Cited by 28Salivary Gland Disorders and FunctionsCystic Fibrosis Research AdvancesDental Health and Care Utilization

Salivary flow rate and biochemical composition analysis in stimulated whole saliva of children with cystic fibrosis

da Silva Modesto, Karine Barros, de Godói Simões, Jéssica Bueno, de Souza, Amanda Ferreira, Damaceno, Neiva, Duarte, Danilo Antonio, Leite, Mariana Ferreira, de Almeida, Eliete Rodrigues·2015·Archives of Oral Biology

Abstract

Objective It is recognized that cystic fibrosis (CF) patients present a risk for oral diseases, since it affects exocrine glands, and the treatment consists of a carbohydrate-rich diet. Recognizing the protective function of saliva on maintaining oral health, the aim of the study was to evaluate salivary parameters in stimulated whole saliva from children with CF. Methods A case-control study was conducted comparing stimulated whole saliva of healthy (n=28; control group) and CF children (n=21; experimental group). Salivary flow rate, initial pH, buffer capacity (total and in each range of pH), total protein and sialic acid (total, free, and conjugated) concentration, α-amylase and salivary peroxidase activities were evaluated. Data were compared by two-tailed Student t test (95% CI; p ≤ 0.05). Results CF patients presented a significant reduction in salivary parameters compared with the control group (p ≤ 0.05): salivary flow rate (36%), buffer capacity (pH range from 6.9 to 6.0), sialic acid concentration (total 75%, free 61%, and conjugated 83%); α-amylase and salivary peroxidase activities (55%). Additionally, a significant increase in total protein concentration (180%) of stimulated whole saliva from CF patients was verified compared with the control group (p ≤ 0.05). Conclusion Children with CF presented significant changes in salivary composition, including salivary flow rate, buffering capacity and protective proteins of the oral cavity, compared with children without…

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Crossref · 10.1016/j.archoralbio.2015.08.007

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Authors
da Silva Modesto, K. B., de Godói Simões, J. B., de Souza, A. F., Damaceno, N., Duarte, D. A., Leite, M. F., & de Almeida, E. R.
Affiliations
  • Faculdade de Ciências Médicas da Santa Casa de São Paulo (BR)
  • Universidade Cruzeiro do Sul (BR)
Corresponding author
Leite, Mariana Ferreira
Venue
Archives of Oral Biology
Publisher
Elsevier BV
Published
2015-11
Volume
60
Issue
11
Pages
1650-1654
ISSN
0003-9969 (ISSN-L)
OpenAlex
W2103656294
Cited by
28
References
39
Citations by year
2026: 4 · 2024: 2 · 2023: 2 · 2022: 3 · 2021: 6 · 2020: 3 · 2019: 3 · 2018: 1 · 2017: 3 · 2016: 1
FWCI
1.23
Type
journal article
Language
en
Open access
closed
Locations
  • Archives of Oral Biology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Physiology › Salivary Gland Disorders and Functions
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Cystic Fibrosis Research Advances
  • Health Sciences › Dentistry › Periodontics › Dental Health and Care Utilization
Keywords
cystic fibrosis, salivary flow rate, stimulated whole saliva, salivary buffering capacity, salivary pH, sialic acid, salivary proteins, alpha-amylase, salivary peroxidase, oral health, children
MeSH terms
alpha-Amylases, Buffers, Child, Cystic Fibrosis, Female, Humans, Hydrogen-Ion Concentration, Male, Peroxidase, Saliva, Salivary Proteins and Peptides, Secretory Rate, Case-Control Studies, N-Acetylneuraminic Acid

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