Microfluidic systems for modeling digestive cancer: a review of recent progress

The price of innovation: new estimates of drug development costs

DiMasi, J. A., Hansen, R. W., & Grabowski, H. G. (2003) · Journal of Health Economics · doi:10.1016/s0167-6296(02)00126-1 · Cited by 4,265 · see citing works

Principles of early drug discovery

Hughes, J., Rees, S., Kalindjian, S., & Philpott, K. (2011) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2010.01127.x · Cited by 2,859 · see citing works

Why 90% of clinical drug development fails and how to improve it?

Sun, D., Gao, W., Hu, H., & Zhou, S. (2022) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2022.02.002 · Cited by 1,763 · see citing works

Human organs-on-chips for disease modelling, drug development and personalized medicine

Ingber, D. E. (2022) · Nature Reviews Genetics · doi:10.1038/s41576-022-00466-9 · Cited by 1,589 · see citing works

Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME

Godoy, P., Hewitt, N. J., Albrecht, U., Andersen, M. E., Ansari, N., Bhattacharya, S., Bode, J. G., Bolleyn, J., Borner, C., Böttger, J., et al. (2013) · Archives of Toxicology · doi:10.1007/s00204-013-1078-5 · Cited by 1,280 · see citing works

Origin of Antibiotics and Antibiotic Resistance, and Their Impacts on Drug Development: A Narrative Review

Muteeb, G., Rehman, M. T., Shahwan, M. J., & Aatif, M. (2023) · Pharmaceuticals · doi:10.3390/ph16111615 · Cited by 1,238 · see citing works

Cytochrome P450 Enzymes and Drug Metabolism in Humans

Zhao, M., Ma, J., Li, M., Zhang, Y., Jiang, B., Zhao, X., Huai, C., Shen, L., Zhang, N., He, L., et al. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222312808 · Cited by 1,070 · see citing works

Organs-on-chips: into the next decade

Low, L. A., Mummery, C., Berridge, B. R., Austin, C. P., & Tagle, D. A. (2021) · Nature Reviews Drug Discovery · doi:10.1038/s41573-020-0079-3 · Cited by 1,029 · see citing works

Small molecule metabolites: discovery of biomarkers and therapeutic targets

Qiu, S., Cai, Y., Yao, H., Lin, C., Xie, Y., Tang, S., & Zhang, A. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01399-3 · Cited by 939 · see citing works

Colorectal Cancer: A Review of Carcinogenesis, Global Epidemiology, Current Challenges, Risk Factors, Preventive and Treatment Strategies

Hossain, M. S., Karuniawati, H., Jairoun, A. A., Urbi, Z., Ooi, D. J., John, A., Lim, Y. C., Kibria, K. M. K., Mohiuddin, A. K. M., Ming, L. C., et al. (2022) · Cancers · doi:10.3390/cancers14071732 · Cited by 920 · see citing works

PDMS with designer functionalities—Properties, modifications strategies, and applications

Wolf, M., Salieb–Beugelaar, G. B., & Hunziker, P. (2018) · Progress in Polymer Science · doi:10.1016/j.progpolymsci.2018.06.001 · Cited by 856 · see citing works

Human 3D vascularized organotypic microfluidic assays to study breast cancer cell extravasation

Jeon, J. S., Bersini, S., Gilardi, M., Dubini, G., Charest, J. L., Moretti, M., & Kamm, R. D. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1417115112 · Cited by 723 · see citing works

Organ-on-a-Chip: A New Paradigm for Drug Development

Ma, C., Peng, Y., Li, H., & Chen, W. (2020) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2020.11.009 · Cited by 589 · see citing works

Liver sinusoidal endothelial cells — gatekeepers of hepatic immunity

Shetty, S., Lalor, P. F., & Adams, D. H. (2018) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-018-0020-y · Cited by 523 · see citing works

Controlled anti-cancer drug release through advanced nano-drug delivery systems: Static and dynamic targeting strategies

Moradi Kashkooli, F., Soltani, M., & Souri, M. (2020) · Journal of Controlled Release · doi:10.1016/j.jconrel.2020.08.012 · Cited by 514 · see citing works

Colorectal cancer cell lines are representative models of the main molecular subtypes of primary cancer

Mouradov, D., Sloggett, C., Jorissen, R. N., Love, C. G., Li, S., Burgess, A. W., Arango, D., Strausberg, R. L., Buchanan, D., Wormald, S., et al. (2014) · Cancer Research · doi:10.1158/0008-5472.can-14-0013 · Cited by 375 · see citing works

Organoid cultures for the analysis of cancer phenotypes

Sachs, N., & Clevers, H. C. (2014) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2013.11.012 · Cited by 373 · see citing works

Organotypic liver culture models: meeting current challenges in toxicity testing

LeCluyse, E. L., Witek, R. P., Andersen, M. E., & Powers, M. J. (2012) · Critical Reviews in Toxicology · doi:10.3109/10408444.2012.682115 · Cited by 363 · see citing works

How much does it cost to research and develop a new drug? A systematic review and assessment

Schlander (2021) · PharmacoEconomics · doi:10.1007/s40273-021-01065-y · Cited by 360 · see citing works

Building consensus on definition and nomenclature of hepatic, pancreatic, and biliary organoids

Marsee, A., Roos, F. J. M., Verstegen, M. M. A., Marsee, A., Roos, F., Verstegen, M., Clevers, H., Vallier, L., Takebe, T., Huch, M., et al. (2021) · Cell Stem Cell · doi:10.1016/j.stem.2021.04.005 · Cited by 310 · see citing works

3D bioprinted silk fibroin hydrogels for tissue engineering

Kim, S. H., Hong, H., Ajiteru, O., Sultan, M. T., Lee, Y. J., Lee, J. S., Lee, O. J., Lee, H., Park, H. S., Choi, K. Y., et al. (2021) · Nature Protocols · doi:10.1038/s41596-021-00622-1 · Cited by 294 · see citing works

Drug compound screening in single and integrated multi-organoid body-on-a-chip systems

Skardal, A., Aleman, J., Forsythe, S. D., Rajan, S. A. P., Murphy, S. V., Devarasetty, M., Zarandi, N. P., Nzou, G., Wicks, R. T., Sadri‐Ardekani, H., et al. (2020) · Biofabrication · doi:10.1088/1758-5090/ab6d36 · Cited by 277 · see citing works

Aptamer-Enabled Efficient Isolation of Cancer Cells from Whole Blood Using a Microfluidic Device

Sheng, W., Chen, T., Kamath, R., Xiong, X., Tan, W., & Fan, Z. H. (2012) · Analytical Chemistry · doi:10.1021/ac3005633 · Cited by 236 · see citing works

Engineered Liver-On-A-Chip Platform to Mimic Liver Functions and Its Biomedical Applications: A Review

Deng, J., Wei, W., Chen, Z., Lin, B., Zhao, W., Luo, Y., & Zhang, X. (2019) · Micromachines · doi:10.3390/mi10100676 · Cited by 232 · see citing works

Biomedical Applications of Microfluidic Devices: A Review

Gharib, G., Bütün, İ., Muganlı, Z., Kozalak, G., Namlı, İ., Sarraf, S. S., Ahmadi, V. E., Toyran, E., van Wijnen, A. J., & Koşar, A. (2022) · Biosensors · doi:10.3390/bios12111023 · Cited by 230 · see citing works

Cancer stem cell-targeted bio-imaging and chemotherapeutic perspective

Han, J., Won, M., Kim, J. H., Jung, E., Min, K., Jangili, P., & Kim, J. S. (2020) · Chemical Society Reviews · doi:10.1039/d0cs00379d · Cited by 217 · see citing works

Microfluidic organ-on-a-chip models of human liver tissue

Moradi, E., Jalili‐Firoozinezhad, S., & Solati‐Hashjin, M. (2020) · Acta Biomaterialia · doi:10.1016/j.actbio.2020.08.041 · Cited by 206 · see citing works

Microfluidic organ-on-chip system for multi-analyte monitoring of metabolites in 3D cell cultures

Dornhof, J., Kieninger, J., Muralidharan, H., Maurer, J., Urban, G. A., & Weltin, A. (2021) · Lab on a Chip · doi:10.1039/d1lc00689d · Cited by 199 · see citing works

Recent advances in nonbiofouling PDMS surface modification strategies applicable to microfluidic technology

Gökaltun, A., Yarmush, M. L., Asatekin, A., & Usta, O. B. (2017) · TECHNOLOGY · doi:10.1142/s2339547817300013 · Cited by 188 · see citing works

Engineered strategies to enhance tumor penetration of drug-loaded nanoparticles

Souri, M., Soltani, M., Moradi Kashkooli, F., & Kiani Shahvandi, M. (2022) · Journal of Controlled Release · doi:10.1016/j.jconrel.2021.11.024 · Cited by 178 · see citing works

Investigating Nonalcoholic Fatty Liver Disease in a Liver-on-a-Chip Microfluidic Device

Gori, M., Simonelli, M. C., Giannitelli, S. M., Businaro, L., Trombetta, M., & Rainer, A. (2016) · PLoS ONE · doi:10.1371/journal.pone.0159729 · Cited by 177 · see citing works

Patient-specific modeling of stroma-mediated chemoresistance of pancreatic cancer using a three-dimensional organoid-fibroblast co-culture system

Schuth, S., Blanc, S. L., Krieger, T. G., Jabs, J., Schenk, M., Giese, N. A., Büchler, M. W., Eils, R., Conrad, C., & Strobel, O. (2022) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-022-02519-7 · Cited by 162 · see citing works

Towards principled design of cancer nanomedicine to accelerate clinical translation

Souri, M., Soltani, M., Moradi Kashkooli, F., Kiani Shahvandi, M., Chiani, M., Shariati, F. S., Mehrabi, M. R., & Munn, L. L. (2022) · Materials Today Bio · doi:10.1016/j.mtbio.2022.100208 · Cited by 159 · see citing works

The effects of monocytes on tumor cell extravasation in a 3D vascularized microfluidic model

Boussommier-Calleja, A., Atiyas, Y., Haase, K., Headley, M., Lewis, C., & Kamm, R. D. (2019) · Biomaterials · doi:10.1016/j.biomaterials.2018.03.005 · Cited by 158 · see citing works

A Comprehensive Review of Organ-on-a-Chip Technology and Its Applications

Doost, N. F., & Srivastava, S. K. (2024) · Biosensors · doi:10.3390/bios14050225 · Cited by 156 · see citing works

The basics of preclinical drug development for neurodegenerative disease indications

Steinmetz, K. L., & Spack, E. G. (2009) · BMC Neurology · doi:10.1186/1471-2377-9-s1-s2 · Cited by 155 · see citing works

A Four-Chemokine Signature Is Associated with a T-cell–Inflamed Phenotype in Primary and Metastatic Pancreatic Cancer

Romero, J. M., Grünwald, B., Jang, G.-H., Bavi, P. P., Jhaveri, A., Masoomian, M., Fischer, S. E., Zhang, A., Denroche, R. E., Lungu, I. M., et al. (2020) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-19-2803 · Cited by 146 · see citing works

Pancreatic Ductal Adenocarcinoma: Epidemiology and Risk Factors

Ushio, J., Kanno, A., Ikeda, E., Ando, K., Nagai, H., Miwata, T., Kawasaki, Y., Tada, Y., Yokoyama, K., Numao, N., et al. (2021) · Diagnostics · doi:10.3390/diagnostics11030562 · Cited by 132 · see citing works

Tumor-on-chip modeling of organ-specific cancer and metastasis

Piccolo, N. D., Shirure, V. S., Bi, Y., Goedegebuure, S. P., Gholami, S., Hughes, C. C. W., Fields, R. C., & George, S. C. (2021) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2021.05.008 · Cited by 130 · see citing works

Emerging trends in organ-on-a-chip systems for drug screening

Wang, Y., Gao, Y., Pan, Y., Zhou, D., Liu, Y., Yin, Y. B., Yang, J., Wang, Y., & Song, Y. (2023) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2023.02.006 · Cited by 130 · see citing works

Liver-on-a-Chip models of fatty liver disease

Hassan, S., Sebastian, S., Maharjan, S., Lesha, A., Carpenter, A., Liu, X., Xie, X., Livermore, C., Zhang, Y. S., & Zarrinpar, A. (2020) · Hepatology · doi:10.1002/hep.31106 · Cited by 127 · see citing works

Current Advances on 3D‐Bioprinted Liver Tissue Models

Ma, L., Wu, Y., Li, Y., Aazmi, A., Zhou, H., Zhang, B., & Yang, H. (2020) · Advanced Healthcare Materials · doi:10.1002/adhm.202001517 · Cited by 126 · see citing works

3D Printing Techniques and Their Applications to Organ-on-a-Chip Platforms: A Systematic Review

Carvalho, V. M., Gonçalves, I. M., Lage, T., Rodrigues, R. O., Minas, G. M. H., Teixeira, S., Moita, A., Hori, T., Kaji, H., & Lima, R. A. (2021) · Sensors · doi:10.3390/s21093304 · Cited by 126 · see citing works

Nanofibrous Composite with Tailorable Electrical and Mechanical Properties for Cardiac Tissue Engineering

Roshanbinfar, K., Vogt, L., Ruther, F., Roether, J. A., Boccaccini, A. R., & Engel, F. B. (2019) · Advanced Functional Materials · doi:10.1002/adfm.201908612 · Cited by 120 · see citing works

Nexus between in silico and in vivo models to enhance clinical translation of nanomedicine

Moradi Kashkooli, F., Soltani, M., Souri, M., Meaney, C., & Kohandel, M. (2021) · Nano Today · doi:10.1016/j.nantod.2020.101057 · Cited by 120 · see citing works

Patient-derived Organoid Pharmacotyping is a Clinically Tractable Strategy for Precision Medicine in Pancreatic Cancer

Seppälä, T. T., Zimmerman, J. W., Sereni, E., Plenker, D., Suri, R., Rozich, N., Blair, A. B., Thomas, D. L., Teinor, J. A., Javed, A. A., et al. (2020) · Annals of Surgery · doi:10.1097/sla.0000000000004200 · Cited by 118 · see citing works

Organ-on-a-chip platforms for accelerating the evaluation of nanomedicine

Chen, X., Zhang, Y. S., Zhang, X., & Liu, C. (2020) · Bioactive Materials · doi:10.1016/j.bioactmat.2020.09.022 · Cited by 108 · see citing works

Characteristics and Outcomes of Pancreatic Cancer by Histological Subtypes

Luo, G., Fan, Z., Gong, Y., Jin, K., Yang, C., Cheng, H., Huang, D., Ni, Q., Liu, C., & Yu, X. (2019) · Pancreas · doi:10.1097/mpa.0000000000001338 · Cited by 106 · see citing works

Fast and efficient microfluidic cell filter for isolation of circulating tumor cells from unprocessed whole blood of colorectal cancer patients

Ribeiro‐Samy, S., Oliveira, M. I., Pereira‐Veiga, T., Muinelo‐Romay, L., Carvalho, S., Gaspar, J., Freitas, P. P., López‐López, R., Costa, C., & Diéguez, L. (2019) · Scientific Reports · doi:10.1038/s41598-019-44401-1 · Cited by 104 · see citing works

Impaired Wound Healing of Alveolar Lung Epithelial Cells in a Breathing Lung-On-A-Chip

Felder, M., Trüeb, B. S., Stucki, A., Borcard, S., Stucki, J. D., Schnyder, B., Geiser, T., & Guenat, O. T. (2019) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2019.00003 · Cited by 103 · see citing works

Improving Pharmaceutical Product Development and Manufacturing: Impact on Cost of Drug Development and Cost of Goods Sold of Pharmaceuticals

Suresh, P., & Basu, P. K. (2008) · Journal of Pharmaceutical Innovation · doi:10.1007/s12247-008-9043-1 · Cited by 103 · see citing works

3D In Vitro Models for Investigating the Role of Stiffness in Cancer Invasion

Micalet, A., Moeendarbary, E., & Cheema, U. (2021) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.0c01530 · Cited by 97 · see citing works

Promising dawn in tumor microenvironment therapy: engineering oral bacteria

Wang, Z., Sun, W., Hua, R., Wang, Y., Li, Y., & Zhang, H. (2024) · International Journal of Oral Science · doi:10.1038/s41368-024-00282-3 · Cited by 97 · see citing works

Microfluidic Organoids-on-a-Chip: Quantum Leap in Cancer Research

Düzağaç, F., Saorin, G., Memeo, L., Canzonieri, V., & Rizzolio, F. (2021) · Cancers · doi:10.3390/cancers13040737 · Cited by 94 · see citing works

3d organ-on-a-chip: the convergence of microphysiological systems and organoids

Baptista, L. S., Porrini, C., Kronemberger, G. S., Kelly, D. J., & Perrault, C. M. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.1043117 · Cited by 90 · see citing works

Isolation of exosomes from whole blood by a new microfluidic device: proof of concept application in the diagnosis and monitoring of pancreatic cancer

Sancho‐Albero, M., Sebastián, V., Sese, J., Pazo-Cid, R., Mendoza, G., Arruebo, M., Martín-Duque, P., & Santamarı́a, J. (2020) · Journal of Nanobiotechnology · doi:10.1186/s12951-020-00701-7 · Cited by 89 · see citing works

Organotypic cancer tissue models for drug screening: 3D constructs, bioprinting and microfluidic chips

Radhakrishnan, J., Varadaraj, S., Dash, S. K., Sharma, A., & Verma, R. S. (2020) · Drug Discovery Today · doi:10.1016/j.drudis.2020.03.002 · Cited by 87 · see citing works

Complex in vitro model: A transformative model in drug development and precision medicine

Wang, L., Hu, D., Xu, J., Hu, J., & Wang, Y. (2023) · Clinical and Translational Science · doi:10.1111/cts.13695 · Cited by 87 · see citing works

Insights into the Hexose Liver Metabolism—Glucose versus Fructose

Geidl-Flueck, B., & Gerber, P. (2017) · Nutrients · doi:10.3390/nu9091026 · Cited by 85 · see citing works

A Human Liver‐on‐a‐Chip Platform for Modeling Nonalcoholic Fatty Liver Disease

Lasli, S., Kim, H., Lee, K., Suurmond, C. E., Goudie, M. J., Bandaru, P., Sun, W., Zhang, S., Zhang, N., Ahadian, S., et al. (2019) · Advanced Biosystems · doi:10.1002/adbi.201900104 · Cited by 85 · see citing works

Immunocompetent cancer-on-chip models to assess immuno-oncology therapy

Maulana, T. I., Kromidas, E., Wallstabe, L., Cipriano, M., Alb, M., Zaupa, C., Hudecek, M., Fogal, B., & Loskill, P. (2021) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2021.03.015 · Cited by 82 · see citing works

Enhancing Clinical Translation of Cancer Using Nanoinformatics

Soltani, M., Moradi Kashkooli, F., Souri, M., Zare Harofte, S., Harati, T., Khadem, A., Haeri Pour, M., & Raahemifar, K. (2021) · Cancers · doi:10.3390/cancers13102481 · Cited by 82 · see citing works

Effects of hypoxia and nanocarrier size on pH-responsive nano-delivery system to solid tumors

Soltani, M., Souri, M., & Moradi Kashkooli, F. (2021) · Scientific Reports · doi:10.1038/s41598-021-98638-w · Cited by 82 · see citing works

A 3D View of Colorectal Cancer Models in Predicting Therapeutic Responses and Resistance

Reidy, E., Leonard, N. A., Treacy, O., & Ryan, A. E. (2021) · Cancers · doi:10.3390/cancers13020227 · Cited by 81 · see citing works

Integration of AI and traditional medicine in drug discovery

Khan, S. R., Rijjal, D. A., Piro, A., & Wheeler, M. B. (2021) · Drug Discovery Today · doi:10.1016/j.drudis.2021.01.008 · Cited by 79 · see citing works

Human colorectal cancer-on-chip model to study the microenvironmental influence on early metastatic spread

Strelez, C., Chilakala, S., Ghaffarian, K., Lau, R., Spiller, E. R., Ung, N. M., Hixon, D., Yoon, A. Y., Sun, R., Lenz, H., et al. (2021) · iScience · doi:10.1016/j.isci.2021.102509 · Cited by 79 · see citing works

Organ-on-a-chip platforms for evaluation of environmental nanoparticle toxicity

Lu, R. X. Z., & Radisic, M. (2021) · Bioactive Materials · doi:10.1016/j.bioactmat.2021.01.021 · Cited by 78 · see citing works

Biomedical Application of Functional Materials in Organ-on-a-Chip

Ding, C., Chen, X., Kang, Q., & Yan, X. (2020) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2020.00823 · Cited by 77 · see citing works

Membrane integration into PDMS-free microfluidic platforms for organ-on-chip and analytical chemistry applications

Schneider, S., Gruner, D., Richter, A., & Loskill, P. (2021) · Lab on a Chip · doi:10.1039/d1lc00188d · Cited by 76 · see citing works

Organ on Chip Technology to Model Cancer Growth and Metastasis

Imparato, G., Urciuolo, F., & Netti, P. A. (2022) · Bioengineering · doi:10.3390/bioengineering9010028 · Cited by 76 · see citing works

An Oxygen-Concentration-Controllable Multiorgan Microfluidic Platform for Studying Hypoxia-Induced Lung Cancer-Liver Metastasis and Screening Drugs

Zheng, L., Wang, B., Sun, Y., Dai, B., Fu, Y., Zhang, Y., Wang, Y., Yang, Z., Sun, Z., Zhuang, S., et al. (2021) · ACS Sensors · doi:10.1021/acssensors.0c01846 · Cited by 75 · see citing works

Mesenchymal stem cell therapy for non-healing diabetic foot ulcer infection: New insight

Mahmoudvand, G., Rouzbahani, A. K., Razavi, Z. S., Mahjoor, M., & Afkhami, H. (2023) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2023.1158484 · Cited by 74 · see citing works

User-Friendly and Parallelized Generation of Human Induced Pluripotent Stem Cell-Derived Microtissues in a Centrifugal Heart-on-a-Chip

Schneider, O., Zeifang, L., Fuchs, S., Sailer, C., & Loskill, P. (2019) · Tissue Engineering Part A · doi:10.1089/ten.tea.2019.0002 · Cited by 73 · see citing works

In vitro vascularized liver and tumor tissue microenvironments on a chip for dynamic determination of nanoparticle transport and toxicity

Ozkan, A., Ghousifam, N., Hoopes, P. J., Yankeelov, T. E., & Rylander, M. N. (2019) · Biotechnology and Bioengineering · doi:10.1002/bit.26919 · Cited by 73 · see citing works

Molecular Regulation of Bile Acid Homeostasis

Choudhuri, S., & Klaassen, C. D. (2021) · Drug Metabolism and Disposition · doi:10.1124/dmd.121.000643 · Cited by 72 · see citing works

Cancer-on-a-Chip: Models for Studying Metastasis

Zhang, X., Karim, M., Hasan, M. M., Hooper, J., Wahab, R., Roy, S., & Al-Hilal, T. A. (2022) · Cancers · doi:10.3390/cancers14030648 · Cited by 72 · see citing works

Microfluidics meets 3D cancer cell migration

Mehta, P., Rahman, Z., ten Dijke, P., & Boukany, P. E. (2022) · Trends in cancer · doi:10.1016/j.trecan.2022.03.006 · Cited by 72 · see citing works

Microfluidic Organ-on-a-Chip Devices for Liver Disease Modeling In Vitro

Kanabekova, P., Kadyrova, A., & Kulsharova, G. (2022) · Micromachines · doi:10.3390/mi13030428 · Cited by 72 · see citing works

Pharmaceutical Preformulation and Formulation

(2016) · CRC Press eBooks · doi:10.3109/9781420073188 · Cited by 71 · see citing works

Organoid model: A new hope for pancreatic cancer treatment?

Chen, H., Zhuo, Q., Zeng, Y., Xu, X., & Ji, S. (2020) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2020.188466 · Cited by 67 · see citing works

A Microfluidic Tumor‐on‐a‐Chip for Assessing Multifunctional Liposomes' Tumor Targeting and Anticancer Efficacy

Ran, R., Wang, H., Hou, F., Liu, Y., Hui, Y., Petrovsky, N., Zhang, F., & Zhao, C. (2019) · Advanced Healthcare Materials · doi:10.1002/adhm.201900015 · Cited by 66 · see citing works

Construction of Exosome SORL1 Detection Platform Based on 3D Porous Microfluidic Chip and its Application in Early Diagnosis of Colorectal Cancer

Li, P., Chen, J., Chen, Y., Song, S., Huang, X., Yang, Y., Li, Y., Tong, Y., Yan, X., Li, J., et al. (2023) · Small · doi:10.1002/smll.202207381 · Cited by 66 · see citing works

Screening of aptamers specific to colorectal cancer cells and stem cells by utilizing On-chip Cell-SELEX

Hung, L.-Y., Wang, C., Che, Y.-J., Fu, C.-Y., Chang, H., Wang, K., & Lee, G. (2015) · Scientific Reports · doi:10.1038/srep10326 · Cited by 65 · see citing works

Myocardial slices come to age: an intermediate complexity in vitro cardiac model for translational research

Pitoulis, F. G., Watson, S. A., Perbellini, F., & Terracciano, C. M. (2019) · Cardiovascular Research · doi:10.1093/cvr/cvz341 · Cited by 64 · see citing works

Oxygen-carrying microfluidic microcapsules for enhancing chemo-sonodynamic therapy on patient-derived tumor organoid models

Huang, D., Zhao, C., Wen, B., Fu, X., Shang, L., Kong, W., & Zhao, Y. (2022) · Chemical Engineering Journal · doi:10.1016/j.cej.2022.134871 · Cited by 64 · see citing works

Primary Human Pancreatic Cancer Cells Cultivation in Microfluidic Hydrogel Microcapsules for Drug Evaluation

Song, T., Zhang, H., Luo, Z., Shang, L., & Zhao, Y. (2023) · Advanced Science · doi:10.1002/advs.202206004 · Cited by 64 · see citing works

Advances in high throughput cell culture technologies for therapeutic screening and biological discovery applications

Ryoo, H., Kimmel, H., Rondo, E., & Underhill, G. H. (2023) · Bioengineering & Translational Medicine · doi:10.1002/btm2.10627 · Cited by 64 · see citing works

Advancements in tissue engineering for cardiovascular health: a biomedical engineering perspective

Razavi, Z.-S., Soltani, M., Mahmoudvand, G., Farokhi, S., Karimi-Rouzbahani, A., Farasati-Far, B., Tahmasebi-Ghorabi, S., Pazoki-Toroudi, H., & Afkhami, H. (2024) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2024.1385124 · Cited by 64 · see citing works

Biomaterial substrate-derived compact cellular spheroids mimicking the behavior of pancreatic cancer and microenvironment

Wong, C., Han, H., Tien, Y., & Hsu, S. (2019) · Biomaterials · doi:10.1016/j.biomaterials.2019.05.013 · Cited by 62 · see citing works

Computational modeling of thermal combination therapies by magneto-ultrasonic heating to enhance drug delivery to solid tumors

Souri, M., Soltani, M., & Moradi Kashkooli, F. (2021) · Scientific Reports · doi:10.1038/s41598-021-98554-z · Cited by 61 · see citing works

Advances on colorectal cancer 3D models: The needed translational technology for nanomedicine screening

Castro, F., Pereira, C. L., Macedo, M. H., Almeida, A., Silveira, M. J., Dias, S., Cardoso, A. P., Oliveira, M. J., & Sarmento, B. F. C. C. (2021) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2021.06.001 · Cited by 61 · see citing works

Intestinal Models for Personalized Medicine: from Conventional Models to Microfluidic Primary Intestine-on-a-chip

Li, X., Chen, M., Zhao, S., & Wang, X. (2021) · Stem Cell Reviews and Reports · doi:10.1007/s12015-021-10205-y · Cited by 61 · see citing works

Microfluidic-Based Droplets for Advanced Regenerative Medicine: Current Challenges and Future Trends

Nazari, H., Heirani‐Tabasi, A., Ghorbani, S., Eyni, H., Bazaz, S. R., Khayati, M., Gheidari, F., Moradpour, K., Kehtari, M., Tafti, S. M. A., et al. (2021) · Biosensors · doi:10.3390/bios12010020 · Cited by 61 · see citing works

Establishment of Colorectal Cancer Organoids in Microfluidic-Based System

Pinho, D., Santos, D. R. D., Vila, A., & Carvalho, S. (2021) · Micromachines · doi:10.3390/mi12050497 · Cited by 59 · see citing works

A synergic approach to enhance long-term culture and manipulation of MiaPaCa-2 pancreatic cancer spheroids

Cavo, M., Cave, D. D., D’Amone, E., Gigli, G., Lonardo, E., & del Mercato, L. L. (2020) · Scientific Reports · doi:10.1038/s41598-020-66908-8 · Cited by 58 · see citing works

Recent advances in microfluidic technology and applications for anti-cancer drug screening

Shi, Y., Cai, Y., Cao, Y., Hong, Z., & Chai, Y. (2020) · TrAC Trends in Analytical Chemistry · doi:10.1016/j.trac.2020.116118 · Cited by 57 · see citing works

The application of organ-on-chip models for the prediction of human pharmacokinetic profiles during drug development

Keuper-Navis, M., Walles, M., Poller, B., Myszczyszyn, A., van der Made, T. K., Donkers, J. M., Amirabadi, H. E., Wilmer, M. J. G., Aan, S., Spee, B., et al. (2023) · Pharmacological Research · doi:10.1016/j.phrs.2023.106853 · Cited by 56 · see citing works

Cancer-initiating cells in human pancreatic cancer organoids are maintained by interactions with endothelial cells

Choi, J.-I., Jang, S. I., Hong, J., Kim, C. H., Kwon, S. S., Park, J. S., & Lim, J. (2020) · Cancer Letters · doi:10.1016/j.canlet.2020.10.012 · Cited by 55 · see citing works

Improving tumor treatment through intratumoral injection of drug-loaded magnetic nanoparticles and low-intensity ultrasound

Hosseinpour, A., Soltani, M., & Souri, M. (2024) · Scientific Reports · doi:10.1038/s41598-024-52003-9 · Cited by 53 · see citing works

Associations between vitamin D levels and periodontal attachment loss

Liu, X., Dai, B., Chuai, Y., Hu, M., & Zhang, H. (2023) · Clinical Oral Investigations · doi:10.1007/s00784-023-05100-4 · Cited by 53 · see citing works

Omentum-on-a-chip: a multicellular, vascularized microfluidic model of the human peritoneum for the study of ovarian cancer metastases

Ibrahim, L. I., Hajal, C., Offeddu, G. S., Gillrie, M. R., & Kamm, R. D. (2022) · Biomaterials · doi:10.1016/j.biomaterials.2022.121728 · Cited by 53 · see citing works

Intestine-on-a-chip: Next level in vitro research model of the human intestine

Donkers, J. M., Amirabadi, H. E., & van de Steeg, E. (2020) · Current Opinion in Toxicology · doi:10.1016/j.cotox.2020.11.002 · Cited by 52 · see citing works

Gastric Cancer Stem Cells: Current Insights into the Immune Microenvironment and Therapeutic Targets

Fu, L., Bu, L., Yasuda, T., Koiwa, M., Akiyama, T., Uchihara, T., Baba, H., & Ishimoto, T. (2020) · Biomedicines · doi:10.3390/biomedicines8010007 · Cited by 50 · see citing works

A spatiotemporal computational model of focused ultrasound heat-induced nano-sized drug delivery system in solid tumors

Kashkooli, F. M., Souri, M., Tavakkoli, J., & Kolios, M. C. (2023) · Drug Delivery · doi:10.1080/10717544.2023.2219871 · Cited by 50 · see citing works

Association of vitamin K, fibre intake and progression of periodontal attachment loss in American adults

Chuai, Y., Dai, B., Liu, X., Hu, M., Wang, Y., & Zhang, H. (2023) · BMC Oral Health · doi:10.1186/s12903-023-02929-9 · Cited by 49 · see citing works

Stimuli-sensitive nano-drug delivery with programmable size changes to enhance accumulation of therapeutic agents in tumors

Souri, M., Shahvandi, M. K., Chiani, M., Kashkooli, F. M., Farhangi, A. A., Mehrabi, M. R., Rahmim, A., Savage, V. M., & Soltani, M. (2023) · Drug Delivery · doi:10.1080/10717544.2023.2186312 · Cited by 47 · see citing works

Charge-Switchable nanoparticles to enhance tumor penetration and accumulation

Souri, M., Golzaryan, A., & Soltani, M. (2024) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2024.114310 · Cited by 47 · see citing works

Role of Endocytosis in Nanoparticle Penetration of 3D Pancreatic Cancer Spheroids

Durymanov, M. O., Kroll, C., Permyakova, A., & Reineke, J. (2019) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.8b01078 · Cited by 46 · see citing works

Generation and initial characterization of novel tumour organoid models to study human pancreatic cancer‐induced cachexia

Vaes, R. D. W., van Dijk, D. P. J., Welbers, T. T. J., Blok, M. J., Aberle, M. R., Heij, L. R., Boj, S. F., Damink, S. W. M. O., & Rensen, S. S. (2020) · Journal of Cachexia Sarcopenia and Muscle · doi:10.1002/jcsm.12627 · Cited by 46 · see citing works

Controlled pharmacokinetic anti-cancer drug concentration profiles lead to growth inhibition of colorectal cancer cells in a microfluidic device

Komen, J., Westerbeek, E. Y., Kolkman, R. W., Roesthuis, J., Lievens, C., van den Berg, A., & van der Meer, A. D. (2020) · Lab on a Chip · doi:10.1039/d0lc00419g · Cited by 45 · see citing works

Microfluidic co-culture of liver tumor spheroids with stellate cells for the investigation of drug resistance and intercellular interactions

Chen, Y., Sun, W., Lu, K., Wang, Y., Zhang, M., Zhang, H., & Hu, P. (2019) · The Analyst · doi:10.1039/c9an00612e · Cited by 44 · see citing works

Analysis of Magneto-Hyperthermia Duration in Nano-sized Drug Delivery System to Solid Tumors Using Intravascular-Triggered Thermosensitive-Liposome

Souri, M., Moradi Kashkooli, F., & Soltani, M. (2022) · Pharmaceutical Research · doi:10.1007/s11095-022-03255-5 · Cited by 44 · see citing works

The Revolutionary Roads to Study Cell–Cell Interactions in 3D In Vitro Pancreatic Cancer Models

Cave, D. D., Rizzo, R., Sáinz, B., Gigli, G., del Mercato, L. L., & Lonardo, E. (2021) · Cancers · doi:10.3390/cancers13040930 · Cited by 43 · see citing works

CRISPR-microfluidics nexus: Advancing biomedical applications for understanding and detection

Razavi, Z.-S., Soltani, M., Pazoki–Toroudi, H., & Chen, P. (2024) · Sensors and Actuators A Physical · doi:10.1016/j.sna.2024.115625 · Cited by 43 · see citing works

Cancer-on-chip: a 3D model for the study of the tumor microenvironment

Cauli, E., Polidoro, M. A., Marzorati, S., Bernardi, C., Rasponi, M., & Lleò, A. (2023) · Journal of Biological Engineering · doi:10.1186/s13036-023-00372-6 · Cited by 41 · see citing works

<i>In vitro</i> functional models for human liver diseases and drug screening: beyond animal testing

Paradiso, A., Volpi, M., Rinoldi, C., Celikkin, N., Contessi Negrini, N., Bilgen, M., Dallera, G., Pierini, F., Costantini, M., Święszkowski, W., et al. (2023) · Biomaterials Science · doi:10.1039/d1bm01872h · Cited by 40 · see citing works

Modelling of pancreatic cancer biology: transcriptomic signature for 3D PDX-derived organoids and primary cell line organoid development

Nelson, S. R., Zhang, C., Roche, S., O’Neill, F., Swan, N., Luo, Y., Larkin, A., Crown, J. P., & Walsh, N. (2020) · Scientific Reports · doi:10.1038/s41598-020-59368-7 · Cited by 40 · see citing works

Malnutrition and Alcohol-Associated Hepatitis

McClain, C. J., Rios, C. D., Condon, S., & Marsano, L. S. (2021) · Clinics in Liver Disease · doi:10.1016/j.cld.2021.03.002 · Cited by 39 · see citing works

Biomimetic lung-on-a-chip to model virus infection and drug evaluation

Tan, J., Guo, Q., Tian, L., Pei, Z., Li, D., Wu, M., Zhang, J., & Gao, X. (2022) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2022.106329 · Cited by 39 · see citing works

A comparative study between conventional chemotherapy and photothermal activated nano-sized targeted drug delivery to solid tumor

Kiani Shahvandi, M., Souri, M., Tavasoli, S., Moradi Kashkooli, F., Kar, S., & Soltani, M. (2023) · Computers in Biology and Medicine · doi:10.1016/j.compbiomed.2023.107574 · Cited by 37 · see citing works

Interactions of tumour-derived micro(nano)vesicles with human gastric cancer cells

Stec, M., Szatanek, R., Baj‐Krzyworzeka, M., Baran, J., Zembala, M., Barbasz, J., Waligórska, A., Dobrucki, J. W., Mytar, B., Szczepanik, A., et al. (2015) · Journal of Translational Medicine · doi:10.1186/s12967-015-0737-0 · Cited by 37 · see citing works

Multi-Organs-on-Chips for Testing Small-Molecule Drugs: Challenges and Perspectives

Çeçen, B., Karavasili, C., Nazir, M., Bhusal, A., Dogan, E., Shahriyari, F., Tamburacı, S., Büyüköz, M., Kozacı, L. D., & Miri, A. K. (2021) · Pharmaceutics · doi:10.3390/pharmaceutics13101657 · Cited by 37 · see citing works

A YAP/TAZ-CD54 axis is required for CXCR2 −CD44 − tumor-specific neutrophils to suppress gastric cancer

Nie, P., Zhang, W., Meng, Y., Lin, M., Guo, F., Zhang, H., Tong, Z., Wang, M., Chen, F., An, L., et al. (2022) · Protein & Cell · doi:10.1093/procel/pwac045 · Cited by 37 · see citing works

Organ-Chip Models: Opportunities for Precision Medicine in Pancreatic Cancer

Haque, M. R., Rempert, T. H., Al-Hilal, T. A., Wang, C., Bhushan, A., & Bishehsari, F. (2021) · Cancers · doi:10.3390/cancers13174487 · Cited by 35 · see citing works

Distinct biological characterization of the CD44 and CD90 phenotypes of cancer stem cells in gastric cancer cell lines

Shu, X., Liu, H., Pan, Y., Sun, L., Yu, L., Sun, L., Yang, Z., & Ran, Y. (2019) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-019-03548-1 · Cited by 35 · see citing works

Impact of tumor-parenchyma biomechanics on liver metastatic progression: a multi-model approach

Wang, Y., Brodin, E., Nishii, K., Frieboes, H. B., Mumenthaler, S. M., Sparks, J. L., & Macklin, P. (2021) · Scientific Reports · doi:10.1038/s41598-020-78780-7 · Cited by 34 · see citing works

SIRT1 activation attenuates palmitate induced apoptosis in C2C12 muscle cells

Taheripak, G., Sabeti, N., Najar, N., Razavi, Z., Saharkhiz, S., & Alipourfard, I. (2024) · Molecular Biology Reports · doi:10.1007/s11033-024-09250-w · Cited by 33 · see citing works

Anti-COVID-19 Nanomaterials: Directions to Improve Prevention, Diagnosis, and Treatment

Souri, M., Chiani, M., Farhangi, A. A., Mehrabi, M. R., Nourouzian, D., Raahemifar, K., & Soltani, M. (2022) · Nanomaterials · doi:10.3390/nano12050783 · Cited by 32 · see citing works

Physical Biomarkers of Disease Progression: On-Chip Monitoring of Changes in Mechanobiology of Colorectal Cancer Cells

Armistead, F. J., de Pablo, J. G., Gadêlha, H., Peyman, S. A., & Evans, S. D. (2020) · Scientific Reports · doi:10.1038/s41598-020-59952-x · Cited by 31 · see citing works

Towards embedding Caco-2 model of gut interface in a microfluidic device to enable multi-organ models for systems biology

Sakharov, D. A., Maltseva, D. V., Knyazev, E. N., Nikulin, S. V., Poloznikov, A. A., Shilin, S. A., Baranova, A. V., Tsypina, I. M., & Tonevitsky, A. (2019) · BMC Systems Biology · doi:10.1186/s12918-019-0686-y · Cited by 31 · see citing works

Identification of novel biomarkers, MUC5AC, MUC1, KRT7, GAPDH, CD44 for gastric cancer

Yang, J. (2020) · Medical Oncology · doi:10.1007/s12032-020-01362-0 · Cited by 31 · see citing works

Emerging roles of CD133 in the treatment of gastric cancer, a novel stem cell biomarker and beyond

Soleimani, A., Dadjoo, P., Avan, A., Soleimanpour, S., Rajabian, M., Ferns, G. A., Ryzhikov, M., Khazaei, M., & Hassanian, S. M. (2022) · Life Sciences · doi:10.1016/j.lfs.2021.120050 · Cited by 31 · see citing works

Intratumoral implantable drug delivery system for targeted localized chemotherapy in breast cancer

Souri, M., Elahi, S., & Soltani, M. (2024) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2024.105519 · Cited by 31 · see citing works

Biomimetic Microfluidic Platforms for the Assessment of Breast Cancer Metastasis

Sigdel, I., Gupta, N. K., Faizee, F., Khare, V. M., Tiwari, A. K., & Tang, Y. (2021) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2021.633671 · Cited by 30 · see citing works

Programmable intratumoral drug delivery to breast cancer using wireless bioelectronic device with electrochemical actuation

Souri, M., Elahi, S., & Soltani, M. (2024) · Expert Opinion on Drug Delivery · doi:10.1080/17425247.2024.2323211 · Cited by 28 · see citing works

An engineered pancreatic cancer model with intra-tumoral heterogeneity of driver mutations

Moon, H., Özçelikkale, A., Yang, Y., Elzey, B. D., Konieczny, S. F., & Han, B. (2020) · Lab on a Chip · doi:10.1039/d0lc00707b · Cited by 27 · see citing works

MEK inhibition suppresses metastatic progression of KRAS ‐mutated gastric cancer

Yamasaki, J., Hirata, Y., Otsuki, Y., Suina, K., Saito, Y., Masuda, K., Okazaki, S., Ishimoto, T., Saya, H., & Nagano, O. (2021) · Cancer Science · doi:10.1111/cas.15244 · Cited by 27 · see citing works

Unmasking the Deceptive Nature of Cancer Stem Cells: The Role of CD133 in Revealing Their Secrets

Pospieszna, J., Dams‐Kozlowska, H., Udomsak, W., Murias, M., & Kucińska, M. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241310910 · Cited by 27 · see citing works

Analysis of the Effect of Increased α2,3-Sialylation on RTK Activation in MKN45 Gastric Cancer Spheroids Treated with Crizotinib

Balmaña, M., Diniz, F., Feijão, T., Barrias, C. C., Mereiter, S., & Reis, C. A. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21030722 · Cited by 26 · see citing works

Cell Culture Model Evolution and Its Impact on Improving Therapy Efficiency in Lung Cancer

Roman, V., Mihaila, M. A., Radu, N., Marineata, S., Diaconu, C. C., & Bostan, M. (2023) · Cancers · doi:10.3390/cancers15204996 · Cited by 25 · see citing works

HER2+ advanced gastric cancer: Current state and opportunities (Review)

Hu, H.-H., Wang, S., Zhao, H., Chen, Z., Shi, X., & Chen, X. (2024) · International Journal of Oncology · doi:10.3892/ijo.2024.5624 · Cited by 25 · see citing works

The origin of gastric cancer stem cells and their effects on gastric cancer: Novel therapeutic targets for gastric cancer

Yang, Y., Meng, W., & Wang, Z. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.960539 · Cited by 24 · see citing works

Localized radiotherapy of solid tumors using radiopharmaceutical loaded implantable system: insights from a mathematical model

Piranfar, A., Souri, M., Rahmim, A., & Soltani, M. (2024) · Frontiers in Oncology · doi:10.3389/fonc.2024.1320371 · Cited by 24 · see citing works

Study of paraquat-induced pulmonary fibrosis using biomimetic micro-lung chips

Xia, J., Xiong, Z., Guo, J., Wang, Y., Luo, Y., Sun, Y., Guo, Z., Lu, B., Zhang, T., & Sun, W. (2022) · Biofabrication · doi:10.1088/1758-5090/ac999e · Cited by 23 · see citing works

Intercellular communication among liver cells in the perisinusoidal space of the injured liver: Pathophysiology and therapeutic directions

Ezhilarasan, D., & Najimi, M. (2022) · Journal of Cellular Physiology · doi:10.1002/jcp.30915 · Cited by 22 · see citing works

Expression of ALDH1A1 and CD133 is associated with the prognosis and effect of different chemotherapeutic regimens in gastric cancer

Liu, W., Liu, W., Gao, M., Zhang, Y., & Gu, K. (2019) · Oncology Letters · doi:10.3892/ol.2019.10798 · Cited by 22 · see citing works

Molecular mechanism of therapeutic approaches for human gastric cancer stem cells

Hsieh, H., Yu, M., Cheng, L.-C., Yeh, T., & Tsai, M.-M. (2022) · World Journal of Stem Cells · doi:10.4252/wjsc.v14.i1.76 · Cited by 22 · see citing works

Microphysiological systems to study colorectal cancer: state-of-the-art

Ramos, P., Carvalho, M. R., Chen, W., Yan, L., Zhang, C., He, Y., Reis, R. L., & Oliveira, J. M. (2023) · Biofabrication · doi:10.1088/1758-5090/acc279 · Cited by 20 · see citing works

Construction and application of liver cancer models in vitro

Shao, C., Zhang, Q., Kuang, G., Fan, Q., & Ye, F. (2022) · Engineered Regeneration · doi:10.1016/j.engreg.2022.07.004 · Cited by 18 · see citing works

Clinical translation of gold nanoparticles: obstacles and perspectives

Souri, M., & Soltani, M. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-19061-2.00010-9 · Cited by 17 · see citing works

Characteristics of immunophenotypes and immunological in tumor microenvironment and analysis of immune implication of CXCR4 in gastric cancer

Wen, F., Lu, X., Huang, W., Chen, X., Ruan, S., Gu, S., Gu, P., Li, Y., Liu, J., Liu, S., et al. (2022) · Scientific Reports · doi:10.1038/s41598-022-08622-1 · Cited by 17 · see citing works

A Brief Report on the Effect of Covid 19 Pandemic on Patients Undergoing Skin Graft Surgery in a Burns Hospital from March 2019 to March 2020

(2022) · Journal of Case Reports and Medical History · doi:10.54289/jcrmh2200138 · Cited by 15 · see citing works

CASC15: A Tumor-Associated Long Non-Coding RNA

Wang, B. L., Xu, W., Cai, Y., Guo, C., Zhou, G., & Yuan, C. (2020) · Current Pharmaceutical Design · doi:10.2174/1381612826666200922153701 · Cited by 14 · see citing works

A novel 4D cell culture mimicking stomach peristalsis altered gastric cancer spheroids growth and malignance

Zhao, J., Wang, R. L., Zhang, J., Zhao, Y., Qiao, S., Crouzier, T., Yan, H., & Tian, W. (2021) · Biofabrication · doi:10.1088/1758-5090/abf6bf · Cited by 14 · see citing works

Digitalization of toxicology: improving preclinical to clinical translation

Berridge, B. R., Baran, S. W., Kumar, V., Bratcher-Petersen, N., Ellis, M., Liu, C., & Robertson, T. L. (2024) · Frontiers in Toxicology · doi:10.3389/ftox.2024.1377542 · Cited by 14 · see citing works

Progress and application of lung-on-a-chip for lung cancer

Li, L., Bo, W., Wang, G., Juan, X., Xue, H., & Zhang, H. (2024) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2024.1378299 · Cited by 14 · see citing works

Microfluidic devices in tissue engineering

Bahrami, S., Baheiraei, N., Najafi-Ashtiani, M., Nour, S., & Razavi, M. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-818791-3.00008-5 · Cited by 13 · see citing works

Aberrant Expression TFR1/CD71 in Gastric Cancer Identifies a Novel Potential Prognostic Marker and Therapeutic Target

Cao, J., Hu, C., Xu, J., Han, J., Zhang, R., Cao, M., Li, Y., & Xu, Z. (2022) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2022/4257342 · Cited by 13 · see citing works

Cancer stem cells: advances in biology and clinical translation—a Keystone Symposia report

Cable, J., Pei, D., Reid, L., Wang, X. W., Bhatia, S., Karras, P., Melenhorst, J., Grompe, M., Lathia, J., Song, E., et al. (2021) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.14719 · Cited by 9 · see citing works

Circulating Metabolic Markers Related to the Diagnosis of Hepatocellular Carcinoma

Xie, D., Zhang, G., Ma, Y., Wu, D., Jiang, S., Zhou, S., & Jiang, X. (2022) · Journal of Oncology · doi:10.1155/2022/7840606 · Cited by 9 · see citing works

Modulation of Spheroid Forming Capacity and TRAIL Sensitivity by KLF4 and Nanog in Gastric Cancer Cells

To, H. T. N., Le, Q. A., Bui, H. T. T., Park, J., & Kang, D. (2022) · Current Issues in Molecular Biology · doi:10.3390/cimb45010018 · Cited by 9 · see citing works

Determination of therapeutic agents efficiencies of microsatellite instability high colon cancer cells in post‐metastatic liver biochip modeling

Garbioglu, D. B., Demir, N., Özel, C., Avcı, H., & Dinçer, M. (2021) · The FASEB Journal · doi:10.1096/fj.202100333r · Cited by 7 · see citing works

Microfluidics as a promising technology for personalized medicine

Roudsari, Z. O., Esmaeili, Z., Nasirzadeh, N., Keshel, S. H., Sefat, F., Bakhtyari, H., & Nadri, S. (2024) · Bioimpacts · doi:10.34172/bi.29944 · Cited by 6 · see citing works

Bioengineering of the liver

Redaelli, A. C. L., & Long, M. (2022) · APL Bioengineering · doi:10.1063/5.0087886 · Cited by 4 · see citing works

Pancreas-on-a-chip

Mirzababaei, S., Nigjeh, M. N., & Abdollahi, M. R. (2023) · Elsevier eBooks · doi:10.1016/b978-0-12-823536-2.00006-7 · Cited by 3 · see citing works

Engineering Microscale Biomimetic Hydroscaffold for Dynamic Three-Dimensional Modeling of Pancreatic Cancer

de Miollis, F., Souguir, Z., Poiraud, C., de Saxcé, J., Dercourt, L., Vandenhaute, E., Vincent, A., Maubon, N., SEUNINGEN, I. V., & Senez, V. (2021) · IEEE International Conference on Micro Electro Mechanical Systems (MEMS) · doi:10.1109/mems51782.2021.9375317 · Cited by 2 · see citing works

Microfluidic Models of the Tumor Microenvironment

Chang, C.-S., Holter, J. C., & Song, J. W. (2022) · Royal Society of Chemistry eBooks · doi:10.1039/9781839166013-00252 · Cited by 2 · see citing works

Advancing neurological disorders therapies: Organic nanoparticles as a key to blood-brain barrier penetration

Razavi, Z. S., Alizadeh, S. S., Razavi, F. S., Souri, M., & Soltani, M. (2025) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2025.125186 · Cited by 58 · see citing works

CRISPR innovations in tissue engineering and gene editing

Razavi, Z.-S., Soltani, M., Souri, M., & van Wijnen, A. J. (2024) · Life Sciences · doi:10.1016/j.lfs.2024.123120 · Cited by 50 · see citing works

CRISPR-Driven Biosensors: A New Frontier in Rapid and Accurate Disease Detection

Razavi, Z., Soltani, M., Souri, M., & Pazoki-Toroudi, H. (2026) · Critical Reviews in Analytical Chemistry · doi:10.1080/10408347.2024.2400267 · Cited by 45 · see citing works

Inorganic nanoparticles and blood-brain barrier modulation: Advancing targeted neurological therapies

Razavi, Z. S., Razavi, F. S., & Alizadeh, S. S. (2025) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2025.117357 · Cited by 38 · see citing works

Mesenchymal stromal cells in bone marrow niche of patients with multiple myeloma: a double-edged sword

Kamrani, S., Naseramini, R., Khani, P., Razavi, Z. S., Afkhami, H., Atashzar, M. R., Nasri, F., Alavimanesh, S., Saeidi, F., & Ronaghi, H. (2025) · Cancer Cell International · doi:10.1186/s12935-025-03741-x · Cited by 27 · see citing works

Application of novel strategies in chronic wound management with focusing on pressure ulcers: new perspective

Razavi, Z.-S., Sharafshadehi, S. A., Yousefi, M. H., Javaheri, F., Barghani, M. R. R., Afkhami, H., & Heidari, F. (2025) · Archives of Dermatological Research · doi:10.1007/s00403-024-03790-8 · Cited by 26 · see citing works

Stem cells and bio scaffolds for the treatment of cardiovascular diseases: new insights

Razavi, Z. S., Farokhi, S., Mahmoudvand, G., Rouzbahani, A. K., Far, B. F., Ghorabi, S. T., Pazoki–Toroudi, H., Fakhr, M. S., & Afkhami, H. (2024) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2024.1472103 · Cited by 24 · see citing works

Advancements in photoacoustic imaging for cancer diagnosis and treatment

Farajollahi, A., & Baharvand, M. (2024) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2024.124736 · Cited by 22 · see citing works

Mesenchymal stem cells and their exosomes: a novel approach to skin regeneration via signaling pathways activation

Kananivand, M., Nouri, F., Yousefi, M. H., Pajouhi, A., Ghorbani, H., Afkhami, H., & Razavi, Z. S. (2025) · Journal of Molecular Histology · doi:10.1007/s10735-025-10394-7 · Cited by 20 · see citing works

Current Research in Drug-Free Cancer Therapies

Andavar, A., Bhagavathi, V. R., Cousin, J., Parekh, N., Razavi, Z. S., & Tan, B. (2025) · Bioengineering · doi:10.3390/bioengineering12040341 · Cited by 20 · see citing works

Advanced synthesis and biomedical applications of colloidal quantum dots: Innovations in Imaging, drug delivery, and theranostics

Razavi, F. S., Razavi, Z. S., & Shahsavari, H. (2025) · Inorganic Chemistry Communications · doi:10.1016/j.inoche.2025.114533 · Cited by 19 · see citing works

Modern therapeutic approaches for hepatic tumors: progress, limitations, and future directions

Sadrinasab, S., Saket, S., Pourmohammadi, N., Khosravi, F., & Fakhr, M. S. (2025) · Discover Oncology · doi:10.1007/s12672-025-02773-z · Cited by 21 · see citing works

Advances and applications of hyperthermia in tumor therapy: Mechanisms, techniques, and clinical integration

Gu, C.-H., Zhang, J., Gao, W., Wang, J., Mou, K., Zhang, X., & Qi, J. (2025) · International Communications in Heat and Mass Transfer · doi:10.1016/j.icheatmasstransfer.2025.108895 · Cited by 18 · see citing works

Lessons Learned from Liver-on-Chip Platform

Razavi, Z. S., Razavi, F. S., Soltani, M., Pazoki–Toroudi, H., Farokhi, S., Azimi, I., & Ahmadi, N. (2025) · Annals of Biomedical Engineering · doi:10.1007/s10439-025-03779-y · Cited by 7 · see citing works

Role of Nuclear Receptors on the Progression of Multiple Sclerosis: A Review

Babaalizadeh, B., Kalaki-Jouybari, F., Kahaki, F. A., Afkhami, H., & Razavi, Z.-S. (2025) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-025-01563-z · Cited by 7 · see citing works

Mechano-Organ-on-Chip for Cancer Research

Wang, L., Cheung, J. C., Zhao, X., Khoo, B. L., & Wong, S. H. D. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27031330 · Cited by 7 · see citing works

Integrative insights into the oral microbiome's role in systemic diseases: novel therapeutic strategies and future directions

Yarahmadi, A., Emrahoglu, S., Afkhami, H., Mehdipour, A., & Aghaali, M. (2025) · Antonie van Leeuwenhoek · doi:10.1007/s10482-025-02190-w · Cited by 4 · see citing works

The role of the tumor microenvironment in mediating radiopharmaceutical therapy: bridging nuclear medicine and cancer immunotherapy

Wang, Z.-P., Li, A.-Q., Wusiman, D., Wu, R., Zhu, J.-M., Li, X.-R., Guo, Y.-N., Chaipanichkul, P., Okoli, U. A., Koh, S., et al. (2026) · Military Medical Research · doi:10.1016/j.mmr.2026.100038 · Cited by 4 · see citing works

Advancing Congenital Heart Defect Treatments: Synergistic Approaches with Stem Cells and Functional Scaffolds

Razavi, Z. S., & Afkhami, H. (2025) · Stem Cell Reviews and Reports · doi:10.1007/s12015-025-10996-4 · Cited by 2 · see citing works

Genetic-bioengineering of nanotechnology in cell-specific pharmaceutical targeting: Biological, pharmacological, and biochemical impact of nanomaterials-based breast cancer therapies

Mohammadi, J., Ebrahimi, S., Ghodousi, M., Mahmoodi, M., Hheidari, A., Pishbin, E., Kharaba, Z. J., Rahdar, A., & Ferreira, L. F. R. (2024) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2024.106249 · Cited by 3 · see citing works

Navigating the challenges: ultrasound innovations in brain glioma surgery

Sadrinasab, S., Aminiyan, A., Saket, S., Khosravi, F., Pourmohammadi, N., & Fakhr, M. S. (2025) · Frontiers in Neurology · doi:10.3389/fneur.2025.1553018 · Cited by 1 · see citing works

Precision Nanotechnology: Revolutionizing Therapeutic Strategies Against Drug-Resistant Breast Cancer

Razavi, Z.-S., Mottaghi, A., Dmitrieva, L., Fallahianshafiei, S., Olfat, E., & Ahmadi, N. (2026) · Annals of Biomedical Engineering · doi:10.1007/s10439-025-03963-0 · Cited by 1 · see citing works

Iron, inflammation, and intestinal tumors: the crucial triad in colorectal cancer progression and therapy

Abediasl, M., Siavash, M., Esfahani, S. S., Amini, Z., Amiri, K., Saket, S., Esmaeili, E., Rafizadeh, F., Saraei, R., & Fakhr, M. S. (2026) · Clinical & Translational Oncology · doi:10.1007/s12094-026-04225-8 · Cited by 1 · see citing works

Theranostic Potential of Extracellular Vesicles

Afkhami, H., Razavi, Z. S., Yousefi, M. H., Yang, P., Reza, M. A. S., & Sheykhhasan, M. (2026) · Molecular and translational medicine · doi:10.1007/978-3-032-23810-8_11

Complex in vitro 3D models of digestive system tumors to advance precision medicine and drug testing: Progress, challenges, and trends

Song, S., Li, B., Carvalho, M. R., Wang, H., Mao, D., Wei, J., Chen, W., Weng, Z.-H., Chen, Y., Deng, C., et al. (2022) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2022.108276 · Cited by 10 · see citing works

Recent Advances of Organ-on-a-Chip in Cancer Modeling Research

Liu, X., Su, Q., Zhang, X., Yang, W., Ning, J., Jia, K., Xin, J., Li, H., Yu, L., Liao, Y., et al. (2022) · Biosensors · doi:10.3390/bios12111045 · Cited by 68 · see citing works

Organ on Chip Technology to Model Cancer Growth and Metastasis

Imparato, G., Urciuolo, F., & Netti, P. A. (2022) · Bioengineering · doi:10.3390/bioengineering9010028 · Cited by 76 · see citing works

Tumor-on-chip modeling of organ-specific cancer and metastasis

Piccolo, N. D., Shirure, V. S., Bi, Y., Goedegebuure, S. P., Gholami, S., Hughes, C. C. W., Fields, R. C., & George, S. C. (2021) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2021.05.008 · Cited by 130 · see citing works

Recent advances in cancer-on-a-chip tissue models to dissect the tumour microenvironment

Seaman, K., Sun, Y., & You, L. (2023) · Med-X · doi:10.1007/s44258-023-00011-1 · Cited by 20 · see citing works