Maturation par bêtaméthasone au cours d'une grossesse de femme présentant un diabète compliqué: le mieux est-il l'ennemi du bien?
Abstract
Diabetic pregnancy is a precarious situation, both for mother and fetus, because it increases the risk of prematurity and respiratory distress. We report 3 cases of severe acute complications following antenatal betamethasone treatment in mothers presenting with severe diabetes. Corticosteroids are strongly recommended to prevent prematurity complications in newborns. We highlight the high risk profile of theses pregnancies, the effect of this treatment on the mother and the child, and question the real benefit of corticotherapy for these fragile newborns. The metabolic and blood pressure balance is dangerously disturbed in such pregnancies by this treatment. This brings the question of how justified are corticosteroids in such cases?
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In pregnancy, the baseline insulin-resistant state amplifies glucocorticoid effects, explaining the dramatic increases in insulin requirements and heightened risk of severe decompensation.
“In pregnancy, the baseline insulin‐resistant state amplifies GC effects, explaining the dramatic increases in insulin requirements and heightened risk of severe decompensation.”
From A systematic review of glucocorticoid use in type 1 diabetes: Glycaemic effects and clinical management strategies (2026) · cites this paper as [43]
Cites
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- Authors
- Barondiot, C., Morel, O., Vieux, R., Sery, G.-A., Floriot, M., & Hascoet, J.-M.
- Affiliations
- Centre Hospitalier Régional et Universitaire de Nancy (FR)
- Venue
- Archives de Pédiatrie
- Publisher
- Elsevier BV
- Published
- 2007-08
- Volume
- 14
- Issue
- 8
- Pages
- 989-992
- ISSN
- 0929-693X (ISSN-L)
- OpenAlex
- W1976536665
- Cited by
- 8
- References
- 16
- Citations by year
- 2026: 2 · 2025: 1 · 2024: 1 · 2016: 1 · 2013: 2
- FWCI
- 0.39
- Type
- journal article
- Language
- fr
- Open access
- closed
- Locations
- Archives de Pédiatrie (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Obstetrics and Gynecology › Gestational Diabetes Research and Management
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Neonatal Respiratory Health Research
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Pregnancy and Medication Impact
- Keywords
- betamethasone, antenatal corticosteroids, diabetes in pregnancy, preterm birth, respiratory distress syndrome, corticosteroid adverse effects, maternal blood pressure, neonatal outcomes
- MeSH terms
- Adult, Betamethasone, Female, Glucocorticoids, Humans, Hyaline Membrane Disease, Infant, Newborn, Infant, Premature, Infant, Premature, Diseases, Male, Pregnancy, Pregnancy in Diabetics, Severity of Illness Index, Pregnancy, High-Risk, Paraparesis, Spastic
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