Why 90% of clinical drug development fails and how to improve it?

Cited by (1,000)

Items 201–300 of 1,000

1. A deep learning based multi-model approach for predicting drug-like chemical compound’s toxicity
   Konda Mani Saravanan, Jiangfan Wan, Liujiang Dai, Jiajun Zhang, John Z. H. Zhang, Haiping Zhang · 2024 · Methods
2. Bioprinted Patient‐Derived Organoid Arrays Capture Intrinsic and Extrinsic Tumor Features for Advanced Personalized Medicine
   Jonghyeuk Han, Hye‐Jin Jeong, Jeonghan Choi, Hyeonseo Kim, Taejoon Kwon, Kyungjae Myung, Kyemyung Park, Jung In Park, Samuel Sánchez, Deok‐Beom Jung et al. · 2025 · Advanced Science
3. Digital Alchemy: The Rise of Machine and Deep Learning in Small-Molecule Drug Discovery
   Abdul Manan, Eunhye Baek, Sidra Ilyas, Donghun Lee · 2025 · International Journal of Molecular Sciences
4. Bridging data and drug development: Machine learning approaches for next-generation ADMET prediction
   Ning Fan, Jing Chen, Jinghui Wang, Zhe‐Sheng Chen, Yinfeng Yang · 2025 · Drug Discovery Today
5. Machine learning prediction of empirical polarity using SMILES encoding of organic solvents
   Vaneet Saini · 2022 · Molecular Diversity
6. A Human Ovarian Tumor & Liver Organ-on-Chip for Simultaneous and More Predictive Toxo-Efficacy Assays
   Arianna Fedi, Chiara Vitale, Marco Fato, Silvia Scaglione · 2023 · Bioengineering
7. Harms with placebo in trials of biological therapies and small molecules as induction therapy in inflammatory bowel disease: a systematic review and meta-analysis
   Shahida Din, Jonathan Philip Segal, Jonathan Blackwell, Beatriz Gros, Christopher J. Black, Alexander Charles Ford · 2024 · The Lancet. Gastroenterology & hepatology
8. Liver organoids: Current advances and future applications for hepatology
   Kim, Yohan, Kang, Minseok, Mamo, Michael Girma, Adisasmita, Michael, Huch, Meritxell, Choi, Dongho · 2025 · Clinical and Molecular Hepatology
9. Exploiting Matrix Stiffness to Overcome Drug Resistance
   Hakan Berk Aydın, Altuğ Özçelikkale, Ahmet Acar · 2024 · ACS Biomaterials Science & Engineering
10. Microfluidic systems for modeling digestive cancer: a review of recent progress
    Razavi, ZahraSadat, Soltani, Madjid, Pazoki-Toroudi, Hamidreza, Dabagh, Mahsa · 2024 · Biomedical Physics & Engineering Express
11. The Dawn of a New Pharmaceutical Epoch: Can AI and Robotics Reshape Drug Formulation?
    Pauric Bannigan, Riley J. Hickman, Alán Aspuru‐Guzik, Christine J. Allen · 2024 · Advanced Healthcare Materials
12. ADMET evaluation in drug discovery: 21. Application and industrial validation of machine learning algorithms for Caco-2 permeability prediction
    Dong Wang, Jieyu Jin, Guqin Shi, Jingxiao Bao, Zheng Wang, Shimeng Li, Peichen Pan, Dan Li, Yu Kang, Tingjun Hou · 2025 · Journal of Cheminformatics
13. A gut–brain axis on-a-chip platform for drug testing challenged with donepezil
    Francesca Fanizza, Simone Perottoni, Lucia Boeri, Francesca Donnaloja, Francesca Negro, francesca pugli, Gianluigi Forloni, Carmen Giordano, Diego Albani · 2025 · Lab on a Chip
14. CardioGenAI: a machine learning-based framework for re-engineering drugs for reduced hERG liability
    Gregory W. Kyro, Matthew T. Martin, Eric D. Watt, Víctor S. Batista · 2025 · Journal of Cheminformatics
15. Nanomedicine-induced pyroptosis for anti-tumor immunotherapy: Mechanism analysis and application prospects
    Yuelin Huang, Chunting Wang, Yanhong Chen, Dengbin Wang, Defan Yao · 2025 · Acta Pharmaceutica Sinica B
16. Structure‒tissue exposure/selectivity relationship (STR) correlates with clinical efficacy/safety
    Wei Gao, Hongxiang Hu, Lipeng Dai, Miao He, Hebao Yuan, Huixia Zhang, Jinhui Liao, Bo Wen, Yan Li, Maria Palmisano et al. · 2022 · Acta Pharmaceutica Sinica B
17. Optimization of the Prodrug Moiety of Remdesivir to Improve Lung Exposure/Selectivity and Enhance Anti-SARS-CoV-2 Activity
    Hongxiang Hu, Mohamed Dit Mady Traore, Ruiting Li, Hebao Yuan, Miao He, Bo Wen, Wei Gao, Colleen Beth Jonsson, Elizabeth Ann Fitzpatrick, Duxin Sun · 2022 · Journal of Medicinal Chemistry
18. Preformulation Studies: A Versatile Tool in Formulation Design
    Kailash Ahirwar, Rahul Shukla · 2023 · IntechOpen eBooks
19. The landscape of global research on diabetic neuropathy
    Mitra Tavakoli, Doris Klingelhöfer, Hassan Fadavi, David Alexander Groneberg · 2023 · Frontiers in Endocrinology
20. Artemisinin production strategies for industrial scale: Current progress and future directions
    Firdaus Qamar, Kudsiya Ashrafi, Anupam Singh, Prasanta Kumar Dash, Malik Zainul Abdin · 2024 · Industrial Crops and Products
21. Nanoscale Metal–Organic Frameworks and Nanoscale Coordination Polymers: From Synthesis to Cancer Therapy and Biomedical Imaging
    Xianghui Cao, Nana Feng, Qingqing Huang, Yang Liu · 2024 · ACS Applied Bio Materials
22. Intravitreal therapeutic nanoparticles for age-related macular degeneration: Design principles, progress and opportunities
    Yuhang Zhang, Stephanie Louise Watson, Yogambha Ramaswamy, Gurvinder Singh · 2024 · Advances in Colloid and Interface Science
23. Standardized generation of human iPSC-derived hematopoietic organoids and macrophages utilizing a benchtop bioreactor platform under fully defined conditions
    M. Ackermann, Fawaz Saleh, S. Abdin, Anna Rafiei Hashtchin, I. Gensch, Julia Golgath, Marco Carvalho Oliveira, A. H. H. Nguyen, Svenja Gaedcke, Arno Fenske et al. · 2024 · Stem cell research & therapeutics
24. Integrating natural commensals and pathogens into preclinical mouse models
    Barbara Rehermann, Andrea L. Graham, David Masopust, Sara E. Hamilton · 2024 · Nature reviews. Immunology
25. Conformalized Graph Learning for Molecular ADMET Property Prediction and Reliable Uncertainty Quantification
    Peiyao Li, Lan Hua, Zhechao Ma, Wenbo Hu, Ye Liu, Jun Zhu · 2024 · Journal of Chemical Information and Modeling
26. Advancing predictive toxicology: overcoming hurdles and shaping the future
    Sara Masarone, Katie V. Beckwith, Matthew R. Wilkinson, Shreshth Tuli, Amy Lane, Sam Windsor, Jordan S. Lane, Layla Hosseini-Gerami · 2025 · Digital Discovery
27. DrugGen enhances drug discovery with large language models and reinforcement learning
    Mahsa Naghavi Sheikholeslami, Navid Mazrouei, Yousof Gheisari, Afshin Fassihi, Matin Irajpour, Ali Motahharynia · 2025 · Scientific Reports
28. Sensorization of microfluidic brain-on-a-chip devices: Towards a new generation of integrated drug screening systems
    Attilio Marino, Matteo Battaglini, Marie Celine Lefevre, Maria Cristina Ceccarelli, Kamil Ziaja, Gianni Ciofani · 2023 · TrAC Trends in Analytical Chemistry
29. Vascular organs-on-chip made with patient-derived endothelial cells: technologies to transform drug discovery and disease modeling
    Chloe P. Whitworth, William J. Polacheck · 2023 · Expert Opinion on Drug Discovery
30. Standardization of zebrafish drug testing parameters for muscle diseases
    Muthukumar Karuppasamy, Katherine G. English, Clarissa A. Henry, M. Chiara Manzini, John M. Parant, Melissa A. Wright, Avnika Ashok Ruparelia, Peter David Currie, Vandana Gupta, James J. Dowling et al. · 2024 · Disease Models & Mechanisms
31. Basic models to advanced systems: harnessing the power of organoids-based microphysiological models of the human brain
    Katherine Boylin, Grace V. Aquino, Michael Purdon, Kimia Abedi, Magdalena J. Kasendra, Riccardo Barrile · 2024 · Biofabrication
32. TarKG: a comprehensive biomedical knowledge graph for target discovery
    Cong Zhou, Chuipu Cai, Xiaotian Huang, Song Wu, Junlin Yu, Jingwei Wu, Jiansong Fang, Guo‐Bo Li · 2024 · Bioinformatics
33. Drug pricing models, no ‘one-size-fits-all’ approach: a systematic review and critical evaluation of pricing models in an evolving pharmaceutical landscape
    Evert A. Manders, Sibren van den Berg, Saco J. de Visser, Carla E. M. Hollak · 2024 · The European Journal of Health Economics
34. Protective effects of herbal compounds against cyclophosphamide-induced organ toxicity: a pathway-centered approach
    Prathap Srirangan, Sabina Evan Prince · 2025 · Drug and Chemical Toxicology
35. Induced Pluripotent (iPSC) and Mesenchymal (MSC) Stem Cells for In Vitro Disease Modeling and Regenerative Medicine
    Egor Panferov, Maria Dodina, Vasiliy V. Reshetnikov, Anastasia Ryapolova, Roman A. Ivanov, Alexander V. Karabelsky, Ekaterina Minskaia · 2025 · International Journal of Molecular Sciences
36. Integrating New Approach Methodologies (NAMs) into Preclinical Regulatory Evaluation of Oncology Drugs
    Maryam Sadat Mirlohi, Tooba Yousefi, Amir Reza Aref, Amir Seyfoori · 2025 · Biomimetics
37. Gentamicin–Ascorbic Acid Encapsulated in Chitosan Nanoparticles Improved In Vitro Antimicrobial Activity and Minimized Cytotoxicity
    Mohamed A. Abdel-Hakeem, Ahmed I. Abd El Maksoud, Mohammed Abdullah Aladhadh, Khalid Abdulrahman Almuryif, Rafaat Mohamed Elsanhoty, Dalia Elebeedy · 2022 · Antibiotics
38. Organoids technology for advancing the clinical translation of cancer nanomedicine
    Dong‐Kun Zhao, Jie Liang, Xiao‐Yi Huang, Song Shen, Jun Wang · 2023 · Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology
39. Bioethical implications of organ‐on‐a‐chip on modernizing drug development
    Rahul G. Thakar, Kathleen N. Fenton · 2023 · Artificial Organs
40. A Drug Discovery Perspective on FDA Expedited Development and Incentive Programs
    Dean G. Brown · 2024 · Journal of Medicinal Chemistry
41. Design of new molecules against cervical cancer using DFT, theoretical spectroscopy, 2D/3D-QSAR, molecular docking, pharmacophore and ADMET investigations
    Said El Rhabori, Abdellah El Aissouq, Ossama Daouı, Souad Elkhattabi, Samir Chtita, Fouad Khalil · 2024 · Heliyon
42. Gigantol, a promising natural drug for inflammation: a literature review and computational based study
    Raihan Chowdhury, Md. Shimul Bhuia, Asraful Islam Rakib, Sakib Al Hasan, Manik Chandra Shill, Heba A. S. El‐Nashar, Mohamed El‐Shazly, Muhammad Torequl Islam · 2024 · Natural Product Research
43. Renal Organic Anion Transporters 1 and 3 In Vitro: Gone but Not Forgotten
    Pedro Caetano-Pinto, Simone H. Stahl · 2023 · International Journal of Molecular Sciences
44. Quantum-to-Classical Neural Network Transfer Learning Applied to Drug Toxicity Prediction
    Anthony M. Smaldone, Víctor S. Batista · 2024 · Journal of Chemical Theory and Computation
45. Mothra: Multiobjective de novo Molecular Generation Using Monte Carlo Tree Search
    Takamasa Suzuki, Dian Ma, Nobuaki Yasuo, Masakazu Sekijima · 2024 · Journal of Chemical Information and Modeling
46. Metabolic Stability of Fluorinated Small Molecules: A Physical Organic Chemistry Perspective
    Pankaj Bhattarai, Trevor A. Trombley, Ryan A. Altman · 2026 · Journal of Medicinal Chemistry
47. Toward better drug development: Three-dimensional bioprinting in toxicological research
    Diána Szűcs, Zsolt Fekete, Melinda Guba, Lajos Vince Kemény, Katalin Jemnitz, Emese Kis, Zoltán Veréb · 2023 · International Journal of Bioprinting
48. Compound combinations targeting longevity: Challenges and perspectives
    Olga Y. Rybina, Alexander V. Symonenko, ELENA G. PASYUKOVA · 2023 · Ageing Research Reviews
49. Generation of a drug-induced renal injury list to facilitate the development of new approach methodologies for nephrotoxicity
    Connor, Skylar, Li, Ting, Qu, Yanyan, Roberts, Ruth A, Tong, Weida · 2024 · Drug Discovery Today
50. Dose selection of novel anticancer drugs: exposing the gap between selected and required doses
    Catharina J. P. Op ’t Hoog, Niven Mehra, Marc Maliepaard, Kalijn F. Bol, Hans A. J. Gelderblom, Gabe S. Sonke, Adrianus Johannes De Langen, Niels W.C.J. van de Donk, Jeroen J. W. M. Janssen, Monique C. Minnema et al. · 2024 · The Lancet Oncology
51. 3D bioprinted breast cancer model reveals stroma-mediated modulation of extracellular matrix and radiosensitivity
    Théo Désigaux, Léo Comperat, Nathalie Dusserre, Marie‐Laure Stachowicz, Malou Lea, Jean‐William Dupuy, Anthony Vial, Michaël Molinari, Jean‐Christophe Fricain, François Paris et al. · 2024 · Bioactive Materials
52. How organ-on-a-chip is advancing cancer research and oncology - a cancer hallmarks’ perspective
    Leela Rani Avula, Piotr A. Grodzinski · 2024 · Frontiers in Lab on a Chip Technologies
53. Accelerating Parkinson’s Disease drug development with federated learning approaches
    Khanna, Amit, Adams, Jamie, Antoniades, Chrystalina, Bloem, Bastiaan R., Carroll, Camille, Cedarbaum, Jesse, Cosman, Joshua, Dexter, David T., Dockendorf, Marissa F., Edgerton, Jeremy et al. · 2024 · npj Parkinson's Disease
54. Microphysiological systems as reliable drug discovery and evaluation tools: Evolution from innovation to maturity
    Hye‐ran Moon, Nishanth Surianarayanan, Tarun Singh, Bumsoo Han · 2023 · Biomicrofluidics
55. Innovative Approaches for Drug Discovery: Quantifying Drug Distribution and Response with Raman Imaging
    Erin L. Dunnington, Brian S. Wong, Dan Fu · 2024 · Analytical Chemistry
56. Deciphering the physiopathology of neurodevelopmental disorders using brain organoids
    Olivier Dionne, Salomé Sabatié, Benoît Laurent · 2024 · Brain
57. Combined Chemo- and Photothermal Therapies of Non-Small Cell Lung Cancer Using Polydopamine/Au Hollow Nanospheres Loaded with Doxorubicin
    Xinbo Zhang, Bin Xu, Jiangwei Ni, Yucheng Xiang, Zhifeng He · 2024 · International Journal of Nanomedicine
58. Advancements, challenges, and future frontiers in covalent inhibitors and covalent drugs: A review
    Muhammad Salman Hameed, Hongxuan Cao, Guo Li, Lei Zeng, Yanliang Ren · 2024 · European Journal of Medicinal Chemistry Reports
59. AI-Based Computational Methods in Early Drug Discovery and Post Market Drug Assessment: A Survey
    Flora Rajaei, Cristian Minoccheri, Emily M. Wittrup, Richard C. Wilson, Brian D. Athey, Gilbert S. Omenn, Kayvan Najarian · 2024 · IEEE Transactions on Computational Biology and Bioinformatics
60. ToxSTK: A multi-target toxicity assessment utilizing molecular structure and stacking ensemble learning
    Surapong Boonsom, Panisara Chamnansil, Sarote Boonseng, Tarapong Srisongkram · 2024 · Computers in Biology and Medicine
61. A 3D spheroid model for assessing nanocarrier-based drug delivery to solid tumors
    Chitra Yadav, Alexander S. Evtushenko, Andrea Bistrović, Beatriz Lozano Torres, Ishtiaq Ahmed, Liuba Dvinskikh, Clemens F. Kaminski, Ljiljana Fruk · 2025 · npj Biomedical Innovations.
62. Genomics of drug target prioritization for complex diseases
    Robert K. Chen, Áine Duffy, Ron Do · 2025 · Nature Reviews Genetics
63. New developments and applications of human organoids
    Amanda Andersson-Rolf, Hans C. Clevers · 2026 · Nature Reviews Molecular Cell Biology
64. Toward 3D‐Bioprinted Models of the Liver to Boost Drug Development
    Giuseppe Guagliano, Cristina Volpini, Francesco Briatico Vangosa, Antonia Icaro Cornaglia, Livia Visai, Paola Petrini · 2022 · Macromolecular Bioscience
65. Dual-View Learning Based on Images and Sequences for Molecular Property Prediction
    Xiang Zhang, Hongxin Xiang, Xixi Yang, Jingxin Dong, Xiangzheng Fu, Xiangxiang Zeng, Haowen Chen, Keqin Li · 2023 · IEEE Journal of Biomedical and Health Informatics
66. Characterization of prevalent tyrosine kinase inhibitors and their challenges in glioblastoma treatment
    Mahdie Rahban, Sara Joushi, Hamideh Bashiri, Luciano Saso, Vahid Sheibani · 2024 · Frontiers in Chemistry
67. Modeling on in vivo disposition and cellular transportation of RNA lipid nanoparticles via quantum mechanics/physiologically-based pharmacokinetic approaches
    Wei Wang, Shiwei Deng, Jinzhong Lin, Defang Ouyang · 2024 · Acta Pharmaceutica Sinica B
68. Advances in Modeling Approaches for Oral Drug Delivery: Artificial Intelligence, Physiologically-Based Pharmacokinetics, and First-Principles Models
    Yehuda Arav · 2024 · Pharmaceutics
69. Translational Nanomedicines Across Human Reproductive Organs Modeling on Microfluidic Chips: State-of-the-Art and Future Prospects
    Ankur Sood, Anuj Kumar, Vijai Kumar Gupta, Chul Min Kim, Sung Soo Han · 2022 · ACS Biomaterials Science & Engineering
70. Comprehensive Two-Dimensional Gas Chromatography as a Bioanalytical Platform for Drug Discovery and Analysis
    Atiqah Zaid, Norfarizah Hanim Hassan, Philip John Marriott, Yong Foo Wong · 2023 · Pharmaceutics
71. Integrating Liver-Chip data into pharmaceutical decision-making processes
    Daniel Levner, Lorna C. Ewart · 2023 · Expert Opinion on Drug Discovery
72. The role of myelin in neurodegeneration: implications for drug targets and neuroprotection strategies
    Gabriella E Parrilla, Vivek Gupta, Roshana Vander Wall, Akanksha Salkar, Devaraj K. Basavarajappa, Mehdi Mirzaei, Nitin Chitranshi, Stuart L. Graham, Yuyi You · 2023 · Reviews in the Neurosciences
73. Building reproducible bridges to cross the “valley of death”
    Timothy M. Errington · 2024 · Journal of Clinical Investigation
74. 3D modeling of normal skin and cutaneous squamous cell carcinoma. A comparative study in 2D cultures, spheroids, and 3D bioprinted systems
    Agata Kurzyk, Anna Szumera‐Ciećkiewicz, Joanna Miłoszewska, Magdalena Chechlińska · 2024 · Biofabrication
75. Organoid models: the future companions of personalized drug development
    Francesco Piraino, Mariana Costa, Marine Meyer, Georgina H. Cornish, Camilla Ceroni, Virginie Garnier, Sylke Hoehnel, Nathalie Brandenberg · 2024 · Biofabrication
76. Toward structure–multiple activity relationships (SMARts) using computational approaches: A polypharmacological perspective
    Edgar López‐López, José L. Medina‐Franco · 2024 · Drug Discovery Today
77. Integrating transformers and many-objective optimization for drug design
    Nicholas Aksamit, Jinqiang Hou, Yifeng Li, Beatrice M. Ombuki-Berman · 2024 · BMC Bioinformatics
78. 3D Humanized Bioprinted Tubulointerstitium Model to Emulate Renal Fibrosis In Vitro
    Gabriele Addario, Julia Fernández‐Pérez, Chiara Formica, Konstantinos Karyniotakis, Lea Herkens, Sonja Djudjaj, Peter Boor, Lorenzo Moroni, Carlos Mota · 2024 · Advanced Healthcare Materials
79. Improving tumor microenvironment assessment in chip systems through next-generation technology integration
    Daniela Gaebler, Stephanie J. Hachey, Christopher C.W. Hughes · 2024 · Frontiers in Bioengineering and Biotechnology
80. New indolin-2-ones, possessing sunitinib scaffold as HDAC inhibitors and anti-cancer agents with potential VEGFR inhibition activity; design, synthesis and biological evaluation
    Mozhdeh Yousefian, Maryam Hashemi, Vahid Eskandarpour, Afshin Zarghi, Farzin Hadizadeh, Razieh Ghodsi · 2025 · Bioorganic Chemistry
81. Quetiapine fumarate-loaded mixed micelles in nasal in-situ gels: Enhancing efficacy for schizophrenia management
    Prashant Keshao Puranik, Yogesh Dhanraj Chainani, Ujban Hussain · 2025 · Next research.
82. Microfluidic organoid-slice-on-a-chip system for studying anti-cholangiocarcinoma drug efficacy and hepatorenal toxicity
    Jie Liu, Guohua Wu, Di Wu, Lin Wu, Chenwei Sun, Wenlong Zhang, Qijun Du, Qinrui Lu, Wenqi Hu, Hongyu Meng et al. · 2025 · Lab on a Chip
83. Generating 3D small binding molecules using shape-conditioned diffusion models with guidance
    Ziqi Chen, Bo Peng, T. Zhai, Daniel Adu‐Ampratwum, Xia Ning · 2025 · Nature Machine Intelligence
84. Drug innovation via integration of traditional Chinese and Western medicine
    Zhineng Li, Le Yang, Ling Kong, Hui Juan Sun, Ye Sun, Xiangmei Chen, Fengting Yin, Guangli Yan, Xijun Wang · 2025 · Science of Traditional Chinese Medicine
85. Dynamic clinical trial success rates for drugs in the 21st century
    Ying Zhou, Yintao Zhang, Hangwei Xu, Zhen Chen, Shijie Huang, Yinghong Li, Jianbo Fu, Hongning Zhang, Donghai Zhao, Xichen Lian et al. · 2025 · Nature Communications
86. Intracellular Pathways and Mechanisms of Colored Secondary Metabolites in Cancer Therapy
    Ani-Simona Sevastre, Elena Victoria Manea, Ştefana Oana Popescu, Daniela Elise Tache, Suzana Dănoiu, Veronica Sfredel, Ligia Gabriela Tătăranu, Anica Dricu · 2022 · International Journal of Molecular Sciences
87. Utilization of Cancer Cell Line Screening to Elucidate the Anticancer Activity and Biological Pathways Related to the Ruthenium-Based Therapeutic BOLD-100
    Brian Park, Paromita Raha, Jim Pankovich, Mark Bazett · 2022 · Cancers
88. Development of membrane‐active peptide therapeutics in oncology
    Charles H. Chen, Bing Zan, Jakob P. Ulmschneider, William C. Wimley, Timothy K. Lu, Martin B. Ulmschneider, Liping Zhou · 2023 · Journal of Peptide Science
89. Phytochemical Profiling, Biological Activities, and In Silico Molecular Docking Studies of Causonis trifolia (L.) Mabb. & J.Wen Shoot
    Samik Hazra, Anindya Sundar Ray, Swetarka Das, Arunava Das Gupta, Chowdhury Habibur Rahaman · 2023 · Plants
90. Unlocking the potential of snake venom-based molecules against the malaria, Chagas disease, and leishmaniasis triad
    José Rafael Almeida, Ana Gomes, Bruno de Souza Mendes, Luísa Aguiar, Mariana Caroline Ferreira, Mariana B.C. Brioschi, Denise Duarte, Fátima Nogueira, Sofia Cortes, David Salazar‐Valenzuela et al. · 2023 · International Journal of Biological Macromolecules
91. Nickel sulfide and dysprosium-doped nickel sulfide nanoparticles: Dysprosium-induced variation in properties, in vitro chemo-photothermal behavior, and antibacterial activity
    Govindaraj Sri Varalakshmi, Charan Singh Pawar, Rajakar Selvam, Wrenit Gem Pearl, Varnitha Manikantan, Archana Sumohan Pillai, Aleyamma Alexander, N. Rajendra Prasad, Israel V.M.V. Enoch, Premnath Dhanaraj · 2023 · International Journal of Pharmaceutics
92. Machine learning hypothesis-generation for patient stratification and target discovery in rare disease: our experience with Open Science in ALS
    Joseph Geraci, Ravi Bhargava, Bessi Qorri, Paul Leonchyk, Douglas J. Cook, Moses Cook, Fanny Sie, Luca Pani · 2024 · Frontiers in Computational Neuroscience
93. Advances of Layered Double Hydroxide‐Based Materials for Tumor Imaging and Therapy
    Ke Ma, Kezheng Chen, Sheng‐Lin Qiao · 2024 · The Chemical Record
94. Semiconducting polymer dots for multifunctional integrated nanomedicine carriers
    Ze Zhang, Chenhao Yu, Yuyang Wu, Zhe Wang, Haotian Xu, Yining Yan, Zhixin Zhan, Shengyan Yin · 2024 · Materials Today Bio
95. The potential of zebrafish as drug discovery research tool in immune-mediated inflammatory disease
    Carine Smith · 2024 · Inflammopharmacology
96. Tracking Drugs and Lipids: Quantitative Mass Spectrometry Imaging of Liposomal Doxorubicin Delivery and Bilayer Fate in Three-Dimensional Tumor Models
    Arbil Lopez, Joseph H. Holbrook, Gabrielle E. Kemper, Jessica K. Lukowski, William T. Andrews, Amanda B. Hummon · 2024 · Analytical Chemistry
97. In silico approaches for drug repurposing in oncology: a scoping review
    Bruno Raphael Ribeiro Cavalcante, Raíza Dias Freitas, Leonardo de Oliveira Siquara da Rocha, Roberto de Souza Batista dos Santos, Bruno Solano de Freitas Souza, Pablo Ivan Pereira Ramos, Gisele Vieira Rocha, Clarissa Araújo Gurgel Rocha · 2024 · Frontiers in Pharmacology
98. Advancements and Applications of Artificial Intelligence in Pharmaceutical Sciences: A Comprehensive Review
    N. Mottaghi-Dastjerdi, M. Soltany-Rezaee-Rad · 2024 · Iranian journal of pharmaceutical research
99. Orodispersible films prepared by hot-melt extrusion versus solvent casting
    Mathieu Reuther, Nicolas Rollet, Frédéric Debeaufort, Odile Chambin · 2025 · International Journal of Pharmaceutics
100. Discovery of Naphthyridinone Derivatives as Selective and Potent PKMYT1 Inhibitors with Antitumor Efficacy
     Bo Chen, Xiaofeng Liu, Tong Mu, Jiasu Xu, Dan Zhao, Fabian Dey, Yang Tang, Zhiheng Xu, June Yang, Ke Huang et al. · 2025 · Journal of Medicinal Chemistry