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An in vitro comparison of dentifrice formulations in three distinct oral microbiotas

Ledder, Ruth G., McBain, Andrew J.·2012·Archives of Oral Biology
DOI 10.1016/j.archoralbio.2011.08.004
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Abstract

Objectives In vitro biofilm models, representative of some aspects of nascent, supra-gingival plaques (Hydroxyapatite Disc Biofilm Models), developed supra-gingival plaques (Modified Drip-flow Biofilm Reactors) and sub-gingival plaques (Multiple Sorbarod Devices) were used to compare the antimicrobial effects of a triclosan-containing dentifrice with a stannous fluoride and zinc lactate combination. Design Triplicate salivary biofilm microcosms were maintained for 2d (hydroxyapatite discs), 5d (Sorbarods) or up to 6d (drip flow reactors). Dentifrice slurries (10%, w/v) were added once to the discs and repeatedly to the Drip Flow Reactors and Sorbarods. Plaques were analysed by differential culture and gravimetrically. Results Whilst both dentifrices were comparably effective at reducing viability and plaque accumulation in mature supragingival plaques, the triclosan dentifrice produced comparatively larger reductions in total streptococci and anaerobes in nascent plaques (p Conclusions We have used a multi-model approach to determine the effectiveness and specificity of dentifrices against compositionally distinct plaques. Whilst both formations reduced bacterial viability and plaque accumulation, their effects could be differentiated in nascent and deep plaques where the triclosan dentifrice caused larger viability reductions.

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Metadata

Authors
Ledder, R. G., & McBain, A. J.
Venue
Archives of Oral Biology
Publisher
Elsevier BV
Published
2012-02
Volume
57
Issue
2
Pages
139-147
ISSN
0003-9969
DOI
10.1016/j.archoralbio.2011.08.004
Cited by
17
References
0
Language
en
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)

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