delivery Systems
- Keywords
- drug delivery systems, drug carriers, drug release, bioavailability, tissue distribution, drug solubility, drug aggregation, targeted drug delivery, drug delivery methods
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